KEGG   PATHWAY: cimi04630
Entry
cimi04630                   Pathway                                
Name
JAK-STAT signaling pathway - Cebus imitator (Panamanian white-faced capuchin)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
cimi04630  JAK-STAT signaling pathway
cimi04630

Other DBs
GO: 0007259
Organism
Cebus imitator (Panamanian white-faced capuchin) [GN:cimi]
Gene
108297648  IL2; interleukin-2 [KO:K05429]
108307166  IL4; interleukin-4 isoform X1 [KO:K05430]
108299533  IL7; interleukin-7 [KO:K05431]
108307015  IL9; interleukin-9 [KO:K05432]
108308514  IL15; interleukin-15 isoform X1 [KO:K05433]
108304183  IL21; interleukin-21 [KO:K05434]
108303365  thymic stromal lymphopoietin [KO:K05436]
108292344  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
108289466  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
108294787  IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070]
108308561  IL4R; interleukin-4 receptor subunit alpha isoform X2 [KO:K05071]
108317638  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
108294359  IL9R; LOW QUALITY PROTEIN: interleukin-9 receptor [KO:K05073]
108292343  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
108308565  IL21R; LOW QUALITY PROTEIN: interleukin-21 receptor [KO:K05075]
108316293  LOW QUALITY PROTEIN: interleukin-21 receptor-like [KO:K05075]
108296373  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
108307022  IL3; interleukin-3 [KO:K04736]
108307172  IL5; interleukin-5 isoform X2 [KO:K05428]
108307021  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
108296372  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
108288383  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
108296380  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
108289459  CSF2RB; cytokine receptor common subunit beta isoform X3 [KO:K04738]
108303199  IL6; interleukin-6 isoform X1 [KO:K05405]
108316631  IL11; interleukin-11 [KO:K05417]
108307167  IL13; interleukin-13 isoform X1 [KO:K05435]
108296634  IL27; interleukin-27 subunit alpha [KO:K22629]
108315152  IL31; interleukin-31 [KO:K22631]
108283330  OSM; oncostatin-M isoform X1 [KO:K05418]
108283332  LIF; leukemia inhibitory factor [KO:K05419]
108282883  CNTF; ciliary neurotrophic factor [KO:K05420]
108293909  cardiotrophin-1 isoform X1 [KO:K05422]
108293862  cardiotrophin-2 [KO:K24382]
108310363  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
108292449  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
108317975  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
108314211  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
108291072  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
108293378  IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
108281940  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
108317995  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
108287469  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
108287464  LIFR; leukemia inhibitory factor receptor [KO:K05058]
108314202  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
108302085  IL10; interleukin-10 [KO:K05443]
108301977  IL19; interleukin-19 [KO:K05444]
108291784  IL22; interleukin-22 [KO:K05445]
108301978  IL20; interleukin-20 [KO:K22667]
108302090  IL24; interleukin-24 [KO:K22668]
108291790  IL26; interleukin-26 [KO:K05446]
108300584  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
108305707  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
108304201  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
108308661  IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138]
108305658  IL22RA2; interleukin-22 receptor subunit alpha-2 [KO:K05139]
108284144  IL12A; interleukin-12 subunit alpha [KO:K05406]
108285116  IL12B; interleukin-12 subunit beta [KO:K05425]
108309777  IL23A; interleukin-23 subunit alpha [KO:K05426]
108284619  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
108307107  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
108307131  IL23R; interleukin-23 receptor [KO:K05065]
119472011  EPO; erythropoietin isoform X1 [KO:K05437]
108318254  somatotropin-like isoform X1 [KO:K05438]
108298937  somatotropin-like [KO:K05438]
108295581  GH1; somatotropin isoform X1 [KO:K05438]
108298936  LOW QUALITY PROTEIN: somatotropin-like [KO:K05438]
108318314  somatotropin-like [KO:K05438]
119474203  somatotropin-like [KO:K05438]
108318256  somatotropin-like [KO:K05438]
108314939  PRL; prolactin [KO:K05439]
108311082  THPO; LOW QUALITY PROTEIN: thrombopoietin [KO:K06854]
108281508  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
108318455  leptin isoform X1 [KO:K05424]
108281988  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
108307700  GHR; growth hormone receptor isoform X1 [KO:K05080]
108317640  PRLR; prolactin receptor [KO:K05081]
108313359  MPL; thrombopoietin receptor [KO:K05082]
108290072  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
108294051  LEPR; leptin receptor isoform X1 [KO:K05062]
108296181  interferon alpha-8-like [KO:K05414]
108296168  interferon alpha-8-like [KO:K05414]
108296165  IFNA21; interferon alpha-21 [KO:K05414]
108296167  interferon alpha-2-like [KO:K05414]
108296180  interferon alpha-5-like [KO:K05414]
108296183  interferon alpha-1/13 [KO:K05414]
108296184  interferon alpha-8-like [KO:K05414]
108296169  IFNB1; interferon beta [KO:K05415]
108316270  IFNE; LOW QUALITY PROTEIN: interferon epsilon [KO:K05442]
108289449  IFNK; interferon kappa [KO:K05441]
108285720  IFNL1; interferon lambda-1 [KO:K05447]
108285721  interferon lambda-3 [KO:K22669]
108296164  interferon omega-1-like [KO:K05440]
108296170  interferon omega-1-like [KO:K05440]
108302441  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
108302508  interferon alpha/beta receptor 2 isoform X3 [KO:K05131]
108308662  IFNLR1; interferon lambda receptor 1 [KO:K05140]
108291791  IFNG; interferon gamma [KO:K04687]
108305706  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
108302512  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
108290027  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
108289011  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
108315299  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
108294535  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108312367  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108306401  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108313230  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
108281443  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
108284528  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
108283688  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
108284049  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
108309779  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
108289826  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
108284047  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
108289825  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
108289827  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
108309713  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
108315378  IRF9; interferon regulatory factor 9 isoform X2 [KO:K04693]
108283201  CISH; cytokine-inducible SH2-containing protein isoform X1 [KO:K04701]
108312172  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
108317927  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
108301748  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
108294062  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
108292092  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
108281500  SOCS7; suppressor of cytokine signaling 7 [KO:K04699]
108303606  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
108304605  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
108316470  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
108293471  BCL2L1; bcl-2-like protein 1 [KO:K04570]
108299974  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
108283896  MYC; myc proto-oncogene protein [KO:K04377]
108294139  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108316314  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108317085  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
108299987  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
108315708  aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
108315709  LOW QUALITY PROTEIN: aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
108315736  aldehyde oxidase 2 isoform X1 [KO:K00157] [EC:1.2.3.1]
108318334  glial fibrillary acidic protein isoform X2 [KO:K05640]
108300433  STAM2; signal transducing adapter molecule 2 [KO:K04705]
108305225  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
108282483  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X2 [KO:K18026] [EC:3.1.3.48]
108294988  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
108290506  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
108286559  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
108292616  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
108305131  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
108293674  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
108288455  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:2.3.2.27]
108292964  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
108314188  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
108309416  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108287976  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
108293763  SOS1; son of sevenless homolog 1 [KO:K03099]
108288791  HRAS; GTPase HRas isoform X1 [KO:K02833]
108284634  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108287732  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108300786  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108286022  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108312772  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108284538  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108295514  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108285792  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108306856  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108287186  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108285700  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
Reference
PMID:22383755
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
PMID:22339650
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
PMID:21372217
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
PMID:25217450
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
PMID:21034406
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
PMID:25587654
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
PMID:24069565
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
PMID:16204702
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
PMID:23735217
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
PMID:24606160
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
PMID:10851053
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
PMID:11114747
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Related
pathway
cimi04010  MAPK signaling pathway
cimi04060  Cytokine-cytokine receptor interaction
cimi04110  Cell cycle
cimi04120  Ubiquitin mediated proteolysis
cimi04151  PI3K-Akt signaling pathway
cimi04210  Apoptosis
KO pathway
ko04630   
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