KEGG   PATHWAY: mleu05415
Entry
mleu05415                   Pathway                                
Name
Diabetic cardiomyopathy - Mandrillus leucophaeus (drill)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
mleu05415  Diabetic cardiomyopathy
mleu05415

Organism
Mandrillus leucophaeus (drill) [GN:mleu]
Gene
105555046  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
105549897  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
105543201  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X1 [KO:K00820] [EC:2.6.1.16]
105537273  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
105551865  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
105547509  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
105541945  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
105543432  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
105551621  TNNI3; troponin I, cardiac muscle [KO:K12044]
105536906  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
105540116  PLN; cardiac phospholamban [KO:K05852]
105552249  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
105539979  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
105541379  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
105554908  SP1; transcription factor Sp1 [KO:K04684]
105528652  AGT; angiotensinogen isoform X1 [KO:K09821]
105547062  REN; renin [KO:K01380] [EC:3.4.23.15]
105532747  CMA1; chymase [KO:K01329] [EC:3.4.21.39]
105545146  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105531507  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
105536139  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
105550330  NCF1; neutrophil cytosol factor 1 [KO:K08011]
105533389  cytochrome b-245 light chain [KO:K08009]
105550426  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
105538913  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
105551438  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105546567  ras-related protein Rac1-like [KO:K04392]
105538902  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
105534119  AGTR1; type-1 angiotensin II receptor isoform X1 [KO:K04166]
105548314  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105528449  RELA; transcription factor p65 isoform X1 [KO:K04735]
105543603  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105543619  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105544221  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105544400  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105547365  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
105554734  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105537274  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105533444  MMP2; 72 kDa type IV collagenase isoform X1 [KO:K01398] [EC:3.4.24.24]
105542292  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
105553265  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105535560  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
105535239  COL3A1; collagen alpha-1(III) chain [KO:K19720]
105542552  TGFB1; transforming growth factor beta-1 [KO:K13375]
105544786  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105540815  TGFB3; transforming growth factor beta-3 [KO:K13377]
105543914  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
105542493  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
105543613  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
105545187  PDK3; pyruvate dehydrogenase kinase, isozyme 3 [KO:K00898] [EC:2.7.11.2]
105553268  PDK2; pyruvate dehydrogenase kinase, isozyme 2 isoform X1 [KO:K00898] [EC:2.7.11.2]
105535572  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
105548239  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105543983  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
105532862  PPP2R4; serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605]
105552307  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105533954  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105544467  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105545336  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
105544659  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
105534872  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
105545324  INS; insulin isoform X1 [KO:K04526]
105541159  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
105543176  IRS1; insulin receptor substrate 1 [KO:K16172]
105539923  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105552763  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105549588  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105547376  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105543389  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105531763  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105546962  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105540494  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105541755  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105542359  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105551388  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105544615  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105531538  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
105539163  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
105533533  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
105539750  MPC1L; LOW QUALITY PROTEIN: mitochondrial pyruvate carrier 1-like protein [KO:K22138]
105553525  MPC1; mitochondrial pyruvate carrier 1 [KO:K22138]
105539582  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
105552202  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
105549604  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial isoform X1 [KO:K00161] [EC:1.2.4.1]
105550780  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
105552661  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform X1 [KO:K00162] [EC:1.2.4.1]
105544481  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
105542372  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
105555594  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
105537526  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105528352  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X1 [KO:K03946]
105539213  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105552516  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105545563  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
105553667  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105547320  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105539723  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
105550883  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
105538803  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105529172  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105546320  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
105551123  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
105531588  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105531888  acyl carrier protein, mitochondrial [KO:K03955]
105545140  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105530057  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105546990  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
105547363  NDUFA13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
105547955  NDUFB1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
105550513  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
105535428  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
105533216  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105539929  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
105539631  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
105540981  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105533683  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
105537752  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
105554617  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
105529740  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105541684  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial isoform X1 [KO:K11351]
105549398  NDUFS1; LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105536733  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
105554828  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105553460  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
105537917  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
105531487  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105551946  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
105544487  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105543644  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
105546505  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
105528135  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
105537465  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
105552727  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105540160  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like isoform X1 [KO:K00235] [EC:1.3.5.1]
105548772  LOW QUALITY PROTEIN: succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
105536578  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
105529588  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
105550790  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
105551506  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
105537410  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
105550366  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
105536314  cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
105540380  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
105545124  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
105531777  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
105532363  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
105538730  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
105531338  cytochrome b-c1 complex subunit 8 [KO:K00418]
105550714  cytochrome b-c1 complex subunit 9 [KO:K00419]
105551955  cytochrome b-c1 complex subunit 10 [KO:K00420]
105539498  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
105533155  uncharacterized protein LOC105533155 isoform X1 [KO:K02263]
105528615  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
105553641  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
105554110  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
105531657  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
105543464  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
105541474  cytochrome c oxidase subunit 6A2, mitochondrial isoform X1 [KO:K02266]
105527930  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
105551631  cytochrome c oxidase subunit 6B2 [KO:K02267]
105543089  cytochrome c oxidase subunit 6B1 isoform X1 [KO:K02267]
105529563  cytochrome c oxidase subunit 6C [KO:K02268]
105528871  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
105543058  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
105537923  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
105538345  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
105530782  cytochrome c oxidase subunit 7B, mitochondrial isoform X1 [KO:K02271]
105538264  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
105550036  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
105547937  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
105549087  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
105532785  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
105538285  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
105545548  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105535712  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
105551985  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
105548343  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105554307  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105553294  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
105548040  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128]
105548527  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
105549301  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105531850  ATP synthase subunit d, mitochondrial [KO:K02138]
105536822  ATP5H; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
105533182  ATP synthase subunit O, mitochondrial [KO:K02137]
105553154  ATP5O; ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
105545476  ATP5J; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
105544969  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
105531327  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
105543895  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
105554537  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105553981  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105554244  ADP/ATP translocase 3-like [KO:K05863]
105537518  SLC25A5; ADP/ATP translocase 2 isoform X1 [KO:K05863]
105538390  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105535696  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
105539692  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105542707  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
105541790  GAPDH; glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
105548857  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
105552341  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
105534279  G6PD; glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
105538000  GSR; LOW QUALITY PROTEIN: glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
105549297  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
105543507  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
105531149  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
105530839  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
105546224  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105552818  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105553023  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
105549095  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
105551749  angiotensin-converting enzyme-like [KO:K01283] [EC:3.4.15.1]
105551750  angiotensin-converting enzyme-like [KO:K01283] [EC:3.4.15.1]
105551751  LOW QUALITY PROTEIN: angiotensin-converting enzyme-like [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
DOI:10.1016/j.pharmthera.2014.01.003
Reference
PMID:28231848
  Authors
Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
  Title
Diagnostic approaches for diabetic cardiomyopathy.
  Journal
Cardiovasc Diabetol 16:28 (2017)
DOI:10.1186/s12933-017-0506-x
Reference
PMID:32080423
  Authors
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
  Title
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
  Journal
Nat Rev Cardiol 17:585-607 (2020)
DOI:10.1038/s41569-020-0339-2
Reference
PMID:31212580
  Authors
Zamora M, Villena JA
  Title
Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E2833 (2019)
DOI:10.3390/ijms20112833
Reference
PMID:29605388
  Authors
Palomer X, Pizarro-Delgado J, Vazquez-Carrera M
  Title
Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
  Journal
Trends Pharmacol Sci 39:452-467 (2018)
DOI:10.1016/j.tips.2018.02.010
Reference
PMID:28439258
  Authors
Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata SK
  Title
Diabetic Cardiomyopathy: An Immunometabolic Perspective.
  Journal
Front Endocrinol (Lausanne) 8:72 (2017)
DOI:10.3389/fendo.2017.00072
Reference
PMID:28177068
  Authors
Chong CR, Clarke K, Levelt E
  Title
Metabolic Remodeling in Diabetic Cardiomyopathy.
  Journal
Cardiovasc Res 113:422-430 (2017)
DOI:10.1093/cvr/cvx018
Reference
PMID:11742414
  Authors
Brownlee M
  Title
Biochemistry and molecular cell biology of diabetic complications.
  Journal
Nature 414:813-20 (2001)
DOI:10.1038/414813a
Reference
PMID:32821697
  Authors
Gollmer J, Zirlik A, Bugger H
  Title
Established and Emerging Mechanisms of Diabetic Cardiomyopathy.
  Journal
J Lipid Atheroscler 8:26-47 (2019)
DOI:10.12997/jla.2019.8.1.26
Reference
PMID:17592090
  Authors
Boudina S, Abel ED
  Title
Diabetic cardiomyopathy revisited.
  Journal
Circulation 115:3213-23 (2007)
DOI:10.1161/CIRCULATIONAHA.106.679597
Reference
PMID:29109032
  Authors
Varma U, Koutsifeli P, Benson VL, Mellor KM, Delbridge LMD
  Title
Molecular mechanisms of cardiac pathology in diabetes - Experimental insights.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1949-1959 (2018)
DOI:10.1016/j.bbadis.2017.10.035
Reference
PMID:23147391
  Authors
Mandavia CH, Aroor AR, Demarco VG, Sowers JR
  Title
Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.
  Journal
Life Sci 92:601-8 (2013)
DOI:10.1016/j.lfs.2012.10.028
Reference
PMID:21626163
  Authors
Falcao-Pires I, Leite-Moreira AF
  Title
Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment.
  Journal
Heart Fail Rev 17:325-44 (2012)
DOI:10.1007/s10741-011-9257-z
Reference
PMID:27148064
  Authors
Westermeier F, Riquelme JA, Pavez M, Garrido V, Diaz A, Verdejo HE, Castro PF, Garcia L, Lavandero S
  Title
New Molecular Insights of Insulin in Diabetic Cardiomyopathy.
  Journal
Front Physiol 7:125 (2016)
DOI:10.3389/fphys.2016.00125
Reference
PMID:33276047
  Authors
Randhawa VK, Dhanvantari S, Connelly K
  Title
How Diabetes and Heart Failure Modulate Each Other and Condition Management.
  Journal
Can J Cardiol S0828-282X(20)31115-6 (2020)
DOI:10.1016/j.cjca.2020.11.014
Reference
PMID:31641426
  Authors
Athithan L, Gulsin GS, McCann GP, Levelt E
  Title
Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date.
  Journal
World J Diabetes 10:490-510 (2019)
DOI:10.4239/wjd.v10.i10.490
Reference
PMID:21111987
  Authors
Murarka S, Movahed MR
  Title
Diabetic cardiomyopathy.
  Journal
J Card Fail 16:971-9 (2010)
DOI:10.1016/j.cardfail.2010.07.249
Reference
PMID:25085967
  Authors
Thomas CM, Yong QC, Rosa RM, Seqqat R, Gopal S, Casarini DE, Jones WK, Gupta S, Baker KM, Kumar R
  Title
Cardiac-specific suppression of NF-kappaB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system.
  Journal
Am J Physiol Heart Circ Physiol 307:H1036-45 (2014)
DOI:10.1152/ajpheart.00340.2014
Reference
PMID:28236380
  Authors
Brahma MK, Pepin ME, Wende AR
  Title
My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.
  Journal
Diabetes Metab J 41:1-9 (2017)
DOI:10.4093/dmj.2017.41.1.1
Reference
PMID:18829990
  Authors
Singh VP, Le B, Khode R, Baker KM, Kumar R
  Title
Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis.
  Journal
Diabetes 57:3297-306 (2008)
DOI:10.2337/db08-0805
Reference
PMID:18296558
  Authors
Singh VP, Baker KM, Kumar R
  Title
Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production.
  Journal
Am J Physiol Heart Circ Physiol 294:H1675-84 (2008)
DOI:10.1152/ajpheart.91493.2007
Reference
PMID:26678809
  Authors
Jia G, DeMarco VG, Sowers JR
  Title
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.
  Journal
Nat Rev Endocrinol 12:144-53 (2016)
DOI:10.1038/nrendo.2015.216
Reference
PMID:18309108
  Authors
Kim JA, Wei Y, Sowers JR
  Title
Role of mitochondrial dysfunction in insulin resistance.
  Journal
Circ Res 102:401-14 (2008)
DOI:10.1161/CIRCRESAHA.107.165472
Reference
PMID:30170598
  Authors
Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuniga FA
  Title
Association between insulin resistance and the development of cardiovascular disease.
  Journal
Cardiovasc Diabetol 17:122 (2018)
DOI:10.1186/s12933-018-0762-4
Reference
PMID:31269778
  Authors
Evangelista I, Nuti R, Picchioni T, Dotta F, Palazzuoli A
  Title
Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E3264 (2019)
DOI:10.3390/ijms20133264
Reference
PMID:24307101
  Authors
Joshi M, Kotha SR, Malireddy S, Selvaraju V, Satoskar AR, Palesty A, McFadden DW, Parinandi NL, Maulik N
  Title
Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria.
  Journal
Mol Cell Biochem 386:233-49 (2014)
DOI:10.1007/s11010-013-1861-x
Reference
PMID:29867137
  Authors
Knapp M, Tu X, Wu R
  Title
Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy.
  Journal
Acta Pharmacol Sin 40:1-8 (2019)
DOI:10.1038/s41401-018-0042-6
Reference
PMID:16487830
  Authors
Asbun J, Villarreal FJ
  Title
The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy.
  Journal
J Am Coll Cardiol 47:693-700 (2006)
DOI:10.1016/j.jacc.2005.09.050
Reference
PMID:32024054
  Authors
Levick SP, Widiapradja A
  Title
The Diabetic Cardiac Fibroblast: Mechanisms Underlying Phenotype and Function.
  Journal
Int J Mol Sci 21:E970 (2020)
DOI:10.3390/ijms21030970
Related
pathway
mleu00010  Glycolysis / Gluconeogenesis
mleu00020  Citrate cycle (TCA cycle)
mleu00190  Oxidative phosphorylation
mleu00520  Amino sugar and nucleotide sugar metabolism
mleu03320  PPAR signaling pathway
mleu04071  Sphingolipid signaling pathway
mleu04150  mTOR signaling pathway
mleu04210  Apoptosis
mleu04260  Cardiac muscle contraction
mleu04350  TGF-beta signaling pathway
mleu04614  Renin-angiotensin system
mleu04910  Insulin signaling pathway
mleu04930  Type II diabetes mellitus
mleu04931  Insulin resistance
mleu04933  AGE-RAGE signaling pathway in diabetic complications
mleu04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

DBGET integrated database retrieval system