KEGG   PATHWAY: gvr04810
Entry
gvr04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Galeopterus variegatus (Sunda flying lemur)
Class
Cellular Processes; Cell motility
Pathway map
gvr04810  Regulation of actin cytoskeleton
gvr04810

Other DBs
GO: 0030036
Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103595136  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103588129  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103594330  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103608094  CXCL12; stromal cell-derived factor 1 [KO:K10031]
103591817  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103603381  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
103610123  LOW QUALITY PROTEIN: proteinase-activated receptor 1-like [KO:K03914]
103604130  F2R; LOW QUALITY PROTEIN: proteinase-activated receptor 1 [KO:K03914]
103588497  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103590682  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103594351  FGF18; fibroblast growth factor 18 [KO:K04358]
103588673  FGF7; fibroblast growth factor 7 [KO:K04358]
103588746  FGF20; fibroblast growth factor 20 [KO:K04358]
103609408  FGF6; fibroblast growth factor 6 [KO:K04358]
103602136  FGF10; fibroblast growth factor 10 isoform X1 [KO:K04358]
103610085  FGF22; fibroblast growth factor 22 [KO:K04358]
103595413  FGF8; fibroblast growth factor 8 [KO:K04358]
103597068  FGF16; fibroblast growth factor 16 [KO:K04358]
103604998  fibroblast growth factor 2-like [KO:K04358]
103604999  FGF3; fibroblast growth factor 3 [KO:K04358]
103591744  FGF9; fibroblast growth factor 9 [KO:K04358]
103586304  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
103593962  FGF17; fibroblast growth factor 17 [KO:K04358]
103604091  FGF19; fibroblast growth factor 19 [KO:K22603]
103587751  FGF21; fibroblast growth factor 21 [KO:K22429]
103603960  FGF23; fibroblast growth factor 23 [KO:K22428]
103595105  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
103600468  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103590948  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
103586679  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103588552  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
103595295  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103604776  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
103598755  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
103601242  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103587648  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103593101  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
103589787  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103585042  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103595436  FN1; fibronectin [KO:K05717]
103591125  ITGA1; integrin alpha-1 [KO:K06480]
103591124  ITGA2; integrin alpha-2 [KO:K06481]
103606240  ITGA2B; integrin alpha-IIb [KO:K06476]
103589765  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
103592980  integrin alpha-4-like [KO:K06483]
103603577  ITGA5; integrin alpha-5 [KO:K06484]
103600955  integrin alpha-6 [KO:K06485]
103599053  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
103586296  ITGA8; integrin alpha-8 [KO:K06584]
103595867  ITGA10; integrin alpha-10 [KO:K06586]
103610734  integrin alpha-11 [KO:K06587]
103604851  ITGAV; integrin alpha-V [KO:K06487]
103606818  integrin alpha-V-like [KO:K06487]
103609616  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
103610124  ITGAM; integrin alpha-M [KO:K06461]
103608802  ITGAX; integrin alpha-X [KO:K06462]
103608804  ITGAD; integrin alpha-D [KO:K06594]
103587545  ITGAE; integrin alpha-E [KO:K06524]
103601646  ITGB1; integrin beta-1 [KO:K05719]
103599334  ITGB2; integrin beta-2 [KO:K06464]
103603628  ITGB3; integrin beta-3 [KO:K06493]
103585197  ITGB4; integrin beta-4 [KO:K06525]
103594431  ITGB5; integrin beta-5 [KO:K06588]
103582319  ITGB6; integrin beta-6 [KO:K06589]
103592221  ITGB7; integrin beta-7 [KO:K06590]
103590521  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
103598676  KNG1; kininogen-1 isoform X1 [KO:K03898]
103605884  BDKRB1; B1 bradykinin receptor [KO:K03915]
103610748  BDKRB2; B2 bradykinin receptor [KO:K03916]
103591105  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
103606149  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
103586690  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
103588713  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
103584462  muscarinic acetylcholine receptor M5 [KO:K04133]
103597458  muscarinic acetylcholine receptor M5-like [KO:K04133]
103591011  C5; complement C5 [KO:K03994]
103597654  C6; complement component C6 [KO:K03995]
103600071  C7; complement component C7 [KO:K03996]
103603589  C8A; LOW QUALITY PROTEIN: complement component C8 alpha chain [KO:K03997]
103603579  C8B; LOW QUALITY PROTEIN: complement component C8 beta chain [KO:K03998]
103610990  C8G; LOW QUALITY PROTEIN: complement component C8 gamma chain [KO:K03999]
103585712  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103587812  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
103604274  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
103593258  FGD3; LOW QUALITY PROTEIN: FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
103587023  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103592708  CRKL; crk-like protein [KO:K04438]
103608491  CRK; adapter molecule crk isoform X1 [KO:K04438]
103592660  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
103589434  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103610513  HRAS; GTPase HRas isoform X1 [KO:K02833]
103599501  KRAS; GTPase KRas [KO:K07827]
103589329  NRAS; GTPase NRas [KO:K07828]
103592600  RRAS; ras-related protein R-Ras [KO:K07829]
103600364  RRAS2; ras-related protein R-Ras2 [KO:K07830]
103604133  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
103607015  rho guanine nucleotide exchange factor 7-like [KO:K05729]
103607163  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
103586572  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103586784  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103587883  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103585463  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103593683  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103608454  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103597255  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
103599527  VAV1; proto-oncogene vav [KO:K05730]
103607777  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
103585520  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
103594183  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
103596180  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103590618  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103605965  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
103596129  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103600170  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
103592192  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103600324  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103596384  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103590279  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103598325  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103605698  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
103603384  RGCC; regulator of cell cycle RGCC [KO:K26108]
103586090  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
103588513  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
103592989  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
103584948  RHOA; transforming protein RhoA [KO:K04513]
103594082  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103606391  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103593345  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103598977  cell division control protein 42 homolog isoform X1 [KO:K04393]
103600263  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103586253  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103594793  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
103599260  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
103603905  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
103591302  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
103583006  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
103585406  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
103592848  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
103590666  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
103588665  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
103596627  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103596703  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
103594036  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
103582032  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
103589995  PPP1CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103585436  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103598453  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103607967  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
103585507  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
103597866  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
103594694  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
103605741  MYL2; LOW QUALITY PROTEIN: myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103587981  MYL5; LOW QUALITY PROTEIN: myosin light chain 5 [KO:K12753]
103592960  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
103586929  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103583521  myosin regulatory light chain 10 [KO:K12756]
103606469  myosin regulatory light chain 10 [KO:K12756]
103596620  myosin regulatory light chain 12B [KO:K12757]
103596621  myosin regulatory light polypeptide 9 [KO:K12757]
103609561  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
103602912  MYH9; myosin-9 [KO:K10352]
103603280  MYH11; myosin-11 isoform X1 [KO:K10352]
103606789  myosin-10 [KO:K10352]
103593096  MYH14; myosin-14 [KO:K10352]
103587896  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
103594341  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
103601876  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
103596896  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
103598843  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
103600026  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
103594206  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
103589381  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
103597026  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
103599593  LOW QUALITY PROTEIN: 1-phosphatidylinositol 3-phosphate 5-kinase-like [KO:K00921] [EC:2.7.1.150]
103597746  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
103605064  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
103610543  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
103587391  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
103586691  ENAH; protein enabled homolog [KO:K05746]
103588944  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
103601959  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
103591888  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
103599473  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
103603580  NCKAP1L; nck-associated protein 1-like [KO:K05750]
103584912  NCKAP1; nck-associated protein 1 [KO:K05750]
103598271  ABI2; abl interactor 2 isoform X1 [KO:K05751]
103607321  BRK1; protein BRICK1 [KO:K05752]
103589521  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
103601754  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
103594572  actin-related protein 3B isoform X1 [KO:K18584]
103597840  ACTR3; actin-related protein 3 [KO:K18584]
103602067  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
103602068  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
103588903  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
103588681  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
103594278  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
103595276  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
103583591  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
103586641  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
103593038  actin, cytoplasmic 1 [KO:K05692]
103587384  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103588428  PFN1; profilin-1 [KO:K05759]
103594907  PFN3; profilin-3 [KO:K05759]
103609374  PFN4; profilin-4 isoform X1 [KO:K05759]
103608474  profilin-2-like [KO:K05759]
103599798  PXN; paxillin [KO:K05760]
103585772  EZR; ezrin [KO:K08007]
103604456  RDX; radixin isoform X1 [KO:K05762]
103597673  MSN; moesin [KO:K05763]
103595881  putative thymosin beta-4-like protein 6 [KO:K05764]
103597041  thymosin beta-4 [KO:K05764]
103591327  CFL2; cofilin-2 [KO:K05765]
103599224  CFL1; cofilin-1 [KO:K05765]
103588170  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103589975  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103585401  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103595124  VCL; vinculin isoform X1 [KO:K05700]
103584252  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
103588733  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
103588398  SCIN; adseverin isoform X1 [KO:K05768]
103591006  GSN; gelsolin isoform X1 [KO:K05768]
103591293  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103591478  ACTN4; alpha-actinin-4 [KO:K05699]
103608971  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
103586841  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
103596237  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
gvr04010  MAPK signaling pathway
gvr04510  Focal adhesion
gvr04520  Adherens junction
KO pathway
ko04810   
LinkDB

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