KEGG   PATHWAY: cvg04060
Entry
cvg04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Cyprinodon variegatus (sheepshead minnow)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cvg04060  Cytokine-cytokine receptor interaction
cvg04060

Organism
Cyprinodon variegatus (sheepshead minnow) [GN:cvg]
Gene
107087944  C-C motif chemokine 25-like [KO:K13072]
107085925  C-C motif chemokine 25-like [KO:K13072]
107083983  C-C motif chemokine 20-like [KO:K05512]
107096536  C-C motif chemokine 3-like [KO:K05408]
107096537  C-C motif chemokine 4-like [KO:K05408]
107103361  monocyte chemotactic protein 1B-like [KO:K12964]
107103362  monocyte chemotactic protein 1B-like [KO:K12964]
107083215  monocyte chemotactic protein 1B-like [KO:K12964]
107091861  C-C motif chemokine 7-like [KO:K14625]
107091862  C-C motif chemokine 20-like isoform X1 [KO:K14625]
107091868  C-C motif chemokine 20-like [KO:K14625]
107094808  C-C motif chemokine 20-like [KO:K14625]
107092313  C-C motif chemokine 4 homolog [KO:K14625]
107092314  C-C motif chemokine 20-like [KO:K14625]
107083987  C-C motif chemokine 20-like [KO:K14625]
107091863  C-C motif chemokine 14-like [KO:K14625]
107085231  growth-regulated alpha protein-like [KO:K05505]
107085241  alveolar macrophage chemotactic factor-like [KO:K05505]
107085709  alveolar macrophage chemotactic factor-like [KO:K10030]
107085244  permeability factor 2-like [KO:K10030]
107086570  C-X-C motif chemokine 10-like [KO:K05416]
107101673  C-X-C motif chemokine 10-like [KO:K12671]
107083988  cxcl13; C-X-C motif chemokine 13 isoform X1 [KO:K10032]
107086564  cxcl12; stromal cell-derived factor 1 [KO:K10031]
107083437  stromal cell-derived factor 1-like [KO:K10031]
107083806  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
107097854  il15; interleukin-15 [KO:K05433]
107084110  epo; erythropoietin [KO:K05437]
107089309  somatotropin [KO:K05438]
107083471  somatolactin-like [KO:K05438]
107100946  prolactin-1-like [KO:K05439]
107100947  prolactin-1-like [KO:K05439]
107100864  prolactin-like [KO:K05439]
107101664  leptin-B-like [KO:K05424]
107085859  interleukin-6-like [KO:K05405]
107081893  interleukin-12 subunit alpha-like [KO:K05406]
107089666  interleukin-12 subunit beta-like [KO:K05425]
107084201  interleukin-12 subunit beta-like isoform X1 [KO:K05425]
107086324  interleukin-12 subunit beta-like [KO:K05425]
107101001  uncharacterized protein LOC107101001 [KO:K22629]
107093026  ebi3; interleukin-27 subunit beta [KO:K24476]
107085690  clcf1; cardiotrophin-like cytokine factor 1 [KO:K05421]
107083320  il10; interleukin-10 [KO:K05443]
107083321  interleukin-20-like [KO:K22667]
107092889  interferon a3-like [KO:K05414]
107099476  interleukin-1 beta-like [KO:K04519]
107099154  interleukin-1 beta-like [KO:K04519]
107103272  interleukin-18-like [KO:K05482]
107104555  interleukin-17A-like [KO:K05489]
107102626  interleukin-17F-like [KO:K05494]
107095673  interleukin-17F-like [KO:K05494]
107093715  il17c; interleukin-17C [KO:K05491]
107087362  il17d; interleukin-17D [KO:K05492]
107088383  uncharacterized protein LOC107088383 [KO:K22628]
107090433  il34; interleukin-34 isoform X1 [KO:K22633]
107103845  tumor necrosis factor-like [KO:K03156]
107104043  tumor necrosis factor-like [KO:K05468]
107101479  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
107093404  tumor necrosis factor ligand superfamily member 6-like isoform X1 [KO:K05477]
107095892  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
107089263  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
107085098  tnfsf10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
107103203  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
107093446  eda; ectodysplasin-A isoform X1 [KO:K05480]
107101302  nerve growth factor-like [KO:K02582]
107087023  nerve growth factor-like [KO:K02582]
107101899  tumor necrosis factor ligand superfamily member 11-like [KO:K05473]
107095620  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
107093456  tumor necrosis factor ligand superfamily member 13B-like [KO:K05476]
107096493  tnfsf13b; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
107103699  transforming growth factor beta-1-like [KO:K13375]
107087932  tgfb2; transforming growth factor beta-2 [KO:K13376]
107083120  transforming growth factor beta-3-like [KO:K13377]
107092398  tgfb3; transforming growth factor beta-3 isoform X1 [KO:K13377]
107095130  inhibin beta E chain-like [KO:K05504]
107098557  bmp10; bone morphogenetic protein 10 [KO:K22670]
107088435  bone morphogenetic protein 10-like [KO:K22670]
107096250  growth/differentiation factor 2-like [KO:K22670]
107084234  inha; inhibin alpha chain [KO:K05500]
107083995  bmp3; bone morphogenetic protein 3 [KO:K05496]
107101535  growth/differentiation factor 10-like [KO:K22674]
107086617  growth/differentiation factor 10-like [KO:K22674]
107100813  growth/differentiation factor 11-like isoform X1 [KO:K22679]
107104398  growth/differentiation factor 8-like [KO:K05497]
107092274  mstn; growth/differentiation factor 8 [KO:K05497]
107104447  inhibin beta A chain-like [KO:K04667]
107080995  inhibin beta A chain-like [KO:K04667]
107103470  inhibin beta B chain-like [KO:K22687]
107096022  inhibin beta B chain-like [KO:K22687]
107103013  inhibin beta B chain-like [KO:K22687]
107097387  LOW QUALITY PROTEIN: protein DVR-1-like [KO:K22672]
107090956  nodal homolog 2-A-like [KO:K04666]
107103685  nodal homolog [KO:K04666]
107100846  nodal; nodal homolog [KO:K04666]
107101665  gdf9; growth/differentiation factor 9 [KO:K22673]
107081273  muellerian-inhibiting factor-like [KO:K04665]
107089713  muellerian-inhibiting factor-like [KO:K04665]
107096868  bone morphogenetic protein 2-like isoform X1 [KO:K21283]
107097808  bmp2; bone morphogenetic protein 2 [KO:K21283]
107085933  bone morphogenetic protein 2-like [KO:K21283]
107096913  bmp4; bone morphogenetic protein 4 [KO:K04662]
107087939  gdf5; growth/differentiation factor 5 [KO:K04664]
107096755  gdf6; growth/differentiation factor 6 [KO:K20012]
107091520  bone morphogenetic protein 15-like [KO:K05498]
107084608  bmp5; bone morphogenetic protein 5 [KO:K04663]
107098545  bone morphogenetic protein 6-like [KO:K16620]
107088175  bmp7; bone morphogenetic protein 7 [KO:K16621]
107102021  bone morphogenetic protein 7-like [KO:K16621]
107090168  bmp8a; bone morphogenetic protein 8A [KO:K16622]
107104786  C-C chemokine receptor type 9-like isoform X1 [KO:K04184]
107085443  C-C chemokine receptor type 9-like [KO:K04184]
107098253  C-C chemokine receptor type 9-like [KO:K04184]
107104266  atypical chemokine receptor 4-like [KO:K04186]
107094583  ackr4; atypical chemokine receptor 4 [KO:K04186]
107101844  C-C chemokine receptor type 7-like [KO:K04182]
107085479  ccr7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
107099256  C-C chemokine receptor type 4-like [KO:K04179]
107101582  C-C chemokine receptor type 8-like [KO:K04179]
107101581  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
107101583  C-C chemokine receptor type 1-like [KO:K04180]
107088841  C-C chemokine receptor type 6-like [KO:K04181]
107089578  ccr6; C-C chemokine receptor type 6 [KO:K04181]
107089595  C-C chemokine receptor type 6-like [KO:K04181]
107099279  C-C chemokine receptor type 6-like [KO:K04181]
107095740  C-X-C chemokine receptor type 2-like [KO:K05050]
107092717  C-X-C chemokine receptor type 2-like [KO:K05050]
107082556  C-X-C chemokine receptor type 2-like [KO:K05050]
107100210  C-X-C chemokine receptor type 4-B-like [KO:K04188]
107100215  C-X-C chemokine receptor type 3-like [KO:K04188]
107100216  C-X-C chemokine receptor type 3-like [KO:K04188]
107100217  C-X-C chemokine receptor type 3-like [KO:K04188]
107100220  C-X-C chemokine receptor type 3-like [KO:K04188]
107090647  cxcr5; C-X-C chemokine receptor type 5 [KO:K04190]
107086826  C-X-C chemokine receptor type 4-like [KO:K04189]
107101500  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
107101512  ackr3; atypical chemokine receptor 3 [KO:K04304]
107102199  atypical chemokine receptor 3-like [KO:K04304]
107081967  chemokine XC receptor 1-like [KO:K04193]
107081673  chemokine XC receptor 1-like [KO:K04193]
107081699  chemokine XC receptor 1-like [KO:K04193]
107087156  interleukin-2 receptor subunit beta-like [KO:K05069]
107084266  uncharacterized protein LOC107084266 [KO:K05069]
107084171  cytokine receptor common subunit gamma-like isoform X1 [KO:K05070]
107086945  uncharacterized protein LOC107086945 isoform X1 [KO:K05071]
107095097  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
107101598  interleukin-2 receptor subunit beta-like [KO:K05073]
107096225  il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
107089554  interleukin-21 receptor-like [KO:K05075]
107101599  interleukin-21 receptor-like isoform X1 [KO:K05075]
107087162  il4r; interleukin-4 receptor subunit alpha [KO:K04738]
107099657  interleukin-13 receptor subunit alpha-1-like [KO:K05076]
107089837  interleukin-13 receptor subunit alpha-2-like [KO:K05077]
107096550  erythropoietin receptor-like [KO:K05079]
107094674  growth hormone receptor-like isoform X1 [KO:K05080]
107093843  ghr; growth hormone receptor [KO:K05080]
107096826  growth hormone receptor-like [KO:K05080]
107085830  prlr; prolactin receptor isoform X1 [KO:K05081]
107095200  mpl; thrombopoietin receptor [KO:K05082]
107084721  interleukin-6 receptor subunit beta-like [KO:K05061]
107087230  lepr; leptin receptor isoform X1 [KO:K05062]
107096289  interleukin-6 receptor subunit alpha-like isoform X1 [KO:K05055]
107088409  uncharacterized protein LOC107088409 [KO:K05055]
107102482  il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
107084616  interleukin-6 receptor subunit beta-like isoform X1 [KO:K05060]
107091061  interleukin-11 receptor subunit alpha-like [KO:K05056]
107099666  il12rb1; interleukin-12 receptor subunit beta-1 [KO:K05063]
107099583  interleukin-12 receptor subunit beta-2-like [KO:K05064]
107099584  interleukin-12 receptor subunit beta-2-like [KO:K05064]
107080713  interleukin-6 receptor subunit beta-like isoform X1 [KO:K22630]
107092850  interleukin-31 receptor subunit alpha-like isoform X1 [KO:K22630]
107091063  ciliary neurotrophic factor receptor subunit alpha-like [KO:K05059]
107092589  leukemia inhibitory factor receptor-like [KO:K05058]
107103740  leukemia inhibitory factor receptor-like [KO:K05058]
107086358  interferon alpha/beta receptor 1-like [KO:K05134]
107095536  interferon alpha/beta receptor 1a-like [KO:K05135]
107095538  interleukin-10 receptor subunit beta-like [KO:K05135]
107084606  interleukin-20 receptor subunit alpha-like [KO:K05136]
107096995  uncharacterized protein LOC107096995 [KO:K05136]
107095537  interferon alpha/beta receptor 2-like [KO:K05137]
107101650  interleukin-20 receptor subunit beta-like isoform X1 [KO:K05137]
107098124  uncharacterized protein LOC107098124 isoform X1 [KO:K05132]
107087363  interleukin-1 receptor type 1-like [KO:K04386]
107086872  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
107101752  interleukin-1 receptor type 2-like [KO:K04387]
107082511  interleukin-1 receptor-like 1 [KO:K05173]
107082524  interleukin-1 receptor-like 1 [KO:K05173]
107082515  interleukin-18 receptor accessory protein-like isoform X1 [KO:K05174]
107087355  interleukin-1 receptor-like 1 [KO:K05171]
107087346  interleukin-1 receptor-like 1 [KO:K05171]
107095042  interleukin-17 receptor A-like [KO:K05164]
107101084  il17ra; interleukin-17 receptor A [KO:K05164]
107094773  interleukin-17 receptor C-like isoform X1 [KO:K05166]
107090256  uncharacterized protein LOC107090256 [KO:K05166]
107086682  il17rb; interleukin-17 receptor B [KO:K05165]
107090260  il17re; interleukin-17 receptor E [KO:K05168]
107082188  carcinoembryonic antigen-related cell adhesion molecule 2-like [KO:K06454]
107102293  macrophage colony-stimulating factor 1 receptor 2-like [KO:K05090] [EC:2.7.10.1]
107095001  macrophage colony-stimulating factor 1 receptor 1-like [KO:K05090] [EC:2.7.10.1]
107082260  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
107087524  tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K05141]
107082174  ltbr; tumor necrosis factor receptor superfamily member 3 [KO:K03159]
107100803  tumor necrosis factor receptor superfamily member 6-like [KO:K05152]
107094453  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
107094454  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
107104315  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
107081026  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
107100804  tumor necrosis factor receptor superfamily member 5-like [KO:K05152]
107098877  tumor necrosis factor receptor superfamily member 5-like [KO:K05152]
107084929  tumor necrosis factor receptor superfamily member 6B-like [KO:K05143]
107084944  uncharacterized protein LOC107084944 [KO:K05143]
107090491  tumor necrosis factor receptor superfamily member 6B-like [KO:K05143]
107088506  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
107092852  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
107094654  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
107104273  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
107095713  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
107090448  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
107082315  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
107085087  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
107092801  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
107090490  tumor necrosis factor receptor superfamily member 11B-like [KO:K05148]
107094196  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
107097500  tumor necrosis factor receptor superfamily member 26-like [KO:K03160]
107083714  tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K03160]
107083927  tumor necrosis factor receptor superfamily member 9-like isoform X1 [KO:K05146]
107097496  tumor necrosis factor receptor superfamily member 4-like [KO:K05142]
107090320  tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
107093094  uncharacterized protein LOC107093094 [KO:K05151]
107101891  tumor necrosis factor receptor superfamily member 19-like [KO:K05155]
107093953  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
107080763  protein PRRC2C-like [KO:K26541]
107087744  RELT-like protein 1 [KO:K26541]
107100676  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
107086189  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
107098322  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
107086786  activin receptor type-1-like [KO:K13594] [EC:2.7.11.30]
107091036  activin receptor type-2A-like [KO:K04670] [EC:2.7.11.30]
107082824  acvr2a; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
107087239  bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
107103972  bone morphogenetic protein receptor type-2-like [KO:K04671] [EC:2.7.11.30]
107089450  activin receptor type-2B-like [KO:K13596] [EC:2.7.11.30]
107103356  acvr2b; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
107086775  acvr1b; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
107087126  acvr1c; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
107087143  acvr1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
107093036  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
107100132  bmpr1a; bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
107088457  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
107084462  bmpr1b; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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