KEGG   PATHWAY: cimi04151
Entry
cimi04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Cebus imitator (Panamanian white-faced capuchin)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
cimi04151  PI3K-Akt signaling pathway
cimi04151

Other DBs
GO: 0043491
Organism
Cebus imitator (Panamanian white-faced capuchin) [GN:cimi]
Gene
108281443  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
108281508  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
108281617  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108281637  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
108281919  PKN1; serine/threonine-protein kinase N1 isoform X3 [KO:K06071] [EC:2.7.11.13]
108281988  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
108282470  [KO:K02991]
108282567  LAMA3; laminin subunit alpha-3 isoform X3 [KO:K06240]
108282680  [KO:K04368] [EC:2.7.12.2]
108282777  [KO:K10159]
108283043  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
108283047  LAMC3; laminin subunit gamma-3 [KO:K06247]
108283129  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
108283330  OSM; oncostatin-M isoform X1 [KO:K05418]
108283402  [KO:K04542]
108283470  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
108283473  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
108283527  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
108283584  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
108283826  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
108283895  FGF21; fibroblast growth factor 21 [KO:K22429]
108283896  MYC; myc proto-oncogene protein [KO:K04377]
108283908  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
108283919  NTF4; neurotrophin-4 [KO:K12457]
108283938  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
108284011  RPS6; 40S ribosomal protein S6 [KO:K02991]
108284042  [KO:K04079]
108284343  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
108284528  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
108284538  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108284565  [KO:K04659]
108284600  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
108284634  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108284810  PTK2; focal adhesion kinase 1 isoform X11 [KO:K05725] [EC:2.7.10.2]
108284857  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
108284859  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
108284882  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
108284888  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
108284916  ITGA5; integrin alpha-5 [KO:K06484]
108284967  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
108285523  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
108285700  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
108285792  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108285893  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
108285951  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
108285965  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
108286022  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108286191  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
108286254  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
108286285  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
108286451  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
108286458  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
108286470  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
108286649  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
108286842  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
108287069  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
108287186  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108287442  [KO:K16197]
108287469  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
108287732  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108287735  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
108287976  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
108287982  LAMB2; laminin subunit beta-2 [KO:K06243]
108288452  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
108288453  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108288458  THBS4; thrombospondin-4 [KO:K04659]
108288514  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
108288622  THBS2; thrombospondin-2 [KO:K04659]
108288725  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
108288726  INS; insulin [KO:K04526]
108288791  HRAS; GTPase HRas isoform X1 [KO:K02833]
108288833  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
108289011  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
108289120  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
108289188  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
108289201  [KO:K07828]
108289213  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
108289254  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
108289419  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
108289466  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
108289636  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
108289721  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
108289781  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
108289795  G6PC1; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
108290027  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
108290072  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
108290257  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
108290359  [KO:K06238]
108290360  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
108290362  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
108290619  [KO:K04079]
108290889  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
108290923  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
108290925  TSC2; tuberin isoform X1 [KO:K07207]
108291018  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
108291902  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
108291940  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
108292150  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
108292177  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
108292190  AREG; amphiregulin [KO:K09782]
108292191  EREG; proepiregulin [KO:K09784]
108292290  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
108292344  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
108292377  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
108292437  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
108292449  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
108292473  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
108292474  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
108292476  EFNA1; ephrin-A1 [KO:K05462]
108292480  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
108292494  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
108292532  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
108292565  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
108292610  ITGA11; integrin alpha-11 [KO:K06587]
108293106  ANGPT2; angiopoietin-2 [KO:K05466]
108293173  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
108293330  [KO:K06252]
108293471  BCL2L1; bcl-2-like protein 1 [KO:K04570]
108293672  ITGA10; integrin alpha-10 [KO:K06586]
108293763  SOS1; son of sevenless homolog 1 [KO:K03099]
108293791  ANGPT4; angiopoietin-4 [KO:K05467]
108293817  [KO:K04374]
108293848  [KO:K21289] [EC:2.7.1.153]
108294016  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3 [KO:K05631]
108294085  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
108294129  FGF19; fibroblast growth factor 19 [KO:K22603]
108294131  FGF3; fibroblast growth factor 3 [KO:K04358]
108294139  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108294146  FGF4; fibroblast growth factor 4 [KO:K04358]
108294289  ITGA2B; integrin alpha-IIb [KO:K06476]
108294299  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
108294345  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
108294362  MTCP1; protein p13 MTCP-1 [KO:K16837]
108294535  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108294558  ITGB5; integrin beta-5 [KO:K06588]
108294625  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
108294787  IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070]
108294842  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
108294997  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
108295005  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
108295422  TSC1; hamartin [KO:K07206]
108295463  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
108295514  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108295581  GH1; somatotropin isoform X1 [KO:K05438]
108295808  MYB; transcriptional activator Myb isoform X2 [KO:K09420]
108295976  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
108296165  IFNA21; interferon alpha-21 [KO:K05414]
108296167  [KO:K05414]
108296168  [KO:K05414]
108296169  IFNB1; interferon beta [KO:K05415]
108296180  [KO:K05414]
108296181  [KO:K05414]
108296183  [KO:K05414]
108296184  [KO:K05414]
108296197  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108296237  KITLG; kit ligand [KO:K05461]
108296372  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
108296669  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108296697  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
108296806  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
108296818  ITGA7; integrin alpha-7 isoform X3 [KO:K06583]
108296929  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108297042  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
108297394  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
108297459  RHEB; GTP-binding protein Rheb [KO:K07208]
108297500  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
108297648  IL2; interleukin-2 [KO:K05429]
108297770  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
108298093  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
108298112  FGF16; fibroblast growth factor 16 [KO:K04358]
108298936  [KO:K05438]
108298937  [KO:K05438]
108299127  [KO:K16198]
108299533  IL7; interleukin-7 [KO:K05431]
108299641  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
108299802  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
108299803  TNXB; tenascin-X [KO:K06252]
108299987  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
108300171  [KO:K04542]
108300229  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108300247  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
108300272  KRAS; GTPase KRas isoform X2 [KO:K07827]
108300275  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X10 [KO:K05629]
108300342  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
108300364  RELN; reelin [KO:K06249] [EC:3.4.21.-]
108300464  [KO:K03258]
108300786  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108301073  [KO:K06626]
108301149  NGF; beta-nerve growth factor [KO:K02582]
108301162  NRAS; GTPase NRas isoform X2 [KO:K07828]
108301352  LAMC1; laminin subunit gamma-1 [KO:K05635]
108301356  LAMC2; laminin subunit gamma-2 [KO:K06246]
108301563  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
108301831  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
108301833  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
108301835  COL1A2; collagen alpha-2(I) chain [KO:K06236]
108301909  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
108301985  YWHAQ; 14-3-3 protein theta [KO:K16197]
108302115  LAMB3; laminin subunit beta-3 [KO:K06244]
108302212  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
108302426  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
108302441  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
108302508  [KO:K05131]
108302840  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
108303183  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
108303199  IL6; interleukin-6 isoform X1 [KO:K05405]
108303281  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
108303410  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
108303482  [KO:K04392]
108303733  F2R; proteinase-activated receptor 1 [KO:K03914]
108303992  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
108303993  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
108304025  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
108304038  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
108304047  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
108304133  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
108304136  PSPN; persephin [KO:K25416]
108304180  FGF2; fibroblast growth factor 2 [KO:K18497]
108304249  NRTN; neurturin [KO:K25414]
108304303  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
108304333  [KO:K02991]
108304334  [KO:K02089] [EC:2.7.11.22]
108304340  [KO:K08524]
108304451  PGF; placenta growth factor isoform X1 [KO:K16859]
108304500  [KO:K16197]
108304534  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
108304605  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
108304636  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
108304688  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
108304798  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
108304799  [KO:K06237]
108304802  IRS1; insulin receptor substrate 1 [KO:K16172]
108304847  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
108304874  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
108305181  ITGA8; integrin alpha-8 [KO:K06584]
108305347  TNR; tenascin-R isoform X1 [KO:K06252]
108305357  TNN; tenascin-N [KO:K06252]
108305379  [KO:K04389]
108305380  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108305445  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
108305511  TNC; tenascin [KO:K06252]
108305527  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
108306054  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
108306127  THBS1; thrombospondin-1 [KO:K16857]
108306328  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
108306378  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
108306401  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108306404  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
108306509  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
108306510  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
108306559  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
108306599  [KO:K04542]
108306856  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108307022  IL3; interleukin-3 [KO:K04736]
108307078  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108307097  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
108307144  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108307166  IL4; interleukin-4 isoform X1 [KO:K05430]
108307357  ITGA4; integrin alpha-4 isoform X2 [KO:K06483]
108307684  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
108307700  GHR; growth hormone receptor isoform X1 [KO:K05080]
108307737  FGF10; fibroblast growth factor 10 [KO:K04358]
108307754  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
108307755  ITGA1; integrin alpha-1 [KO:K06480]
108307784  LAMA2; laminin subunit alpha-2 [KO:K05637]
108307873  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108307928  YWHAG; 14-3-3 protein gamma [KO:K16198]
108307981  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
108308224  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
108308561  IL4R; interleukin-4 receptor subunit alpha isoform X2 [KO:K05071]
108308919  FN1; fibronectin isoform X1 [KO:K05717]
108308938  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
108308984  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
108309195  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
108309416  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108309429  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
108309541  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
108309569  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108309741  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
108309759  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
108309821  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108309877  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
108309889  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
108309953  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
108309970  FGFR1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
108310266  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
108310302  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108310311  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
108310354  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
108310400  RELA; transcription factor p65 isoform X2 [KO:K04735]
108310422  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
108310455  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
108310668  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
108310921  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
108310980  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
108311016  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
108311184  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
108311185  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
108311306  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
108311571  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
108311624  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
108311658  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
108311978  FGF20; fibroblast growth factor 20 [KO:K04358]
108312078  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
108312269  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
108312274  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
108312284  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
108312289  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
108312303  CHAD; chondroadherin [KO:K06248]
108312357  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
108312361  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
108312367  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108312418  HSP90B1; endoplasmin [KO:K09487]
108312452  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
108312706  ARTN; artemin isoform X1 [KO:K25415]
108312755  [KO:K06630]
108312772  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108313004  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
108313230  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
108313247  [KO:K02089] [EC:2.7.11.22]
108313340  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
108313596  VTN; vitronectin [KO:K06251]
108313703  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
108313717  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
108313950  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
108314253  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
108314715  FOXO3; forkhead box protein O3 [KO:K09408]
108314807  FGF7; fibroblast growth factor 7 [KO:K04358]
108314822  LAMA1; laminin subunit alpha-1 [KO:K05637]
108314880  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
108314939  PRL; prolactin [KO:K05439]
108315292  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
108315299  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
108315364  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
108315446  PDGFD; platelet-derived growth factor D [KO:K05450]
108315634  ITGAV; integrin alpha-V [KO:K06487]
108315672  SPP1; osteopontin [KO:K06250]
108315674  [KO:K06253]
108316108  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465]
108316185  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108316314  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108316317  FGF23; fibroblast growth factor 23 [KO:K22428]
108316319  FGF6; fibroblast growth factor 6 [KO:K04358]
108316332  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
108316350  VWF; von Willebrand factor [KO:K03900]
108316354  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
108316400  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
108316470  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
108316552  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
108316553  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
108316708  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
108316753  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
108316760  LAMB1; laminin subunit beta-1 [KO:K05636]
108316764  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
108317063  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
108317085  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
108317111  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
108317142  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
108317309  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
108317321  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
108317559  FGF9; fibroblast growth factor 9 [KO:K04358]
108317612  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
108317638  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
108317640  PRLR; prolactin receptor [KO:K05081]
108318076  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
108318254  [KO:K05438]
108318256  [KO:K05438]
108318295  [KO:K11583]
108318297  ITGB3; integrin beta-3 [KO:K06493]
108318314  [KO:K05438]
108318375  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
108318544  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
108318653  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
119469394  [KO:K04542]
119472011  EPO; erythropoietin isoform X1 [KO:K05437]
119472440  [KO:K02991]
119474203  [KO:K05438]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
cimi00010  Glycolysis / Gluconeogenesis
cimi04010  MAPK signaling pathway
cimi04012  ErbB signaling pathway
cimi04062  Chemokine signaling pathway
cimi04064  NF-kappa B signaling pathway
cimi04068  FoxO signaling pathway
cimi04110  Cell cycle
cimi04115  p53 signaling pathway
cimi04150  mTOR signaling pathway
cimi04210  Apoptosis
cimi04370  VEGF signaling pathway
cimi04510  Focal adhesion
cimi04620  Toll-like receptor signaling pathway
cimi04630  JAK-STAT signaling pathway
cimi04662  B cell receptor signaling pathway
cimi04910  Insulin signaling pathway
KO pathway
ko04151   

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