KEGG   PATHWAY: hsp04060
Entry
hsp04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Hippoglossus stenolepis (Pacific halibut)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
hsp04060  Cytokine-cytokine receptor interaction
hsp04060

Organism
Hippoglossus stenolepis (Pacific halibut) [GN:hsp]
Gene
118098126  [KO:K05058]
118098266  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
118098397  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
118098463  [KO:K13596] [EC:2.7.11.30]
118098510  bmp6; bone morphogenetic protein 6 [KO:K16620]
118098522  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
118098693  ackr4b; atypical chemokine receptor 4b [KO:K04186]
118098754  ccr9b; C-C chemokine receptor type 9 [KO:K04184]
118098876  ccl20b; C-C motif chemokine 20b [KO:K14625]
118098892  inhbaa; inhibin subunit beta Aa [KO:K04667]
118098900  [KO:K04179]
118099031  bmp2b; bone morphogenetic protein 2b [KO:K21283]
118099060  ifngr1; interferon gamma receptor 1 [KO:K05132]
118099356  [KO:K13377]
118099542  il17a/f3; interleukin 17a/f3 [KO:K05494]
118099760  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
118099784  [KO:K05414]
118099808  [KO:K05173]
118099875  [KO:K22630]
118099926  il20ra; interleukin-20 receptor subunit alpha [KO:K05136]
118100421  [KO:K05150]
118100555  [KO:K05149]
118100748  [KO:K05414]
118100772  [KO:K05414]
118100798  ngfrb; nerve growth factor receptor b [KO:K02583]
118100819  [KO:K05075]
118100847  ndr2; nodal-related 2 [KO:K04666]
118100928  [KO:K05414]
118101036  gdf10b; growth/differentiation factor 10b [KO:K22674]
118101037  gdf2; growth/differentiation factor 2 [KO:K05503]
118101670  il17ra1a; interleukin 17 receptor A1a isoform X1 [KO:K05164]
118101710  [KO:K05424]
118101718  [KO:K05439]
118101889  [KO:K22679]
118102331  rell1; LOW QUALITY PROTEIN: RELT-like protein 1 [KO:K26541]
118102377  bmp15; bone morphogenetic protein 15 [KO:K05498]
118102629  epoa; erythropoietin isoform X1 [KO:K05437]
118102700  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
118102711  [KO:K22687]
118103008  [KO:K10030]
118103100  si:ch73-361p23.3; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
118103157  [KO:K05080]
118103208  [KO:K04671] [EC:2.7.11.30]
118103259  [KO:K05497]
118103478  [KO:K04670] [EC:2.7.11.30]
118103496  inha; inhibin alpha chain [KO:K05500]
118103647  [KO:K22687]
118103678  [KO:K05050]
118104029  ccr6a; C-C chemokine receptor type 6a [KO:K04181]
118104485  [KO:K16621]
118104764  ngfb; nerve growth factor [KO:K02582]
118104786  il17rc; interleukin-17 receptor C [KO:K05166]
118104842  tnfrsf1b; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
118104973  il10; interleukin-10 [KO:K05443]
118104985  gdf5; growth/differentiation factor 5 [KO:K04664]
118105214  il19l; interleukin 19 like [KO:K22667]
118105475  [KO:K13567] [EC:2.7.11.30]
118105694  smtla; somatolactin alpha [KO:K05438]
118105886  tnfrsf19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155]
118105928  [KO:K04190]
118105944  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
118106088  il17a/f1; interleukin 17a/f1 [KO:K05494]
118106168  il10ra; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
118106172  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
118106338  [KO:K05174]
118106494  [KO:K04723]
118106541  il12a; interleukin-12 subunit alpha [KO:K05406]
118106647  bmp16; bone morphogenetic protein 16 [KO:K21283]
118106760  il15l; interleukin 15, like [KO:K05433]
118107140  il16; pro-interleukin-16 isoform X1 [KO:K22628]
118108747  [KO:K05491]
118109008  [KO:K12964]
118109063  il17c; interleukin-17C [KO:K05491]
118109419  [KO:K05439]
118110033  [KO:K05164]
118110223  il34; interleukin-34 [KO:K22633]
118110412  [KO:K05165]
118110421  ngfa; neurotrophin-7 [KO:K02582]
118110834  [KO:K05152]
118110871  cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
118110947  [KO:K05152]
118110960  [KO:K05152]
118110999  bmp7b; bone morphogenetic protein 7b isoform X1 [KO:K16621]
118111242  [KO:K05168]
118111256  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
118111340  acvrl1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
118111366  wu:fl23c11; uncharacterized protein wu:fl23c11 isoform X1 [KO:K05166]
118111865  cd40lg; CD40 ligand [KO:K04389]
118111901  il21; interleukin-21 [KO:K05434]
118111906  gdf9; growth/differentiation factor 9 [KO:K22673]
118112132  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
118112140  eda; ectodysplasin-A isoform X1 [KO:K05480]
118112143  [KO:K05476]
118112176  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
118112354  il12ba; interleukin 12Ba [KO:K05425]
118112558  rell2; RELT-like protein 2 [KO:K26541]
118112690  csf1ra; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
118112768  clcf1; uncharacterized protein clcf1 [KO:K05421]
118113116  [KO:K04188]
118113118  cxcr3.1; C-X-C chemokine receptor type 3.1 [KO:K04188]
118113121  il21r.1; interleukin 21 receptor, tandem duplicate 1 [KO:K05075]
118113203  cd4-2.2; CD4-2 molecule, tandem duplicate 2 [KO:K06454]
118113213  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118113227  [KO:K03160]
118113248  il11a; uncharacterized protein il11a [KO:K05417]
118113319  gdf6a; growth/differentiation factor 6-A [KO:K20012]
118113326  [KO:K05073]
118113351  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
118113366  ifnlr1; interferon lambda receptor 1 [KO:K05136]
118113442  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
118113452  si:dkey-92i15.4; uncharacterized protein si:dkey-92i15.4 [KO:K22628]
118113455  il6r; interleukin-6 receptor subunit alpha [KO:K05055]
118113688  cabz01093075.1; C-C chemokine receptor type 4 isoform X1 [KO:K04179]
118113748  [KO:K04388] [EC:2.7.11.30]
118113802  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
118113972  ccr2; C-C chemokine receptor type 1 [KO:K04180]
118114149  cxcr3.2; C-X-C chemokine receptor type 3-2 [KO:K04188]
118114236  nradd; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
118114252  [KO:K05148]
118114253  [KO:K05143]
118114497  ccl27a; C-C motif chemokine 27a [KO:K05513]
118114545  ghra; growth hormone receptor a [KO:K05080]
118114782  lifra; LIF receptor subunit alpha a [KO:K05058]
118115104  spaw; southpaw [KO:K04666]
118115136  [KO:K04519]
118115284  bmp10; bone morphogenetic protein 10 [KO:K22670]
118115444  bmpr1ba; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
118115472  [KO:K05477]
118115479  [KO:K10032]
118115521  bmp3; bone morphogenetic protein 3 [KO:K05496]
118115530  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
118115660  si:dkey-88e18.2; interleukin-12 subunit beta [KO:K05425]
118116105  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
118116363  acvr1l; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
118116455  [KO:K04721]
118116518  [KO:K05069]
118116535  [KO:K12964]
118116593  ccr6b; C-C chemokine receptor type 6 [KO:K04181]
118116597  ebi3; interleukin-27 subunit beta [KO:K24476]
118116784  [KO:K05060]
118117006  bmp4; bone morphogenetic protein 4 [KO:K04662]
118117185  thpo; thrombopoietin isoform X1 [KO:K06854]
118117211  ackr4a; atypical chemokine receptor 4 [KO:K04186]
118117229  ccl25a; C-C motif chemokine 25 [KO:K13072]
118117381  [KO:K05406]
118117468  inhbab; inhibin subunit beta Ab [KO:K04667]
118117470  ccr9a; C-C chemokine receptor type 9a [KO:K04184]
118117487  ccr7; C-C chemokine receptor type 7 [KO:K04182]
118117639  crfb16; cytokine receptor family member B16 isoform X1 [KO:K05137]
118117733  ccr12a; chemokine (C-C motif) receptor 12a [KO:K04179]
118117763  [KO:K13596] [EC:2.7.11.30]
118117927  [KO:K04193]
118117980  [KO:K14625]
118118021  ccl20a.3; C-C motif chemokine 20a.3 [KO:K14625]
118118143  [KO:K05504]
118118153  [KO:K21283]
118118351  [KO:K04189]
118118634  gdf10a; growth/differentiation factor 10 [KO:K22674]
118118814  [KO:K04673] [EC:2.7.11.30]
118118857  bmp5; bone morphogenetic protein 5 [KO:K04663]
118119117  [KO:K05063]
118119334  cxcl12a; chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) [KO:K10031]
118119490  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
118119530  ifngr1l; interferon gamma receptor 1-like isoform X1 [KO:K05132]
118119650  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
118119681  gdf3; protein DVR-1 [KO:K22672]
118119824  acvr2aa; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
118119885  il1rl1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
118119887  [KO:K04386]
118119888  [KO:K04387]
118119902  [KO:K04671] [EC:2.7.11.30]
118119939  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118120001  [KO:K04675] [EC:2.7.11.30]
118120010  il10rb; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
118120051  [KO:K05050]
118120143  il17d; interleukin-17D [KO:K05492]
118120193  tnfsf13b; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
118120246  mstnb; growth/differentiation factor 8 [KO:K05497]
118120322  [KO:K05131]
118120375  ackr3a; atypical chemokine receptor 3a [KO:K04304]
118120418  [KO:K13568] [EC:2.7.11.30]
118120444  [KO:K05135]
118120513  inhbb; inhibin beta B chain [KO:K22687]
118120574  [KO:K04189]
118120664  [KO:K05063]
118120701  lepr; leptin receptor isoform X1 [KO:K05062]
118120815  il12rb2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
118120885  mpl; thrombopoietin receptor isoform X1 [KO:K05082]
118121068  ccl44; chemokine (C-C motif) ligand 44 [KO:K21083]
118121152  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118121173  il23r; interleukin-23 receptor [KO:K05064]
118121217  ccl25b; C-C motif chemokine 25b [KO:K13072]
118121246  cxcl12b; chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) [KO:K10031]
118121600  [KO:K10030]
118121668  il13ra2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
118121744  [KO:K22629]
118121975  [KO:K05070]
118121976  [KO:K05070]
118122246  [KO:K05425]
118122375  csf1rb; macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
118122769  il12rb2l; interleukin 12 receptor, beta 2a, like [KO:K05060]
118122841  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
118123462  epor; erythropoietin receptor [KO:K05079]
118123594  prl; prolactin [KO:K05439]
118123890  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118124008  csf2rb; cytokine receptor common subunit beta [KO:K04738]
118124013  il2rb; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
118124061  gh1; somatotropin [KO:K05438]
118124332  [KO:K05143]
118124620  bmp8a; bone morphogenetic protein 8A isoform X2 [KO:K16622]
118124722  [KO:K05405]
118124881  [KO:K04388] [EC:2.7.11.30]
118125159  gdf6b; growth/differentiation factor 6-B [KO:K20012]
118125433  [KO:K22670]
118125459  il11ra; interleukin-11 receptor subunit alpha [KO:K05056]
118125487  ghrb; growth hormone receptor b isoform X1 [KO:K05080]
118125675  cntfr; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
118125680  bmpr1bb; bone morphogenetic protein receptor, type IBb [KO:K13578] [EC:2.7.11.30]
118125828  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
118125885  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
118125941  prlra; prolactin receptor a isoform X1 [KO:K05081]
118125991  il6st; interleukin-6 receptor subunit beta [KO:K05060]
118126040  [KO:K04666]
124851085  [KO:K05152]
124851105  si:cabz01093077.1; C-C chemokine receptor type 2 [KO:K04179]
124851139  [KO:K05152]
124852369  [KO:K12671]
124852426  [KO:K05512]
124854654  xcr1a.1; chemokine (C motif) receptor 1a, duplicate 1 [KO:K04193]
124854784  amh; muellerian-inhibiting factor isoform X1 [KO:K04665]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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