KEGG   PATHWAY: ko05014
Entry
ko05014                     Pathway                                
Name
Amyotrophic lateral sclerosis
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ko05014  Amyotrophic lateral sclerosis
ko05014

Disease
H00058  Amyotrophic lateral sclerosis (ALS)
Orthology
K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
K00236  SDHC, SDH3; succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
K00411  UQCRFS1, RIP1, petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]
K00412  CYTB, petB; ubiquinol-cytochrome c reductase cytochrome b subunit
K00413  CYC1, CYT1, petC; ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00414  QCR1, UQCRC1; ubiquinol-cytochrome c reductase core subunit 1
K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
K00416  QCR6, UQCRH; ubiquinol-cytochrome c reductase subunit 6
K00417  QCR7, UQCRB; ubiquinol-cytochrome c reductase subunit 7
K00418  QCR8, UQCRQ; ubiquinol-cytochrome c reductase subunit 8
K00419  QCR9, UCRC; ubiquinol-cytochrome c reductase subunit 9
K00420  QCR10, UQCR; ubiquinol-cytochrome c reductase subunit 10
K00432  gpx, btuE, bsaA; glutathione peroxidase [EC:1.11.1.9]
K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
K01370  CASP1; caspase 1 [EC:3.4.22.36]
K02084  APAF1; apoptotic protease-activating factor
K02125  ATPeF08, MTATP8, ATP8; F-type H+-transporting ATPase subunit 8
K02126  ATPeF0A, MTATP6, ATP6; F-type H+-transporting ATPase subunit a
K02127  ATPeF0B, ATP5F1, ATP4; F-type H+-transporting ATPase subunit b
K02128  ATPeF0C, ATP5G, ATP9; F-type H+-transporting ATPase subunit c
K02131  ATPeF0F6, ATP5J; F-type H+-transporting ATPase subunit 6
K02132  ATPeF1A, ATP5A1, ATP1; F-type H+-transporting ATPase subunit alpha
K02133  ATPeF1B, ATP5B, ATP2; F-type H+-transporting ATPase subunit beta [EC:7.1.2.2]
K02134  ATPeF1D, ATP5D, ATP16; F-type H+-transporting ATPase subunit delta
K02135  ATPeF1E, ATP5E, ATP15; F-type H+-transporting ATPase subunit epsilon
K02136  ATPeF1G, ATP5C1, ATP3; F-type H+-transporting ATPase subunit gamma
K02137  ATPeF0O, ATP5O, ATP5; F-type H+-transporting ATPase subunit O
K02138  ATPeF0D, ATP5H, ATP7; F-type H+-transporting ATPase subunit d
K02158  BAD; Bcl-2-antagonist of cell death
K02159  BAX; apoptosis regulator BAX
K02161  BCL2; apoptosis regulator Bcl-2
K02187  CASP3; caspase 3 [EC:3.4.22.56]
K02256  COX1; cytochrome c oxidase subunit 1 [EC:7.1.1.9]
K02261  COX2; cytochrome c oxidase subunit 2
K02262  COX3; cytochrome c oxidase subunit 3
K02263  COX4; cytochrome c oxidase subunit 4
K02264  COX5A; cytochrome c oxidase subunit 5a
K02265  COX5B; cytochrome c oxidase subunit 5b
K02266  COX6A; cytochrome c oxidase subunit 6a
K02267  COX6B; cytochrome c oxidase subunit 6b
K02268  COX6C; cytochrome c oxidase subunit 6c
K02270  COX7A; cytochrome c oxidase subunit 7a
K02271  COX7B; cytochrome c oxidase subunit 7b
K02272  COX7C; cytochrome c oxidase subunit 7c
K02273  COX8; cytochrome c oxidase subunit 8
K02308  DAXX; death-associated protein 6
K02725  PSMA1; 20S proteasome subunit alpha 6 [EC:3.4.25.1]
K02726  PSMA2; 20S proteasome subunit alpha 2 [EC:3.4.25.1]
K02727  PSMA3; 20S proteasome subunit alpha 7 [EC:3.4.25.1]
K02728  PSMA4; 20S proteasome subunit alpha 3 [EC:3.4.25.1]
K02729  PSMA5; 20S proteasome subunit alpha 5 [EC:3.4.25.1]
K02730  PSMA6; 20S proteasome subunit alpha 1 [EC:3.4.25.1]
K02731  PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
K02732  PSMB1; 20S proteasome subunit beta 6 [EC:3.4.25.1]
K02734  PSMB2; 20S proteasome subunit beta 4 [EC:3.4.25.1]
K02735  PSMB3; 20S proteasome subunit beta 3 [EC:3.4.25.1]
K02736  PSMB4; 20S proteasome subunit beta 7 [EC:3.4.25.1]
K02737  PSMB5; 20S proteasome subunit beta 5 [EC:3.4.25.1]
K02738  PSMB6; 20S proteasome subunit beta 1 [EC:3.4.25.1]
K02739  PSMB7; 20S proteasome subunit beta 2 [EC:3.4.25.1]
K03028  PSMD2, RPN1; 26S proteasome regulatory subunit N1
K03029  PSMD4, RPN10; 26S proteasome regulatory subunit N10
K03030  PSMD14, RPN11, POH1; 26S proteasome regulatory subunit N11
K03031  PSMD8, RPN12; 26S proteasome regulatory subunit N12
K03032  PSMD1, RPN2; 26S proteasome regulatory subunit N2
K03033  PSMD3, RPN3; 26S proteasome regulatory subunit N3
K03035  PSMD12, RPN5; 26S proteasome regulatory subunit N5
K03036  PSMD11, RPN6; 26S proteasome regulatory subunit N6
K03037  PSMD6, RPN7; 26S proteasome regulatory subunit N7
K03038  PSMD7, RPN8; 26S proteasome regulatory subunit N8
K03039  PSMD13, RPN9; 26S proteasome regulatory subunit N9
K03061  PSMC2, RPT1; 26S proteasome regulatory subunit T1
K03062  PSMC1, RPT2; 26S proteasome regulatory subunit T2
K03063  PSMC4, RPT3; 26S proteasome regulatory subunit T3
K03064  PSMC6, RPT4; 26S proteasome regulatory subunit T4
K03065  PSMC3, RPT5; 26S proteasome regulatory subunit T5
K03066  PSMC5, RPT6; 26S proteasome regulatory subunit T6
K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K03237  EIF2S1; translation initiation factor 2 subunit 1
K03781  katE, CAT, catB, srpA; catalase [EC:1.11.1.6]
K03878  ND1; NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]
K03879  ND2; NADH-ubiquinone oxidoreductase chain 2 [EC:7.1.1.2]
K03880  ND3; NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2]
K03881  ND4; NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]
K03882  ND4L; NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2]
K03883  ND5; NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2]
K03884  ND6; NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2]
K03934  NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2]
K03935  NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2]
K03936  NDUFS3; NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:7.1.1.2]
K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
K03938  NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5
K03939  NDUFS6; NADH dehydrogenase (ubiquinone) Fe-S protein 6
K03940  NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2]
K03941  NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2]
K03942  NDUFV1; NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2]
K03943  NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2]
K03944  NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3
K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
K03946  NDUFA2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2
K03947  NDUFA3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3
K03948  NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4
K03949  NDUFA5; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5
K03950  NDUFA6; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6
K03951  NDUFA7; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7
K03952  NDUFA8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8
K03953  NDUFA9; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9
K03954  NDUFA10; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10
K03955  NDUFAB1; NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1, acyl-carrier protein
K03956  NDUFA11; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11
K03957  NDUFB1; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1
K03958  NDUFB2; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2
K03959  NDUFB3; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3
K03960  NDUFB4; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4
K03961  NDUFB5; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5
K03962  NDUFB6; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6
K03963  NDUFB7; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7
K03964  NDUFB8; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8
K03965  NDUFB9; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9
K03966  NDUFB10; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10
K03967  NDUFC1; NADH dehydrogenase (ubiquinone) 1 subunit C1
K03968  NDUFC2; NADH dehydrogenase (ubiquinone) 1 subunit C2
K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
K04399  CASP9; caspase 9 [EC:3.4.22.62]
K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04441  P38; p38 MAP kinase [EC:2.7.11.24]
K04451  TP53, P53; tumor protein p53
K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
K04523  UBQLN, DSK2; ubiquilin
K04556  PARK2; parkin [EC:2.3.2.31]
K04565  SOD1; superoxide dismutase, Cu-Zn family [EC:1.15.1.1]
K04569  CCS; copper chaperone for superoxide dismutase
K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K04572  NEFL, NF-L; neurofilament light polypeptide
K04573  NEF3, NF-M; neurofilament medium polypeptide (neurofilament 3)
K04574  NEFH, NF-H; neurofilament heavy polypeptide
K04575  ALS2; amyotrophic lateral sclerosis 2 protein
K04647  HAP1; huntingtin-associated protein 1
K04648  DCTN1; dynactin 1
K04726  BID; BH3 interacting domain death agonist
K04741  CASP12; caspase 12 [EC:3.4.22.-]
K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1]
K05141  TNFRSF1B, TNFR2, CD120b; tumor necrosis factor receptor superfamily member 1B
K05197  GRIA1; glutamate receptor 1
K05198  GRIA2; glutamate receptor 2
K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
K05211  GRIN2C; glutamate receptor ionotropic, NMDA 2C
K05212  GRIN2D; glutamate receptor ionotropic, NMDA 2D
K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
K05455  NRG1; neuregulin 1
K05456  NRG2; neuregulin 2
K05457  NRG3; neuregulin 3
K05458  NRG4; neuregulin 4
K05613  SLC1A2, EAAT2; solute carrier family 1 (glial high affinity glutamate transporter), member 2
K05688  PINK1; PTEN induced putative kinase 1 [EC:2.7.11.1]
K05692  ACTB_G1; actin beta/gamma 1
K05759  PFN; profilin
K05862  VDAC1; voltage-dependent anion channel protein 1
K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
K06691  RPN13; 26S proteasome regulatory subunit N13
K06693  PSMD9, RPN4; 26S proteasome regulatory subunit N4
K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K07374  TUBA; tubulin alpha
K07375  TUBB; tubulin beta
K07607  PRPH; peripherin
K07874  RAB1A; Ras-related protein Rab-1A
K07887  RAB5A; Ras-related protein Rab-5A
K07901  RAB8A, MEL; Ras-related protein Rab-8A
K07925  RAB39B; Ras-related protein Rab-39B
K08269  ULK2, ATG1; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
K08331  ATG13; autophagy-related protein 13
K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
K08334  BECN, VPS30, ATG6; beclin
K08738  CYC; cytochrome c
K08852  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
K09027  XBP1; X box-binding protein 1
K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
K09291  TPR, MLP1, MLP2; nucleoprotein TPR
K09490  HSPA5, BIP; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
K10396  KIF5; kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:5.6.1.3]
K10407  KLC; kinesin light chain
K10408  DNAH; dynein axonemal heavy chain
K10409  DNAI1; dynein axonemal intermediate chain 1
K10410  DNALI; dynein axonemal light intermediate chain 1
K10411  DNAL1; dynein axonemal light chain 1
K10412  DNAL4; dynein axonemal light chain 4
K10424  DCTN2; dynactin 2
K10425  DCTN3; dynactin 3
K10426  DCTN4; dynactin 4
K10427  DCTN5; dynactin 5
K10428  DCTN6; dynactin 6
K10435  MAP1LC; microtubule-associated protein 1 light chain
K10706  SETX, ALS4, SEN1; ATP-dependent RNA/DNA helicase, senataxin [EC:5.6.2.5 5.6.2.3]
K10707  VAPB, ALS8; vesicle-associated membrane protein-associated protein B
K10881  SHFM1, DSS1, RPN15; 26 proteasome complex subunit DSS1
K11143  DNAI2; dynein axonemal intermediate chain 2
K11351  NDUFB11; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11
K11352  NDUFA12; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12
K11353  NDUFA13; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13
K11407  HDAC6; histone deacetylase 6 [EC:3.5.1.98]
K11518  TOM40; mitochondrial import receptor subunit TOM40
K11519  DERL1; Derlin-1
K12172  RANBP2, NUP358; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]
K12192  CHMP2B; charged multivesicular body protein 2B
K12650  TANK; TRAF family member-associated NF-kappa-B activator
K12741  HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3
K12881  THOC4, ALY; THO complex subunit 4
K12882  NCBP1, CBP80; nuclear cap-binding protein subunit 1
K12892  SRSF3, SFRS3; serine/arginine-rich splicing factor 3
K12896  SRSF7, SFRS7; serine/arginine-rich splicing factor 7
K13098  TLS, FUS; RNA-binding protein FUS
K13158  HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1
K13213  MATR3; matrin 3
K13240  NOS1; nitric-oxide synthase, brain [EC:1.14.13.39]
K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K13525  VCP, CDC48; transitional endoplasmic reticulum ATPase
K14004  SEC13; protein transport protein SEC13
K14284  NXF, TAP, MEX67; nuclear RNA export factor
K14285  NXT1_2, P15; NTF2-related export protein 1/2
K14295  NUP50, NPAP60; nuclear pore complex protein Nup50
K14296  NUP153; nuclear pore complex protein Nup153
K14297  NUP98, ADAR2, NUP116; nuclear pore complex protein Nup98-Nup96
K14298  RAE1, GLE2; mRNA export factor
K14299  SEH1; nucleoporin SEH1
K14300  NUP133; nuclear pore complex protein Nup133
K14301  NUP107, NUP84; nuclear pore complex protein Nup107
K14302  NUP37; nuclear pore complex protein Nup37
K14303  NUP160, NUP120; nuclear pore complex protein Nup160
K14304  NUP85; nuclear pore complex protein Nup85
K14305  NUP43; nuclear pore complex protein Nup43
K14306  NUP62, NSP1; nuclear pore complex protein Nup62
K14307  NUPL1, NUP49; nucleoporin p58/p45
K14308  NUP54, NUP57; nuclear pore complex protein Nup54
K14309  NUP93, NIC96; nuclear pore complex protein Nup93
K14310  NUP205, NUP192; nuclear pore complex protein Nup205
K14311  NUP188; nuclear pore complex protein Nup188
K14312  NUP155, NUP170, NUP157; nuclear pore complex protein Nup155
K14313  NUP35, NUP53; nuclear pore complex protein Nup53
K14314  NUP210, GP210; nuclear pore complex protein Nup210
K14315  NDC1, TMEM48; nucleoporin NDC1
K14316  POM121, NUP121; nuclear pore complex protein Nup121
K14317  NUP214, CAN; nuclear pore complex protein Nup214
K14318  NUP88; nuclear pore complex protein Nup88
K14381  SQSTM1; sequestosome 1
K16575  ACTR1, ARP1; centractin
K16576  ACTR10, ARP11; actin-related protein 10
K16631  ANG, RNASE5; angiogenin [EC:3.1.27.-]
K17095  ANXA7_11; annexin A7/11
K17589  RB1CC1; RB1-inducible coiled-coil protein 1
K17889  ATG14L, ATG14; beclin 1-associated autophagy-related key regulator
K17906  ATG2; autophagy-related protein 2
K17908  WIPI1_2, ATG18; autophagy-related protein 18
K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
K18723  GLE1; nucleoporin GLE1
K19026  SPG11; spatacsin
K19730  ATG101; autophagy-related protein 101
K19946  OPTN, FIP2; optineurin
K20719  SIGMAR1; sigma non-opioid intracellular receptor
K20858  MCU; calcium uniporter protein, mitochondrial
K21246  NRBF2; nuclear receptor-binding factor 2
K21357  ULK1; serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
K22759  CHCHD10; coiled-coil-helix-coiled-coil-helix domain-containing protein 10
K22913  FIG4; phosphatidylinositol 3,5-bisphosphate 5-phosphatase [EC:3.1.3.-]
K23600  TARDBP, TDP43; TAR DNA-binding protein 43
K23609  C9ORF72; guanine nucleotide exchange protein C9orf72
K23610  WDR41; WD repeat-containing protein 41
K23611  SMCR8; guanine nucleotide exchange protein SMCR8
K23625  ATXN2_2L; ataxin 2/2L
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
Reference
PMID:28700839
  Authors
Brown RH, Al-Chalabi A
  Title
Amyotrophic Lateral Sclerosis.
  Journal
N Engl J Med 377:162-172 (2017)
DOI:10.1056/NEJMra1603471
Reference
PMID:28512398
  Authors
Webster CP, Smith EF, Shaw PJ, De Vos KJ
  Title
Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
  Journal
Front Mol Neurosci 10:123 (2017)
DOI:10.3389/fnmol.2017.00123
Reference
PMID:30879475
  Authors
Valko K, Ciesla L
  Title
Amyotrophic lateral sclerosis.
  Journal
Prog Med Chem 58:63-117 (2019)
DOI:10.1016/bs.pmch.2018.12.001
Reference
PMID:30870681
  Authors
Mathis S, Goizet C, Soulages A, Vallat JM, Masson GL
  Title
Genetics of amyotrophic lateral sclerosis: A review.
  Journal
J Neurol Sci 399:217-226 (2019)
DOI:10.1016/j.jns.2019.02.030
Reference
PMID:23415570
  Authors
Turner MR, Hardiman O, Benatar M, Brooks BR, Chio A, de Carvalho M, Ince PG, Lin C, Miller RG, Mitsumoto H, Nicholson G, Ravits J, Shaw PJ, Swash M, Talbot K, Traynor BJ, Van den Berg LH, Veldink JH, Vucic S, Kiernan MC
  Title
Controversies and priorities in amyotrophic lateral sclerosis.
  Journal
Lancet Neurol 12:310-22 (2013)
DOI:10.1016/S1474-4422(13)70036-X
Reference
PMID:16924260
  Authors
Pasinelli P, Brown RH
  Title
Molecular biology of amyotrophic lateral sclerosis: insights from genetics.
  Journal
Nat Rev Neurosci 7:710-23 (2006)
DOI:10.1038/nrn1971
Reference
PMID:16723044
  Authors
Goodall EF, Morrison KE
  Title
Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment.
  Journal
Expert Rev Mol Med 8:1-22 (2006)
DOI:10.1017/S1462399406010854
Reference
PMID:28669745
  Authors
Smith EF, Shaw PJ, De Vos KJ
  Title
The role of mitochondria in amyotrophic lateral sclerosis.
  Journal
Neurosci Lett 710:132933 (2019)
DOI:10.1016/j.neulet.2017.06.052
Reference
PMID:32344665
  Authors
Kodavati M, Wang H, Hegde ML
  Title
Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective.
  Journal
Cells 9:E1065 (2020)
DOI:10.3390/cells9041065
Reference
PMID:16372325
  Authors
Hervias I, Beal MF, Manfredi G
  Title
Mitochondrial dysfunction and amyotrophic lateral sclerosis.
  Journal
Muscle Nerve 33:598-608 (2006)
DOI:10.1002/mus.20489
Reference
PMID:16603792
  Authors
Bacman SR, Bradley WG, Moraes CT
  Title
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Related
pathway
ko00190  Oxidative phosphorylation
ko03013  Nucleocytoplasmic transport
ko03050  Proteasome
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04020  Calcium signaling pathway
ko04115  p53 signaling pathway
ko04137  Mitophagy - animal
ko04140  Autophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04724  Glutamatergic synapse
ko04810  Regulation of actin cytoskeleton

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