KEGG   PATHWAY: ko04080
Entry
ko04080                     Pathway                                
Name
Neuroactive ligand-receptor interaction
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ko04080  Neuroactive ligand-receptor interaction
ko04080

Drug
D02546  Kainic acid hydrate (JP18)
D03694  Deslorelin (USAN/INN)
D04174  Fertirelin acetate (USAN)
D05076  Morantel tartrate (USP)
D08230  Morantel (BAN)
D08231  Morantel citrate
Orthology
K01312  PRSS1_2_3; trypsin [EC:3.4.21.4]
K01313  F2; coagulation factor II (thrombin) [EC:3.4.21.5]
K01315  PLG; plasminogen [EC:3.4.21.7]
K01319  CTSG; cathepsin G [EC:3.4.21.20]
K01352  GZMA; granzyme A [EC:3.4.21.78]
K03898  KNG, BK; kininogen
K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
K03915  BDKRB1; bradykinin receptor B1
K03916  BDKRB2; bradykinin receptor B2
K03990  C3; complement component 3
K03994  C5; complement component 5
K04009  C3AR1; C3a anaphylatoxin chemotactic receptor
K04010  C5AR1, CD88; C5a anaphylatoxin chemotactic receptor 1
K04129  CHRM1; muscarinic acetylcholine receptor M1
K04130  CHRM2; muscarinic acetylcholine receptor M2
K04131  CHRM3; muscarinic acetylcholine receptor M3
K04132  CHRM4; muscarinic acetylcholine receptor M4
K04133  CHRM5; muscarinic acetylcholine receptor M5
K04134  CHRMN; muscarinic acetylcholine receptor
K04135  ADRA1A; adrenergic receptor alpha-1A
K04136  ADRA1B; adrenergic receptor alpha-1B
K04137  ADRA1D; adrenergic receptor alpha-1D
K04138  ADRA2A; adrenergic receptor alpha-2A
K04139  ADRA2B; adrenergic receptor alpha-2B
K04140  ADRA2C; adrenergic receptor alpha-2C
K04141  ADRB1; adrenergic receptor beta-1
K04142  ADRB2; adrenergic receptor beta-2
K04143  ADRB3; adrenergic receptor beta-3
K04144  DRD1; dopamine receptor D1
K04145  DRD2; dopamine receptor D2
K04146  DRD3; dopamine receptor D3
K04147  DRD4; dopamine receptor D4
K04148  DRD1N; dopamine receptor D1-like
K04149  HRH1; histamine receptor H1
K04150  HRH2; histamine receptor H2
K04151  HRH3; histamine receptor H3
K04152  HRH4; histamine receptor H4
K04153  HTR1; 5-hydroxytryptamine receptor 1
K04157  HTR2; 5-hydroxytryptamine receptor 2
K04160  HTR4; 5-hydroxytryptamine receptor 4
K04161  HTR5; 5-hydroxytryptamine receptor 5
K04162  HTR6; 5-hydroxytryptamine receptor 6
K04163  HTR7; 5-hydroxytryptamine receptor 7
K04166  AGTR1; angiotensin II receptor type 1
K04167  AGTR2; angiotensin II receptor type 2
K04168  NMBR; neuromedin B receptor
K04169  GRPR; gastrin-releasing peptide receptor
K04170  BRS3; bombesin receptor subtype-3
K04172  FPR1; formyl peptide receptor 1
K04173  FPRL; formyl peptide receptor-like
K04174  APLNR; apelin receptor
K04194  CCKAR; cholecystokinin A receptor
K04195  CCKBR; cholecystokinin B receptor
K04197  EDNRA; endothelin receptor type A
K04198  EDNRB; endothelin receptor type B
K04199  MC1R; melanocortin 1 receptor
K04200  MC2R; melanocortin 2 receptor
K04201  MC3R; melanocortin 3 receptor
K04202  MC4R; melanocortin 4 receptor
K04203  MC5R; melanocortin 5 receptor
K04204  NPY1R; neuropeptide Y receptor type 1
K04205  NPY2R; neuropeptide Y receptor type 2
K04206  NPY4R; neuropeptide Y receptor type 4
K04207  NPY5R; neuropeptide Y receptor type 5
K04208  NPY6R; neuropeptide Y receptor type 6
K04210  GPR83, GPR72; G protein-coupled receptor 83
K04211  NTSR1; neurotensin receptor 1
K04212  NTSR2; neurotensin receptor 2
K04213  OPRD1; delta-type opioid receptor
K04214  OPRK1; kappa-type opioid receptor
K04215  OPRM1; mu-type opioid receptor
K04216  OPRL1; nociceptin receptor
K04217  SSTR1; somatostatin receptor 1
K04218  SSTR2; somatostatin receptor 2
K04219  SSTR3; somatostatin receptor 3
K04220  SSTR4; somatostatin receptor 4
K04221  SSTR5; somatostatin receptor 5
K04222  TACR1; tachykinin receptor 1
K04223  TACR2; tachykinin receptor 2
K04224  TACR3; tachykinin receptor 3
K04226  AVPR1A; arginine vasopressin receptor 1A
K04227  AVPR1B; arginine vasopressin receptor 1B
K04228  AVPR2; arginine vasopressin receptor 2
K04229  OXTR; oxytocin receptor
K04230  GALR1; galanin receptor 1
K04231  GALR2; galanin receptor 2
K04232  GALR3; galanin receptor 3
K04234  F2RL1, PAR2; coagulation factor II (thrombin) receptor-like 1
K04235  F2RL2, PAR3; coagulation factor II (thrombin) receptor-like 2
K04236  F2RL3, PAR4; coagulation factor II (thrombin) receptor-like 3
K04238  HCRTR1; hypocretin (orexin) receptor 1
K04239  HCRTR2; hypocretin (orexin) receptor 2
K04240  NPFFR1; neuropeptide FF receptor 1
K04241  UTS2R; urotensin 2 receptor
K04247  FSHR; follicle stimulating hormone receptor
K04248  LHCGR; lutropin-choriogonadotropic hormone receptor
K04249  TSHR; thyrotropin receptor
K04258  PTGER1; prostaglandin E receptor 1
K04259  PTGER2; prostaglandin E receptor 2
K04260  PTGER3; prostaglandin E receptor 3
K04261  PTGER4; prostaglandin E receptor 4
K04262  PTGFR; prostaglandin F receptor
K04263  PTGIR; prostacyclin receptor
K04264  TBXA2R; thromboxane A2 receptor
K04265  ADORA1; adenosine receptor A1
K04266  ADORA2A, ADOR; adenosine receptor A2a
K04267  ADORA2B; adenosine receptor A2b
K04268  ADORA3; adenosine receptor A3
K04269  P2RY2; P2Y purinoceptor 2
K04270  P2RY1; P2Y purinoceptor 1
K04271  P2RY4; P2Y purinoceptor 4
K04272  P2RY6; P2Y purinoceptor 6
K04273  LPAR6, P2RY5; lysophosphatidic acid receptor 6
K04274  P2RY10; P2Y purinoceptor 10
K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
K04276  CXCR8, GPR35; C-X-C chemokine receptor type 8
K04277  CNR1; cannabinoid receptor 1
K04278  CNR2; cannabinoid receptor 2
K04279  PTAFR; platelet-activating factor receptor
K04280  GNRHR; gonadotropin-releasing hormone receptor
K04282  TRHR; thyrotropin-releasing hormone receptor
K04284  GHSR; growth hormone secretagogue receptor
K04285  MTNR1A; melatonin receptor type 1A
K04286  MTNR1B; melatonin receptor type 1B
K04287  GPR50; G protein-coupled receptor 50
K04288  S1PR1, EDG1, CD363; sphingosine 1-phosphate receptor 1
K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
K04290  S1PR3, EDG3; sphingosine 1-phosphate receptor 3
K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
K04292  S1PR2, EDG5; sphingosine 1-phosphate receptor 2
K04293  S1PR4, EDG6; sphingosine 1-phosphate receptor 4
K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
K04295  S1PR5, EDG8; sphingosine 1-phosphate receptor 5
K04296  LTB4R1; leukotriene B4 receptor 1
K04297  LTB4R2; leukotriene B4 receptor 2
K04299  P2RY14; P2Y purinoceptor 14
K04303  MAS1; proto-oncogene Mas
K04306  RXFP1, LGR7; relaxin family peptide receptor 1
K04307  RXFP2, LGR8; relaxin family peptide receptor 2
K04314  PRLHR, GPR10; prolactin releasing hormone receptor
K04320  MCHR1; melanin-concentrating hormone receptor 1
K04322  CYSLTR1; cysteinyl leukotriene receptor 1
K04323  CYSLTR2; cysteinyl leukotriene receptor 2
K04332  PTGDR; prostaglandin D2 receptor
K04576  CALCR; calcitonin receptor
K04577  CALCRL; calcitonin receptor-like
K04578  CRHR1; corticotropin releasing hormone receptor 1
K04579  CRHR2; corticotropin releasing hormone receptor 2
K04580  GIPR; gastric inhibitory polypeptide receptor
K04581  GLP1R; glucagon-like peptide 1 receptor
K04582  GLP2R; glucagon-like peptide 2 receptor
K04583  GCGR; glucagon receptor
K04584  GHRHR; growth hormone releasing hormone receptor
K04585  PTH1R, PTHR1; parathyroid hormone receptor 1
K04586  PTHR2; parathyroid hormone receptor 2
K04587  ADCYAP1R1, PACAPRI; pituitary adenylate cyclase-activating polypeptide type I receptor
K04588  SCTR; secretin receptor
K04589  VIPR1; vasoactive intestinal peptide receptor 1
K04590  VIPR2; vasoactive intestinal peptide receptor 2
K04603  GRM1; metabotropic glutamate receptor 1
K04604  GRM5; metabotropic glutamate receptor 5
K04605  GRM2; metabotropic glutamate receptor 2
K04606  GRM3; metabotropic glutamate receptor 3
K04607  GRM4; metabotropic glutamate receptor 4
K04608  GRM6; metabotropic glutamate receptor 6
K04609  GRM7; metabotropic glutamate receptor 7
K04610  GRM8; metabotropic glutamate receptor 8
K04615  GABBR; gamma-aminobutyric acid type B receptor
K04617  GPR156, GABABL; gamma-aminobutyric acid type B receptor-like
K04803  CHRNA1; nicotinic acetylcholine receptor alpha-1
K04804  CHRNA2; nicotinic acetylcholine receptor alpha-2
K04805  CHRNA3; nicotinic acetylcholine receptor alpha-3
K04806  CHRNA4; nicotinic acetylcholine receptor alpha-4
K04807  CHRNA5; nicotinic acetylcholine receptor alpha-5
K04808  CHRNA6; nicotinic acetylcholine receptor alpha-6
K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
K04810  CHRNA9; nicotinic acetylcholine receptor alpha-9
K04811  CHRNA10; nicotinic acetylcholine receptor alpha-10
K04812  CHRNB1; nicotinic acetylcholine receptor beta-1
K04813  CHRNB2; nicotinic acetylcholine receptor beta-2
K04814  CHRNB3; nicotinic acetylcholine receptor beta-3
K04815  CHRNB4; nicotinic acetylcholine receptor beta-4
K04816  CHRND; nicotinic acetylcholine receptor delta
K04817  CHRNE; nicotinic acetylcholine receptor epsilon
K04818  CHRNG; nicotinic acetylcholine receptor gamma
K05051  TAAR; trace amine associated receptor
K05052  NMUR1; neuromedin U receptor 1
K05053  NMUR2; neuromedin U receptor 2
K05054  MCHR2; melanin-concentrating hormone receptor 2
K05062  LEPR, CD295; leptin receptor
K05080  GHR; growth hormone receptor
K05081  PRLR; prolactin receptor
K05175  GABRA; gamma-aminobutyric acid receptor subunit alpha
K05181  GABRB; gamma-aminobutyric acid receptor subunit beta
K05184  GABRD; gamma-aminobutyric acid receptor subunit delta
K05185  GABRE; gamma-aminobutyric acid receptor subunit epsilon
K05186  GABRG; gamma-aminobutyric acid receptor subunit gamma
K05189  GABRP; gamma-aminobutyric acid receptor subunit pi
K05190  GABRR; gamma-aminobutyric acid receptor subunit rho
K05192  GABRQ; gamma-aminobutyric acid receptor subunit theta
K05193  GLRA1; glycine receptor alpha-1
K05194  GLRA2; glycine receptor alpha-2
K05195  GLRA3; glycine receptor alpha-3
K05196  GLRB; glycine receptor beta
K05197  GRIA1; glutamate receptor 1
K05198  GRIA2; glutamate receptor 2
K05199  GRIA3; glutamate receptor 3
K05200  GRIA4; glutamate receptor 4
K05201  GRIK1; glutamate receptor, ionotropic kainate 1
K05202  GRIK2; glutamate receptor, ionotropic kainate 2
K05203  GRIK3; glutamate receptor, ionotropic kainate 3
K05204  GRIK4; glutamate receptor, ionotropic kainate 4
K05205  GRIK5; glutamate receptor, ionotropic kainate 5
K05206  GRID1; glutamate receptor delta-1 subunit
K05207  GRID2; glutamate receptor delta-2 subunit
K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
K05211  GRIN2C; glutamate receptor ionotropic, NMDA 2C
K05212  GRIN2D; glutamate receptor ionotropic, NMDA 2D
K05213  GRIN3A; glutamate receptor ionotropic, NMDA 3A
K05214  GRIN3B; glutamate receptor ionotropic, NMDA 3B
K05215  P2RX1; P2X purinoceptor 1
K05216  P2RX2; P2X purinoceptor 2
K05217  P2RX3; P2X purinoceptor 3
K05218  P2RX4; P2X purinoceptor 4
K05219  P2RX5; P2X purinoceptor 5
K05220  P2RX7; P2X purinoceptor 7
K05221  P2RX6, P2RXL1; P2X purinoceptor 6
K05222  TRPV1; transient receptor potential cation channel subfamily V member 1
K05223  NMB; neuromedin B
K05224  GRP; gastrin-releasing peptide
K05225  APLN; apelin
K05226  CCK; cholecystokinin
K05227  EDN3; endothelin-3
K05228  POMC; proopiomelanocortin
K05229  PMCH; pro-melanin-concentrating hormone
K05232  NPY; neuropeptide Y
K05233  PYY; peptide YY
K05234  PPY; pancreatic polypeptide
K05235  NTS; neurotensin
K05237  SST; somatostatin
K05238  CORT; cortistatin
K05239  TAC1; tachykinin 1
K05240  TAC3; tachykinin 3
K05241  TAC4; tachykinin 4
K05242  AVP; arginine vasopressin
K05243  OXT; oxytocin-neurophysin 1
K05244  GAL; galanin
K05246  HCRT; hypocretin (orexin) neuropeptide
K05247  NPFF; neuropeptide FF-amide peptide
K05248  UTS2; urotensin 2
K05249  NMU; neuromedin U
K05250  FSHB; follitropin subunit beta
K05251  TSHB; thyrotropin subunit beta
K05252  GNRH; gonadotropin-releasing hormone
K05253  TRH; thyrotropin-releasing hormone
K05254  GHRL; ghrelin
K05256  CRH; corticotropin-releasing hormone
K05257  UCN2_3; urocortin 2/3
K05258  GIP; gastric inhibitory polypeptide
K05259  GCG; glucagon
K05260  GHRH; growth hormone-releasing hormone
K05261  PTH; parathyroid hormone
K05262  ADCYAP; pituitary adenylate cyclase-activating polypeptide
K05263  SCT; secretin
K05264  VIP; vasoactive intestinal peptide
K05265  MLN; motilin
K05266  MLNR; motilin receptor
K05267  NPB; preproneuropeptide B
K05268  NPBWR1; neuropeptides B/W receptor 1
K05269  PRH; prolactin-releasing peptide
K05424  LEP; leptin
K05438  GH; growth hormone
K05439  PRL; prolactin
K05547  THRA, NR1A1; thyroid hormone receptor alpha
K05770  TSPO, BZRP; translocator protein
K05771  NR3C1, GR; glucocorticoid receptor
K05840  DRD5; dopamine receptor D5
K08039  IAPP; islet amyloid polypeptide
K08362  THRB, NR1A2; thyroid hormone receptor beta
K08374  KISS1R; KISS1 receptor
K08375  NPFFR2; neuropeptide FF receptor 2
K08376  NPSR1, GPR154; neuropeptide S receptor
K08377  NPBWR2; neuropeptides B/W receptor 2
K08378  QRFPR, GPR103; pyroglutamylated RFamide peptide receptor
K08386  P2RY8; P2Y purinoceptor 8
K08387  P2RY11; P2Y purinoceptor 11
K08388  P2RY13; P2Y purinoceptor 13
K08397  RXFP3, RLN3R1; relaxin family peptide receptor 3
K08398  RXFP4, RLN3R2; relaxin family peptide receptor 4
K08521  LHB; lutropin subunit beta
K08522  CGA; glycoprotein hormones alpha chain
K09821  AGT, SERPINA8; angiotensinogen
K12332  CALC; calcitonin
K12333  ADM; adrenomedullin
K15840  PDYN, PENKB; proenkephalin B (prodynorphin)
K16366  EDN1; endothelin-1
K16367  EDN2; endothelin-2
K17278  PGRMC1_2; membrane-associated progesterone receptor component
K18832  PENK; proenkephalin A
K21998  RLN1_2; relaxin 1/2
K21999  INSL3; insulin-like 3
K22000  RLN3; relaxin 3
K22001  INSL5; insulin-like 5
K23140  KISS1; metastasis-suppressor KiSS-1
K23141  NPW; neuropeptide W
K23142  UCN; urocortin
K23143  PTH2, TIP39; tuberoinfundibular peptide of 39 residues
K23681  SLURP1; secreted Ly-6/uPAR-related protein 1
K23682  SLURP2; secreted Ly-6/uPAR-related protein 2
K24267  UTS2B; urotensin-2B
K25343  ADM2; adrenomedullin-2
K25355  APELA; apelin receptor early endogenous ligand
K25367  LYPD6; Ly-6/uPAR domain-containing protein 6
K25368  LYPD6B; Ly-6/uPAR domain-containing protein 6B
K25369  LYNX1; Ly-6/neurotoxin-like protein 1
K25370  PATE; prostate and testis expressed protein
K25482  GALP; galanin-like peptide
K25483  GPHA2; glycoprotein hormone alpha-2
K25484  GPHB5; glycoprotein hormone beta-5
K25690  NMS; neuromedin S
K25691  NPS; neuropeptide S
K25692  NPVF; pro-FMRFamide-related neuropeptide VF
K25693  QRFP; orexigenic neuropeptide QRFP
K25694  SPX; spexin
K25695  VGF; neurosecretory protein VGF
K25696  PNOC; prepronociceptin
K26169  PAQR6; membrane progestin receptor delta
K26170  PAQR9; membrane progestin receptor epsilon
K26171  TMEM97, S2R; sigma intracellular receptor 2
K27951  OGFR, OGFRL; opioid growth factor receptor
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00025  L-Glutamate
C00037  Glycine
C00049  L-Aspartate
C00075  UTP
C00099  beta-Alanine
C00212  Adenosine
C00245  Taurine
C00334  4-Aminobutanoate
C00388  Histamine
C00398  Tryptamine
C00410  Progesterone
C00483  Tyramine
C00506  L-Cysteate
C00547  L-Noradrenaline
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C00696  Prostaglandin D2
C00735  Cortisol
C00780  Serotonin
C00788  L-Adrenaline
C01120  Sphinganine 1-phosphate
C01312  Prostaglandin I2
C01516  Morphine
C01598  Melatonin
C01829  Thyroxine
C01996  Acetylcholine
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C02465  Triiodothyronine
C03758  Dopamine
C04227  Octopamine
C04598  2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
C05113  Porphyrin
C05951  Leukotriene D4
C05952  Leukotriene E4
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C06865  Calcitonin
C11695  Anandamide
C12270  N-Acetylaspartylglutamate
C12271  N-Arachidonyldopamine
C12272  N-Oleoyldopamine
C13856  2-Arachidonoylglycerol
C15890  Endomorphin-1
C15891  Endomorphin-2
C15995  Bombesin
C16511  L-Homocysteic acid
C16512  Palmitoylethanolamide

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