KEGG   PATHWAY: gvr04010
Entry
gvr04010                    Pathway                                
Name
MAPK signaling pathway - Galeopterus variegatus (Sunda flying lemur)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
gvr04010  MAPK signaling pathway
gvr04010

Other DBs
GO: 0000165
Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103581745  [KO:K04869]
103581771  [KO:K02583]
103582054  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
103582159  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103582610  [KO:K04440] [EC:2.7.11.24]
103582623  [KO:K03283]
103583282  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103583388  [KO:K19663] [EC:2.7.11.13]
103583476  [KO:K04460] [EC:3.1.3.16]
103583578  [KO:K04449]
103585042  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103585043  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103585050  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103585077  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
103585085  STMN1; stathmin [KO:K04381]
103585135  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103585172  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
103585224  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
103585407  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
103585423  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
103585476  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
103585600  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
103585627  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103585638  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
103585712  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103585760  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
103585764  SRF; serum response factor [KO:K04378]
103585960  TGFB3; transforming growth factor beta-3 [KO:K13377]
103586032  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
103586186  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
103586225  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
103586230  VEGFB; vascular endothelial growth factor B [KO:K16858]
103586253  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103586269  PGF; placenta growth factor isoform X1 [KO:K16859]
103586304  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
103586448  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
103586524  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
103586679  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103586833  [KO:K04424] [EC:2.7.11.25]
103586838  [KO:K12362]
103587175  KITLG; kit ligand isoform X1 [KO:K05461]
103587310  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
103587362  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
103587477  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
103587478  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
103587514  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
103587648  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103587696  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
103587751  FGF21; fibroblast growth factor 21 [KO:K22429]
103587766  NTF4; neurotrophin-4 [KO:K12457]
103587820  MYC; myc proto-oncogene protein [KO:K04377]
103588087  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
103588100  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
103588190  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
103588261  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
103588373  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103588410  ARRB2; beta-arrestin-2 [KO:K04439]
103588451  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
103588497  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103588563  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
103588652  ARTN; artemin [KO:K25415]
103588673  FGF7; fibroblast growth factor 7 [KO:K04358]
103588723  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
103588746  FGF20; fibroblast growth factor 20 [KO:K04358]
103588777  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
103588798  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103588862  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
103588927  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
103588981  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
103589229  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
103589266  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103589329  NRAS; GTPase NRas [KO:K07828]
103589434  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103589530  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103589593  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
103589787  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103589910  RAP1A; ras-related protein Rap-1A [KO:K04353]
103589952  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
103590239  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
103590266  AREG; amphiregulin [KO:K09782]
103590268  EREG; proepiregulin [KO:K09784]
103590279  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103590309  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103590468  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
103590605  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
103590618  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103590620  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
103590682  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103590765  NRTN; neurturin [KO:K25414]
103590810  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
103590948  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
103591114  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
103591194  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
103591307  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
103591400  TP53; cellular tumor antigen p53 [KO:K04451]
103591456  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
103591473  MAP4K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
103591480  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
103591666  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103591744  FGF9; fibroblast growth factor 9 [KO:K04358]
103591821  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
103591856  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
103591905  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
103591967  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103591972  NGF; beta-nerve growth factor [KO:K02582]
103592005  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
103592019  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
103592192  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103592355  HSPA1A; heat shock 70 kDa protein 1A/1B isoform X1 [KO:K03283]
103592356  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
103592383  TNF; tumor necrosis factor [KO:K03156]
103592390  JUN; transcription factor AP-1 [KO:K04448]
103592574  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103592600  RRAS; ras-related protein R-Ras [KO:K07829]
103592617  [KO:K05454]
103592618  [KO:K05454]
103592692  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103592708  CRKL; crk-like protein [KO:K04438]
103592768  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103592883  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
103592934  PSPN; persephin [KO:K25416]
103592936  [KO:K25416]
103592973  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
103593030  STK3; serine/threonine-protein kinase 3 [KO:K04412]
103593058  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103593101  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
103593345  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103593462  NTF3; neurotrophin-3 [KO:K04356]
103593622  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
103593717  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
103593930  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
103593962  FGF17; fibroblast growth factor 17 [KO:K04358]
103593998  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
103594082  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103594183  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
103594186  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
103594198  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
103594326  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
103594351  FGF18; fibroblast growth factor 18 [KO:K04358]
103595029  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
103595098  FLNA; filamin-A isoform X1 [KO:K04437]
103595100  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103595105  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
103595208  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
103595283  IGF2; insulin-like growth factor II [KO:K13769]
103595295  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103595332  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
103595334  RELA; transcription factor p65 [KO:K04735]
103595400  RAP1B; ras-related protein Rap-1b [KO:K07836]
103595406  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
103595413  FGF8; fibroblast growth factor 8 [KO:K04358]
103595699  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103595701  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
103595819  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
103595825  IL1B; interleukin-1 beta [KO:K04519]
103595826  IL1A; interleukin-1 alpha [KO:K04383]
103595912  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103595980  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
103595998  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103596129  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103596138  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103596180  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103596384  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103596394  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
103596721  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103596809  ELK4; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-4 [KO:K04376]
103596885  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
103597016  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103597025  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103597068  FGF16; fibroblast growth factor 16 [KO:K04358]
103597189  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103597229  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103597236  [KO:K12362]
103597262  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
103597355  VEGFC; vascular endothelial growth factor C [KO:K05449]
103597588  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
103597950  DAXX; death domain-associated protein 6 [KO:K02308]
103598106  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103598115  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
103598189  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
103598210  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103598325  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103598337  [KO:K04373] [EC:2.7.11.1]
103598410  ARRB1; beta-arrestin-1 [KO:K04439]
103598580  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
103598652  MAPT; microtubule-associated protein tau [KO:K04380]
103598755  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
103598824  [KO:K04463] [EC:2.7.12.2]
103598878  MAX; protein max isoform X1 [KO:K04453]
103598977  [KO:K04393]
103599065  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
103599172  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103599185  [KO:K13375]
103599191  [KO:K13375]
103599295  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103599298  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103599396  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103599501  KRAS; GTPase KRas [KO:K07827]
103599661  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
103599662  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
103599668  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
103599669  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103599674  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
103599709  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
103599846  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
103599847  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103599960  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
103600170  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
103600263  [KO:K04409] [EC:2.7.11.1]
103600274  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103600311  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
103600324  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103600330  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103600364  RRAS2; ras-related protein R-Ras2 [KO:K07830]
103600441  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103600468  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103600501  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
103600537  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103600693  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
103600714  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103601056  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
103601167  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103601216  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
103601242  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103601302  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
103601449  CD14; monocyte differentiation antigen CD14 [KO:K04391]
103601524  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103601711  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103601761  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
103601907  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
103602098  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
103602129  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
103602136  FGF10; fibroblast growth factor 10 isoform X1 [KO:K04358]
103602190  RELB; transcription factor RelB [KO:K09253]
103602272  RASA2; ras GTPase-activating protein 2 [KO:K08053]
103602281  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
103602700  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
103602841  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
103602860  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
103602980  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
103603004  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
103603020  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
103603040  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
103603077  [KO:K04851]
103603245  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
103603252  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
103603521  [KO:K04440] [EC:2.7.11.24]
103603645  [KO:K04860]
103603673  [KO:K04412]
103603769  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103603960  FGF23; fibroblast growth factor 23 [KO:K22428]
103604028  FIGF; vascular endothelial growth factor D [KO:K05449]
103604091  FGF19; fibroblast growth factor 19 [KO:K22603]
103604133  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
103604367  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103604429  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
103604521  PPP3R2; calcineurin subunit B type 2 isoform X1 [KO:K06268]
103604564  [KO:K04527] [EC:2.7.10.1]
103604574  [KO:K04849]
103604608  NF1; neurofibromin [KO:K08052]
103604625  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
103604671  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
103604709  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
103604776  [KO:K04361] [EC:2.7.10.1]
103604998  [KO:K04358]
103604999  FGF3; fibroblast growth factor 3 [KO:K04358]
103605022  EFNA5; ephrin-A5 [KO:K05462]
103605028  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103605206  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
103605275  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103605365  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103605698  [KO:K04456] [EC:2.7.11.1]
103605891  FOS; proto-oncogene c-Fos [KO:K04379]
103605929  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103605950  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103606391  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103606635  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103606904  [KO:K04406] [EC:2.7.11.1]
103606935  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
103607184  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103607255  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
103607312  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
103607428  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
103607442  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103608309  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
103608324  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
103608346  EFNA1; ephrin-A1 [KO:K05462]
103608456  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
103608491  CRK; adapter molecule crk isoform X1 [KO:K04438]
103609169  [KO:K17534] [EC:2.7.11.25]
103609408  FGF6; fibroblast growth factor 6 [KO:K04358]
103610047  [KO:K03173] [EC:2.3.2.27]
103610085  FGF22; fibroblast growth factor 22 [KO:K04358]
103610259  DUSP5; LOW QUALITY PROTEIN: dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103610401  HSPB1; LOW QUALITY PROTEIN: heat shock protein beta-1 [KO:K04455]
103610513  HRAS; GTPase HRas isoform X1 [KO:K02833]
103610657  [KO:K04869]
103610948  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
103610970  [KO:K05092] [EC:2.7.10.1]
103610988  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103611005  [KO:K05467]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
gvr04070  Phosphatidylinositol signaling system
gvr04110  Cell cycle
gvr04115  p53 signaling pathway
gvr04210  Apoptosis
gvr04310  Wnt signaling pathway
gvr04668  TNF signaling pathway
KO pathway
ko04010   

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