KEGG   PATHWAY: ko04081
Entry
ko04081                     Pathway                                
Name
Hormone signaling
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ko04081  Hormone signaling
ko04081

Orthology
K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K01562  DIO1; type I thyroxine 5'-deiodinase [EC:1.21.99.4]
K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04135  ADRA1A; adrenergic receptor alpha-1A
K04136  ADRA1B; adrenergic receptor alpha-1B
K04137  ADRA1D; adrenergic receptor alpha-1D
K04138  ADRA2A; adrenergic receptor alpha-2A
K04139  ADRA2B; adrenergic receptor alpha-2B
K04140  ADRA2C; adrenergic receptor alpha-2C
K04141  ADRB1; adrenergic receptor beta-1
K04142  ADRB2; adrenergic receptor beta-2
K04143  ADRB3; adrenergic receptor beta-3
K04144  DRD1; dopamine receptor D1
K04145  DRD2; dopamine receptor D2
K04146  DRD3; dopamine receptor D3
K04147  DRD4; dopamine receptor D4
K04166  AGTR1; angiotensin II receptor type 1
K04167  AGTR2; angiotensin II receptor type 2
K04194  CCKAR; cholecystokinin A receptor
K04195  CCKBR; cholecystokinin B receptor
K04199  MC1R; melanocortin 1 receptor
K04200  MC2R; melanocortin 2 receptor
K04201  MC3R; melanocortin 3 receptor
K04202  MC4R; melanocortin 4 receptor
K04203  MC5R; melanocortin 5 receptor
K04213  OPRD1; delta-type opioid receptor
K04214  OPRK1; kappa-type opioid receptor
K04215  OPRM1; mu-type opioid receptor
K04216  OPRL1; nociceptin receptor
K04217  SSTR1; somatostatin receptor 1
K04218  SSTR2; somatostatin receptor 2
K04219  SSTR3; somatostatin receptor 3
K04220  SSTR4; somatostatin receptor 4
K04221  SSTR5; somatostatin receptor 5
K04226  AVPR1A; arginine vasopressin receptor 1A
K04227  AVPR1B; arginine vasopressin receptor 1B
K04228  AVPR2; arginine vasopressin receptor 2
K04229  OXTR; oxytocin receptor
K04238  HCRTR1; hypocretin (orexin) receptor 1
K04239  HCRTR2; hypocretin (orexin) receptor 2
K04246  GPER1, GPR30; G-protein coupled estrogen receptor 1
K04247  FSHR; follicle stimulating hormone receptor
K04248  LHCGR; lutropin-choriogonadotropic hormone receptor
K04249  TSHR; thyrotropin receptor
K04280  GNRHR; gonadotropin-releasing hormone receptor
K04282  TRHR; thyrotropin-releasing hormone receptor
K04284  GHSR; growth hormone secretagogue receptor
K04314  PRLHR, GPR10; prolactin releasing hormone receptor
K04320  MCHR1; melanin-concentrating hormone receptor 1
K04345  PKA; protein kinase A [EC:2.7.11.11]
K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
K04501  SMAD4; mothers against decapentaplegic homolog 4
K04513  RHOA; Ras homolog gene family, member A
K04526  INS; insulin
K04527  INSR, CD220; insulin receptor [EC:2.7.10.1]
K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
K04576  CALCR; calcitonin receptor
K04578  CRHR1; corticotropin releasing hormone receptor 1
K04579  CRHR2; corticotropin releasing hormone receptor 2
K04580  GIPR; gastric inhibitory polypeptide receptor
K04581  GLP1R; glucagon-like peptide 1 receptor
K04583  GCGR; glucagon receptor
K04584  GHRHR; growth hormone releasing hormone receptor
K04585  PTH1R, PTHR1; parathyroid hormone receptor 1
K04589  VIPR1; vasoactive intestinal peptide receptor 1
K04590  VIPR2; vasoactive intestinal peptide receptor 2
K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K04635  GNA11; guanine nucleotide-binding protein subunit alpha-11
K04636  GNA14; guanine nucleotide-binding protein subunit alpha-14
K04637  GNA15; guanine nucleotide-binding protein subunit alpha-15
K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
K04665  AMH; anti-mullerian hormone
K04672  AMHR2; anti-mullerian hormone receptor type-2 [EC:2.7.11.30]
K04673  BMPR1A, ALK3, CD292; bone morphogenetic protein receptor type-1A [EC:2.7.11.30]
K04675  ACVR1, ALK2; activin receptor type-1 [EC:2.7.11.30]
K04676  SMAD1; mothers against decapentaplegic homolog 1
K04692  STAT3; signal transducer and activator of transcription 3
K05054  MCHR2; melanin-concentrating hormone receptor 2
K05062  LEPR, CD295; leptin receptor
K05079  EPOR; erythropoietin receptor
K05080  GHR; growth hormone receptor
K05081  PRLR; prolactin receptor
K05082  TPOR, MPL, CD110; thrombopoietin receptor
K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05226  CCK; cholecystokinin
K05228  POMC; proopiomelanocortin
K05229  PMCH; pro-melanin-concentrating hormone
K05237  SST; somatostatin
K05242  AVP; arginine vasopressin
K05243  OXT; oxytocin-neurophysin 1
K05246  HCRT; hypocretin (orexin) neuropeptide
K05250  FSHB; follitropin subunit beta
K05251  TSHB; thyrotropin subunit beta
K05252  GNRH; gonadotropin-releasing hormone
K05253  TRH; thyrotropin-releasing hormone
K05254  GHRL; ghrelin
K05256  CRH; corticotropin-releasing hormone
K05257  UCN2_3; urocortin 2/3
K05258  GIP; gastric inhibitory polypeptide
K05259  GCG; glucagon
K05260  GHRH; growth hormone-releasing hormone
K05261  PTH; parathyroid hormone
K05264  VIP; vasoactive intestinal peptide
K05265  MLN; motilin
K05266  MLNR; motilin receptor
K05269  PRH; prolactin-releasing peptide
K05424  LEP; leptin
K05437  EPO; erythropoietin
K05438  GH; growth hormone
K05439  PRL; prolactin
K05459  IGF1; insulin-like growth factor 1
K05547  THRA, NR1A1; thyroid hormone receptor alpha
K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K05840  DRD5; dopamine receptor D5
K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K06487  ITGAV, CD51; integrin alpha V
K06493  ITGB3, CD61; integrin beta 3
K06854  THPO; thrombopoietin
K07187  IRS2; insulin receptor substrate 2
K07296  ADIPOQ, ACDC; adiponectin
K07297  ADIPOR; adiponectin receptor
K07298  STK11, LKB1; serine/threonine-protein kinase 11 [EC:2.7.11.1]
K07376  PRKG1; cGMP-dependent protein kinase 1 [EC:2.7.11.12]
K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
K08039  IAPP; islet amyloid polypeptide
K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K08187  SLC16A10; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 10
K08231  SLC16A2; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 2
K08362  THRB, NR1A2; thyroid hormone receptor beta
K08447  RAMP1; receptor activity modifying protein 1
K08448  RAMP2; receptor activity modifying protein 2
K08449  RAMP3; receptor activity modifying protein 3
K08521  LHB; lutropin subunit beta
K08522  CGA; glycoprotein hormones alpha chain
K08550  ESR1, NR3A1; estrogen receptor alpha
K08551  ESR2, NR3A2; estrogen receptor beta
K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
K08747  SLCO1C; solute carrier organic anion transporter family, member 1C
K09821  AGT, SERPINA8; angiotensinogen
K11223  STAT5A; signal transducer and activator of transcription 5A
K11224  STAT5B; signal transducer and activator of transcription 5B
K12320  GUCY2C; heat-stable enterotoxin receptor [EC:4.6.1.2]
K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A [EC:4.6.1.2]
K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B [EC:4.6.1.2]
K12325  NPR3; atrial natriuretic peptide clearance receptor
K12332  CALC; calcitonin
K12334  NPPA; natriuretic peptide A
K12335  NPPB; natriuretic peptide B
K12336  NPPC; natriuretic peptide C
K13240  NOS1; nitric-oxide synthase, brain [EC:1.14.13.39]
K13578  BMPR1B, ALK6, CDw293; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]
K13768  GAST; gastrin
K13769  IGF2; insulin-like growth factor 2
K14685  SLC40A1, FPN1; solute carrier family 40 (iron-regulated transporter), member 1
K14735  HEPH; hephaestin [EC:1.16.3.1]
K15840  PDYN, PENKB; proenkephalin B (prodynorphin)
K16172  IRS1; insulin receptor substrate 1
K16790  SMAD5; mothers against decapentaplegic homolog 5
K16791  SMAD9, SMAD8; mothers against decapentaplegic homolog 9
K17445  IRS3; insulin receptor substrate 3
K17446  IRS4; insulin receptor substrate 4
K17904  DIO2; type II thyroxine 5'-deiodinase [EC:1.21.99.4]
K18832  PENK; proenkephalin A
K19477  PRKG2; cGMP-dependent protein kinase 2 [EC:2.7.11.12]
K22608  PTHLH, PTHRP; parathyroid hormone-related hormone
K23106  HAMP; hepcidin
K23142  UCN; urocortin
K25556  GUCA2; guanylate cyclase activator 2
K25696  PNOC; prepronociceptin
Compound
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00788  L-Adrenaline
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01829  Thyroxine
C02017  Corticotropin
C02210  beta-Endorphin
C02465  Triiodothyronine
C02758  alpha-Melanotropin
C03758  Dopamine
C14818  Fe2+
C14819  Fe3+
C16000  Urodilatin
C16048  Glucagon-like peptide 1
C16125  Calcitonin gene-related peptide 1
C16126  Calcitonin gene-related peptide 2
C16136  beta-Melanotropin
C16137  gamma-Melanotropin
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Reference
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Reference
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Reference
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PMID:37193881
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Prossnitz ER, Barton M
  Title
The G protein-coupled oestrogen receptor GPER in health and disease: an update.
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Nat Rev Endocrinol 19:407-424 (2023)
DOI:10.1038/s41574-023-00822-7
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PMID:33902691
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Roy B, Palaniyandi SS
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Tissue-specific role and associated downstream signaling pathways of adiponectin.
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Cell Biosci 11:77 (2021)
DOI:10.1186/s13578-021-00587-4
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PMID:37724323
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Liu J, Lai F, Hou Y, Zheng R
  Title
Leptin signaling and leptin resistance.
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Med Rev (2021) 2:363-384 (2022)
DOI:10.1515/mr-2022-0017
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PMID:35642485
  Authors
Kuter DJ
  Title
Treatment of chemotherapy-induced thrombocytopenia in patients with non-hematologic malignancies.
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Haematologica 107:1243-1263 (2022)
DOI:10.3324/haematol.2021.279512
Related
pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04630  JAK-STAT signaling pathway

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