KEGG   PATHWAY: phas05202
Entry
phas05202                   Pathway                                
Name
Transcriptional misregulation in cancer - Phyllostomus hastatus (greater spear-nosed bat)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
phas05202  Transcriptional misregulation in cancer
phas05202

Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123827989  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
123813249  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
123817428  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
123811909  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
123833163  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
123821996  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
123831782  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
123825225  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
123809294  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
123823885  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
123823156  PER2; period circadian protein homolog 2 [KO:K02633]
123810220  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
123813215  CD14; monocyte differentiation antigen CD14 [KO:K04391]
123825513  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
123804515  FCGR1A; high affinity immunoglobulin gamma Fc receptor I isoform X1 [KO:K06498]
123817475  junction plakoglobin [KO:K10056]
123825168  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
123817049  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
123818843  CCNA1; cyclin-A1 [KO:K06627]
123813988  CCNA2; cyclin-A2 [KO:K06627]
123820478  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
123809673  BCL2A1; bcl-2-related protein A1 [KO:K02162]
123817320  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
123833339  MYC; myc proto-oncogene protein [KO:K04377]
123813527  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
123813765  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
123818382  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
123824050  WNT16; protein Wnt-16 [KO:K01558]
123812466  ETV6; transcription factor ETV6 isoform X1 [KO:K03211]
123822182  ETV7; transcription factor ETV7 isoform X1 [KO:K03211]
123816833  uncharacterized protein LOC123816833 [KO:K10784]
123807450  defensin-6-like [KO:K05230]
123807636  neutrophil defensin 6-like [KO:K05230]
123807643  alpha-defensin 1-like [KO:K05230]
123807648  defensin-5-like [KO:K05230]
123807671  alpha-defensin 1-like [KO:K05230]
123807678  alpha-defensin 1-like [KO:K05230]
123807680  alpha-defensin 1-like [KO:K05230]
123807710  alpha-defensin 1-like [KO:K05230]
123820443  granzyme H-like [KO:K01353] [EC:3.4.21.79]
123820457  granzyme B(G,H)-like [KO:K01353] [EC:3.4.21.79]
123818140  KMT2A; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
123806677  AFF1; AF4/FMR2 family member 1 isoform X1 [KO:K15184]
123823510  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
123812477  CCNT1; cyclin-T1 [KO:K15188]
123810294  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
123819689  MLLT3; protein AF-9 isoform X1 [KO:K15187]
123813821  MLLT1; protein ENL isoform X1 [KO:K15187]
123813761  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
123810133  LMO2; rhombotin-2 isoform X1 [KO:K15612]
123823582  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
123821528  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
123814099  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
123815970  KLF3; Krueppel-like factor 3 [KO:K15605]
123824549  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
123811552  HOXA9; homeobox protein Hox-A9 [KO:K21950]
123811571  HOXA10; homeobox protein Hox-A10 [KO:K17443]
123820921  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
123812845  HMGA2; high mobility group protein HMGI-C [KO:K09283]
123832843  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
123821529  SUPT3H; transcription initiation protein SPT3 homolog isoform X1 [KO:K11313]
123815758  PROM1; prominin-1 isoform X1 [KO:K06532]
123822727  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
123831143  BMP2K; BMP-2-inducible protein kinase isoform X1 [KO:K08854] [EC:2.7.11.1]
123809769  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123812935  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
123811730  CDK14; cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
123811670  MEIS1; homeobox protein Meis1 isoform X1 [KO:K15613]
123811572  HOXA11; homeobox protein Hox-A11 [KO:K21951]
123808332  SIX1; homeobox protein SIX1 [KO:K15614]
123808244  SIX4; homeobox protein SIX4 isoform X1 [KO:K15615]
123833330  EYA1; eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
123830717  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
123814041  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
123827777  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
123808421  FUT8; alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
123812503  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
123828922  TLX1; T-cell leukemia homeobox protein 1 isoform X1 [KO:K09340]
123808564  BCL11B; B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
123828804  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
123828188  LYL1; protein lyl-1 [KO:K15604]
123829147  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
123822076  PTCRA; pre T-cell antigen receptor alpha [KO:K06056]
123811921  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
123813418  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123805465  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
123805489  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
123819750  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
123814855  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
123827458  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
123814884  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
123826766  BCL6; B-cell lymphoma 6 protein [KO:K15618]
123805768  MAF; transcription factor Maf isoform X1 [KO:K09035]
123812639  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
123815732  NSD2; histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
123804353  histone H3.1 [KO:K11253]
123804385  histone H3-like [KO:K11253]
123804386  histone H3-like [KO:K11253]
123826655  histone H3.1 [KO:K11253]
123833495  histone H3.v1-like [KO:K11253]
123804793  histone H3.1 [KO:K11253]
123804794  histone H3.1 [KO:K11253]
123804813  histone H3.1-like [KO:K11253]
123827825  histone H3.3A-like [KO:K11253]
123828119  histone H3.3A-like [KO:K11253]
123816874  histone H3.3A [KO:K11253]
123832524  histone H3.3A [KO:K11253]
123804377  histone H3 [KO:K11253]
123826658  uncharacterized protein LOC123826658 [KO:K11253]
123819912  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
123812093  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
123814448  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
123823408  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
123815812  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
123818443  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
123804749  PRCC; proline-rich protein PRCC [KO:K13105]
123832728  TFE3; transcription factor E3 isoform X1 [KO:K09105]
123822234  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
123827961  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
123828115  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
123820826  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
123807487  PLAT; tissue-type plasminogen activator isoform X1 [KO:K01343] [EC:3.4.21.68]
123805510  stromelysin-1-like [KO:K01394] [EC:3.4.24.17]
123815340  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
123831103  ZEB1; zinc finger E-box-binding homeobox 1 [KO:K09299]
123811723  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
123808049  SPINT1; kunitz-type protease inhibitor 1 [KO:K15619]
123811651  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
123817118  ETV4; ETS translocation variant 4 isoform X1 [KO:K15592]
123827246  ETV5; ETS translocation variant 5 [KO:K15593]
123820614  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
123820551  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
123816707  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
123822531  MYCN; N-myc proto-oncogene protein [KO:K09109]
123808565  MAX; protein max isoform X1 [KO:K04453]
123813040  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
123833261  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123809443  TP53; cellular tumor antigen p53 [KO:K04451]
123831111  BMI1; polycomb complex protein BMI-1 isoform X1 [KO:K11459]
123812402  SP1; transcription factor Sp1 [KO:K04684]
123832338  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
123804735  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123817259  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
123829580  MEN1; menin isoform X1 [KO:K14970]
123810776  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
123832555  FLI1; Friend leukemia integration 1 transcription factor isoform X1 [KO:K09436]
123810596  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123826430  DNA-binding protein inhibitor ID-2-like [KO:K17693]
123822497  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
123830471  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
123812162  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
123828842  FEV; protein FEV [KO:K09437]
123812546  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
123809661  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
123818096  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
123814406  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
123810138  WT1; Wilms tumor protein [KO:K09234]
123810721  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123816246  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
123807175  BAIAP3; BAI1-associated protein 3 isoform X1 [KO:K15621]
123832744  TSPAN7; tetraspanin-7 [KO:K06571]
123827069  MLF1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
123820010  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
123817148  TAF15; TATA-binding protein-associated factor 2N isoform X1 [KO:K14651]
123825569  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
123812775  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
123815375  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
123811876  IL6; interleukin-6 isoform X1 [KO:K05405]
123827213  NFKBIZ; NF-kappa-B inhibitor zeta [KO:K14242]
123806785  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123829518  RELA; transcription factor p65 [KO:K04735]
123831231  CXCL8; interleukin-8 [KO:K10030]
123831253  C-X-C motif chemokine 15-like [KO:K10030]
123829324  PAX3; paired box protein Pax-3 isoform X1 [KO:K09381]
123832014  PAX7; paired box protein Pax-7 isoform X1 [KO:K09381]
123818794  FOXO1; forkhead box protein O1 [KO:K07201]
123822657  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
123826065  SS18; protein SSXT isoform X1 [KO:K15623]
123814958  SS18L1; calcium-responsive transactivator [KO:K15623]
123832710  putative protein SSX6 [KO:K15624]
123825703  NUPR1; nuclear protein 1 [KO:K15626]
123817212  ASPSCR1; tether containing UBX domain for GLUT4 [KO:K15627]
123824375  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123813874  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
123815560  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
123816474  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
123830279  BAX; apoptosis regulator BAX [KO:K02159]
123816219  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
123810170  DDB2; DNA damage-binding protein 2 [KO:K10140]
123824532  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
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Reference
PMID:11313274
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Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
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Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
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Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
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PMID:12670461
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Zuzel M, Cawley JC.
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The biology of hairy cells.
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Best Pract Res Clin Haematol 16:1-13 (2003)
DOI:10.1016/S1521-6926(02)00082-8
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PMID:14998494
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Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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Cancer Cell 5:191-9 (2004)
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Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD
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The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
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Blood 117:211-20 (2011)
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PMID:19059936
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Brito JL, Walker B, Jenner M, Dickens NJ, Brown NJ, Ross FM, Avramidou A, Irving JA, Gonzalez D, Davies FE, Morgan GJ
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MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
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Haematologica 94:78-86 (2009)
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PMID:10350329
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Iida S, Rao PH, Ueda R, Chaganti RS, Dalla-Favera R
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Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32).
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Leuk Lymphoma 34:25-33 (1999)
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PMID:10784387
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Ohno H, Ueda C, Akasaka T
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The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
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Leuk Lymphoma 36:435-45 (2000)
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PMID:19233641
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Prensner JR, Chinnaiyan AM
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Oncogenic gene fusions in epithelial carcinomas.
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Curr Opin Genet Dev 19:82-91 (2009)
DOI:10.1016/j.gde.2008.11.008
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PMID:19406209
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Brenner JC, Chinnaiyan AM
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Translocations in epithelial cancers.
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Biochim Biophys Acta 1796:201-15 (2009)
DOI:10.1016/j.bbcan.2009.04.005
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PMID:16946003
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Reddi HV, McIver B, Grebe SK, Eberhardt NL
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
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PMID:19422821
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Medendorp K, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG
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The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
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Exp Cell Res 315:2399-409 (2009)
DOI:10.1016/j.yexcr.2009.04.022
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Kumar-Sinha C, Tomlins SA, Chinnaiyan AM
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Recurrent gene fusions in prostate cancer.
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Nat Rev Cancer 8:497-511 (2008)
DOI:10.1038/nrc2402
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PMID:20478527
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Yu J, Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X, Wu L, Li J, Hu M, Gong Y, Cheng H, Laxman B, Vellaichamy A, Shankar S, Li Y, Dhanasekaran SM, Morey R, Barrette T, Lonigro RJ, Tomlins SA, Varambally S, Qin ZS, Chinnaiyan AM
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An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
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Cancer Cell 17:443-54 (2010)
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PMID:21747944
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Leshem O, Madar S, Kogan-Sakin I, Kamer I, Goldstein I, Brosh R, Cohen Y, Jacob-Hirsch J, Ehrlich M, Ben-Sasson S, Goldfinger N, Loewenthal R, Gazit E, Rotter V, Berger R
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
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PLoS One 6:e21650 (2011)
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PMID:17505060
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Cai C, Hsieh CL, Omwancha J, Zheng Z, Chen SY, Baert JL, Shemshedini L
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
DOI:10.1210/me.2006-0480
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PMID:18172298
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Helgeson BE, Tomlins SA, Shah N, Laxman B, Cao Q, Prensner JR, Cao X, Singla N, Montie JE, Varambally S, Mehra R, Chinnaiyan AM
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
DOI:10.1158/0008-5472.CAN-07-5352
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PMID:21849159
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Westermark UK, Wilhelm M, Frenzel A, Henriksson MA
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The MYCN oncogene and differentiation in neuroblastoma.
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Semin Cancer Biol 21:256-66 (2011)
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Reference
PMID:20153925
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Bell E, Chen L, Liu T, Marshall GM, Lunec J, Tweddle DA
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MYCN oncoprotein targets and their therapeutic potential.
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Cancer Lett 293:144-57 (2010)
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Reference
PMID:15644444
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Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A, Shohet JM
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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Proc Natl Acad Sci U S A 102:731-6 (2005)
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PMID:20190806
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Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T
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Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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Oncogene 29:2681-90 (2010)
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PMID:20145147
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Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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Cancer Res 70:1377-88 (2010)
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PMID:17327229
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Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM
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N-MYC regulates focal adhesion kinase expression in human neuroblastoma.
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J Biol Chem 282:12503-16 (2007)
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PMID:21123453
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Iraci N, Diolaiti D, Papa A, Porro A, Valli E, Gherardi S, Herold S, Eilers M, Bernardoni R, Della Valle G, Perini G
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A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.
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Cancer Res 71:404-12 (2011)
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PMID:17024155
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Dreijerink KM, Hoppener JW, Timmers HM, Lips CJ
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Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.
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Nat Clin Pract Endocrinol Metab 2:562-70 (2006)
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Wu X, Hua X
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Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
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Curr Mol Med 8:805-15 (2008)
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PMID:19564705
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Sakurai A, Murakami A, Sano K, Uchino S, Fukushima Y
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Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1.
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Endocr J 56:887-95 (2009)
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PMID:17222504
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Yang Y, Hua X
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In search of tumor suppressing functions of menin.
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Mol Cell Endocrinol 265-266:34-41 (2007)
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PMID:15826838
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Aman P
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Fusion oncogenes in tumor development.
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Semin Cancer Biol 15:236-43 (2005)
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PMID:12527902
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Fukuma M, Okita H, Hata J, Umezawa A
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
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Oncogene 22:1-9 (2003)
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PMID:18648544
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Cironi L, Riggi N, Provero P, Wolf N, Suva ML, Suva D, Kindler V, Stamenkovic I
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IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
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PLoS One 3:e2634 (2008)
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PMID:17250957
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Riggi N, Stamenkovic I.
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The Biology of Ewing sarcoma.
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Cancer Lett 254:1-10 (2007)
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PMID:20490326
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Jedlicka P
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Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.
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Int J Clin Exp Pathol 3:338-47 (2010)
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PMID:19738075
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Ordonez JL, Osuna D, Herrero D, de Alava E, Madoz-Gurpide J
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Advances in Ewing's sarcoma research: where are we now and what lies ahead?
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Cancer Res 69:7140-50 (2009)
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PMID:12527906
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Jishage M, Fujino T, Yamazaki Y, Kuroda H, Nakamura T
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Identification of target genes for EWS/ATF-1 chimeric transcription factor.
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Oncogene 22:41-9 (2003)
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PMID:15826834
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Gerald WL, Haber DA
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The EWS-WT1 gene fusion in desmoplastic small round cell tumor.
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Semin Cancer Biol 15:197-205 (2005)
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PMID:18855877
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Filion C, Motoi T, Olshen AB, Lae M, Emnett RJ, Gutmann DH, Perry A, Ladanyi M, Labelle Y
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The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene.
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J Pathol 217:83-93 (2009)
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PMID:18330902
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Kim S, Lee HJ, Jun HJ, Kim J
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The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator.
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Int J Cancer 122:2446-53 (2008)
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PMID:10537274
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Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
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Cancer Res 59:5064-7 (1999)
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PMID:15688424
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Goransson M, Elias E, Stahlberg A, Olofsson A, Andersson C, Aman P
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Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression.
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Int J Cancer 115:556-60 (2005)
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Reference
PMID:18850010
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Goransson M, Andersson MK, Forni C, Stahlberg A, Andersson C, Olofsson A, Mantovani R, Aman P
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The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
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Oncogene 28:270-8 (2009)
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Reference
PMID:20863376
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Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovee JV
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Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
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Mol Cancer 9:257 (2010)
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PMID:18457914
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Linardic CM
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Cancer Lett 270:10-8 (2008)
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PMID:11863357
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Barber TD, Barber MC, Tomescu O, Barr FG, Ruben S, Friedman TB
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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PMID:17101797
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Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
DOI:10.1128/MCB.00658-06
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PMID:19472090
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Jun HJ, Lee J, Lim do H, Park JO, Ahn G, Seo SW, Sung KS, Lim do H, Yoo KH, Choi YL
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Expression of MET in alveolar soft part sarcoma.
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Med Oncol 27:459-65 (2010)
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PMID:21779514
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Rivlin N, Brosh R, Oren M, Rotter V
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Genes Cancer 2:466-74 (2011)
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Reference
PMID:21765642
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Suzuki K, Matsubara H
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
DOI:10.1155/2011/978312
Related
pathway
phas04115  p53 signaling pathway
phas05211  Renal cell carcinoma
phas05215  Prostate cancer
phas05216  Thyroid cancer
phas05221  Acute myeloid leukemia
KO pathway
ko05202   
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