KEGG   Homo sapiens (human): 2353
Entry
2353              CDS       T01001                                 
Symbol
FOS, AP-1, C-FOS, p55
Name
(RefSeq) Fos proto-oncogene, AP-1 transcription factor subunit
  KO
K04379  proto-oncogene protein c-fos
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04024  cAMP signaling pathway
hsa04210  Apoptosis
hsa04380  Osteoclast differentiation
hsa04620  Toll-like receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04668  TNF signaling pathway
hsa04713  Circadian entrainment
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04932  Non-alcoholic fatty liver disease
hsa04935  Growth hormone synthesis, secretion and action
hsa05031  Amphetamine addiction
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05135  Yersinia infection
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05161  Hepatitis B
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05224  Breast cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05323  Rheumatoid arthritis
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06210  ERK signaling (cancer)
nt06211  Other MAPK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06223  TNF signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06461  Huntington disease
nt06516  TNF signaling
nt06517  TLR signaling
nt06526  MAPK signaling
  Element
N00188  IL1-IL1R-JNK signaling pathway
N00438  TLR2/4-MAPK signaling pathway
N00446  TNF-JNK signaling pathway
N00447  HIV Vpr/Tat to TNF-JNK signaling pathway
N00509  HTLV-1 Tax to SRF-mediated transcription
N00545  HBV HBx to ERK signaling pathway
N01344  NNK/NNN to RAS-ERK signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01353  E2 to RAS-ERK signaling pathway
N01407  Metals to JNK signaling pathway
N01408  Metals to RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    2353 (FOS)
   04668 TNF signaling pathway
    2353 (FOS)
   04024 cAMP signaling pathway
    2353 (FOS)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    2353 (FOS)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    2353 (FOS)
   04660 T cell receptor signaling pathway
    2353 (FOS)
   04658 Th1 and Th2 cell differentiation
    2353 (FOS)
   04659 Th17 cell differentiation
    2353 (FOS)
   04657 IL-17 signaling pathway
    2353 (FOS)
   04662 B cell receptor signaling pathway
    2353 (FOS)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    2353 (FOS)
   04917 Prolactin signaling pathway
    2353 (FOS)
   04921 Oxytocin signaling pathway
    2353 (FOS)
   04926 Relaxin signaling pathway
    2353 (FOS)
   04935 Growth hormone synthesis, secretion and action
    2353 (FOS)
   04928 Parathyroid hormone synthesis, secretion and action
    2353 (FOS)
  09156 Nervous system
   04725 Cholinergic synapse
    2353 (FOS)
   04728 Dopaminergic synapse
    2353 (FOS)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    2353 (FOS)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2353 (FOS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2353 (FOS)
   05207 Chemical carcinogenesis - receptor activation
    2353 (FOS)
   05208 Chemical carcinogenesis - reactive oxygen species
    2353 (FOS)
   05231 Choline metabolism in cancer
    2353 (FOS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    2353 (FOS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    2353 (FOS)
   05224 Breast cancer
    2353 (FOS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    2353 (FOS)
   05170 Human immunodeficiency virus 1 infection
    2353 (FOS)
   05161 Hepatitis B
    2353 (FOS)
   05171 Coronavirus disease - COVID-19
    2353 (FOS)
   05162 Measles
    2353 (FOS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2353 (FOS)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    2353 (FOS)
   05132 Salmonella infection
    2353 (FOS)
   05135 Yersinia infection
    2353 (FOS)
   05133 Pertussis
    2353 (FOS)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    2353 (FOS)
   05142 Chagas disease
    2353 (FOS)
  09163 Immune disease
   05323 Rheumatoid arthritis
    2353 (FOS)
  09165 Substance dependence
   05031 Amphetamine addiction
    2353 (FOS)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    2353 (FOS)
   05418 Fluid shear stress and atherosclerosis
    2353 (FOS)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    2353 (FOS)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    2353 (FOS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2353 (FOS)
   04131 Membrane trafficking [BR:hsa04131]
    2353 (FOS)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, Fos
    2353 (FOS)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    2353 (FOS)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf MIC19_MIC25 DUF3450 HALZ Macoilin
Other DBs
NCBI-GeneID: 2353
NCBI-ProteinID: NP_005243
OMIM: 164810
HGNC: 3796
Ensembl: ENSG00000170345
UniProt: P01100 Q6FG41
Structure
LinkDB
Position
14:75278828..75282230
AA seq 380 aa
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL
NT seq 1143 nt   +upstreamnt  +downstreamnt
atgatgttctcgggcttcaacgcagactacgaggcgtcatcctcccgctgcagcagcgcg
tccccggccggggatagcctctcttactaccactcacccgcagactccttctccagcatg
ggctcgcctgtcaacgcgcaggacttctgcacggacctggccgtctccagtgccaacttc
attcccacggtcactgccatctcgaccagtccggacctgcagtggctggtgcagcccgcc
ctcgtctcctccgtggccccatcgcagaccagagcccctcaccctttcggagtccccgcc
ccctccgctggggcttactccagggctggcgttgtgaagaccatgacaggaggccgagcg
cagagcattggcaggaggggcaaggtggaacagttatctccagaagaagaagagaaaagg
agaatccgaagggaaaggaataagatggctgcagccaaatgccgcaaccggaggagggag
ctgactgatacactccaagcggagacagaccaactagaagatgagaagtctgctttgcag
accgagattgccaacctgctgaaggagaaggaaaaactagagttcatcctggcagctcac
cgacctgcctgcaagatccctgatgacctgggcttcccagaagagatgtctgtggcttcc
cttgatctgactgggggcctgccagaggttgccaccccggagtctgaggaggccttcacc
ctgcctctcctcaatgaccctgagcccaagccctcagtggaacctgtcaagagcatcagc
agcatggagctgaagaccgagccctttgatgacttcctgttcccagcatcatccaggccc
agtggctctgagacagcccgctccgtgccagacatggacctatctgggtccttctatgca
gcagactgggagcctctgcacagtggctccctggggatggggcccatggccacagagctg
gagcccctgtgcactccggtggtcacctgtactcccagctgcactgcttacacgtcttcc
ttcgtcttcacctaccccgaggctgactccttccccagctgtgcagctgcccaccgcaag
ggcagcagcagcaatgagccttcctctgactcgctcagctcacccacgctgctggccctg
tga

KEGG   Homo sapiens (human): 3725
Entry
3725              CDS       T01001                                 
Symbol
JUN, AP-1, AP1, c-Jun, cJUN, p39
Name
(RefSeq) Jun proto-oncogene, AP-1 transcription factor subunit
  KO
K04448  transcription factor AP-1
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04024  cAMP signaling pathway
hsa04137  Mitophagy - animal
hsa04210  Apoptosis
hsa04310  Wnt signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04530  Tight junction
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04668  TNF signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05135  Yersinia infection
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05161  Hepatitis B
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05224  Breast cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05321  Inflammatory bowel disease
hsa05323  Rheumatoid arthritis
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06210  ERK signaling (cancer)
nt06211  Other MAPK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06223  TNF signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06461  Huntington disease
nt06516  TNF signaling
nt06517  TLR signaling
nt06526  MAPK signaling
  Element
N00188  IL1-IL1R-JNK signaling pathway
N00438  TLR2/4-MAPK signaling pathway
N00446  TNF-JNK signaling pathway
N00447  HIV Vpr/Tat to TNF-JNK signaling pathway
N00503  HTLV-1 Tax to TNF-JNK signaling pathway
N00543  HBV HBx to JNK signaling pathway
N00545  HBV HBx to ERK signaling pathway
N01344  NNK/NNN to RAS-ERK signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01353  E2 to RAS-ERK signaling pathway
N01407  Metals to JNK signaling pathway
N01408  Metals to RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    3725 (JUN)
   04012 ErbB signaling pathway
    3725 (JUN)
   04310 Wnt signaling pathway
    3725 (JUN)
   04668 TNF signaling pathway
    3725 (JUN)
   04024 cAMP signaling pathway
    3725 (JUN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    3725 (JUN)
  09143 Cell growth and death
   04210 Apoptosis
    3725 (JUN)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    3725 (JUN)
   04530 Tight junction
    3725 (JUN)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    3725 (JUN)
   04621 NOD-like receptor signaling pathway
    3725 (JUN)
   04625 C-type lectin receptor signaling pathway
    3725 (JUN)
   04660 T cell receptor signaling pathway
    3725 (JUN)
   04658 Th1 and Th2 cell differentiation
    3725 (JUN)
   04659 Th17 cell differentiation
    3725 (JUN)
   04657 IL-17 signaling pathway
    3725 (JUN)
   04662 B cell receptor signaling pathway
    3725 (JUN)
  09152 Endocrine system
   04912 GnRH signaling pathway
    3725 (JUN)
   04915 Estrogen signaling pathway
    3725 (JUN)
   04921 Oxytocin signaling pathway
    3725 (JUN)
   04926 Relaxin signaling pathway
    3725 (JUN)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    3725 (JUN)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    3725 (JUN)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3725 (JUN)
   05207 Chemical carcinogenesis - receptor activation
    3725 (JUN)
   05208 Chemical carcinogenesis - reactive oxygen species
    3725 (JUN)
   05203 Viral carcinogenesis
    3725 (JUN)
   05231 Choline metabolism in cancer
    3725 (JUN)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    3725 (JUN)
  09162 Cancer: specific types
   05210 Colorectal cancer
    3725 (JUN)
   05211 Renal cell carcinoma
    3725 (JUN)
   05224 Breast cancer
    3725 (JUN)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3725 (JUN)
   05170 Human immunodeficiency virus 1 infection
    3725 (JUN)
   05161 Hepatitis B
    3725 (JUN)
   05171 Coronavirus disease - COVID-19
    3725 (JUN)
   05162 Measles
    3725 (JUN)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3725 (JUN)
   05169 Epstein-Barr virus infection
    3725 (JUN)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    3725 (JUN)
   05130 Pathogenic Escherichia coli infection
    3725 (JUN)
   05132 Salmonella infection
    3725 (JUN)
   05131 Shigellosis
    3725 (JUN)
   05135 Yersinia infection
    3725 (JUN)
   05133 Pertussis
    3725 (JUN)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    3725 (JUN)
   05142 Chagas disease
    3725 (JUN)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3725 (JUN)
   05321 Inflammatory bowel disease
    3725 (JUN)
  09165 Substance dependence
   05030 Cocaine addiction
    3725 (JUN)
   05031 Amphetamine addiction
    3725 (JUN)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3725 (JUN)
   05418 Fluid shear stress and atherosclerosis
    3725 (JUN)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    3725 (JUN)
   04933 AGE-RAGE signaling pathway in diabetic complications
    3725 (JUN)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    3725 (JUN)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    3725 (JUN)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, Jun
    3725 (JUN)
SSDB
Motif
Pfam: Jun bZIP_1 bZIP_2 bZIP_Maf ZapB PspA_IM30 Fib_alpha DUF3450 TFIIA FlaC_arch
Other DBs
NCBI-GeneID: 3725
NCBI-ProteinID: NP_002219
OMIM: 165160
HGNC: 6204
Ensembl: ENSG00000177606
UniProt: P05412
Structure
LinkDB
Position
1:complement(58780791..58784047)
AA seq 331 aa
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
NT seq 996 nt   +upstreamnt  +downstreamnt
atgactgcaaagatggaaacgaccttctatgacgatgccctcaacgcctcgttcctcccg
tccgagagcggaccttatggctacagtaaccccaagatcctgaaacagagcatgaccctg
aacctggccgacccagtggggagcctgaagccgcacctccgcgccaagaactcggacctc
ctcacctcgcccgacgtggggctgctcaagctggcgtcgcccgagctggagcgcctgata
atccagtccagcaacgggcacatcaccaccacgccgacccccacccagttcctgtgcccc
aagaacgtgacagatgagcaggagggcttcgccgagggcttcgtgcgcgccctggccgaa
ctgcacagccagaacacgctgcccagcgtcacgtcggcggcgcagccggtcaacggggca
ggcatggtggctcccgcggtagcctcggtggcagggggcagcggcagcggcggcttcagc
gccagcctgcacagcgagccgccggtctacgcaaacctcagcaacttcaacccaggcgcg
ctgagcagcggcggcggggcgccctcctacggcgcggccggcctggcctttcccgcgcaa
ccccagcagcagcagcagccgccgcaccacctgccccagcagatgcccgtgcagcacccg
cggctgcaggccctgaaggaggagcctcagacagtgcccgagatgcccggcgagacaccg
cccctgtcccccatcgacatggagtcccaggagcggatcaaggcggagaggaagcgcatg
aggaaccgcatcgctgcctccaagtgccgaaaaaggaagctggagagaatcgcccggctg
gaggaaaaagtgaaaaccttgaaagctcagaactcggagctggcgtccacggccaacatg
ctcagggaacaggtggcacagcttaaacagaaagtcatgaaccacgttaacagtgggtgc
caactcatgctaacgcagcagttgcaaacattttga

KEGG   Homo sapiens (human): 4609
Entry
4609              CDS       T01001                                 
Symbol
MYC, MRTL, MYCC, bHLHe39, c-Myc
Name
(RefSeq) MYC proto-oncogene, bHLH transcription factor
  KO
K04377  Myc proto-oncogene protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04110  Cell cycle
hsa04151  PI3K-Akt signaling pathway
hsa04218  Cellular senescence
hsa04310  Wnt signaling pathway
hsa04350  TGF-beta signaling pathway
hsa04390  Hippo signaling pathway
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04630  JAK-STAT signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa05132  Salmonella infection
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05210  Colorectal cancer
hsa05213  Endometrial cancer
hsa05216  Thyroid cancer
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06181  Salmonella
nt06210  ERK signaling (cancer)
nt06215  WNT signaling (cancer)
nt06227  Nuclear receptor signaling (cancer)
nt06230  Cell cycle (cancer)
nt06240  Transcription (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06267  Small cell lung cancer
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06275  Acute myeloid leukemia
nt06505  WNT signaling
nt06526  MAPK signaling
  Element
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00056  Wnt signaling pathway
N00057  Mutation-inactivated APC to Wnt signaling pathway
N00058  Mutation-activated CTNNB1 to Wnt signaling pathway
N00059  FZD7-overexpression to Wnt signaling pathway
N00060  LRP6-overexpression to Wnt signaling pathway
N00061  CDH1-reduced expression to beta-catenin signaling pathway
N00077  HRAS-overexpression to ERK signaling pathway
N00078  Mutation-activated HRAS to ERK signaling pathway
N00088  Amplified MYC to p15-cell cycle G1/S
N00089  Amplified MYC to cell cycle G1/S
N00090  p15-Cell cycle G1/S
N00092  Amplified MYC to p27-cell cycle G1/S
N00110  PLZF-RARA fusion to transcriptional activtion
N00133  EWSR1-FLI1 fusion to transcriptional activation
N00225  EBV EBNA2 to RBP-Jk-mediated transcription
N00242  Mutation-inactivated AXIN to Wnt signaling pathway
N00257  Loss of CDH1 to beta-catenin signaling pathway
N00258  Mutation-inactivated CDH1 to beta-catenin signaling pathway
N00287  ESR1-positive to nuclear-initiated estrogen signaling pathway
N00489  HTLV-1 p30II to c-myc-mediated transcription
N00512  HTLV-1 Tax to c-myc-mediated transcription
N00529  HCV core to RXRA/PPARA-mediated transcription
N00530  HCV core to RXRA/LXRA-mediated transcription
N01124  Salmonella AvrA to beta-catenin signaling pathway
N01344  NNK/NNN to RAS-ERK signaling pathway
N01602  ERK-MYC signaling pathway
Disease
H00001  B-cell acute lymphoblastic leukemia
H00002  T-cell acute lymphoblastic leukemia
H00008  Burkitt lymphoma
H00010  Multiple myeloma
H00013  Small cell lung cancer
H00016  Oral cancer
H00025  Penile cancer
H00027  Ovarian cancer
H00028  Choriocarcinoma
H00036  Osteosarcoma
H00041  Kaposi sarcoma
H00048  Hepatocellular carcinoma
H00055  Laryngeal cancer
H01463  Mycosis fungoides
H01509  Tonsillar cancer
H01554  Fallopian tube cancer
H01667  Medulloblastoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Drug target
Omacetaxine mepesuccinate: D08956
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4609 (MYC)
   04012 ErbB signaling pathway
    4609 (MYC)
   04310 Wnt signaling pathway
    4609 (MYC)
   04350 TGF-beta signaling pathway
    4609 (MYC)
   04390 Hippo signaling pathway
    4609 (MYC)
   04630 JAK-STAT signaling pathway
    4609 (MYC)
   04151 PI3K-Akt signaling pathway
    4609 (MYC)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    4609 (MYC)
   04218 Cellular senescence
    4609 (MYC)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    4609 (MYC)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    4609 (MYC)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4609 (MYC)
   05202 Transcriptional misregulation in cancer
    4609 (MYC)
   05206 MicroRNAs in cancer
    4609 (MYC)
   05205 Proteoglycans in cancer
    4609 (MYC)
   05207 Chemical carcinogenesis - receptor activation
    4609 (MYC)
   05230 Central carbon metabolism in cancer
    4609 (MYC)
  09162 Cancer: specific types
   05210 Colorectal cancer
    4609 (MYC)
   05225 Hepatocellular carcinoma
    4609 (MYC)
   05226 Gastric cancer
    4609 (MYC)
   05216 Thyroid cancer
    4609 (MYC)
   05221 Acute myeloid leukemia
    4609 (MYC)
   05220 Chronic myeloid leukemia
    4609 (MYC)
   05219 Bladder cancer
    4609 (MYC)
   05213 Endometrial cancer
    4609 (MYC)
   05224 Breast cancer
    4609 (MYC)
   05222 Small cell lung cancer
    4609 (MYC)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    4609 (MYC)
   05161 Hepatitis B
    4609 (MYC)
   05160 Hepatitis C
    4609 (MYC)
   05163 Human cytomegalovirus infection
    4609 (MYC)
   05167 Kaposi sarcoma-associated herpesvirus infection
    4609 (MYC)
   05169 Epstein-Barr virus infection
    4609 (MYC)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    4609 (MYC)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    4609 (MYC)
   03019 Messenger RNA biogenesis [BR:hsa03019]
    4609 (MYC)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
   Cell cycle controlling factors, Myc
    4609 (MYC)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Factors involved in mRNA localization
    Factors that have mRNA localization signals
     4609 (MYC)
SSDB
Motif
Pfam: Myc_N Myc-LZ HLH TRH bHLH_INO2
Other DBs
NCBI-GeneID: 4609
NCBI-ProteinID: NP_002458
OMIM: 190080
HGNC: 7553
Ensembl: ENSG00000136997
UniProt: P01106
Structure
LinkDB
Position
8:127735434..127742951
AA seq 454 aa
MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAP
SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTEL
LGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPA
RGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLS
STESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAG
GHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSP
RSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILS
VQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
NT seq 1365 nt   +upstreamnt  +downstreamnt
ctggatttttttcgggtagtggaaaaccagcagcctcccgcgacgatgcccctcaacgtt
agcttcaccaacaggaactatgacctcgactacgactcggtgcagccgtatttctactgc
gacgaggaggagaacttctaccagcagcagcagcagagcgagctgcagcccccggcgccc
agcgaggatatctggaagaaattcgagctgctgcccaccccgcccctgtcccctagccgc
cgctccgggctctgctcgccctcctacgttgcggtcacacccttctcccttcggggagac
aacgacggcggtggcgggagcttctccacggccgaccagctggagatggtgaccgagctg
ctgggaggagacatggtgaaccagagtttcatctgcgacccggacgacgagaccttcatc
aaaaacatcatcatccaggactgtatgtggagcggcttctcggccgccgccaagctcgtc
tcagagaagctggcctcctaccaggctgcgcgcaaagacagcggcagcccgaaccccgcc
cgcggccacagcgtctgctccacctccagcttgtacctgcaggatctgagcgccgccgcc
tcagagtgcatcgacccctcggtggtcttcccctaccctctcaacgacagcagctcgccc
aagtcctgcgcctcgcaagactccagcgccttctctccgtcctcggattctctgctctcc
tcgacggagtcctccccgcagggcagccccgagcccctggtgctccatgaggagacaccg
cccaccaccagcagcgactctgaggaggaacaagaagatgaggaagaaatcgatgttgtt
tctgtggaaaagaggcaggctcctggcaaaaggtcagagtctggatcaccttctgctgga
ggccacagcaaacctcctcacagcccactggtcctcaagaggtgccacgtctccacacat
cagcacaactacgcagcgcctccctccactcggaaggactatcctgctgccaagagggtc
aagttggacagtgtcagagtcctgagacagatcagcaacaaccgaaaatgcaccagcccc
aggtcctcggacaccgaggagaatgtcaagaggcgaacacacaacgtcttggagcgccag
aggaggaacgagctaaaacggagcttttttgccctgcgtgaccagatcccggagttggaa
aacaatgaaaaggcccccaaggtagttatccttaaaaaagccacagcatacatcctgtcc
gtccaagcagaggagcaaaagctcatttctgaagaggacttgttgcggaaacgacgagaa
cagttgaaacacaaacttgaacagctacggaactcttgtgcgtaa

KEGG   Homo sapiens (human): 596
Entry
596               CDS       T01001                                 
Symbol
BCL2, Bcl-2, PPP1R50
Name
(RefSeq) BCL2 apoptosis regulator
  KO
K02161  apoptosis regulator Bcl-2
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04064  NF-kappa B signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04115  p53 signaling pathway
hsa04140  Autophagy - animal
hsa04141  Protein processing in endoplasmic reticulum
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04340  Hedgehog signaling pathway
hsa04510  Focal adhesion
hsa04621  NOD-like receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04915  Estrogen signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05162  Measles
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05210  Colorectal cancer
hsa05215  Prostate cancer
hsa05222  Small cell lung cancer
hsa05226  Gastric cancer
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06210  ERK signaling (cancer)
nt06227  Nuclear receptor signaling (cancer)
nt06231  Apoptosis (cancer)
nt06260  Colorectal cancer
nt06267  Small cell lung cancer
nt06270  Breast cancer
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06524  Apoptosis
  Element
N00098  Intrinsic apoptotic pathway
N00100  BCL2-overexpression to intrinsic apoptotic pathway
N00286  Nuclear-initiated estrogen signaling pathway
N00451  HIV Tat to intrinsic apoptotic pathway
N00453  HIV Vpr to intrinsic apoptotic pathway
N00475  EBV BHRF1 to intrinsic apoptotic pathway
N00478  EBV BARF1 to intrinsic apoptotic pathway
N01135  Mutation-caused aberrant SOD1 to intrinsic apoptotic pathway
N01344  NNK/NNN to RAS-ERK signaling pathway
Disease
H00005  Chronic lymphocytic leukemia
H00013  Small cell lung cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00041  Kaposi sarcoma
H00054  Nasopharyngeal cancer
H01613  Follicular lymphoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Drug target
Obatoclax mesylate: D08954
Oblimersen (DG00728): D05216 D08290
Sonrotoclax: D12883
Surzetoclax: D13082
Venetoclax: D10679<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    596 (BCL2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    596 (BCL2)
   04630 JAK-STAT signaling pathway
    596 (BCL2)
   04064 NF-kappa B signaling pathway
    596 (BCL2)
   04066 HIF-1 signaling pathway
    596 (BCL2)
   04071 Sphingolipid signaling pathway
    596 (BCL2)
   04151 PI3K-Akt signaling pathway
    596 (BCL2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    596 (BCL2)
  09143 Cell growth and death
   04210 Apoptosis
    596 (BCL2)
   04215 Apoptosis - multiple species
    596 (BCL2)
   04217 Necroptosis
    596 (BCL2)
   04115 p53 signaling pathway
    596 (BCL2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    596 (BCL2)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    596 (BCL2)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    596 (BCL2)
   04928 Parathyroid hormone synthesis, secretion and action
    596 (BCL2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    596 (BCL2)
  09156 Nervous system
   04725 Cholinergic synapse
    596 (BCL2)
   04722 Neurotrophin signaling pathway
    596 (BCL2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    596 (BCL2)
   05206 MicroRNAs in cancer
    596 (BCL2)
   05207 Chemical carcinogenesis - receptor activation
    596 (BCL2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    596 (BCL2)
   05226 Gastric cancer
    596 (BCL2)
   05215 Prostate cancer
    596 (BCL2)
   05222 Small cell lung cancer
    596 (BCL2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    596 (BCL2)
   05161 Hepatitis B
    596 (BCL2)
   05162 Measles
    596 (BCL2)
   05168 Herpes simplex virus 1 infection
    596 (BCL2)
   05169 Epstein-Barr virus infection
    596 (BCL2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    596 (BCL2)
   05131 Shigellosis
    596 (BCL2)
   05152 Tuberculosis
    596 (BCL2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    596 (BCL2)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    596 (BCL2)
   05022 Pathways of neurodegeneration - multiple diseases
    596 (BCL2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    596 (BCL2)
   05418 Fluid shear stress and atherosclerosis
    596 (BCL2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    596 (BCL2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    596 (BCL2)
   01524 Platinum drug resistance
    596 (BCL2)
   01522 Endocrine resistance
    596 (BCL2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    596 (BCL2)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     596 (BCL2)
SSDB
Motif
Pfam: Bcl-2 BH4 Bcl-2_3 ARMH5
Other DBs
NCBI-GeneID: 596
NCBI-ProteinID: NP_000624
OMIM: 151430
HGNC: 990
Ensembl: ENSG00000171791
UniProt: P10415
Structure
LinkDB
Position
18:complement(63123346..63320090)
AA seq 239 aa
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
NT seq 720 nt   +upstreamnt  +downstreamnt
atggcgcacgctgggagaacagggtacgataaccgggagatagtgatgaagtacatccat
tataagctgtcgcagaggggctacgagtgggatgcgggagatgtgggcgccgcgcccccg
ggggccgcccccgcaccgggcatcttctcctcccagcccgggcacacgccccatccagcc
gcatcccgggacccggtcgccaggacctcgccgctgcagaccccggctgcccccggcgcc
gccgcggggcctgcgctcagcccggtgccacctgtggtccacctgaccctccgccaggcc
ggcgacgacttctcccgccgctaccgccgcgacttcgccgagatgtccagccagctgcac
ctgacgcccttcaccgcgcggggacgctttgccacggtggtggaggagctcttcagggac
ggggtgaactgggggaggattgtggccttctttgagttcggtggggtcatgtgtgtggag
agcgtcaaccgggagatgtcgcccctggtggacaacatcgccctgtggatgactgagtac
ctgaaccggcacctgcacacctggatccaggataacggaggctgggatgcctttgtggaa
ctgtacggccccagcatgcggcctctgtttgatttctcctggctgtctctgaagactctg
ctcagtttggccctggtgggagcttgcatcaccctgggtgcctatctgggccacaagtga

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