KEGG   PATHWAY: ccad04934
Entry
ccad04934                   Pathway                                
Name
Cushing syndrome - Cervus canadensis (wapiti)
Description
Cushing syndrome (CS) is a rare disorder resulting from prolonged exposure to excess glucocorticoids via exogenous and endogenous sources. The typical clinical features of CS are related to hypercortisolism and include accumulation of central fat, moon facies, neuromuscular weakness, osteoporosis or bone fractures, metabolic complications, and mood changes. Traditionally, endogenous CS is classified as adrenocorticotropic hormone (ACTH)-dependent (about 80%) or ACTH- independent (about 20%). Among ACTH-dependent forms, pituitary corticotroph adenoma (Cushing's disease) is most common. Most pituitary tumors are sporadic, resulting from monoclonal expansion of a single mutated cell. Recently recurrent activating somatic driver mutations in the ubiquitin-specific protease 8 gene (USP8) were identified in almost half of corticotroph adenoma. Germline mutations in MEN1 (encoding menin), AIP (encoding aryl-hydrocarbon receptor-interacting protein), PRKAR1A (encoding cAMP-dependent protein kinase type I alpha regulatory subunit) and CDKN1B (encoding cyclin-dependent kinase inhibitor 1B; also known as p27 Kip1) have been identified in familial forms of pituitary adenomas. However, the frequency of familial pituitary adenomas is less than 5% in patients with pituitary adenomas. Among ACTH-independent CS, adrenal adenoma is most common. Rare adrenal causes of CS include primary bilateral macronodular adrenal hyperplasia (BMAH) or primary pigmented nodular adrenocortical disease (PPNAD).
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
ccad04934  Cushing syndrome
ccad04934

Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122451098  CRH; corticoliberin [KO:K05256]
122440095  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
122438423  CRHR2; corticotropin-releasing factor receptor 2 [KO:K04579]
122448612  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
122448614  neuroendocrine secretory protein 55 [KO:K04632]
122454307  uncharacterized protein LOC122454307 [KO:K04632]
122438514  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
122454210  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
122441999  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
122443147  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
122444643  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
122427399  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
122421548  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
122451315  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122432769  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
122440547  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122436774  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122426833  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
122453548  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
122423084  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122444829  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122438693  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
122440234  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
122449620  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
122452823  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
122433265  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
122438446  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
122429308  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
122430782  MEN1; menin isoform X1 [KO:K14970]
122432481  ASH2L; set1/Ash2 histone methyltransferase complex subunit ASH2 [KO:K14964]
122451890  RBBP5; retinoblastoma-binding protein 5 isoform X1 [KO:K14961]
122442370  WDR5; WD repeat-containing protein 5 isoform X1 [KO:K14963]
122444630  WDR5B; WD repeat-containing protein 5B [KO:K14963]
122449209  KMT2A; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
122427655  KMT2D; histone-lysine N-methyltransferase 2D [KO:K09187] [EC:2.1.1.354]
122449984  cyclin-dependent kinase 4 inhibitor C [KO:K06622]
122436995  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
122452872  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
122452871  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
122427215  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
122438094  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122430666  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
122447603  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
122448331  E2F1; transcription factor E2F1 [KO:K17454]
122426579  E2F2; transcription factor E2F2 [KO:K09389]
122429389  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
122443843  RASD1; dexamethasone-induced Ras-related protein 1 [KO:K07843]
122424468  GNAI2; guanine nucleotide-binding protein G(I) subunit alpha-2 [KO:K04630]
122436579  GNAI3; guanine nucleotide-binding protein G(I) subunit alpha-3 [KO:K04630]
122438257  GNAI1; guanine nucleotide-binding protein G(I) subunit alpha-1 [KO:K04630]
122438174  AHR; aryl hydrocarbon receptor [KO:K09093]
122430947  AH receptor-interacting protein isoform X1 [KO:K17767]
122446885  AIPL1; aryl-hydrocarbon-interacting protein-like 1 [KO:K17767]
122434357  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
122423697  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
122427513  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
122421575  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
122450896  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
122429747  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
122424089  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
122424654  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122434769  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
122452261  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
122438529  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
122439705  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
122422042  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
122446388  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
122436539  RAP1A; ras-related protein Rap-1A [KO:K04353]
122427076  RAP1B; ras-related protein Rap-1b [KO:K07836]
122438725  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122443062  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122440231  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
122440910  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
122446062  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
122447261  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
122433033  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122455309  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122427135  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
122424243  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122443615  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
122422170  pro-opiomelanocortin-like [KO:K05228]
122441991  POMC; pro-opiomelanocortin [KO:K05228]
122425747  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
122428797  melanocortin-2 receptor accessory protein [KO:K22398]
122442993  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
122419798  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
122453724  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
122442148  NR5A1; steroidogenic factor 1 [KO:K08560]
122427132  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
122429894  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
122451091  cytochrome P450 11B1, mitochondrial isoform X1 [KO:K00497] [EC:1.14.15.4]
122445953  steroid 17-alpha-hydroxylase/17,20 lyase-like isoform X1 [KO:K00512] [EC:1.14.14.19 1.14.14.32]
122446740  steroid 17-alpha-hydroxylase/17,20 lyase [KO:K00512] [EC:1.14.14.19 1.14.14.32]
122432483  STAR; steroidogenic acute regulatory protein, mitochondrial [KO:K16931]
122444928  NCEH1; neutral cholesterol ester hydrolase 1 [KO:K14349] [EC:3.1.1.-]
122433180  ARMC5; armadillo repeat-containing protein 5 [KO:K22499]
122446567  AGT; angiotensinogen [KO:K09821]
122445077  AGTR1; type-1 angiotensin II receptor [KO:K04166]
122453031  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
122440204  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
122448381  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
122448380  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
122430651  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
122443383  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
122424343  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122423671  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
122430147  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
122452379  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
122443431  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
122433117  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
122423082  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
122423849  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
122449870  KCNA4; potassium voltage-gated channel subfamily A member 4 [KO:K04877]
122441971  KCNK3; potassium channel subfamily K member 3 [KO:K04914]
122440398  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
122424577  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
122455135  cholesterol side-chain cleavage enzyme, mitochondrial [KO:K00498] [EC:1.14.15.6]
122435367  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase isoform X1 [KO:K00070] [EC:1.1.1.145 5.3.3.1]
122429310  steroid 21-hydroxylase isoform X1 [KO:K00513] [EC:1.14.14.16]
122452114  FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
122427439  WNT1; proto-oncogene Wnt-1 [KO:K03209]
122436531  WNT2B; protein Wnt-2b [KO:K00182]
122438339  WNT2; protein Wnt-2 [KO:K00182]
122439332  WNT3A; protein Wnt-3a [KO:K00312]
122440141  WNT3; proto-oncogene Wnt-3 [KO:K00312]
122426808  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
122423100  WNT5B; protein Wnt-5b [KO:K00444]
122424423  WNT5A; protein Wnt-5a [KO:K00444]
122426705  WNT6; protein Wnt-6 [KO:K00445]
122423904  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
122425114  WNT7A; protein Wnt-7a [KO:K00572]
122439209  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
122446043  WNT8B; protein Wnt-8b [KO:K00714]
122440612  WNT9A; protein Wnt-9a [KO:K01064]
122440147  WNT9B; protein Wnt-9b [KO:K01064]
122426703  WNT10A; protein Wnt-10a [KO:K01357]
122427584  WNT10B; protein Wnt-10b [KO:K01357]
122449784  WNT11; protein Wnt-11 [KO:K01384]
122438578  WNT16; protein Wnt-16 [KO:K01558]
122426021  FZD7; frizzled-7 [KO:K02432]
122438068  FZD1; frizzled-1 [KO:K02432]
122440461  FZD2; frizzled-2 [KO:K02235]
122453133  FZD3; frizzled-3 isoform X1 [KO:K02329]
122430895  FZD4; frizzled-4 [KO:K02354]
122448204  FZD8; frizzled-8 [KO:K02375]
122426066  FZD5; frizzled-5 [KO:K02375]
122451193  FZD6; frizzled-6 [KO:K02376]
122432799  FZD9; frizzled-9 [KO:K02842]
122454464  FZD10; frizzled-10 [KO:K02842]
122446196  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
122452413  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
122444865  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
122445589  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122433487  AXIN1; axin-1 isoform X1 [KO:K02157]
122425340  AXIN2; axin-2 isoform X1 [KO:K04385]
122425067  CTNNB1; catenin beta-1 [KO:K02105]
122439955  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
122442941  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
122439921  TCF7; transcription factor 7 isoform X1 [KO:K02620]
122441729  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
122445909  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
122422034  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
Compound
C00020  AMP
C00076  Calcium cation
C00187  Cholesterol
C00238  Potassium cation
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C00735  Cortisol
C01176  17alpha-Hydroxyprogesterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01953  Pregnenolone
C05138  17alpha-Hydroxypregnenolone
C05488  11-Deoxycortisol
C07557  2,3,7,8-Tetrachlorodibenzodioxin
Reference
PMID:26004339
  Authors
Lacroix A, Feelders RA, Stratakis CA, Nieman LK
  Title
Cushing's syndrome.
  Journal
Lancet 386:913-27 (2015)
DOI:10.1016/S0140-6736(14)61375-1
Reference
PMID:27588171
  Authors
Xiong Q, Ge W
  Title
Gene mutations in Cushing's disease.
  Journal
Biomed Rep 5:277-282 (2016)
DOI:10.3892/br.2016.729
Reference
PMID:25877147
  Authors
Fukuoka H, Takahashi Y
  Title
The role of genetic and epigenetic changes in pituitary tumorigenesis.
  Journal
Neurol Med Chir (Tokyo) 54 Suppl 3:943-57 (2014)
DOI:10.2176/nmc.suppl.2014-3
Reference
PMID:18987159
  Authors
Quereda V, Malumbres M
  Title
Cell cycle control of pituitary development and disease.
  Journal
J Mol Endocrinol 42:75-86 (2009)
DOI:10.1677/JME-08-0146
Reference
PMID:27742789
  Authors
Caimari F, Korbonits M
  Title
Novel Genetic Causes of Pituitary Adenomas.
  Journal
Clin Cancer Res 22:5030-5042 (2016)
DOI:10.1158/1078-0432.CCR-16-0452
Reference
PMID:25350067
  Authors
Lecoq AL, Kamenicky P, Guiochon-Mantel A, Chanson P
  Title
Genetic mutations in sporadic pituitary adenomas--what to screen for?
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Nat Rev Endocrinol 11:43-54 (2015)
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Reference
PMID:27625633
  Authors
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  Title
Alterations of Phosphodiesterases in Adrenocortical Tumors.
  Journal
Front Endocrinol (Lausanne) 7:111 (2016)
DOI:10.3389/fendo.2016.00111
Reference
PMID:21423242
  Authors
Melmed S
  Title
Pathogenesis of pituitary tumors.
  Journal
Nat Rev Endocrinol 7:257-66 (2011)
DOI:10.1038/nrendo.2011.40
Reference
PMID:19407507
  Authors
Daly AF, Tichomirowa MA, Beckers A
  Title
Genetic, molecular and clinical features of familial isolated pituitary adenomas.
  Journal
Horm Res 71 Suppl 2:116-22 (2009)
DOI:10.1159/000192448
Reference
PMID:28850717
  Authors
Albani A, Theodoropoulou M, Reincke M
  Title
Genetics of Cushing's disease.
  Journal
Clin Endocrinol (Oxf) 88:3-12 (2018)
DOI:10.1111/cen.13457
Reference
PMID:26045561
  Authors
Duan K, Hernandez KG, Mete O
  Title
Clinicopathological correlates of adrenal Cushing's syndrome.
  Journal
Postgrad Med J 91:331-42 (2015)
DOI:10.1136/postgradmedj-2014-202612rep
Reference
PMID:26264719
  Authors
Drougat L, Espiard S, Bertherat J
  Title
Genetics of primary bilateral macronodular adrenal hyperplasia: a model for early diagnosis of Cushing's syndrome?
  Journal
Eur J Endocrinol 173:M121-31 (2015)
DOI:10.1530/EJE-15-0532
Reference
PMID:17955016
  Authors
Stratakis CA, Boikos SA
  Title
Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias.
  Journal
Nat Clin Pract Endocrinol Metab 3:748-57 (2007)
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Reference
PMID:19906235
  Authors
Refojo D, Holsboer F
  Title
CRH signaling. Molecular specificity for drug targeting in the CNS.
  Journal
Ann N Y Acad Sci 1179:106-19 (2009)
DOI:10.1111/j.1749-6632.2009.04983.x
Reference
PMID:12089357
  Authors
Kovalovsky D, Refojo D, Liberman AC, Hochbaum D, Pereda MP, Coso OA, Stalla GK, Holsboer F, Arzt E
  Title
Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways.
  Journal
Mol Endocrinol 16:1638-51 (2002)
DOI:10.1210/mend.16.7.0863
Reference
PMID:15380809
  Authors
Lacroix A, Baldacchino V, Bourdeau I, Hamet P, Tremblay J
  Title
Cushing's syndrome variants secondary to aberrant hormone receptors.
  Journal
Trends Endocrinol Metab 15:375-82 (2004)
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Reference
PMID:25485838
  Authors
Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M, Komada M
  Title
Mutations in the deubiquitinase gene USP8 cause Cushing's disease.
  Journal
Nat Genet 47:31-8 (2015)
DOI:10.1038/ng.3166
Reference
PMID:25930709
  Authors
Kaiser UB
  Title
Cushing's disease: towards precision medicine.
  Journal
Cell Res 25:649-50 (2015)
DOI:10.1038/cr.2015.53
Reference
PMID:28487882
  Authors
Uzilov AV, Cheesman KC, Fink MY, Newman LC, Pandya C, Lalazar Y, Hefti M, Fowkes M, Deikus G, Lau CY, Moe AS, Kinoshita Y, Kasai Y, Zweig M, Gupta A, Starcevic D, Mahajan M, Schadt EE, Post KD, Donovan MJ, Sebra R, Chen R, Geer EB
  Title
Identification of a novel RASD1 somatic mutation in a USP8-mutated corticotroph adenoma.
  Journal
Cold Spring Harb Mol Case Stud 3:a001602 (2017)
DOI:10.1101/mcs.a001602
Reference
PMID:26285834
  Authors
Huang C, Shi Y, Zhao Y
  Title
USP8 mutation in Cushing's disease.
  Journal
Oncotarget 6:18240-1 (2015)
DOI:10.18632/oncotarget.4856
Reference
PMID:26012588
  Authors
Theodoropoulou M, Reincke M, Fassnacht M, Komada M
  Title
Decoding the genetic basis of Cushing's disease: USP8 in the spotlight.
  Journal
Eur J Endocrinol 173:M73-83 (2015)
DOI:10.1530/EJE-15-0320
Reference
PMID:29370219
  Authors
Yu L, Zhang J, Guo X, Chen X, He Z, He Q
  Title
ARMC5 mutations in familial and sporadic primary bilateral macronodular adrenal hyperplasia.
  Journal
PLoS One 13:e0191602 (2018)
DOI:10.1371/journal.pone.0191602
Reference
PMID:19075677
  Authors
Wu X, Hua X
  Title
Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
  Journal
Curr Mol Med 8:805-15 (2008)
DOI:10.2174/156652408786733702
Reference
PMID:20457215
  Authors
Ozfirat Z, Korbonits M
  Title
AIP gene and familial isolated pituitary adenomas.
  Journal
Mol Cell Endocrinol 326:71-9 (2010)
DOI:10.1016/j.mce.2010.05.001
Related
pathway
ccad00020  Citrate cycle (TCA cycle)
ccad00140  Steroid hormone biosynthesis
ccad04020  Calcium signaling pathway
ccad04024  cAMP signaling pathway
ccad04110  Cell cycle
ccad04310  Wnt signaling pathway
ccad04927  Cortisol synthesis and secretion
ccad04960  Aldosterone-regulated sodium reabsorption
KO pathway
ko04934   
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