KEGG   PATHWAY: mnp04020
Entry
mnp04020                    Pathway                                
Name
Calcium signaling pathway - Mustela nigripes (black-footed ferret)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mnp04020  Calcium signaling pathway
mnp04020

Other DBs
GO: 0019722
Organism
Mustela nigripes (black-footed ferret) [GN:mnp]
Gene
132004989  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
132021319  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
132000077  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
132025632  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
132011558  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
132019371  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
132007493  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
132019827  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
132015171  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
131998679  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
132023859  ADORA2A; adenosine receptor A2a [KO:K04266]
132003952  ADORA2B; adenosine receptor A2b [KO:K04267]
132015398  ADRB1; beta-1 adrenergic receptor [KO:K04141]
132028308  ADRB2; beta-2 adrenergic receptor [KO:K04142]
132006460  ADRB3; beta-3 adrenergic receptor [KO:K04143]
132027843  DRD1; D(1A) dopamine receptor [KO:K04144]
132015124  DRD5; D(1B) dopamine receptor [KO:K05840]
132028441  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
132027778  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
132015532  HTR5A; 5-hydroxytryptamine receptor 5A isoform X1 [KO:K04161]
132013064  5-hydroxytryptamine receptor 5B [KO:K04161]
132000966  HTR6; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 6 [KO:K04162]
132016614  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
132022829  neuroendocrine secretory protein 55 [KO:K04632]
132022063  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
132022064  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
132023466  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
132016088  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
132028199  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
132021183  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
131999850  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
132005324  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
132014306  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
132026955  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
132001064  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
132011072  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
132017334  PLN; cardiac phospholamban [KO:K05852]
132013154  SLN; sarcolipin [KO:K22642]
132015197  MRLN; myoregulin isoform X1 [KO:K22643]
132004058  SMIM6; small integral membrane protein 6 [KO:K26468]
132023139  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
132003946  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
132026779  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
132005770  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
132023627  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
132005219  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
132023129  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
132026592  ORAI2; protein orai-2 isoform X1 [KO:K16057]
132026695  ORAI3; protein orai-3 [KO:K16058]
132019988  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
132011423  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
132007466  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
132026153  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
132011054  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
132024930  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
132025438  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
132003628  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
132027062  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
132019203  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
132029112  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
132024208  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
132026908  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
132020616  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
132004461  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
132005170  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
132024546  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
132010691  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
132003472  P2RX1; P2X purinoceptor 1 [KO:K05215]
132023781  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
132021191  P2RX3; P2X purinoceptor 3 [KO:K05217]
132023136  P2RX4; P2X purinoceptor 4 [KO:K05218]
132003710  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
132023873  P2RX6; P2X purinoceptor 6 [KO:K05221]
132023137  P2RX7; P2X purinoceptor 7 [KO:K05220]
132005592  RYR1; ryanodine receptor 1 [KO:K04961]
132016195  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
131999341  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
132018658  TRDN; triadin [KO:K23449]
132026234  CASQ1; calsequestrin-1 [KO:K23468]
132001345  CASQ2; calsequestrin-2 [KO:K23445]
132014043  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
132006655  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
132008327  CYSLTR2; LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 2 [KO:K04323]
132014913  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
131999769  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
132028373  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
132008113  alpha-1D adrenergic receptor [KO:K04137]
132021752  alpha-1D adrenergic receptor [KO:K04137]
132012148  AGTR1; type-1 angiotensin II receptor [KO:K04166]
132000052  EDNRA; endothelin-1 receptor [KO:K04197]
132002518  EDNRB; endothelin receptor type B [KO:K04198]
132028743  F2R; proteinase-activated receptor 1 [KO:K03914]
132018219  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
132012077  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
132007290  GRPR; gastrin-releasing peptide receptor [KO:K04169]
132009888  HRH1; histamine H1 receptor isoform X1 [KO:K04149]
132002551  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
132013631  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
132006958  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
132022569  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
132022092  NTSR1; neurotensin receptor type 1 [KO:K04211]
132009877  OXTR; oxytocin receptor [KO:K04229]
132019879  AVPR1A; vasopressin V1a receptor [KO:K04226]
132026179  AVPR1B; vasopressin V1b receptor [KO:K04227]
131999847  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
132001912  PTAFR; platelet-activating factor receptor [KO:K04279]
132011082  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
132001012  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
132001946  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
132000240  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
132021414  TACR1; substance-P receptor [KO:K04222]
132016427  TACR2; LOW QUALITY PROTEIN: substance-K receptor [KO:K04223]
132014168  TACR3; neuromedin-K receptor [KO:K04224]
132010782  TBXA2R; thromboxane A2 receptor [KO:K04264]
132022451  thyrotropin-releasing hormone receptor-like [KO:K04282]
132013242  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
132015294  CCKAR; cholecystokinin receptor type A [KO:K04194]
132023541  CCKBR; LOW QUALITY PROTEIN: gastrin/cholecystokinin type B receptor [KO:K04195]
132013919  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
132024788  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
132010764  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
132024789  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
132010767  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
132002212  EGF; pro-epidermal growth factor [KO:K04357]
132021470  TGFA; protransforming growth factor alpha [KO:K08774]
132026405  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
132019214  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
132000852  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
132029044  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
132028621  FGF1; fibroblast growth factor 1 [KO:K18496]
132028444  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
132015368  FGF8; fibroblast growth factor 8 [KO:K04358]
132016131  FGF5; fibroblast growth factor 5 [KO:K04358]
132002632  FGF9; fibroblast growth factor 9 [KO:K04358]
132010674  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
132004528  FGF3; fibroblast growth factor 3 [KO:K04358]
132004607  FGF4; fibroblast growth factor 4 [KO:K04358]
132027828  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
131998728  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
131998918  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
132020822  FGF6; fibroblast growth factor 6 [KO:K04358]
132028292  FGF10; fibroblast growth factor 10 [KO:K04358]
132006489  FGF20; fibroblast growth factor 20 [KO:K04358]
132007507  FGF16; fibroblast growth factor 16 [KO:K04358]
132004742  FGF19; fibroblast growth factor 19 [KO:K22603]
132005252  FGF21; fibroblast growth factor 21 [KO:K22429]
132020823  FGF23; fibroblast growth factor 23 [KO:K22428]
132018637  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
132019569  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
132006384  VEGFC; vascular endothelial growth factor C [KO:K05449]
132006722  VEGFD; vascular endothelial growth factor D [KO:K05449]
132000669  NGF; beta-nerve growth factor [KO:K02582]
132015990  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
132011328  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
132028256  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
132016105  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
132003912  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
132019789  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
132014436  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
132006175  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
132028321  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
132006317  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
132016838  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
132003670  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
132028463  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
132002900  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
132027432  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
132006391  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
132025841  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
132024768  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
131999064  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
132015770  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
132011335  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
132016602  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
131999471  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
131999488  uncharacterized protein LOC131999488 [KO:K06856]
132003329  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
132011663  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
132013548  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
132019538  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
131999626  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
132021732  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
132021734  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
132021927  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
132005665  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
132016639  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
132020627  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
132011514  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
132019550  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
132017890  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
132004751  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
132023186  TPCN1; two pore channel protein 1 isoform X1 [KO:K16896]
132017453  TPCN2; two pore channel protein 2 isoform X1 [KO:K14077]
132010912  MCOLN1; mucolipin-1 [KO:K04992]
132001073  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
132001966  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
132004218  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
132005224  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
132016478  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
131998822  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
132028515  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
132016531  VDAC2; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2 [KO:K15040]
132017710  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
132006612  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
132007616  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
132007730  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
132006375  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
132014518  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
132016544  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
132009808  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
132022772  TNNC2; troponin C, skeletal muscle [KO:K12042]
132015160  calmodulin-1-like [KO:K02183]
132002170  CALML6; calmodulin-like protein 6 [KO:K02183]
132005201  CALM3; calmodulin-3 [KO:K02183]
132020019  calmodulin-like protein 3 [KO:K02183]
132020856  calmodulin-like [KO:K02183]
131999557  CALML4; calmodulin-like protein 4 [KO:K02183]
132021617  CALM2; calmodulin-2 [KO:K02183]
132000098  CALM1; calmodulin-1 [KO:K02183]
132026667  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
132026706  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
132007746  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
132004958  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
132007468  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
132022711  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
132018517  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
132011867  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
132006129  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
132025548  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
132011536  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
132020181  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
132016071  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
132016520  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
132002521  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
132028323  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
132028842  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
132001718  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
132016503  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131999012  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132025071  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
132018070  TFEB; transcription factor EB [KO:K15590]
132023704  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
132022031  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
132005175  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
132012169  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
131999851  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
132023203  NOS1; nitric oxide synthase 1 isoform X1 [KO:K13240] [EC:1.14.13.39]
132003357  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
132015570  NOS3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
132015812  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
132019759  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
132013884  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
131999727  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
132025508  ITPKB; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
132004825  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
131999652  ITPKA; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
132003742  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
132026832  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
132004993  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
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Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
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Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
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Reference
PMID:7861177
  Authors
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Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
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J Neurochem 64:953-60 (1995)
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Reference
PMID:14572802
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Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
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Cell Calcium 34:431-44 (2003)
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Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
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Mol Cell Biochem 193:89-98 (1999)
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Reference
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Mitochondrial intermembrane junctional complexes and their role in cell death.
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
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Reference
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
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Feske S
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Reference
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Seikagaku 80:1123-8 (2008)
Reference
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
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Marty I
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
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Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mnp04010  MAPK signaling pathway
mnp04070  Phosphatidylinositol signaling system
mnp04210  Apoptosis
mnp04720  Long-term potentiation
mnp04730  Long-term depression
KO pathway
ko04020   
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