KEGG   PATHWAY: hai04722
Entry
hai04722                    Pathway                                
Name
Neurotrophin signaling pathway - Hipposideros armiger (great roundleaf bat)
Description
Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory.
Class
Organismal Systems; Nervous system
Pathway map
hai04722  Neurotrophin signaling pathway
hai04722

Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109392809  NGF; beta-nerve growth factor [KO:K02582]
109387036  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
109391022  NTF4; neurotrophin-4 [KO:K12457]
109373318  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
109393379  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
109372375  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
109374619  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
109394772  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
109385028  SH2B2; SH2B adapter protein 2 isoform X1 [KO:K07193]
109382249  SH2B3; SH2B adapter protein 3 isoform X1 [KO:K12459]
109385860  SH2B1; SH2B adapter protein 1 isoform X1 [KO:K12459]
109383688  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
109385471  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109375221  SOS2; son of sevenless homolog 2 [KO:K03099]
109375639  HRAS; GTPase HRas isoform X1 [KO:K02833]
109385150  GTPase HRas-like [KO:K02833]
109389264  KRAS; GTPase KRas isoform X1 [KO:K07827]
109377015  NRAS; GTPase NRas [KO:K07828]
109384548  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109395605  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109385252  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109388626  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109385803  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
109394900  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109395688  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
109386772  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
109373920  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
109382677  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
109392248  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
109390784  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
109386646  KIDINS220; kinase D-interacting substrate of 220 kDa [KO:K12460]
109381689  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
109386906  CRK; adapter molecule crk isoform X1 [KO:K04438]
109376239  CRKL; crk-like protein [KO:K04438]
109380820  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
109373546  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
109381707  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
109380266  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
109385248  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
109377280  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
109395979  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109395980  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
109396629  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
109396630  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109374513  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
109393422  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
109390676  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
109376923  SHC3; SHC-transforming protein 3 [KO:K17448]
109394486  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
109393101  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
109382484  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109395865  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109373811  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
109381238  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109394108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109372681  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109381083  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385878  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
109374859  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385353  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109395326  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
109383860  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
109382858  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
109372541  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109384322  RELA; transcription factor p65 isoform X1 [KO:K04735]
109391421  FOXO3; forkhead box protein O3 [KO:K09408]
109385146  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109384256  BAD; bcl2-associated agonist of cell death [KO:K02158]
109388396  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
109385875  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
109396328  IRS1; insulin receptor substrate 1 [KO:K16172]
109379925  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
109378365  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
109395953  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
109382670  CALM1; calmodulin [KO:K02183]
109380340  calmodulin-like [KO:K02183]
109391149  CALML6; calmodulin-like protein 6 [KO:K02183]
109383794  calmodulin-like protein 3 [KO:K02183]
109383796  calmodulin-like [KO:K02183]
109372230  CALM3; calmodulin [KO:K02183]
109389917  CALM2; calmodulin [KO:K02183]
109372542  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109373019  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109375001  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
109390284  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109391534  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
109380669  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
109382264  PTPN11; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
109391216  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
109388657  megakaryocyte-associated tyrosine-protein kinase isoform X1 [KO:K08888] [EC:2.7.10.2]
109388658  megakaryocyte-associated tyrosine-protein kinase-like isoform X1 [KO:K08888] [EC:2.7.10.2]
109380655  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
109383122  ARHGDIB; rho GDP-dissociation inhibitor 2 isoform X1 [KO:K12462]
109385979  ARHGDIG; rho GDP-dissociation inhibitor 3 [KO:K12462]
109392998  ARHGDIA; rho GDP-dissociation inhibitor 1 [KO:K12462]
109376114  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
109396744  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
109380150  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109385705  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
109385622  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
109396087  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
109392215  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109377948  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
109392748  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
109371251  JUN; transcription factor AP-1 [KO:K04448]
109371257  transcription factor AP-1 [KO:K04448]
109394672  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
109391068  BAX; apoptosis regulator BAX [KO:K02159]
109391198  TP73; tumor protein p73 isoform X1 [KO:K10148]
109381153  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
109375694  ZNF274; neurotrophin receptor-interacting factor homolog isoform X1 [KO:K12458]
109382837  PRDM4; PR domain zinc finger protein 4 isoform X1 [KO:K12463] [EC:2.1.1.-]
109377859  MAGED1; melanoma-associated antigen D1 [KO:K12464]
109376055  BEX3; protein BEX3 [KO:K12465]
109386914  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
109387588  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
109394352  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
109387293  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K04731] [EC:2.7.11.1]
109381681  IRAK3; interleukin-1 receptor-associated kinase 3 isoform X1 [KO:K04732] [EC:2.7.11.1]
109388403  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
109386279  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109375290  SORT1; sortilin isoform X1 [KO:K12388]
109381602  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
109391446  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11399424
  Authors
Patapoutian A, Reichardt LF
  Title
Trk receptors: mediators of neurotrophin action.
  Journal
Curr Opin Neurobiol 11:272-80 (2001)
DOI:10.1016/S0959-4388(00)00208-7
Reference
PMID:16699811
  Authors
Arevalo JC, Wu SH
  Title
Neurotrophin signaling: many exciting surprises!
  Journal
Cell Mol Life Sci 63:1523-37 (2006)
DOI:10.1007/s00018-006-6010-1
Reference
PMID:14704852
  Authors
Teng KK, Hempstead BL
  Title
Neurotrophins and their receptors: signaling trios in complex biological systems.
  Journal
Cell Mol Life Sci 61:35-48 (2004)
DOI:10.1007/s00018-003-3099-3
Reference
PMID:11529497
  Authors
Miller FD, Kaplan DR
  Title
Neurotrophin signalling pathways regulating neuronal apoptosis.
  Journal
Cell Mol Life Sci 58:1045-53 (2001)
DOI:10.1007/PL00000919
Reference
PMID:10851172
  Authors
Kaplan DR, Miller FD
  Title
Neurotrophin signal transduction in the nervous system.
  Journal
Curr Opin Neurobiol 10:381-91 (2000)
DOI:10.1016/S0959-4388(00)00092-1
Reference
PMID:16939974
  Authors
Reichardt LF
  Title
Neurotrophin-regulated signalling pathways.
  Journal
Philos Trans R Soc Lond B Biol Sci 361:1545-64 (2006)
DOI:10.1098/rstb.2006.1894
Reference
PMID:16856873
  Authors
Zampieri N, Chao MV
  Title
Mechanisms of neurotrophin receptor signalling.
  Journal
Biochem Soc Trans 34:607-11 (2006)
DOI:10.1042/BST0340607
Reference
PMID:15499580
  Authors
Rose CR, Blum R, Kafitz KW, Kovalchuk Y, Konnerth A
  Title
From modulator to mediator: rapid effects of BDNF on ion channels.
  Journal
Bioessays 26:1185-94 (2004)
DOI:10.1002/bies.20118
Reference
PMID:10812966
  Authors
Yano H, Chao MV
  Title
Neurotrophin receptor structure and interactions.
  Journal
Pharm Acta Helv 74:253-60 (2000)
DOI:10.1016/s0031-6865(99)00036-9
Reference
PMID:10764727
  Authors
Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA
  Title
NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.
  Journal
J Biol Chem 275:17566-70 (2000)
DOI:10.1074/jbc.C000140200
Reference
PMID:10985348
  Authors
Salehi AH, Roux PP, Kubu CJ, Zeindler C, Bhakar A, Tannis LL, Verdi JM, Barker PA
  Title
NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.
  Journal
Neuron 27:279-88 (2000)
DOI:10.1016/S0896-6273(00)00036-2
Related
pathway
hai04010  MAPK signaling pathway
hai04120  Ubiquitin mediated proteolysis
hai04210  Apoptosis
hai04720  Long-term potentiation
hai04810  Regulation of actin cytoskeleton
KO pathway
ko04722   
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