KEGG   PATHWAY: hai04810
Entry
hai04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Hipposideros armiger (great roundleaf bat)
Class
Cellular Processes; Cell motility
Pathway map
hai04810  Regulation of actin cytoskeleton
hai04810

Other DBs
GO: 0030036
Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109371464  KNG1; kininogen-1 isoform X1 [KO:K03898]
109372101  ITGB2; integrin beta-2 [KO:K06464]
109372218  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
109372273  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
109372393  MYH9; myosin-9 [KO:K10352]
109372566  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
109372637  VCL; vinculin isoform X1 [KO:K05700]
109372681  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109372713  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
109372864  ACTR3; actin-related protein 3 [KO:K18584]
109372936  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
109373005  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
109373149  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
109373436  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
109373530  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
109373640  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
109373692  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
109373751  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
109373811  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
109374154  FGF2; fibroblast growth factor 2 [KO:K18497]
109374167  [KO:K06461]
109374175  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
109374220  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
109374297  [KO:K05730]
109374355  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
109374465  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
109374586  C6; complement component C6 [KO:K03995]
109374603  ITGA8; integrin alpha-8 [KO:K06584]
109374656  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
109374859  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109375002  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
109375211  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
109375221  SOS2; son of sevenless homolog 2 [KO:K03099]
109375381  [KO:K05730]
109375388  EZR; ezrin isoform X1 [KO:K08007]
109375550  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
109375639  HRAS; GTPase HRas isoform X1 [KO:K02833]
109376015  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109376114  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
109376173  C7; complement component C7 [KO:K03996]
109376239  CRKL; crk-like protein [KO:K04438]
109376358  [KO:K05754]
109376563  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
109376974  [KO:K00920] [EC:2.7.1.149]
109377006  C8B; complement component C8 beta chain [KO:K03998]
109377008  C8A; complement component C8 alpha chain [KO:K03997]
109377015  NRAS; GTPase NRas [KO:K07828]
109377191  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
109377459  [KO:K06594]
109377660  SCIN; adseverin [KO:K05768]
109377773  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
109378054  VAV1; proto-oncogene vav [KO:K05730]
109378999  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
109379038  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
109379053  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
109379151  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
109379174  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
109379234  ABI2; abl interactor 2 isoform X1 [KO:K05751]
109379349  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
109379381  FGF18; fibroblast growth factor 18 [KO:K04358]
109379436  EGF; pro-epidermal growth factor [KO:K04357]
109379623  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
109379873  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
109380137  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
109380150  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109380220  ACTB; actin, cytoplasmic 1 [KO:K05692]
109380223  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
109380315  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
109380323  ITGB3; integrin beta-3 [KO:K06493]
109380462  PPP1R12B; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12B [KO:K12329]
109380590  FN1; fibronectin isoform X1 [KO:K05717]
109380595  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
109380798  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
109380829  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
109381083  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109381168  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
109381238  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109381492  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
109381704  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
109381815  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
109381883  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
109381897  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
109381964  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
109382080  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
109382125  ITGA2; integrin alpha-2 [KO:K06481]
109382143  ITGA1; integrin alpha-1 [KO:K06480]
109382193  [KO:K18584]
109382376  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
109382437  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
109382484  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109382719  BDKRB2; B2 bradykinin receptor [KO:K03916]
109382720  BDKRB1; B1 bradykinin receptor [KO:K03915]
109383003  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
109383050  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
109383094  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
109383212  FAM49B; protein FAM49B [KO:K27976]
109383761  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
109383900  CFL2; cofilin-2 isoform X1 [KO:K05765]
109383937  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
109384074  [KO:K05735] [EC:2.7.11.1]
109384108  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
109384109  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
109384139  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109384191  CFL1; cofilin-1 isoform X1 [KO:K05765]
109384471  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
109384548  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109384767  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
109384807  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
109385005  MYL10; myosin regulatory light chain 10 [KO:K12756]
109385063  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
109385150  [KO:K02833]
109385214  ITGA9; integrin alpha-9 [KO:K06585]
109385221  ITGA11; integrin alpha-11 [KO:K06587]
109385252  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109385340  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
109385353  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109385471  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109385677  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
109385680  FGF16; fibroblast growth factor 16 [KO:K04358]
109385685  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109385723  GSN; gelsolin [KO:K05768]
109385735  C5; complement C5 [KO:K03994]
109385803  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
109385878  [KO:K04456] [EC:2.7.11.1]
109386042  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
109386108  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109386121  [KO:K10351]
109386122  [KO:K10351]
109386147  [KO:K05760]
109386148  [KO:K05760]
109386156  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
109386484  PFN4; profilin-4 isoform X1 [KO:K05759]
109386644  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
109386737  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
109386760  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
109386851  RGCC; regulator of cell cycle RGCC [KO:K26108]
109386878  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
109386906  CRK; adapter molecule crk isoform X1 [KO:K04438]
109386921  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
109386990  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
109387068  C9; complement component C9 [KO:K04000]
109387304  BRK1; protein BRICK1 [KO:K05752]
109387357  TMSB4X; thymosin beta-4 [KO:K05764]
109387509  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
109387639  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
109387967  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
109388085  [KO:K00907] [EC:2.7.11.18]
109388160  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109388269  RRAS2; ras-related protein R-Ras2 [KO:K07830]
109388303  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
109388365  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
109388540  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
109388601  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
109388626  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109388703  RDX; radixin isoform X1 [KO:K05762]
109388840  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
109388894  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
109389001  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
109389264  KRAS; GTPase KRas isoform X1 [KO:K07827]
109389288  FGF19; fibroblast growth factor 19 [KO:K22603]
109389289  FGF3; fibroblast growth factor 3 [KO:K04358]
109389290  FGF4; fibroblast growth factor 4 [KO:K04358]
109389577  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
109389641  ACTR3B; actin-related protein 3B [KO:K18584]
109389743  PFN3; profilin-3 [KO:K05759]
109389796  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
109389936  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
109390069  [KO:K05759]
109390078  MSN; moesin [KO:K05763]
109390173  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
109390187  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
109390397  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109390582  FGF22; fibroblast growth factor 22 [KO:K04358]
109390647  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
109390752  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
109390824  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
109390857  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
109390950  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
109390958  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
109391003  MYH14; myosin-14 [KO:K10352]
109391024  FGF21; fibroblast growth factor 21 [KO:K22429]
109391058  RRAS; ras-related protein R-Ras [KO:K07829]
109391341  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
109391467  ENAH; protein enabled homolog isoform X1 [KO:K05746]
109391522  APC; adenomatous polyposis coli protein [KO:K02085]
109391793  NCKAP1L; nck-associated protein 1-like [KO:K05750]
109391828  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
109391860  ITGA5; integrin alpha-5 [KO:K06484]
109391882  ITGAE; integrin alpha-E [KO:K06524]
109392102  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
109392273  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
109392469  FGF23; fibroblast growth factor 23 [KO:K22428]
109392478  FGF6; fibroblast growth factor 6 [KO:K04358]
109392539  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
109392600  ITGA4; integrin alpha-4 [KO:K06483]
109392605  NCKAP1; nck-associated protein 1 [KO:K05750]
109392710  PFN2; profilin-2 isoform X1 [KO:K05759]
109392711  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
109392844  FGF10; fibroblast growth factor 10 [KO:K04358]
109393032  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
109393041  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
109393048  ACTG1; actin, cytoplasmic 2 [KO:K05692]
109393360  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
109393367  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
109393508  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
109393560  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
109393705  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
109393895  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
109394108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109394119  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
109394259  [KO:K04347]
109394455  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
109394502  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109394542  FGF7; fibroblast growth factor 7 [KO:K04358]
109394578  FGF20; fibroblast growth factor 20 [KO:K04358]
109394645  PFN1; profilin-1 [KO:K05759]
109394738  [KO:K12757]
109394739  [KO:K12757]
109394900  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109394938  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
109394948  ITGA2B; integrin alpha-IIb [KO:K06476]
109395110  MYH10; myosin-10 [KO:K10352]
109395242  MYH11; myosin-11 isoform X1 [KO:K10352]
109395369  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
109395380  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
109395605  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109395865  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109395869  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
109395936  INS; insulin [KO:K04526]
109396173  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
109396744  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
109396843  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
109396967  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 isoform X1 [KO:K05720]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
hai04010  MAPK signaling pathway
hai04510  Focal adhesion
hai04520  Adherens junction
KO pathway
ko04810   

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