KEGG   PATHWAY: npd04081
Entry
npd04081                    Pathway                                
Name
Hormone signaling - Nothoprocta perdicaria (Chilean tinamou)
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
npd04081  Hormone signaling
npd04081

Organism
Nothoprocta perdicaria (Chilean tinamou) [GN:npd]
Gene
112942347  PTHLH; parathyroid hormone-related protein [KO:K22608]
112942696  [KO:K02649]
112942706  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112942710  RAMP3; receptor activity-modifying protein 3 isoform X1 [KO:K08449]
112942733  ITGAV; integrin alpha-V [KO:K06487]
112942737  SLC40A1; solute carrier family 40 member 1 [KO:K14685]
112942894  SMAD9; mothers against decapentaplegic homolog 9 [KO:K16791]
112942984  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
112943004  DRD5; D(1B) dopamine receptor [KO:K05840]
112943057  ADRA2C; alpha-2C adrenergic receptor [KO:K04140]
112943164  HCRTR2; orexin receptor type 2 [KO:K04239]
112943354  DIO1; type I iodothyronine deiodinase [KO:K01562] [EC:1.21.99.4]
112943537  PTH; parathyroid hormone [KO:K05261]
112943630  CCK; cholecystokinin [KO:K05226]
112943851  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
112943951  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112944092  APPL1; DCC-interacting protein 13-alpha isoform X1 [KO:K08733]
112944172  [KO:K08747]
112944178  [KO:K08747]
112944205  CRH; corticoliberin [KO:K05256]
112944386  IAPP; islet amyloid polypeptide isoform X1 [KO:K08039]
112944527  IRS4; insulin receptor substrate 4 [KO:K07187]
112944572  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
112944578  AVPR1B; vasopressin V1b receptor [KO:K04227]
112944957  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112945131  IRS2; insulin receptor substrate 2 isoform X1 [KO:K07187]
112945237  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112945240  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
112945254  INS; insulin [KO:K04526]
112945315  SSTR2; somatostatin receptor type 2 [KO:K04218]
112945321  GCGR; glucagon receptor [KO:K04583]
112945522  LEPR; leptin receptor isoform X1 [KO:K05062]
112945554  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112945579  DRD3; D(3) dopamine receptor [KO:K04146]
112945961  GHR; growth hormone receptor [KO:K05080]
112946022  CCKAR; cholecystokinin receptor type A [KO:K04194]
112946149  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
112946169  GCG; glucagon [KO:K05259]
112946238  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112946371  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
112946582  CGA; glycoprotein hormones alpha chain [KO:K08522]
112946612  PMCH; pro-MCH [KO:K05229]
112946628  IGF1; insulin-like growth factor I [KO:K05459]
112946768  PRLR; prolactin receptor [KO:K05081]
112946779  ADIPOQ; adiponectin [KO:K07296]
112946801  [KO:K04635]
112946814  NPR3; atrial natriuretic peptide receptor 3 [KO:K12325]
112946923  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
112947049  SLC16A2; monocarboxylate transporter 8 [KO:K08231]
112947052  [KO:K04228]
112947187  [KO:K08551]
112947220  SSTR4; somatostatin receptor type 4 [KO:K04220]
112947233  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
112947392  CALCR; calcitonin receptor [KO:K04576]
112947452  AGTR1; type-1 angiotensin II receptor [KO:K04166]
112947494  MC1R; melanocyte-stimulating hormone receptor [KO:K04199]
112947568  PTH1R; parathyroid hormone/parathyroid hormone-related peptide receptor [KO:K04585]
112947576  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
112947753  SSTR3; somatostatin receptor type 3 [KO:K04219]
112947867  IRS1; insulin receptor substrate 1 [KO:K16172]
112947911  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112948190  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
112948220  MC5R; melanocortin receptor 5 [KO:K04203]
112948227  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
112948275  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112948383  [KO:K04280]
112948396  [KO:K04280]
112948419  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
112948453  SLC16A10; monocarboxylate transporter 10 [KO:K08187]
112948519  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
112948654  AGTR2; type-2 angiotensin II receptor [KO:K04167]
112948720  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
112948721  PNOC; prepronociceptin [KO:K25696]
112948757  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
112948762  [KO:K04589]
112948766  POMC; pro-opiomelanocortin [KO:K05228]
112948768  GHRHR; growth hormone-releasing hormone receptor [KO:K04584]
112948769  VIPR1; vasoactive intestinal polypeptide receptor 1 [KO:K04589]
112948843  CALCA; calcitonin [KO:K12332]
112948849  FSHB; follitropin subunit beta [KO:K05250]
112948851  [KO:K04314]
112949018  THRA; thyroid hormone receptor alpha [KO:K05547]
112949118  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
112949366  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
112949660  MC3R; melanocortin receptor 3 [KO:K04201]
112949673  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
112949691  OPRL1; nociceptin receptor isoform X1 [KO:K04216]
112949739  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
112950148  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
112950169  [KO:K04314]
112950312  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
112950323  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
112950330  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
112950374  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
112950486  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
112950566  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
112950972  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
112951071  GNRH1; progonadoliberin-1 [KO:K05252]
112951103  [KO:K04546]
112951329  MC4R; melanocortin receptor 4 [KO:K04202]
112951510  TSHB; thyrotropin subunit beta [KO:K05251]
112951647  OPRM1; mu-type opioid receptor isoform X1 [KO:K04215]
112951660  ESR1; estrogen receptor [KO:K08550]
112951674  VIP; VIP peptides isoform X1 [KO:K05264]
112951799  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
112951822  RAMP2; receptor activity-modifying protein 2 [KO:K08448]
112951832  HCRT; orexin [KO:K05246]
112951852  [KO:K11224]
112951866  OPRD1; delta-type opioid receptor [KO:K04213]
112951980  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
112952062  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
112952065  DRD4; D(4) dopamine receptor [KO:K04147]
112952187  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
112952282  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
112952308  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
112952389  THPO; thrombopoietin [KO:K06854]
112952435  SST; somatostatin [KO:K05237]
112952476  NPPC; C-type natriuretic peptide [KO:K12336]
112952492  GHSR; growth hormone secretagogue receptor type 1 isoform X1 [KO:K04284]
112952569  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112952653  THRB; thyroid hormone receptor beta isoform X1 [KO:K08362]
112952698  AMH; muellerian-inhibiting factor [KO:K04665]
112952799  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
112953151  UCN3; urocortin-3 [KO:K05257]
112953204  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
112953407  RHOA; transforming protein RhoA [KO:K04513]
112953660  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
112953791  [KO:K04320]
112953904  PRL; prolactin [KO:K05439]
112954115  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
112954217  [KO:K05438]
112954218  [KO:K04589]
112954272  SMAD5; mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
112954386  DRD1; D(1A) dopamine receptor [KO:K04144]
112954394  ADRB2; beta-2 adrenergic receptor [KO:K04142]
112954450  ADRA1B; alpha-1B adrenergic receptor isoform X1 [KO:K04136]
112954775  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
112954834  [KO:K04247]
112954856  [KO:K04248]
112955004  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
112955018  DIO2; type II iodothyronine deiodinase [KO:K17904] [EC:1.21.99.4]
112955228  PRLH; prolactin-releasing peptide [KO:K05269]
112955254  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112955559  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
112955563  [KO:K05243]
112955565  [KO:K05242]
112955683  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112955745  [KO:K04583]
112955839  RAMP1; receptor activity-modifying protein 1 [KO:K08447]
112956601  OPRK1; kappa-type opioid receptor [KO:K04214]
112956610  PENK; proenkephalin-A [KO:K18832]
112956791  [KO:K05439]
112957004  PRLHR; prolactin-releasing peptide receptor [KO:K04314]
112957142  ADRB1; beta-1 adrenergic receptor [KO:K04141]
112957196  ADRA2A; alpha-2A adrenergic receptor [KO:K04138]
112957358  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
112957491  GUCA2A; guanylin [KO:K25556]
112957508  [KO:K05840]
112957810  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
112958069  SSTR1; somatostatin receptor type 1 [KO:K04217]
112958116  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
112958199  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
112958213  [KO:K04634]
112958320  ADIPOR2; adiponectin receptor protein 2 [KO:K07297]
112958367  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
112958374  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
112958718  OXTR; oxytocin receptor [KO:K04229]
112958723  GHRL; appetite-regulating hormone [KO:K05254]
112958733  TRH; thyrotropin releasing hormone [KO:K05253]
112958893  MPL; thrombopoietin receptor [KO:K05082]
112958919  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
112958952  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112958998  HEPHL1; hephaestin-like protein 1 [KO:K14735] [EC:1.16.3.1]
112959051  VIPR2; vasoactive intestinal polypeptide receptor 2 [KO:K04590]
112959140  MLN; promotilin [KO:K05265]
112959182  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
112959353  AGT; angiotensinogen isoform X1 [KO:K09821]
112959414  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112959596  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112959633  [KO:K12334]
112959654  [KO:K12336]
112959684  [KO:K08551]
112959917  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
112959935  SSTR5; somatostatin receptor type 5 [KO:K04221]
112959999  GPER1; G-protein coupled estrogen receptor 1 [KO:K04246]
112960066  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
112960094  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112960115  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
112960129  [KO:K12336]
112960174  GIP; gastric inhibitory polypeptide [KO:K05258]
112960212  [KO:K04585]
112960283  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
112960286  ITGB3; integrin beta-3 [KO:K06493]
112960291  CRHR1; corticotropin-releasing factor receptor 1 [KO:K04578]
112960325  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
112960419  HEPH; hephaestin isoform X1 [KO:K14735] [EC:1.16.3.1]
Compound
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00788  L-Adrenaline
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01829  Thyroxine
C02017  Corticotropin
C02210  beta-Endorphin
C02465  Triiodothyronine
C02758  alpha-Melanotropin
C03758  Dopamine
C14818  Fe2+
C14819  Fe3+
C16000  Urodilatin
C16048  Glucagon-like peptide 1
C16125  Calcitonin gene-related peptide 1
C16126  Calcitonin gene-related peptide 2
C16136  beta-Melanotropin
C16137  gamma-Melanotropin
Reference
  Authors
Trubacova R, Drastichova Z, Novotny J
  Title
Biochemical and physiological insights into TRH receptor-mediated signaling.
  Journal
Front Cell Dev Biol 10:981452 (2022)
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Reference
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Velez EJ, Unniappan S
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A Comparative Update on the Neuroendocrine Regulation of Growth Hormone in Vertebrates.
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Front Endocrinol (Lausanne) 11:614981 (2020)
DOI:10.3389/fendo.2020.614981
Reference
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Ther Adv Endocrinol Metab 9:209-215 (2018)
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Reference
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Molecular mechanism of prolactin-releasing peptide recognition and signaling via its G protein-coupled receptor.
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Front Mol Neurosci 11:220 (2018)
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Reference
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Lin YT, Hsu KS
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Oxytocin receptor signaling in the hippocampus: Role in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social  memory.
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Prog Neurobiol 171:1-14 (2018)
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Oxytocin and vasopressin signaling in health and disease.
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Trends Biochem Sci 49:361-377 (2024)
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Molecular basis of opioid receptor signaling.
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Front Endocrinol (Lausanne) 13:992883 (2022)
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A Balanced Act: The Effects of GH-GHR-IGF1 Axis on Mitochondrial Function.
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Front Cell Dev Biol 9:630248 (2021)
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  Title
Mechanistic insight into how gonadotropin hormone receptor complexes direct signalingdagger.
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Prog Retin Eye Res 95:101187 (2023)
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Reference
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Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism.
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Reference
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Emerging concepts of receptor endocytosis and concurrent intracellular signaling: Mechanisms of guanylyl cyclase/natriuretic peptide receptor-A activation and  trafficking.
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Cell Signal 60:17-30 (2019)
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Reference
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  Title
alpha(1)-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition.
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Front Pharmacol 11:581098 (2020)
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Immunomodulatory Effects of Dopamine in Inflammatory Diseases.
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Front Immunol 12:663102 (2021)
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Reference
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Molecules 28:molecules28145481 (2023)
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Trends Biochem Sci 41:274-86 (2016)
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Int J Mol Sci 24:ijms241210209 (2023)
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Metabolomics of Type 1 and Type 2 Diabetes.
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Int J Mol Sci 20:ijms20102467 (2019)
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  Title
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Related
pathway
npd04020  Calcium signaling pathway
KO pathway
ko04081   

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