KEGG   PATHWAY: afz04660
Entry
afz04660                    Pathway                                
Name
T cell receptor signaling pathway - Antechinus flavipes (yellow-footed antechinus)
Description
Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells.
Class
Organismal Systems; Immune system
Pathway map
afz04660  T cell receptor signaling pathway
afz04660

Other DBs
GO: 0050852
Organism
Antechinus flavipes (yellow-footed antechinus) [GN:afz]
Gene
127562947  T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
127564449  T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
127547467  T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458]
127547469  T-cell surface glycoprotein CD8 beta chain [KO:K06459]
127562753  receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
127555504  tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
127562100  tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
127545311  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
127550190  lymphocyte cytosolic protein 2 [KO:K07361]
127555820  linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
127550133  tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
127542033  tyrosine-protein kinase Tec [KO:K07364] [EC:2.7.10.2]
127554232  cytoplasmic protein NCK1 isoform X1 [KO:K07365]
127553529  cytoplasmic protein NCK2 [KO:K19862]
127550959  guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
127544858  proto-oncogene vav [KO:K05730]
127559419  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
127538340  GRB2-related adapter protein 2 isoform X1 [KO:K07366]
127560474  growth factor receptor-bound protein 2 [KO:K04364]
127555038  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
127554201  serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
127542476  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
127556142  serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
127548496  serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
127549223  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
127541249  transforming protein RhoA-like isoform X1 [KO:K04513]
127549354  transforming protein RhoA-like [KO:K04513]
127554850  transforming protein RhoA [KO:K04513]
127564730  cell division control protein 42 homolog [KO:K04393]
127555744  cell division control protein 42 homolog isoform X1 [KO:K04393]
127558287  disks large homolog 1 isoform X1 [KO:K12076]
127538834  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
127538838  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
127561225  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
127561226  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
127550395  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
127551919  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127548327  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127540919  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
127548157  calcineurin subunit B type 1 isoform X1 [KO:K06268]
127544078  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
127548924  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
127547866  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
127549759  son of sevenless homolog 2 isoform X1 [KO:K03099]
127547998  son of sevenless homolog 1 isoform X1 [KO:K03099]
127549211  RAS guanyl-releasing protein 1 [KO:K04350]
127540068  GTPase HRas [KO:K02833]
127564364  ras-like protein [KO:K07827]
127564665  ras-like protein [KO:K07827]
127564806  GTPase KRas isoform X1 [KO:K07827]
127564858  GTPase KRas-like [KO:K07827]
127564890  ras-like protein [KO:K07827]
127564892  GTPase NRas-like [KO:K07827]
127541495  ras-like protein [KO:K07827]
127537819  GTPase NRas-like [KO:K07827]
127537860  GTPase NRas-like [KO:K07827]
127538037  ras-like protein [KO:K07827]
127538119  ras-like protein [KO:K07827]
127538128  LOW QUALITY PROTEIN: ras-like protein [KO:K07827]
127538787  ras-like protein [KO:K07827]
127538953  ras-like protein [KO:K07827]
127539191  ras-like protein [KO:K07827]
127539349  GTPase NRas-like [KO:K07827]
127539435  ras-like protein [KO:K07827]
127539441  ras protein let-60-like [KO:K07827]
127541494  ras-like protein [KO:K07828]
127559280  GTPase NRas [KO:K07828]
127538788  GTPase NRas-like [KO:K07828]
127538790  GTPase NRas-like [KO:K07828]
127538791  GTPase NRas-like [KO:K07828]
127538792  GTPase NRas-like [KO:K07828]
127538794  GTPase NRas-like [KO:K07828]
127552087  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
127551242  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127544950  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
127556083  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
127545795  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
127549484  protein c-Fos [KO:K04379]
127563247  transcription factor Jun [KO:K04448]
127538061  protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
127563675  caspase recruitment domain-containing protein 11 [KO:K07367]
127563045  B-cell lymphoma/leukemia 10 [KO:K07368]
127543466  mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
127562007  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
127545314  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
127542137  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127550306  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
127551815  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127548272  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
127542289  NF-kappa-B essential modulator isoform X1 [KO:K07210]
127541094  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
127540746  transcription factor p65 isoform X1 [KO:K04735]
127549751  NF-kappa-B inhibitor alpha [KO:K04734]
127556146  NF-kappa-B inhibitor beta [KO:K02581]
127561799  NF-kappa-B inhibitor epsilon [KO:K05872]
127553204  T-cell-specific surface glycoprotein CD28 [KO:K06470]
127553205  inducible T-cell costimulator [KO:K06713]
127542334  CD40 ligand [KO:K03161]
127563398  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
127558297  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
127545225  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
127555896  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
127552891  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
127554245  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
127563028  LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
127542756  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
127549861  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127556193  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127559596  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127564555  mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
127560369  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
127554112  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
127558338  programmed cell death protein 1 [KO:K06744]
127553202  cytotoxic T-lymphocyte protein 4 [KO:K06538]
127539233  tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
127556035  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
127545492  tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
127549824  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
127539590  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
127539655  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
127556425  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
127554975  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
127550069  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
127552220  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
127547333  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
127540860  protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
127549749  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
127553699  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
127554225  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
127562576  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
127549612  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
127549900  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
127540094  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
127561763  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
127554025  E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
127541142  interleukin-2-like [KO:K05429]
127549848  interleukin-5 [KO:K05428]
127561582  interleukin-10 [KO:K05443]
127564234  interferon gamma [KO:K04687]
127559172  tumor necrosis factor [KO:K03156]
127538222  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15122199
  Authors
Chen L.
  Title
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.
  Journal
Nat Rev Immunol 4:336-47 (2004)
DOI:10.1038/nri1349
Reference
PMID:15928679
  Authors
Macian F.
  Title
NFAT proteins: key regulators of T-cell development and function.
  Journal
Nat Rev Immunol 5:472-84 (2005)
DOI:10.1038/nri1632
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:15084594
  Authors
Huang Y, Wange RL.
  Title
T cell receptor signaling: beyond complex complexes.
  Journal
J Biol Chem 279:28827-30 (2004)
DOI:10.1074/jbc.R400012200
Reference
PMID:14656980
  Authors
Schmitz ML, Bacher S, Dienz O.
  Title
NF-kappaB activation pathways induced by T cell costimulation.
  Journal
FASEB J 17:2187-93 (2003)
DOI:10.1096/fj.02-1100rev
Reference
PMID:11905831
  Authors
Alegre ML, Frauwirth KA, Thompson CB.
  Title
T-cell regulation by CD28 and CTLA-4.
  Journal
Nat Rev Immunol 1:220-8 (2001)
DOI:10.1038/35105024
Reference
PMID:15286727
  Authors
Horejsi V, Zhang W, Schraven B.
  Title
Transmembrane adaptor proteins: organizers of immunoreceptor signalling.
  Journal
Nat Rev Immunol 4:603-16 (2004)
DOI:10.1038/nri1414
Reference
PMID:15343367
  Authors
Baniyash M.
  Title
TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response.
  Journal
Nat Rev Immunol 4:675-87 (2004)
DOI:10.1038/nri1434
Reference
PMID:15099566
  Authors
Sechi AS, Wehland J.
  Title
Interplay between TCR signalling and actin cytoskeleton dynamics.
  Journal
Trends Immunol 25:257-65 (2004)
DOI:10.1016/j.it.2004.03.003
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15489916
  Authors
Palacios EH, Weiss A.
  Title
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
  Journal
Oncogene 23:7990-8000 (2004)
DOI:10.1038/sj.onc.1208074
Reference
PMID:12133805
  Authors
Kane LP, Lin J, Weiss A.
  Title
It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.
  Journal
Trends Immunol 23:413-20 (2002)
DOI:10.1016/S1471-4906(02)02264-0
Reference
PMID:14647476
  Authors
Acuto O, Michel F.
  Title
CD28-mediated co-stimulation: a quantitative support for TCR signalling.
  Journal
Nat Rev Immunol 3:939-51 (2003)
DOI:10.1038/nri1248
Reference
PMID:15308211
  Authors
Finkelstein LD, Schwartzberg PL.
  Title
Tec kinases: shaping T-cell activation through actin.
  Journal
Trends Cell Biol 14:443-51 (2004)
DOI:10.1016/j.tcb.2003.07.001
Reference
PMID:15345216
  Authors
Duan L, Reddi AL, Ghosh A, Dimri M, Band H.
  Title
The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling.
  Journal
Immunity 21:7-17 (2004)
DOI:10.1016/j.immuni.2004.06.012
Reference
PMID:14617194
  Authors
Schrum AG, Turka LA, Palmer E.
  Title
Surface T-cell antigen receptor expression and availability for long-term antigenic signaling.
  Journal
Immunol Rev 196:7-24 (2003)
DOI:10.1046/j.1600-065X.2003.00083.x
Reference
PMID:19132916
  Authors
Smith-Garvin JE, Koretzky GA, Jordan MS
  Title
T cell activation.
  Journal
Annu Rev Immunol 27:591-619 (2009)
DOI:10.1146/annurev.immunol.021908.132706
Reference
PMID:12195013
  Authors
Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO
  Title
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.
  Journal
Proc Natl Acad Sci U S A 99:11796-801 (2002)
DOI:10.1073/pnas.092284399
Reference
PMID:19290929
  Authors
Blonska M, Lin X
  Title
CARMA1-mediated NF-kappaB and JNK activation in lymphocytes.
  Journal
Immunol Rev 228:199-211 (2009)
DOI:10.1111/j.1600-065X.2008.00749.x
Reference
PMID:17395537
  Authors
Rebeaud F, Hailfinger S, Thome M
  Title
Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation.
  Journal
Trends Immunol 28:196-200 (2007)
DOI:10.1016/j.it.2007.03.004
Reference
PMID:16799472
  Authors
Ashwell JD
  Title
The many paths to p38 mitogen-activated protein kinase activation in the immune system.
  Journal
Nat Rev Immunol 6:532-40 (2006)
DOI:10.1038/nri1865
Reference
PMID:17187070
  Authors
Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC
  Title
Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.
  Journal
Nat Immunol 8:154-61 (2007)
DOI:10.1038/ni1422
Related
pathway
afz04010  MAPK signaling pathway
afz04020  Calcium signaling pathway
afz04064  NF-kappa B signaling pathway
afz04120  Ubiquitin mediated proteolysis
afz04151  PI3K-Akt signaling pathway
afz04514  Cell adhesion molecules
afz04810  Regulation of actin cytoskeleton
KO pathway
ko04660   
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