KEGG   PATHWAY: mnp04921
Entry
mnp04921                    Pathway                                
Name
Oxytocin signaling pathway - Mustela nigripes (black-footed ferret)
Description
Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and peripheral effects. However, its best-known and most well-established roles are stimulation of uterine contractions during parturition and milk release during lactation. Oxytocin also influences cardiovascular regulation and various social behaviors. The actions of OT are all mediated by one type of OT receptor (OTR). This is a transmembrane receptor belonging to the G-protein-coupled receptor superfamily. The main signaling pathway is the Gq/PLC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. In the cardiovascular system, OTR is associated with the ANP-cGMP and NO-cGMP pathways, which reduce the force and rate of contraction and increase vasodilatation.
Class
Organismal Systems; Endocrine system
Pathway map
mnp04921  Oxytocin signaling pathway
mnp04921

Organism
Mustela nigripes (black-footed ferret) [GN:mnp]
Gene
132022683  oxytocin-neurophysin 1 [KO:K05243]
132008108  OXT; oxytocin-neurophysin 1 [KO:K05243]
132009877  OXTR; oxytocin receptor [KO:K04229]
132024788  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
132016391  HRAS; GTPase HRas isoform X1 [KO:K02833]
132027717  LOW QUALITY PROTEIN: ras protein let-60-like [KO:K02833]
132019561  KRAS; GTPase KRas isoform X1 [KO:K07827]
132001334  NRAS; GTPase NRas [KO:K07828]
132002077  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
132011570  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131999543  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132010799  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
132008541  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
132023779  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132026755  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132025971  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
131998712  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
131999661  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
131999663  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
131999664  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
132025471  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
131999552  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
132004382  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
132000935  JUN; transcription factor Jun [KO:K04448]
132000157  FOS; protein c-Fos [KO:K04379]
132028792  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
132017399  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
132007431  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
132005592  RYR1; ryanodine receptor 1 [KO:K04961]
132016195  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
131999341  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
132004751  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
132012458  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
132003646  KCNJ2; inward rectifier potassium channel 2 [KO:K04996]
132004312  KCNJ12; ATP-sensitive inward rectifier potassium channel 12 [KO:K05005]
132020461  KCNJ4; inward rectifier potassium channel 4 [KO:K04998]
132004905  KCNJ14; ATP-sensitive inward rectifier potassium channel 14 [KO:K05007]
132019538  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
131999626  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
132021732  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
132021734  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
132003742  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
132026832  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
132004993  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
132026803  EEF2K; eukaryotic elongation factor 2 kinase isoform X1 [KO:K08292] [EC:2.7.11.20]
132010795  EEF2; elongation factor 2 [KO:K03234]
132019988  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
132011423  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
132007466  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
132026153  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
132003132  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
132020126  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
132019634  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
132013746  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
132015988  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
132011360  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
132011433  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
132020402  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
132004492  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
132019263  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
132027192  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
132003741  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
132003732  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
132004834  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
132005379  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
132005024  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
132011514  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
132019550  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
132017890  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
132015160  calmodulin-1-like [KO:K02183]
132002170  CALML6; calmodulin-like protein 6 [KO:K02183]
132005201  CALM3; calmodulin-3 [KO:K02183]
132020019  calmodulin-like protein 3 [KO:K02183]
132020856  calmodulin-like [KO:K02183]
131999557  CALML4; calmodulin-like protein 4 [KO:K02183]
132021617  CALM2; calmodulin-2 [KO:K02183]
132000098  CALM1; calmodulin-1 [KO:K02183]
132001718  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
132016503  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131999012  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132025071  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
132023704  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
132022031  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
132005175  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
132012169  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
131999851  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
132025691  RGS2; regulator of G-protein signaling 2 [KO:K18154]
132012373  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
132023135  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
132000924  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
132028269  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
132023220  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
132001391  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
132015550  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
132019639  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
132012883  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
132025548  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
132011536  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
132020181  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
132016071  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
132016520  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
132002521  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
132028323  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
132028842  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
132015570  NOS3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
132000878  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
132021657  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
132000874  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
132002640  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
132001223  NPPA; natriuretic peptides A isoform X1 [KO:K12334]
132025956  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
132024613  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
132022711  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
132018517  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
132011867  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
132006129  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
132019794  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
132019795  myosin light polypeptide 6 isoform X1 [KO:K12751]
132021891  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
132003745  ACTG1; actin, cytoplasmic 2 [KO:K05692]
132026463  ACTB; actin, cytoplasmic 1 [KO:K05692]
132011318  RHOA; transforming protein RhoA [KO:K04513]
132023518  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
132021141  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
132023151  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
132017911  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
132021249  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
132019394  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
132025613  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
132005432  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
132022829  neuroendocrine secretory protein 55 [KO:K04632]
132022063  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
132022064  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
132016088  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
132028199  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
132021183  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
131999850  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
132011863  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
132019632  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
132005324  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
132014306  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
132026955  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
132001064  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
132011072  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
132001262  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
132015994  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
132011347  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
132005670  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
132016030  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
132003533  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
132004319  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
132021907  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
132013755  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
132012398  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
132025794  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
132012254  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
132016105  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
132018107  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C13050  Cyclic ADP-ribose
Reference
PMID:18655881
  Authors
Devost D, Wrzal P, Zingg HH
  Title
Oxytocin receptor signalling.
  Journal
Prog Brain Res 170:167-76 (2008)
DOI:10.1016/S0079-6123(08)00415-9
Reference
PMID:20626426
  Authors
Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E, Dayanithi G
  Title
REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.
  Journal
CNS Neurosci Ther 16:e138-56 (2010)
DOI:10.1111/j.1755-5949.2010.00185.x
Reference
PMID:21981277
  Authors
Gutkowska J, Jankowski M
  Title
Oxytocin revisited: its role in cardiovascular regulation.
  Journal
J Neuroendocrinol 24:599-608 (2012)
DOI:10.1111/j.1365-2826.2011.02235.x
Reference
PMID:22190926
  Authors
Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z
  Title
The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents.
  Journal
Int J Endocrinol 2011:350546 (2011)
DOI:10.1155/2011/350546
Reference
PMID:19840865
  Authors
Tom N, Assinder SJ
  Title
Oxytocin in health and disease.
  Journal
Int J Biochem Cell Biol 42:202-5 (2010)
DOI:10.1016/j.biocel.2009.10.008
Reference
PMID:9575824
  Authors
Strakova Z, Copland JA, Lolait SJ, Soloff MS
  Title
ERK2 mediates oxytocin-stimulated PGE2 synthesis.
  Journal
Am J Physiol 274:E634-41 (1998)
DOI:10.1152/ajpendo.1998.274.4.E634
Reference
PMID:12009385
  Authors
Slater DM, Zervou S, Thornton S
  Title
Prostaglandins and prostanoid receptors in human pregnancy and parturition.
  Journal
J Soc Gynecol Investig 9:118-24 (2002)
Reference
PMID:16787565
  Authors
Shmygol A, Gullam J, Blanks A, Thornton S
  Title
Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility.
  Journal
Acta Pharmacol Sin 27:827-32 (2006)
DOI:10.1111/j.1745-7254.2006.00393.x
Reference
PMID:11861513
  Authors
Tahara M, Morishige K, Sawada K, Ikebuchi Y, Kawagishi R, Tasaka K, Murata Y
  Title
RhoA/Rho-kinase cascade is involved in oxytocin-induced rat uterine contraction.
  Journal
Endocrinology 143:920-9 (2002)
DOI:10.1210/endo.143.3.8696
Reference
PMID:12433531
  Authors
Slattery MM, Morrison JJ
  Title
Preterm delivery.
  Journal
Lancet 360:1489-97 (2002)
DOI:10.1016/S0140-6736(02)11476-0
Reference
PMID:22902539
  Authors
Pont JN, McArdle CA, Lopez Bernal A
  Title
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
  Journal
Mol Endocrinol 26:1743-56 (2012)
DOI:10.1210/me.2012-1057
Reference
PMID:9326674
  Authors
Gutkowska J, Jankowski M, Lambert C, Mukaddam-Daher S, Zingg HH, McCann SM
  Title
Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart.
  Journal
Proc Natl Acad Sci U S A 94:11704-9 (1997)
DOI:10.1073/pnas.94.21.11704
Reference
PMID:14715914
  Authors
Antunes-Rodrigues J, de Castro M, Elias LL, Valenca MM, McCann SM
  Title
Neuroendocrine control of body fluid metabolism.
  Journal
Physiol Rev 84:169-208 (2004)
DOI:10.1152/physrev.00017.2003
Reference
PMID:18555543
  Authors
Lee ES, Uhm KO, Lee YM, Kwon J, Park SH, Soo KH
  Title
Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.
  Journal
Regul Pept 151:71-4 (2008)
DOI:10.1016/j.regpep.2008.05.001
Reference
PMID:9219843
  Authors
Cassoni P, Sapino A, Fortunati N, Munaron L, Chini B, Bussolati G
  Title
Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A.
  Journal
Int J Cancer 72:340-4 (1997)
DOI:10.1002/(SICI)1097-0215(19970717)72:2<340::AID-IJC23>3.0.CO;2-I
Reference
PMID:23356278
  Authors
Busnelli M, Peverelli E, Mantovani G, Spada A, Chini B
  Title
Deciphering the specific role of G(alphai/o) isoforms: functional selective oxytocin ligands and somatostatin SST5 receptor mutants.
  Journal
Biochem Soc Trans 41:166-71 (2013)
DOI:10.1042/BST20120306
Reference
PMID:16966388
  Authors
Reversi A, Rimoldi V, Brambillasca S, Chini B
  Title
Effects of cholesterol manipulation on the signaling of the human oxytocin receptor.
  Journal
Am J Physiol Regul Integr Comp Physiol 291:R861-9 (2006)
DOI:10.1152/ajpregu.00333.2006
Reference
PMID:20141572
  Authors
Salmina AB, Lopatina O, Ekimova MV, Mikhutkina SV, Higashida H
  Title
CD38/cyclic ADP-ribose system: a new player for oxytocin secretion and regulation of social behaviour.
  Journal
J Neuroendocrinol 22:380-92 (2010)
DOI:10.1111/j.1365-2826.2010.01970.x
Reference
PMID:22227279
  Authors
Higashida H, Yokoyama S, Kikuchi M, Munesue T
  Title
CD38 and its role in oxytocin secretion and social behavior.
  Journal
Horm Behav 61:351-8 (2012)
DOI:10.1016/j.yhbeh.2011.12.011
Reference
PMID:23335873
  Authors
Lopatina O, Inzhutova A, Salmina AB, Higashida H
  Title
The roles of oxytocin and CD38 in social or parental behaviors.
  Journal
Front Neurosci 6:182 (2012)
DOI:10.3389/fnins.2012.00182
Reference
PMID:16156781
  Authors
Guse AH
  Title
Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).
  Journal
FEBS J 272:4590-7 (2005)
DOI:10.1111/j.1742-4658.2005.04863.x
Related
pathway
mnp00590  Arachidonic acid metabolism
mnp04010  MAPK signaling pathway
mnp04020  Calcium signaling pathway
mnp04110  Cell cycle
KO pathway
ko04921   
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