KEGG   PATHWAY: chx05208
Entry
chx05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Capra hircus (goat)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
chx05208  Chemical carcinogenesis - reactive oxygen species
chx05208

Organism
Capra hircus (goat) [GN:chx]
Gene
100861071  AS3MT; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
100860758  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
102174170  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
102188913  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100861222  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
102189813  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
102190481  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
102185621  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
108637838  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
102178383  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
102185021  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
102190488  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
102174444  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
102173702  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
102175171  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
102174708  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
102190016  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
102189370  glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
106503993  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
108633298  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
108636034  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
102179973  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
1485856  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
1485857  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
1485863  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
1485865  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
1485864  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
1485866  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
1485867  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
102184322  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
102176841  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
102183643  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2 [KO:K03944]
102177419  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
102177332  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
102172091  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
102179638  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
100861284  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
102187560  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
102171224  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
102176032  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
102168736  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
102179361  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
102181922  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
102170842  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
102181026  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
102187118  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
102189802  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
102174090  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
102168216  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
102177927  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102189432  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
102182696  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
102171860  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
100861349  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
102188420  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
102168407  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
102188663  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100861376  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
102190747  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
102188065  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
102170635  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
102170016  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
102181207  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
100860782  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
102185248  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
102186141  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
102182202  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
102183107  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
102183195  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
102189176  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
100860881  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
102172289  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
1485868  CYTB; cytochrome b [KO:K00412]
102169976  cytochrome c1, heme protein, mitochondrial [KO:K00413]
102188264  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
100861263  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
102176290  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
102183616  cytochrome b-c1 complex subunit 7 [KO:K00417]
102171149  cytochrome b-c1 complex subunit 8 [KO:K00418]
102187154  cytochrome b-c1 complex subunit 9 [KO:K00419]
108635646  cytochrome b-c1 complex subunit 9 [KO:K00419]
102168533  cytochrome b-c1 complex subunit 10 [KO:K00420]
1485862  COX3; cytochrome c oxidase subunit III [KO:K02262]
1485858  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
1485859  COX2; cytochrome c oxidase subunit II [KO:K02261]
102179296  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
102188434  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
102191741  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
102179291  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102172376  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
102181181  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
102184937  cytochrome c oxidase subunit 6B2 [KO:K02267]
102179036  cytochrome c oxidase subunit 6B1 [KO:K02267]
102173770  cytochrome c oxidase subunit 6C [KO:K02268]
108635087  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102187496  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
102188675  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102175610  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
102186286  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
102184512  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
102170877  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102173562  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108633170  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102188021  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
102184488  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
102186463  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
102171890  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
102188764  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
102188061  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
102173355  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
1485861  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
102178499  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
102180353  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
102168606  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
102168293  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
102173603  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
102170632  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
102187983  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
1485860  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
100860856  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
102173290  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102169457  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102176666  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102173075  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102178813  ADP/ATP translocase 3 [KO:K05863]
102176546  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100861351  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102187374  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100861196  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
100860855  CAT; catalase [KO:K03781] [EC:1.11.1.6]
102190499  SLC26A1; sulfate anion transporter 1 [KO:K14700]
102183319  SLC26A2; sulfate transporter [KO:K14701]
102187722  SLC26A6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
102172831  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
102170554  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
102182294  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
102191547  CYP2F3; cytochrome P450 2F3 precursor [KO:K07416] [EC:1.14.14.1]
102170823  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
102184252  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
100860945  EPHX1; epoxide hydrolase 1 precursor [KO:K01253] [EC:3.3.2.9]
102185835  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
102184515  EPHX3; epoxide hydrolase 3 isoform X1 [KO:K22368] [EC:3.3.2.10]
102169445  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
102181747  AKR1A1; alcohol dehydrogenase [NADP(+)] [KO:K00002] [EC:1.1.1.2]
102190498  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102176622  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102176340  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102177638  dihydrodiol dehydrogenase 3 isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102189495  dihydrodiol dehydrogenase 3 isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102186942  dihydrodiol dehydrogenase 3-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102189109  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102187932  dihydrodiol dehydrogenase 3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102187204  dihydrodiol dehydrogenase 3 isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102187504  prostaglandin F synthase 1-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102188684  prostaglandin F synthase 1 isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102188418  dihydrodiol dehydrogenase 3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102173771  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
108633281  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
102178311  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
102172669  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
102188109  AHR; aryl hydrocarbon receptor [KO:K09093]
100860761  LPO; lactoperoxidase precursor [KO:K12550] [EC:1.11.1.7]
102181655  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
102188617  cytochrome b-245 light chain [KO:K08009]
102178048  NOX1; NADPH oxidase 1 [KO:K08008]
102176291  NCF1; neutrophil cytosol factor 1 [KO:K08011]
102171728  NCF2; neutrophil cytosol factor 2 isoform X2 [KO:K08010]
106502173  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
102172767  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102183288  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102181186  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
102170356  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102185660  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102184154  SOS2; son of sevenless homolog 2 [KO:K03099]
102186668  HRAS; GTPase HRas isoform X1 [KO:K02833]
102172519  KRAS; GTPase KRas isoform X1 [KO:K07827]
102187180  NRAS; GTPase NRas [KO:K07828]
102169370  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102174360  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
108638619  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
102190520  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X4 [KO:K04368] [EC:2.7.12.2]
102175285  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102172156  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102175799  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102173178  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102182774  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102170408  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100861087  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102180926  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100860996  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102189174  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102184510  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102185423  JUN; transcription factor AP-1 [KO:K04448]
102171520  FOS; proto-oncogene c-Fos [KO:K04379]
102179343  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102170135  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102188710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102185042  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102168391  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102177551  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102173438  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102184966  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100860904  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102174051  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102187521  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102188676  FOXO3; forkhead box protein O3 [KO:K09408]
102189930  BAD; bcl2-associated agonist of cell death [KO:K02158]
102191814  PTPN1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
102185891  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102181262  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102177406  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102171591  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102169137  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102174096  RELA; transcription factor p65 [KO:K04735]
102175660  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102171471  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
102174768  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
100861348  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X3 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
102177271  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
102169118  tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
102182890  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102184349  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
102186140  ABL2; Abelson tyrosine-protein kinase 2 isoform X3 [KO:K08887] [EC:2.7.10.2]
102174216  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
106503372  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
102175981  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
102177814  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102174434  PLD1; phospholipase D1 isoform X5 [KO:K01115] [EC:3.1.4.4]
102176556  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
102189617  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100861391  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
102183027  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
100860957  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
102182688  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
102176737  NFE2L2; nuclear factor erythroid 2-related factor 2 [KO:K05638]
100860951  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
Reference
PMID:24281075
  Authors
Henkler F, Brinkmann J, Luch A
  Title
The role of oxidative stress in carcinogenesis induced by metals and xenobiotics.
  Journal
Cancers (Basel) 2:376-96 (2010)
DOI:10.3390/cancers2020376
Reference
PMID:22705365
  Authors
Lee JC, Son YO, Pratheeshkumar P, Shi X
  Title
Oxidative stress and metal carcinogenesis.
  Journal
Free Radic Biol Med 53:742-57 (2012)
DOI:10.1016/j.freeradbiomed.2012.06.002
Reference
PMID:32033297
  Authors
Hu Y, Li J, Lou B, Wu R, Wang G, Lu C, Wang H, Pi J, Xu Y
  Title
The Role of Reactive Oxygen Species in Arsenic Toxicity.
  Journal
Biomolecules 10:E240 (2020)
DOI:10.3390/biom10020240
Reference
PMID:33864199
  Authors
Ozturk M, Metin M, Altay V, Bhat RA, Ejaz M, Gul A, Unal BT, Hasanuzzaman M, Nibir L, Nahar K, Bukhari A, Dervash MA, Kawano T
  Title
Arsenic and Human Health: Genotoxicity, Epigenomic Effects, and Cancer Signaling.
  Journal
Biol Trace Elem Res 10.1007/s12011-021-02719-w (2021)
DOI:10.1007/s12011-021-02719-w
Reference
PMID:23510327
  Authors
Hubaux R, Becker-Santos DD, Enfield KS, Rowbotham D, Lam S, Lam WL, Martinez VD
  Title
Molecular features in arsenic-induced lung tumors.
  Journal
Mol Cancer 12:20 (2013)
DOI:10.1186/1476-4598-12-20
Reference
PMID:21648415
  Authors
Naranmandura H, Xu S, Sawata T, Hao WH, Liu H, Bu N, Ogra Y, Lou YJ, Suzuki N
  Title
Mitochondria are the main target organelle for trivalent monomethylarsonous acid (MMA(III))-induced cytotoxicity.
  Journal
Chem Res Toxicol 24:1094-103 (2011)
DOI:10.1021/tx200156k
Reference
PMID:23583964
  Authors
Faita F, Cori L, Bianchi F, Andreassi MG
  Title
Arsenic-induced genotoxicity and genetic susceptibility to arsenic-related pathologies.
  Journal
Int J Environ Res Public Health 10:1527-46 (2013)
DOI:10.3390/ijerph10041527
Reference
PMID:28179585
  Authors
Sage AP, Minatel BC, Ng KW, Stewart GL, Dummer TJB, Lam WL, Martinez VD
  Title
Oncogenomic disruptions in arsenic-induced carcinogenesis.
  Journal
Oncotarget 8:25736-25755 (2017)
DOI:10.18632/oncotarget.15106
Reference
PMID:21414382
  Authors
Jomova K, Valko M
  Title
Advances in metal-induced oxidative stress and human disease.
  Journal
Toxicology 283:65-87 (2011)
DOI:10.1016/j.tox.2011.03.001
Reference
PMID:16430879
  Authors
Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M
  Title
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
  Journal
Chem Biol Interact 160:1-40 (2006)
DOI:10.1016/j.cbi.2005.12.009
Reference
PMID:32731582
  Authors
Tumolo M, Ancona V, De Paola D, Losacco D, Campanale C, Massarelli C, Uricchio VF
  Title
Chromium Pollution in European Water, Sources, Health Risk, and Remediation Strategies: An Overview.
  Journal
Int J Environ Res Public Health 17:E5438 (2020)
DOI:10.3390/ijerph17155438
Reference
PMID:28860815
  Authors
Wang Y, Su H, Gu Y, Song X, Zhao J
  Title
Carcinogenicity of chromium and chemoprevention: a brief update.
  Journal
Onco Targets Ther 10:4065-4079 (2017)
DOI:10.2147/OTT.S139262
Reference
PMID:24820114
  Authors
Jin X, Chen M, Song L, Li H, Li Z
  Title
The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma.
  Journal
Toxicology 322:99-108 (2014)
DOI:10.1016/j.tox.2014.05.002
Reference
PMID:20370557
  Authors
Liou GY, Storz P
  Title
Reactive oxygen species in cancer.
  Journal
Free Radic Res 44:479-96 (2010)
DOI:10.3109/10715761003667554
Reference
PMID:11275476
  Authors
Murata M, Tamura A, Tada M, Kawanishi S
  Title
Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl.
  Journal
Free Radic Biol Med 30:765-73 (2001)
DOI:10.1016/S0891-5849(01)00463-4
Reference
PMID:31283132
  Authors
  Title
  Journal
Pentachlorophenol and Some Related Compounds (2019)
Reference
PMID:19408893
  Authors
Zhu BZ, Shan GQ
  Title
Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals.
  Journal
Chem Res Toxicol 22:969-77 (2009)
DOI:10.1021/tx900030v
Reference
PMID:22166497
  Authors
McHale CM, Zhang L, Smith MT
  Title
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment.
  Journal
Carcinogenesis 33:240-52 (2012)
DOI:10.1093/carcin/bgr297
Reference
PMID:32977499
  Authors
Scharf P, Broering MF, Oliveira da Rocha GH, Farsky SHP
  Title
Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis.
  Journal
Int J Mol Sci 21:E6996 (2020)
DOI:10.3390/ijms21196996
Reference
PMID:23066403
  Authors
Snyder R
  Title
Leukemia and benzene.
  Journal
Int J Environ Res Public Health 9:2875-93 (2012)
DOI:10.3390/ijerph9082875
Reference
PMID:9118888
  Authors
Snyder R, Hedli CC
  Title
An overview of benzene metabolism.
  Journal
Environ Health Perspect 104 Suppl 6:1165-71 (1996)
DOI:10.1289/ehp.961041165
Reference
PMID:11978484
  Authors
Kawanishi S, Hiraku Y, Murata M, Oikawa S
  Title
The role of metals in site-specific DNA damage with reference to carcinogenesis.
  Journal
Free Radic Biol Med 32:822-32 (2002)
DOI:10.1016/S0891-5849(02)00779-7
Reference
PMID:27919191
  Authors
Das DN, Panda PK, Naik PP, Mukhopadhyay S, Sinha N, Bhutia SK
  Title
Phytotherapeutic approach: a new hope for polycyclic aromatic hydrocarbons induced cellular disorders, autophagic and apoptotic cell death.
  Journal
Toxicol Mech Methods 27:1-17 (2017)
DOI:10.1080/15376516.2016.1268228
Reference
PMID:21910479
  Authors
Shultz CA, Quinn AM, Park JH, Harvey RG, Bolton JL, Maser E, Penning TM.
  Title
Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.
  Journal
Chem Res Toxicol 24:2153-66 (2011)
DOI:10.1021/tx200294c
Reference
PMID:25279998
  Authors
Penning TM
  Title
Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons.
  Journal
Chem Res Toxicol 27:1901-17 (2014)
DOI:10.1021/tx500298n
Reference
PMID:10706104
  Authors
Burczynski ME, Penning TM
  Title
Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.
  Journal
Cancer Res 60:908-15 (2000)
Reference
PMID:15963346
  Authors
Xue W, Warshawsky D
  Title
Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review.
  Journal
Toxicol Appl Pharmacol 206:73-93 (2005)
DOI:10.1016/j.taap.2004.11.006
Reference
PMID:15142886
  Authors
Chen ZH, Hurh YJ, Na HK, Kim JH, Chun YJ, Kim DH, Kang KS, Cho MH, Surh YJ
  Title
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells.
  Journal
Carcinogenesis 25:2005-13 (2004)
DOI:10.1093/carcin/bgh183
Reference
PMID:16684662
  Authors
Rifkind AB
  Title
CYP1A in TCDD toxicity and in physiology-with particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates.
  Journal
Drug Metab Rev 38:291-335 (2006)
DOI:10.1080/03602530600570107
Reference
PMID:9380738
  Authors
Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG
  Title
Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.
  Journal
Proc Natl Acad Sci U S A 94:10937-42 (1997)
DOI:10.1073/pnas.94.20.10937
Reference
PMID:9472688
  Authors
Zhu BT, Conney AH
  Title
Functional role of estrogen metabolism in target cells: review and perspectives.
  Journal
Carcinogenesis 19:1-27 (1998)
DOI:10.1093/carcin/19.1.1
Reference
PMID:19387921
  Authors
McKillop IH, Schrum LW
  Title
Role of alcohol in liver carcinogenesis.
  Journal
Semin Liver Dis 29:222-32 (2009)
DOI:10.1055/s-0029-1214377
Reference
PMID:15603755
  Authors
Gonzalez FJ
  Title
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
  Journal
Mutat Res 569:101-10 (2005)
DOI:10.1016/j.mrfmmm.2004.04.021
Reference
PMID:31864052
  Authors
Montalbano AM, Albano GD, Anzalone G, Moscato M, Gagliardo R, Di Sano C, Bonanno A, Ruggieri S, Cibella F, Profita M
  Title
Cytotoxic and genotoxic effects of the flame retardants (PBDE-47, PBDE-99 and PBDE-209) in human bronchial epithelial cells.
  Journal
Chemosphere 245:125600 (2020)
DOI:10.1016/j.chemosphere.2019.125600
Reference
PMID:33907575
  Authors
Sun HN, Ren CX, Gong YX, Xie DP, Kwon T
  Title
Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer development.
  Journal
Oncol Lett 21:465 (2021)
DOI:10.3892/ol.2021.12726
Reference
PMID:25372613
  Authors
Pluchino LA, Wang HC
  Title
Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties.
  Journal
PLoS One 9:e108698 (2014)
DOI:10.1371/journal.pone.0108698
Reference
PMID:25535943
  Authors
Pluchino LA, Liu AK, Wang HC
  Title
Reactive oxygen species-mediated breast cell carcinogenesis enhanced by multiple carcinogens and intervened by dietary ergosterol and mimosine.
  Journal
Free Radic Biol Med 80:12-26 (2015)
DOI:10.1016/j.freeradbiomed.2014.12.015
Reference
PMID:30327380
  Authors
Moldogazieva NT, Lutsenko SV, Terentiev AA
  Title
Reactive Oxygen and Nitrogen Species-Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy.
  Journal
Cancer Res 78:6040-6047 (2018)
DOI:10.1158/0008-5472.CAN-18-0980
Reference
PMID:32358622
  Authors
Kirtonia A, Sethi G, Garg M
  Title
The multifaceted role of reactive oxygen species in tumorigenesis.
  Journal
Cell Mol Life Sci 77:4459-4483 (2020)
DOI:10.1007/s00018-020-03536-5
Reference
PMID:29449774
  Authors
Kumari S, Badana AK, G MM, G S, Malla R
  Title
Reactive Oxygen Species: A Key Constituent in Cancer Survival.
  Journal
Biomark Insights 13:1177271918755391 (2018)
DOI:10.1177/1177271918755391
Reference
PMID:28881698
  Authors
Gao X, Schottker B
  Title
Reduction-oxidation pathways involved in cancer development: a systematic review of literature reviews.
  Journal
Oncotarget 8:51888-51906 (2017)
DOI:10.18632/oncotarget.17128
Reference
PMID:15769673
  Authors
Storz P
  Title
Reactive oxygen species in tumor progression.
  Journal
Front Biosci 10:1881-96 (2005)
DOI:10.2741/1667
Reference
PMID:28835450
  Authors
Assi M
  Title
The differential role of reactive oxygen species in early and late stages of cancer.
  Journal
Am J Physiol Regul Integr Comp Physiol 313:R646-R653 (2017)
DOI:10.1152/ajpregu.00247.2017
Reference
PMID:15024053
  Authors
Storz P, Doppler H, Toker A
  Title
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling.
  Journal
Mol Cell Biol 24:2614-26 (2004)
DOI:10.1128/MCB.24.7.2614-2626.2004
Reference
PMID:24998536
  Authors
Nourazarian AR, Kangari P, Salmaninejad A
  Title
Roles of oxidative stress in the development and progression of breast cancer.
  Journal
Asian Pac J Cancer Prev 15:4745-51 (2014)
DOI:10.7314/apjcp.2014.15.12.4745
Reference
PMID:32336668
  Authors
Zheng F, Goncalves FM, Abiko Y, Li H, Kumagai Y, Aschner M
  Title
Redox toxicology of environmental chemicals causing oxidative stress.
  Journal
Redox Biol 34:101475 (2020)
DOI:10.1016/j.redox.2020.101475
Related
pathway
chx00190  Oxidative phosphorylation
chx00980  Metabolism of xenobiotics by cytochrome P450
chx04010  MAPK signaling pathway
chx04064  NF-kappa B signaling pathway
chx04066  HIF-1 signaling pathway
chx04151  PI3K-Akt signaling pathway
chx04370  VEGF signaling pathway
chx05207  Chemical carcinogenesis - receptor activation
chx05211  Renal cell carcinoma
chx05215  Prostate cancer
chx05219  Bladder cancer
chx05221  Acute myeloid leukemia
chx05222  Small cell lung cancer
chx05223  Non-small cell lung cancer
chx05224  Breast cancer
chx05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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