KEGG   PATHWAY: myd05014
Entry
myd05014                    Pathway                                
Name
Amyotrophic lateral sclerosis - Myotis davidii (David's myotis)
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
myd05014  Amyotrophic lateral sclerosis
myd05014

Disease
H00058  Amyotrophic lateral sclerosis (ALS)
Organism
Myotis davidii (David's myotis) [GN:myd]
Gene
102751403  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
102751464  NRG3; neuregulin 3 [KO:K05457]
102751479  PSMC5; proteasome 26S subunit, ATPase 5 [KO:K03066]
102751567  PFN4; profilin family member 4 [KO:K05759]
102751578  OPTN; optineurin [KO:K19946]
102751649  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
102751738  CCS; copper chaperone for superoxide dismutase [KO:K04569]
102751750  TPR; translocated promoter region, nuclear basket protein [KO:K09291]
102751770  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
102751838  NUP58; nucleoporin 58 [KO:K14307]
102751843  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
102751916  BID; BH3 interacting domain death agonist [KO:K04726]
102751928  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
102751972  PSMD6; proteasome 26S subunit, non-ATPase 6 [KO:K03037]
102752017  ATG2A; autophagy related 2A [KO:K17906]
102752110  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
102752168  DCTN1; dynactin subunit 1 [KO:K04648]
102752304  NUP62CL; nucleoporin 62 C-terminal like [KO:K14306]
102752324  PSMD3; proteasome 26S subunit, non-ATPase 3 [KO:K03033]
102752342  PSMB5; proteasome subunit beta 5 [KO:K02737] [EC:3.4.25.1]
102752405  TUBA8; tubulin alpha 8 [KO:K07374]
102752458  [KO:K08738]
102752481  ACTR10; actin-related protein 10 homolog [KO:K16576]
102752829  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
102752857  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
102753118  NUP98; nucleoporin 98 [KO:K14297]
102753267  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
102753314  [KO:K02128]
102753514  [KO:K02263]
102753546  [KO:K23609]
102753580  ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
102753591  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
102753621  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
102753690  NEFM; neurofilament medium [KO:K04573]
102753722  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
102753757  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102753860  ANXA7; annexin A7 [KO:K17095]
102753986  BCL2L1; BCL2 like 1 [KO:K04570]
102754038  TUBB4B; tubulin beta 4B class IVb [KO:K07375]
102754140  DNAL1; dynein axonemal light chain 1 [KO:K10411]
102754174  NUP37; nucleoporin 37 [KO:K14302]
102754184  SOD1; superoxide dismutase 1 [KO:K04565] [EC:1.15.1.1]
102754287  NXF1; nuclear RNA export factor 1 [KO:K14284]
102754410  UBQLN1; ubiquilin 1 [KO:K04523]
102754417  [KO:K03948]
102754439  RB1CC1; RB1 inducible coiled-coil 1 [KO:K17589]
102754443  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
102754499  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
102754543  NEFL; neurofilament light [KO:K04572]
102754623  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102754707  [KO:K02267]
102754863  KIF5B; kinesin family member 5B [KO:K10396] [EC:5.6.1.3]
102754952  FUS; FUS RNA binding protein [KO:K13098]
102755118  RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
102755231  PSMB1; proteasome subunit beta 1 [KO:K02732] [EC:3.4.25.1]
102755379  [KO:K02267]
102755407  NUP88; nucleoporin 88 [KO:K14318]
102755480  ATXN2; ataxin 2 [KO:K23625]
102755500  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102755508  PSMC1; proteasome 26S subunit, ATPase 1 [KO:K03062]
102755548  DNAH11; dynein axonemal heavy chain 11 [KO:K10408]
102755559  ATF6; activating transcription factor 6 [KO:K09054]
102755652  SEH1L; SEH1 like nucleoporin [KO:K14299]
102755726  RAE1; ribonucleic acid export 1 [KO:K14298]
102755728  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102755855  ATG14; autophagy related 14 [KO:K17889]
102755889  ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) [KO:K02128]
102756012  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102756353  NUP210L; nucleoporin 210 like [KO:K14314]
102756370  [KO:K08334]
102756535  DNAH8; dynein axonemal heavy chain 8 [KO:K10408]
102756594  DAXX; death domain associated protein [KO:K02308]
102756708  [KO:K00417]
102756756  NUP85; nucleoporin 85 [KO:K14304]
102757009  BECN1; beclin 1 [KO:K08334]
102757032  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5 [KO:K03938]
102757314  VAPB; VAMP associated protein B and C [KO:K10707]
102757318  KLC3; kinesin light chain 3 [KO:K10407]
102757348  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
102757448  [KO:K06693]
102757645  MATR3; matrin 3 [KO:K13213]
102757738  DNAH3; dynein axonemal heavy chain 3 [KO:K10408]
102757859  [KO:K06691]
102757881  FIG4; FIG4 phosphoinositide 5-phosphatase [KO:K22913] [EC:3.1.3.-]
102757960  PARK2; parkin RBR E3 ubiquitin protein ligase [KO:K04556] [EC:2.3.2.31]
102757961  PINK1; PTEN induced putative kinase 1 [KO:K05688] [EC:2.7.11.1]
102758138  ANXA11; annexin A11 [KO:K17095]
102758211  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
102758219  [KO:K02134]
102758322  PSMB4; proteasome subunit beta 4 [KO:K02736] [EC:3.4.25.1]
102758455  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
102758467  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha [KO:K10435]
102758474  PSMA4; proteasome subunit alpha 4 [KO:K02728] [EC:3.4.25.1]
102758613  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
102758655  TUBB6; tubulin beta 6 class V [KO:K07375]
102758738  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
102758773  VDAC1; voltage dependent anion channel 1 [KO:K05862]
102758774  TNF; tumor necrosis factor [KO:K03156]
102759012  TP53; tumor protein p53 [KO:K04451]
102759134  [KO:K02264]
102759225  PFN1; profilin 1 [KO:K05759]
102759239  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
102759247  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102759263  NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285]
102759314  DERL1; derlin 1 [KO:K11519]
102759374  [KO:K12896]
102759477  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102759481  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102759487  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
102759593  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
102759600  PSMA3; proteasome subunit alpha 3 [KO:K02727] [EC:3.4.25.1]
102759782  [KO:K07374]
102759877  [KO:K08738]
102760054  ATG2B; autophagy related 2B [KO:K17906]
102760149  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
102760190  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
102760378  PSMB6; proteasome subunit beta 6 [KO:K02738] [EC:3.4.25.1]
102760414  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
102760641  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
102760710  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
102760712  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
102760722  TOMM40; translocase of outer mitochondrial membrane 40 [KO:K11518]
102760877  TUBA1A; tubulin alpha-1A chain [KO:K07374]
102760882  [KO:K00413]
102760917  PSMD8; proteasome 26S subunit, non-ATPase 8 [KO:K03031]
102760961  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102761017  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
102761101  ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) [KO:K02128]
102761184  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
102761228  [KO:K07374]
102761295  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
102761510  NDC1; NDC1 transmembrane nucleoporin [KO:K14315]
102761581  [KO:K02268]
102761803  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102761812  NUP160; nucleoporin 160 [KO:K14303]
102761840  [KO:K02272]
102762024  PSMC2; proteasome 26S subunit, ATPase 2 [KO:K03061]
102762036  KIF5A; kinesin family member 5A [KO:K10396] [EC:5.6.1.3]
102762038  DNALI1; dynein axonemal light intermediate chain 1 [KO:K10410]
102762058  GPX8; glutathione peroxidase 8 (putative) [KO:K00432] [EC:1.11.1.9]
102762080  TNFRSF1B; TNF receptor superfamily member 1B [KO:K05141]
102762155  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
102762174  TANK; TRAF family member associated NFKB activator [KO:K12650]
102762192  DNAH1; dynein axonemal heavy chain 1 [KO:K10408]
102762248  PSMD1; proteasome 26S subunit, non-ATPase 1 [KO:K03032]
102762321  DCTN2; dynactin subunit 2 [KO:K10424]
102762460  [KO:K02133] [EC:7.1.2.2]
102762580  PSMA1; proteasome subunit alpha 1 [KO:K02725] [EC:3.4.25.1]
102762643  PSMD14; proteasome 26S subunit, non-ATPase 14 [KO:K03030]
102762646  [KO:K03967]
102762680  [KO:K00415]
102762682  NUP214; nucleoporin 214 [KO:K14317]
102762753  [KO:K00414]
102762786  WIPI1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
102762834  DNAH10; dynein axonemal heavy chain 10 [KO:K10408]
102762868  PRPH; peripherin [KO:K07607]
102762935  [KO:K07901]
102763160  [KO:K07374]
102763208  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
102763244  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
102763465  [KO:K03029]
102763571  KLC4; kinesin light chain 4 [KO:K10407]
102763588  PSMD7; proteasome 26S subunit, non-ATPase 7 [KO:K03038]
102763630  [KO:K14284]
102763635  NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
102763654  ATF4; activating transcription factor 4 [KO:K04374]
102763666  [KO:K02132]
102763674  PSMA6; proteasome subunit alpha 6 [KO:K02730] [EC:3.4.25.1]
102763752  ATXN2L; ataxin 2 like [KO:K23625]
102763784  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
102763814  PSMD13; proteasome 26S subunit, non-ATPase 13 [KO:K03039]
102764039  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
102764222  ATG101; autophagy related 101 [KO:K19730]
102764249  MAP1LC3B; microtubule associated protein 1 light chain 3 beta [KO:K10435]
102764280  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
102764395  NUP93; nucleoporin 93 [KO:K14309]
102764429  NRBF2; nuclear receptor binding factor 2 [KO:K21246]
102764508  ACTR1A; ARP1 actin-related protein 1 homolog A, centractin alpha [KO:K16575]
102764661  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102764718  [KO:K02270]
102764728  PSMA5; proteasome subunit alpha 5 [KO:K02729] [EC:3.4.25.1]
102764797  NUP43; nucleoporin 43 [KO:K14305]
102764844  HSPA5; heat shock protein family A (Hsp70) member 5 [KO:K09490] [EC:3.6.4.10]
102764898  HDAC6; histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
102764986  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
102765027  NUP153; nucleoporin 153 [KO:K14296]
102765131  KLC1; kinesin light chain 1 [KO:K10407]
102765189  PFN2; profilin 2 [KO:K05759]
102765234  GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D [KO:K05212]
102765313  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
102765628  UBQLN3; ubiquilin 3 [KO:K04523]
102765674  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
102765830  [KO:K02270]
102765856  NUP133; nucleoporin 133 [KO:K14300]
102765923  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102765925  PSMB3; proteasome subunit beta 3 [KO:K02735] [EC:3.4.25.1]
102765971  TUBA4A; tubulin alpha 4a [KO:K07374]
102766001  ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [KO:K02136]
102766016  TUBB; tubulin beta class I [KO:K07375]
102766068  NEFH; neurofilament heavy [KO:K04574]
102766070  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
102766109  ACTG1; actin gamma 1 [KO:K05692]
102766119  TUBB3; tubulin beta 3 class III [KO:K07375]
102766228  SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
102766253  [KO:K07374]
102766307  ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) [KO:K02128]
102766353  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
102766485  SLC1A2; solute carrier family 1 member 2 [KO:K05613]
102766550  ADRM1; adhesion regulating molecule 1 [KO:K06691]
102766586  [KO:K02268]
102766597  [KO:K02267]
102766630  [KO:K02263]
102766761  DNAL4; dynein axonemal light chain 4 [KO:K10412]
102766824  [KO:K02134]
102766887  PSMD12; proteasome 26S subunit, non-ATPase 12 [KO:K03035]
102766933  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102766991  [KO:K03947]
102767032  [KO:K02270]
102767074  [KO:K08334]
102767111  [KO:K02134]
102767244  DNAH17; dynein axonemal heavy chain 17 [KO:K10408]
102767250  PSMD2; proteasome 26S subunit, non-ATPase 2 [KO:K03028]
102767331  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
102767480  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
102767486  XBP1; X-box binding protein 1 [KO:K09027]
102767488  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
102767532  ACTR1B; ARP1 actin-related protein 1 homolog B, centractin beta [KO:K16575]
102767549  SRSF7; serine and arginine rich splicing factor 7 [KO:K12896]
102767688  TARDBP; TAR DNA binding protein [KO:K23600]
102767782  [KO:K07375]
102767813  [KO:K02265]
102767912  RAB39B; RAB39B, member RAS oncogene family [KO:K07925]
102767968  IL4I1; nuclear pore glycoprotein p62 [KO:K14306]
102767979  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
102768087  NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
102768121  [KO:K00416]
102768253  TUBB1; tubulin beta 1 class VI [KO:K07375]
102768337  DNAH14; dynein axonemal heavy chain 14 [KO:K10408]
102768379  KLC2; kinesin light chain 2 [KO:K10407]
102768382  AMBRA1; autophagy and beclin 1 regulator 1 [KO:K17985]
102768407  NDUFA4L2; NDUFA4, mitochondrial complex associated like 2 [KO:K03948]
102768438  NUP155; nucleoporin 155 [KO:K14312]
102768532  TUBB4A; tubulin beta 4A class IVa [KO:K07375]
102768540  ATP5E; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit [KO:K02135]
102768725  [KO:K02268]
102768744  POM121L2; POM121 transmembrane nucleoporin like 2 [KO:K14316]
102768754  NUP188; nucleoporin 188 [KO:K14311]
102768880  UBQLN4; ubiquilin 4 [KO:K04523]
102768884  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102769113  [KO:K12741]
102769127  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
102769185  ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:7.1.2.2]
102769217  NRG1; neuregulin 1 [KO:K05455]
102769227  DNAH7; dynein axonemal heavy chain 7 [KO:K10408]
102769251  NRG2; neuregulin 2 [KO:K05456]
102769306  MCU; mitochondrial calcium uniporter [KO:K20858]
102769411  DCTN4; dynactin subunit 4 [KO:K10426]
102769473  BCL2; BCL2, apoptosis regulator [KO:K02161]
102769509  DNAH6; dynein axonemal heavy chain 6 [KO:K10408]
102769533  PSMB7; proteasome subunit beta 7 [KO:K02739] [EC:3.4.25.1]
102769631  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
102769655  [KO:K02271]
102769660  CAT; catalase [KO:K03781] [EC:1.11.1.6]
102769688  [KO:K07374]
102769699  [KO:K01370] [EC:3.4.22.36]
102769800  [KO:K00411] [EC:7.1.1.8]
102769833  PSMC3; proteasome 26S subunit, ATPase 3 [KO:K03065]
102769879  NUP35; nucleoporin 35 [KO:K14313]
102770007  CHMP2B; charged multivesicular body protein 2B [KO:K12192]
102770021  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102770040  GRIA2; glutamate ionotropic receptor AMPA type subunit 2 [KO:K05198]
102770207  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
102770227  SMCR8; Smith-Magenis syndrome chromosome region, candidate 8 [KO:K23611]
102770309  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102770419  ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
102770550  [KO:K02271]
102770732  SQSTM1; sequestosome 1 [KO:K14381]
102770736  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
102770825  ALS2; ALS2, alsin Rho guanine nucleotide exchange factor [KO:K04575]
102770920  NXF3; nuclear RNA export factor 3 [KO:K14284]
102770928  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
102770933  PSMB2; proteasome subunit beta 2 [KO:K02734] [EC:3.4.25.1]
102770935  VCP; valosin containing protein [KO:K13525]
102770976  [KO:K14284]
102771029  [KO:K08738]
102771161  [KO:K16631] [EC:3.1.27.-]
102771221  [KO:K02256] [EC:7.1.1.9]
102771249  [KO:K00420]
102771250  PSMA8; proteasome subunit alpha 8 [KO:K02731] [EC:3.4.25.1]
102771257  [KO:K07375]
102771275  [KO:K02266]
102771292  DNAI2; dynein axonemal intermediate chain 2 [KO:K11143]
102771311  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102771313  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
102771330  RAB1A; RAB1A, member RAS oncogene family [KO:K07874]
102771361  DNAH5; dynein axonemal heavy chain 5 [KO:K10408]
102771385  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
102771477  NUP54; nucleoporin 54 [KO:K14308]
102771494  [KO:K14284]
102771505  NCBP1; nuclear cap binding protein subunit 1 [KO:K12882]
102771621  [KO:K00235] [EC:1.3.5.1]
102771665  BAD; BCL2 associated agonist of cell death [KO:K02158]
102771698  [KO:K08334]
102771720  [KO:K00419]
102771729  TOMM40L; translocase of outer mitochondrial membrane 40 like [KO:K11518]
102771881  WDR41; WD repeat domain 41 [KO:K23610]
102771906  NDUFA4; NDUFA4, mitochondrial complex associated [KO:K03948]
102772041  KIF5C; kinesin family member 5C [KO:K10396] [EC:5.6.1.3]
102772094  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6 [KO:K03939]
102772100  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
102772120  NUP107; nucleoporin 107 [KO:K14301]
102772135  NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
102772272  ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D [KO:K02138]
102772361  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102772396  ACTB; actin beta [KO:K05692]
102772683  WIPI2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
102772692  [KO:K12741]
102772721  PSMC6; proteasome 26S subunit, ATPase 6 [KO:K03064]
102772755  SRSF3; serine and arginine rich splicing factor 3 [KO:K12892]
102772927  PSMA2; proteasome subunit alpha 2 [KO:K02726] [EC:3.4.25.1]
102772987  PSMD9; proteasome 26S subunit, non-ATPase 9 [KO:K06693]
102773139  [KO:K00418]
102773153  ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 [KO:K02127]
102773220  SPG11; spastic paraplegia 11 (autosomal recessive) [KO:K19026]
102773255  DCTN6; dynactin subunit 6 [KO:K10428]
102773298  DNAH12; dynein axonemal heavy chain 12 [KO:K10408]
102773354  PSMC4; proteasome 26S subunit, ATPase 4 [KO:K03063]
102773363  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
102773555  GLE1; GLE1, RNA export mediator [KO:K18723]
102773855  TUBAL3; tubulin alpha like 3 [KO:K07374]
102773861  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
102773882  ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102773943  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
102773959  [KO:K04741] [EC:3.4.22.-]
102773996  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
102774084  HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1 [KO:K13158]
102774148  UBQLN2; ubiquilin 2 [KO:K04523]
102774289  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
102774319  ATG13; autophagy related 13 [KO:K08331]
102774359  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
102774402  GRIA1; glutamate ionotropic receptor AMPA type subunit 1 [KO:K05197]
102774469  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
102774648  DCTN3; dynactin subunit 3 [KO:K10425]
102774681  RANBP2; RAN binding protein 2 [KO:K12172] [EC:2.3.2.-]
102774780  NXF2B; nuclear RNA export factor 2 [KO:K14284]
102774832  [KO:K08738]
102774839  [KO:K02267]
102774846  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102775005  GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C [KO:K05211]
102775014  SEM1; SEM1, 26S proteasome complex subunit [KO:K10881]
102775072  [KO:K02264]
102775134  DNAH2; dynein axonemal heavy chain 2 [KO:K10408]
102775153  [KO:K12881]
102775195  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
102775219  DNAI1; dynein axonemal intermediate chain 1 [KO:K10409]
102775234  [KO:K02135]
102775295  NUP50; nucleoporin 50 [KO:K14295]
102775358  PSMA7; proteasome subunit alpha 7 [KO:K02731] [EC:3.4.25.1]
102775375  DCTN5; dynactin subunit 5 [KO:K10427]
102775413  ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 [KO:K02131]
102775490  NUP205; nucleoporin 205 [KO:K14310]
102775535  PSMD11; proteasome 26S subunit, non-ATPase 11 [KO:K03036]
102775549  NUP210; nucleoporin 210 [KO:K14314]
107181822  PSMD4; proteasome 26S subunit, non-ATPase 4 [KO:K03029]
107182784  [KO:K10408]
107184446  ANG; angiogenin [KO:K16631] [EC:3.1.27.-]
22203917  COX2; cytochrome c oxidase subunit II [KO:K02261]
22203918  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
22203919  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
22203920  COX3; cytochrome c oxidase subunit III [KO:K02262]
22203921  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
22203922  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
22203923  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
22203924  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
22203925  CYTB; cytochrome b [KO:K00412]
22203926  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
22203927  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
22203928  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
22203929  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
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Related
pathway
myd00190  Oxidative phosphorylation
myd03013  Nucleocytoplasmic transport
myd03050  Proteasome
myd04010  MAPK signaling pathway
myd04012  ErbB signaling pathway
myd04020  Calcium signaling pathway
myd04115  p53 signaling pathway
myd04137  Mitophagy - animal
myd04140  Autophagy - animal
myd04141  Protein processing in endoplasmic reticulum
myd04210  Apoptosis
myd04724  Glutamatergic synapse
myd04810  Regulation of actin cytoskeleton
KO pathway
ko05014   

DBGET integrated database retrieval system