Entry
Name
Cytokine-cytokine receptor interaction - Echinops telfairi (small Madagascar hedgehog)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
etf04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:
etf ]
Gene
101655814 CNTF; LOW QUALITY PROTEIN: ciliary neurotrophic factor [KO:K05420 ]
101640597 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
101657479 CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453 ]
101661569 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
101646613 TNFSF15; tumor necrosis factor ligand superfamily member 15 isoform X1 [KO:K05478 ]
101655233 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
101659751 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
101652439 TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
101658394 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
101640854 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
101642049 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
101642366 TNFSF18; tumor necrosis factor ligand superfamily member 18 isoform X1 [KO:K05479 ]
105978190 tumor necrosis factor ligand superfamily member 13-like [KO:K05475 ]
101640272 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
101639819 TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376 ]
101639677 LOW QUALITY PROTEIN: growth/differentiation factor 9-like [KO:K22673 ]
101657280 IL2RG; LOW QUALITY PROTEIN: cytokine receptor common subunit gamma [KO:K05070 ]
101647853 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
101655661 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
101646676 IL6ST; interleukin-6 receptor subunit beta isoform X2 [KO:K05060 ]
101641973 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
101642724 IL12RB1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063 ]
101647560 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
101658420 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
101639885 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
101645663 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
101659300 LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein [KO:K05174 ]
101657422 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
101662341 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
101658048 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
123522472 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
101651579 TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160 ]
101643760 tumor necrosis factor receptor superfamily member 21-like [KO:K05157 ]
101648502 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
101652711 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
101662350 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
101659058 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
101662753 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
101664241 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
123522305 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
101648773 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
101641110 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
101641418 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
101650665 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
101645451 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
101657801 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
101650705 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
101644374 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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