KEGG   PATHWAY: hai04010
Entry
hai04010                    Pathway                                
Name
MAPK signaling pathway - Hipposideros armiger (great roundleaf bat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
hai04010  MAPK signaling pathway
hai04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109371236  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
109371251  JUN; transcription factor AP-1 [KO:K04448]
109371257  [KO:K04448]
109371277  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
109371344  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
109371418  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
109371489  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
109371584  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
109371823  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
109371839  EREG; proepiregulin [KO:K09784]
109371841  AREG; amphiregulin [KO:K09782]
109372375  [KO:K04360] [EC:2.7.10.1]
109372383  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
109372443  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109372469  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
109372505  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
109372507  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
109372508  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
109372541  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109372771  RELB; transcription factor RelB [KO:K09253]
109372936  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
109373045  [KO:K03283]
109373073  TNF; tumor necrosis factor isoform X1 [KO:K03156]
109373092  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
109373093  [KO:K03283]
109373149  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
109373318  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
109373530  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
109373546  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
109373644  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109373808  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
109373920  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
109374090  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109374154  FGF2; fibroblast growth factor 2 [KO:K18497]
109374513  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
109374619  [KO:K04360] [EC:2.7.10.1]
109374806  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
109374859  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109374860  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
109374995  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
109375002  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
109375006  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
109375221  SOS2; son of sevenless homolog 2 [KO:K03099]
109375639  HRAS; GTPase HRas isoform X1 [KO:K02833]
109375840  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109375958  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109376015  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109376220  KITLG; kit ligand [KO:K05461]
109376239  CRKL; crk-like protein [KO:K04438]
109376563  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
109376565  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
109376590  TGFB1; transforming growth factor beta-1 [KO:K13375]
109376677  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
109377015  NRAS; GTPase NRas [KO:K07828]
109377126  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109377184  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
109377280  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
109377338  FLNA; filamin-A isoform X1 [KO:K04437]
109377344  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109377773  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
109377855  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
109377948  [KO:K04440] [EC:2.7.11.24]
109378052  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
109379089  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109379237  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
109379363  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
109379381  FGF18; fibroblast growth factor 18 [KO:K04358]
109379436  EGF; pro-epidermal growth factor [KO:K04357]
109379582  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
109379623  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
109379632  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109379970  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
109380137  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
109380150  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109380223  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
109380245  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
109380246  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
109380255  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
109380266  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
109380289  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
109380299  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
109380372  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109380439  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
109380515  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
109380655  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
109380706  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
109380800  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
109380817  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
109380888  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
109381083  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109381153  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
109381204  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
109381205  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
109381402  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
109381519  PGF; placenta growth factor isoform X1 [KO:K16859]
109381526  FOS; proto-oncogene c-Fos [KO:K04379]
109381619  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
109381672  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
109381707  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
109381812  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
109381815  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
109381816  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
109381973  RASA1; ras GTPase-activating protein 1 [KO:K04352]
109381982  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
109382105  MAX; protein max isoform X1 [KO:K04453]
109382258  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
109382421  JUND; transcription factor jun-D [KO:K04449]
109382437  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
109382541  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
109382677  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
109382813  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
109382864  VEGFA; vascular endothelial growth factor A [KO:K05448]
109382938  SRF; serum response factor isoform X1 [KO:K04378]
109383003  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
109383157  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109383198  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109383211  MYC; myc proto-oncogene protein [KO:K04377]
109383362  ARTN; artemin isoform X1 [KO:K25415]
109383470  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
109383688  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
109383789  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
109383851  CDC25B; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
109383984  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
109384003  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
109384004  PLA2G4D; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
109384055  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
109384152  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
109384179  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
109384216  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
109384313  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
109384322  RELA; transcription factor p65 isoform X1 [KO:K04735]
109384326  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
109384341  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
109384548  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109384570  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
109384861  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
109384920  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109384926  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109384987  HSPB1; heat shock protein beta-1 [KO:K04455]
109385097  NF1; neurofibromin [KO:K08052]
109385136  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
109385146  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109385150  [KO:K02833]
109385248  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
109385252  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109385353  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109385384  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
109385440  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109385471  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109385547  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
109385622  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
109385680  FGF16; fibroblast growth factor 16 [KO:K04358]
109385705  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
109385803  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
109385878  [KO:K04456] [EC:2.7.11.1]
109385884  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
109385892  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
109385981  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
109386193  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
109386279  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109386336  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
109386421  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
109386500  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
109386578  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109386602  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
109386678  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
109386772  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
109386780  STMN1; stathmin [KO:K04381]
109386859  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
109386906  CRK; adapter molecule crk isoform X1 [KO:K04438]
109387036  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
109387040  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
109387249  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109387487  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
109387639  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
109387670  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
109387677  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
109387711  MAP3K21; mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
109387785  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
109388131  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
109388180  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
109388191  ANGPT2; angiopoietin-2 [KO:K05466]
109388269  RRAS2; ras-related protein R-Ras2 [KO:K07830]
109388365  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
109388403  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
109388439  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
109388552  NRTN; neurturin [KO:K25414]
109388626  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109388639  PSPN; persephin [KO:K25416]
109388733  [KO:K04424] [EC:2.7.11.25]
109388738  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
109388741  [KO:K04424] [EC:2.7.11.25]
109388799  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
109388949  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
109388950  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
109388987  [KO:K03283]
109389079  [KO:K04860]
109389111  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
109389137  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
109389264  KRAS; GTPase KRas isoform X1 [KO:K07827]
109389288  FGF19; fibroblast growth factor 19 [KO:K22603]
109389289  FGF3; fibroblast growth factor 3 [KO:K04358]
109389290  FGF4; fibroblast growth factor 4 [KO:K04358]
109389346  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
109389408  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
109389413  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
109389465  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109389796  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
109390085  [KO:K05096] [EC:2.7.10.1]
109390108  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109390177  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
109390353  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
109390432  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
109390582  FGF22; fibroblast growth factor 22 [KO:K04358]
109390584  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109390629  EFNA2; ephrin-A2 [KO:K05462]
109390663  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
109390744  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
109390958  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
109391022  NTF4; neurotrophin-4 [KO:K12457]
109391024  FGF21; fibroblast growth factor 21 [KO:K22429]
109391058  RRAS; ras-related protein R-Ras [KO:K07829]
109391102  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
109391615  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
109391825  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
109392025  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109392215  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109392231  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
109392248  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
109392251  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
109392273  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
109392334  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
109392343  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
109392365  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109392423  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
109392469  FGF23; fibroblast growth factor 23 [KO:K22428]
109392478  FGF6; fibroblast growth factor 6 [KO:K04358]
109392740  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
109392748  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
109392791  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
109392809  NGF; beta-nerve growth factor [KO:K02582]
109392844  FGF10; fibroblast growth factor 10 [KO:K04358]
109392941  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
109393041  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
109393268  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
109393359  EFNA1; ephrin-A1 [KO:K05462]
109393364  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
109393379  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
109393398  CD14; monocyte differentiation antigen CD14 [KO:K04391]
109393452  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
109393491  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
109393524  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
109393526  IL1A; interleukin-1 alpha [KO:K04383]
109393559  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
109393705  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
109393855  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
109394013  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
109394119  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
109394225  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
109394251  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
109394259  [KO:K04347]
109394319  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
109394352  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
109394441  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
109394502  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109394542  FGF7; fibroblast growth factor 7 [KO:K04358]
109394578  FGF20; fibroblast growth factor 20 [KO:K04358]
109394672  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
109394691  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
109394900  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109394938  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
109394994  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
109395015  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
109395206  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
109395227  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
109395316  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
109395474  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
109395478  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
109395552  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
109395605  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109395688  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
109395706  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
109395927  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
109395932  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109395935  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
109395936  INS; insulin [KO:K04526]
109395944  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
109395979  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109395980  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
109395998  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
109396062  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
109396087  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
109396628  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
109396629  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
109396630  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109396744  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
109396911  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
hai04070  Phosphatidylinositol signaling system
hai04110  Cell cycle
hai04115  p53 signaling pathway
hai04210  Apoptosis
hai04310  Wnt signaling pathway
hai04668  TNF signaling pathway
KO pathway
ko04010   

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