KEGG   PATHWAY: mnp04010
Entry
mnp04010                    Pathway                                
Name
MAPK signaling pathway - Mustela nigripes (black-footed ferret)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mnp04010  MAPK signaling pathway
mnp04010

Other DBs
GO: 0000165
Organism
Mustela nigripes (black-footed ferret) [GN:mnp]
Gene
132011054  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
132024930  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
132019988  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
132011423  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
132025438  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
132007466  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
132003628  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
132027062  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
132019203  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
132026153  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
132015988  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
132011360  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
132011433  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
132020402  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
132003132  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
132020126  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
132019634  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
132013746  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
132004492  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
132019263  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
132027192  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
132003741  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
132003732  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
132004834  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
132005379  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
132005024  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
132001064  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
132011072  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
132003742  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
132026832  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
132004993  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
132026441  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
132000997  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
132020499  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
132001718  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
132016503  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131999012  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132025071  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
131998959  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
132028774  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
131999617  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
132019319  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
132021284  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
132005631  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
132000687  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
132003893  NF1; neurofibromin isoform X1 [KO:K08052]
132028789  RASA1; ras GTPase-activating protein 1 [KO:K04352]
132012181  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
132001295  RAP1A; ras-related protein Rap-1A [KO:K04353]
132019439  RAP1B; ras-related protein Rap-1b [KO:K07836]
132002212  EGF; pro-epidermal growth factor [KO:K04357]
132021470  TGFA; protransforming growth factor alpha [KO:K08774]
132016006  AREG; amphiregulin [KO:K09782]
132028621  FGF1; fibroblast growth factor 1 [KO:K18496]
132028444  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
132015368  FGF8; fibroblast growth factor 8 [KO:K04358]
132016131  FGF5; fibroblast growth factor 5 [KO:K04358]
132002632  FGF9; fibroblast growth factor 9 [KO:K04358]
132010674  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
132004528  FGF3; fibroblast growth factor 3 [KO:K04358]
132004607  FGF4; fibroblast growth factor 4 [KO:K04358]
132027828  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
131998728  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
131998918  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
132020822  FGF6; fibroblast growth factor 6 [KO:K04358]
132028292  FGF10; fibroblast growth factor 10 [KO:K04358]
132006489  FGF20; fibroblast growth factor 20 [KO:K04358]
132007507  FGF16; fibroblast growth factor 16 [KO:K04358]
132004742  FGF19; fibroblast growth factor 19 [KO:K22603]
132005252  FGF21; fibroblast growth factor 21 [KO:K22429]
132020823  FGF23; fibroblast growth factor 23 [KO:K22428]
132000669  NGF; beta-nerve growth factor [KO:K02582]
132021809  BDNF; brain-derived neurotrophic factor [KO:K04355]
132020814  NTF3; neurotrophin-3 [KO:K04356]
132004785  NTF4; neurotrophin-4 [KO:K12457]
132016807  INS; insulin isoform X1 [KO:K04526]
132019316  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
132016801  IGF2; insulin-like growth factor II [KO:K13769]
132026405  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
132019214  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
132000852  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
132029044  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
132001267  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
132019375  KITLG; kit ligand isoform X1 [KO:K05461]
132005678  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
132018637  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
132019569  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
132000164  PGF; placenta growth factor isoform X1 [KO:K16859]
132006384  VEGFC; vascular endothelial growth factor C [KO:K05449]
132006722  VEGFD; vascular endothelial growth factor D [KO:K05449]
132015990  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
132014233  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
132006457  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
132021804  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
132025910  EFNA1; ephrin-A1 [KO:K05462]
132025912  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
132025913  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
132012576  EFNA2; ephrin-A2 [KO:K05462]
132028830  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
132028256  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
132010842  NRTN; neurturin [KO:K25414]
132000735  ARTN; artemin [KO:K25415]
132010856  PSPN; persephin [KO:K25416]
132016105  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
132003912  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
132019789  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
132014436  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
132006317  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
132016838  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
132003670  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
132028463  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
132003442  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
132025841  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
132024768  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
132010913  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
131999088  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
132006175  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
132028321  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
132028318  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
132006358  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
132002715  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
132002900  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
132027432  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
132006391  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
132015770  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
132024682  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
132001601  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
132016602  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
132003151  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
132021307  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
131999927  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
132016391  HRAS; GTPase HRas isoform X1 [KO:K02833]
132027717  LOW QUALITY PROTEIN: ras protein let-60-like [KO:K02833]
132019561  KRAS; GTPase KRas isoform X1 [KO:K07827]
132001334  NRAS; GTPase NRas [KO:K07828]
132002077  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
132005677  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
132022713  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
132011827  MRAS; ras-related protein M-Ras [KO:K07831]
132007524  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
132015636  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
132011570  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131999543  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132010799  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
132001669  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
132008541  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
132023779  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132026755  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132000821  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
132010740  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
132007608  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
132001847  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
132018459  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
132006966  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
132009003  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
132019205  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
132007431  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
132025666  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
132014301  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
132018038  SRF; serum response factor [KO:K04378]
132000157  FOS; protein c-Fos [KO:K04379]
132003666  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
132001825  STMN1; stathmin [KO:K04381]
132025971  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
131998712  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
131999661  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
131999663  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
131999664  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
132017188  TNF; tumor necrosis factor isoform X1 [KO:K03156]
132022475  IL1A; interleukin-1 alpha [KO:K04383]
132022474  IL1B; interleukin-1 beta [KO:K04519]
132005078  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
132025704  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
132000151  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
132019939  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
132021637  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
132011933  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
132024567  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
132011733  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
132026045  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
132016209  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
132028592  CD14; monocyte differentiation antigen CD14 [KO:K04391]
132026481  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
132019253  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
132004336  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
132000635  cell division control protein 42 homolog [KO:K04393]
132001733  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
132017383  cell division control protein 42 homolog [KO:K04393]
132006073  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
132006389  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
132024227  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
132017881  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
132011660  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
132007541  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
132019603  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
132021320  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
132000996  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
132009643  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
132025201  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
132019209  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
132018229  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
132011012  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
132021313  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
132021634  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
132005666  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
132024667  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
132011906  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
132021964  STK4; serine/threonine-protein kinase 4 [KO:K04411]
132014196  STK3; serine/threonine-protein kinase 3 [KO:K04412]
132019269  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
132020058  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
132028649  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
132018706  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
132013979  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
132004017  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
132000206  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
132005771  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
132016168  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
132019733  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
132011969  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
132013840  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
132001875  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
132018185  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
132018302  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
132018446  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
132023211  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
132004413  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
132026741  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
132003163  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
132010893  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
132004567  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
132004478  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
132008220  C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
132008409  C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
132019067  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
132027035  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
132006882  FLNA; filamin-A isoform X1 [KO:K04437]
132023406  CRKL; crk-like protein [KO:K04438]
132004503  CRK; adapter molecule crk isoform X1 [KO:K04438]
132024474  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
132003138  ARRB2; beta-arrestin-2 [KO:K04439]
132001060  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
132016577  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132027429  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
132017920  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
132017921  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
132019083  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
132019085  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
132023166  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
132025572  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
132011367  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
132000094  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
132019438  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
132008105  M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
132021760  M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
132023704  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
132005175  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
132012169  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
132000935  JUN; transcription factor Jun [KO:K04448]
132011181  JUND; transcription factor JunD [KO:K04449]
132013851  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
132003790  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
132019843  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
132000038  MAX; protein max isoform X1 [KO:K04453]
132028792  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
132027155  HSPB1; heat shock protein beta-1 [KO:K04455]
132000311  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132025379  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132005674  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132000004  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
132019418  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
132022037  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
132025612  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
132028425  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
132022364  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132016729  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132016772  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132011386  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132019497  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132006326  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132019374  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
132006956  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
132026205  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
132003384  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
132004866  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
132021603  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
132017812  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
132017813  heat shock 70 kDa protein 1-like [KO:K03283]
132017814  heat shock 70 kDa protein 1 [KO:K03283]
132026749  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
132027862  heat shock cognate 71 kDa protein-like [KO:K03283]
132013920  heat shock cognate 71 kDa protein-like [KO:K03283]
132012065  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
131999552  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
132004382  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
132019697  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
132004586  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
132016695  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
132006530  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
132006829  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
132003187  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
132001757  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
132016730  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
132018657  RELA; transcription factor p65 [KO:K04735]
132005261  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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PMID:12390245
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Methods Mol Biol 846:1-12 (2012)
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Reference
PMID:19483709
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
mnp04070  Phosphatidylinositol signaling system
mnp04110  Cell cycle
mnp04115  p53 signaling pathway
mnp04210  Apoptosis
mnp04310  Wnt signaling pathway
mnp04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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