KEGG   PATHWAY: nle04148
Entry
nle04148                    Pathway                                
Name
Efferocytosis - Nomascus leucogenys (northern white-cheeked gibbon)
Class
Cellular Processes; Transport and catabolism
Pathway map
nle04148  Efferocytosis
nle04148

Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
100585064  CASP3; caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
100588974  CASP1; caspase-1 isoform X3 [KO:K01370] [EC:3.4.22.36]
100592686  PANX1; pannexin-1 [KO:K03443]
100585422  P2RY2; P2Y purinoceptor 2 [KO:K04269]
100583533  P2RY6; P2Y purinoceptor 6 isoform X1 [KO:K04272]
100581100  P2RY12; P2Y purinoceptor 12 [KO:K04298]
100598765  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
100592000  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
100586896  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
100605211  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X3 [KO:K16343] [EC:3.1.1.4]
100606619  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
100588329  GPR132; probable G-protein coupled receptor 132 isoform X1 [KO:K08426]
100605134  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
100606667  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
100582586  CX3CL1; fractalkine isoform X1 [KO:K05508]
100604041  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
100599959  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100598995  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100605649  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100603627  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100588621  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
100579793  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X3 [KO:K09097]
100607433  EPO; erythropoietin isoform X1 [KO:K05437]
100593505  EPOR; erythropoietin receptor [KO:K05079]
100588880  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100600574  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100584480  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100602991  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
100581046  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
100585339  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
100585952  MFGE8; lactadherin isoform X1 [KO:K17253]
100582557  MERTK; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
100597566  CD36; platelet glycoprotein 4 [KO:K06259]
100603886  THBS1; thrombospondin-1 [KO:K16857]
100579506  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100591827  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100591090  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100581272  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
100594164  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100594618  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
100586647  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100581386  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
100582347  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100586790  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
100597073  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100597007  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100600165  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100591995  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100580290  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X30 [KO:K04515] [EC:2.7.11.17]
100595369  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
100600225  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100580599  MAPK11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
100579643  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100584513  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
100598410  ALOX15; arachidonate 15-lipoxygenase isoform X1 [KO:K00460] [EC:1.13.11.33]
100592473  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100583427  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100588614  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100589601  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100598626  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100593746  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100599841  ANO6; anoctamin-6 [KO:K19500]
101178934  ANO3; anoctamin-3 [KO:K19498]
100588407  ANO4; anoctamin-4 isoform X1 [KO:K19499]
100587082  ANO5; anoctamin-5 [KO:K19480]
100584461  ANO7; anoctamin-7 [KO:K19501]
100603291  ANO9; anoctamin-9 [KO:K19503]
100593167  BSG; basigin isoform X1 [KO:K06535]
100587182  XKR8; XK-related protein 8 [KO:K26813]
100595551  XKR9; XK-related protein 9 [KO:K26814]
100587441  XKR7; XK-related protein 7 isoform X1 [KO:K26811]
115830690  XKR4; XK-related protein 4 [KO:K26811]
100583966  XKR6; XK-related protein 6 [KO:K26811]
100592609  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
100582757  ATP8A2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
100599296  ATP11B; probable phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
100600857  ATP11C; phospholipid-transporting ATPase IG isoform X2 [KO:K26934] [EC:7.6.2.1]
100603161  ATP11A; probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
100585060  TMEM30A; cell cycle control protein 50A [KO:K26935]
100600356  vitamin K-dependent protein S [KO:K03908]
100604485  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100593791  ITGB3; integrin beta-3 [KO:K06493]
100592156  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
100584173  AXL; tyrosine-protein kinase receptor UFO [KO:K05115] [EC:2.7.10.1]
100581495  TYRO3; tyrosine-protein kinase receptor TYRO3 isoform X1 [KO:K05116] [EC:2.7.10.1]
100595684  ADGRB1; LOW QUALITY PROTEIN: adhesion G protein-coupled receptor B1 [KO:K04596]
100597340  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 isoform X1 [KO:K26936]
100597901  HAVCR1; hepatitis A virus cellular receptor 1 isoform X2 [KO:K20413]
100598243  HAVCR2; hepatitis A virus cellular receptor 2 [KO:K20414]
101178250  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
100599991  STAB1; stabilin-1 [KO:K19020]
100607367  STAB2; stabilin-2 [KO:K19013]
100598535  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100595820  CRKL; crk-like protein [KO:K04438]
100601245  CRK; adapter molecule crk isoform X1 [KO:K04438]
100586402  ELMO1; engulfment and cell motility protein 1 isoform X2 [KO:K12366]
100593551  DOCK1; dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
100604516  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100604235  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
100601669  CALR; calreticulin [KO:K08057]
100606692  C1QA; complement C1q subcomponent subunit A [KO:K03986]
100607840  C1QB; complement C1q subcomponent subunit B [KO:K03987]
100607041  C1QC; complement C1q subcomponent subunit C isoform X1 [KO:K03988]
100581845  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
100585807  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
100606229  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X5 [KO:K24068]
100602500  SCARF1; scavenger receptor class F member 1 isoform X1 [KO:K24318]
100585649  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
100594319  RAB17; ras-related protein Rab-17 [KO:K07909]
100585666  RAB5A; ras-related protein Rab-5A [KO:K07887]
100593361  RAB5B; ras-related protein Rab-5B [KO:K07888]
115830348  RAB5C; ras-related protein Rab-5C [KO:K07889]
100604401  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
100586437  VPS8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
100592798  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X2 [KO:K20179]
101179447  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
100586506  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
100605639  VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
100607466  RAB14; ras-related protein Rab-14 [KO:K07881]
100582837  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
100601519  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
100607787  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
100582036  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
100590995  SLC66A1; lysosomal amino acid transporter 1 homolog [KO:K23678]
100589719  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
100603590  ARG1; arginase-1 isoform X1 [KO:K01476] [EC:3.5.3.1]
100581966  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
100583426  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
100605954  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
100581383  NR1H2; oxysterols receptor LXR-beta [KO:K08535]
100588984  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
100591075  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
100605926  cytochrome b-c1 complex subunit Rieske, mitochondrial isoform X1 [KO:K00411] [EC:7.1.1.8]
100605499  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
100591595  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
100580426  IL10; interleukin-10 [KO:K05443]
100583764  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
100593427  PLA2G15; group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
100584681  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
100594511  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
100582053  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
100586194  SGK1; serine/threonine-protein kinase Sgk1 isoform X3 [KO:K13302] [EC:2.7.11.1]
100600239  CD47; leukocyte surface antigen CD47 isoform X2 [KO:K06266]
100600828  signal transducer CD24 [KO:K06469]
115834441  CD24; signal transducer CD24 isoform X1 [KO:K06469]
100605303  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
100595513  SIGLEC10; sialic acid-binding Ig-like lectin 10 isoform X1 [KO:K06749]
115838025  signal-regulatory protein beta-1-like [KO:K06551]
100590224  SIRPA; tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1 [KO:K06551]
100594057  signal-regulatory protein gamma isoform X1 [KO:K06551]
100595088  signal-regulatory protein beta-1 [KO:K06551]
100599057  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
100602671  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100605369  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
nle00010  Glycolysis / Gluconeogenesis
nle04140  Autophagy - animal
nle04145  Phagosome
KO pathway
ko04148   
LinkDB

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