KEGG   PATHWAY: ppam05202
Entry
ppam05202                   Pathway                                
Name
Transcriptional misregulation in cancer - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
ppam05202  Transcriptional misregulation in cancer
ppam05202

Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129074356  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
129066552  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
129080247  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
129066446  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
129066330  interleukin-3-like [KO:K04736]
129084201  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
129069270  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
129067712  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
129064243  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
129068777  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
129083167  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
129068600  PER2; period circadian protein homolog 2 [KO:K02633]
129081512  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
129066417  CD14; monocyte differentiation antigen CD14 [KO:K04391]
129078002  ITGAM; integrin alpha-M [KO:K06461]
129063716  FCGR1A; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
129086957  JUP; junction plakoglobin [KO:K10056]
129064051  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
129087044  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
129061281  CCNA2; cyclin-A2 [KO:K06627]
129081141  CCNA1; cyclin-A1 [KO:K06627]
129074045  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
129083099  BCL2A1; bcl-2-related protein A1 [KO:K02162]
129085863  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
129084081  MYC; myc proto-oncogene protein [KO:K04377]
129075937  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
129081561  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
129082074  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
129062854  WNT16; protein Wnt-16 [KO:K01558]
129085018  ETV6; transcription factor ETV6 isoform X1 [KO:K03211]
129067947  ETV7; transcription factor ETV7 [KO:K03211]
129071919  T cell receptor alpha chain MC.7.G5-like [KO:K10784]
129071926  uncharacterized protein LOC129071926 [KO:K10784]
129080092  ELANE; neutrophil elastase [KO:K01327] [EC:3.4.21.37]
129074073  LOW QUALITY PROTEIN: granzyme H-like [KO:K01353] [EC:3.4.21.79]
129074074  granzyme B-like [KO:K01353] [EC:3.4.21.79]
129085933  KMT2A; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
129085373  AFF1; AF4/FMR2 family member 1 [KO:K15184]
129079252  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
129077572  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
129084882  CCNT1; cyclin-T1 [KO:K15188]
129078351  MLLT3; protein AF-9 isoform X1 [KO:K15187]
129061526  MLLT1; protein ENL isoform X1 [KO:K15187]
129081426  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
129080729  LMO2; rhombotin-2 [KO:K15612]
129079265  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
129067498  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
129061982  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
129077577  KLF3; Krueppel-like factor 3 [KO:K15605]
129074670  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
129063421  HOXA9; homeobox protein Hox-A9 [KO:K21950]
129063408  HOXA10; homeobox protein Hox-A10 [KO:K17443]
129069956  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
129075989  HMGA2; high mobility group protein HMGI-C [KO:K09283]
129065250  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
129067499  SUPT3H; transcription initiation protein SPT3 homolog isoform X1 [KO:K11313]
129077537  PROM1; prominin-1 [KO:K06532]
129073410  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
129085533  BMP2K; BMP-2-inducible protein kinase [KO:K08854] [EC:2.7.11.1]
129061268  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
129085013  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
129063125  CDK14; cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
129081335  MEIS1; homeobox protein Meis1 isoform X1 [KO:K15613]
129062969  HOXA11; homeobox protein Hox-A11 [KO:K21951]
129065986  SIX1; homeobox protein SIX1 [KO:K15614]
129065982  SIX4; homeobox protein SIX4 isoform X1 [KO:K15615]
129084199  EYA1; eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
129069656  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
129072457  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
129073349  GRIA3; glutamate receptor 3 [KO:K05199]
129065955  FUT8; alpha-(1,6)-fucosyltransferase isoform X1 [KO:K00717] [EC:2.4.1.68]
129066347  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
129077288  TLX1; T-cell leukemia homeobox protein 1 isoform X1 [KO:K09340]
129065690  BCL11B; B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
129077136  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
129062537  LYL1; protein lyl-1 [KO:K15604]
129069824  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
129067045  PTCRA; LOW QUALITY PROTEIN: pre T-cell antigen receptor alpha [KO:K06056]
129072034  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
129074231  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
129085864  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
129085986  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
129079617  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
129070790  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
129071710  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
129070434  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
129079870  BCL6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
129064951  Ig heavy chain Mem5-like [KO:K06856]
129075173  MAF; transcription factor Maf isoform X1 [KO:K09035]
129084815  ITGB7; integrin beta-7 [KO:K06590]
129077476  NSD2; histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
129062067  histone H3, embryonic-like [KO:K11253]
129083143  histone H3.3A-like [KO:K11253]
129063327  histone H3.3A-like [KO:K11253]
129063774  histone H3.1 [KO:K11253]
129063775  histone H3.1 [KO:K11253]
129063866  uncharacterized protein LOC129063866 [KO:K11253]
129064363  histone H3.3A-like [KO:K11253]
129072013  histone H3.3A-like [KO:K11253]
129073007  histone H3.3A [KO:K11253]
129086585  histone H3.3A [KO:K11253]
129079688  PAX5; paired box protein Pax-5 [KO:K09383]
129072158  PAX8; paired box protein Pax-8 [KO:K09293]
129088213  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
129079171  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
129067366  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
129082073  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
129062096  PRCC; proline-rich protein PRCC [KO:K13105]
129065209  TFE3; transcription factor E3 isoform X1 [KO:K09105]
129067419  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
129074669  TMPRSS2; transmembrane protease serine 2 isoform X1 [KO:K09633] [EC:3.4.21.122]
129074550  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
129069768  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
129064678  PLAT; LOW QUALITY PROTEIN: tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
129086041  stromelysin-1-like [KO:K01394] [EC:3.4.24.17]
129070437  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
129085829  ZEB1; zinc finger E-box-binding homeobox 1 [KO:K09299]
129074243  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
129064059  SPINT1; LOW QUALITY PROTEIN: kunitz-type protease inhibitor 1 [KO:K15619]
129063420  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
129086630  ETV4; ETS translocation variant 4 isoform X1 [KO:K15592]
129079853  ETV5; ETS translocation variant 5 [KO:K15593]
129062258  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
129062352  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
129070214  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
129065273  MYCN; LOW QUALITY PROTEIN: N-myc proto-oncogene protein [KO:K09109]
129065957  MAX; protein max isoform X1 [KO:K04453]
129075868  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
129084348  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
129072290  TP53; cellular tumor antigen p53 [KO:K04451]
129086293  BMI1; polycomb complex protein BMI-1 [KO:K11459]
129084812  SP1; transcription factor Sp1 [KO:K04684]
129075630  ZBTB17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
129062360  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
129080218  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
129068596  MEN1; menin isoform X1 [KO:K14970]
129078113  LOW QUALITY PROTEIN: RNA-binding protein EWS-like [KO:K13209]
129065573  LOW QUALITY PROTEIN: RNA-binding protein EWS-like [KO:K13209]
129073226  LOW QUALITY PROTEIN: RNA-binding protein EWS-like [KO:K13209]
129087299  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
129075371  FLI1; Friend leukemia integration 1 transcription factor isoform X1 [KO:K09436]
129071377  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
129079004  LOW QUALITY PROTEIN: DNA-binding protein inhibitor ID-2-like [KO:K17693]
129067774  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
129088202  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
129068926  IGFBP3; insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
129080632  FEV; protein FEV [KO:K09437]
129084850  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
129082673  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
129086012  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
129088216  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
129080734  WT1; Wilms tumor protein isoform X1 [KO:K09234]
129065324  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
129071253  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
129083359  BAIAP3; BAI1-associated protein 3 isoform X1 [KO:K15621]
129065268  TSPAN7; tetraspanin-7 [KO:K06571]
129075836  MLF1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
129079394  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
129086575  TAF15; TATA-binding protein-associated factor 2N [KO:K14651]
129078007  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
129073218  RNA-binding protein FUS-like [KO:K13098]
129075812  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
129070619  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
129063428  IL6; interleukin-6 [KO:K05405]
129073695  NFKBIZ; NF-kappa-B inhibitor zeta [KO:K14242]
129085322  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129068571  RELA; transcription factor p65 [KO:K04735]
129083830  CXCL8; interleukin-8 [KO:K10030]
129075566  PAX7; paired box protein Pax-7 isoform X1 [KO:K09381]
129080619  PAX3; paired box protein Pax-3 isoform X1 [KO:K09381]
129080954  FOXO1; forkhead box protein O1 [KO:K07201]
129071112  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
129073492  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
129070589  SS18L1; calcium-responsive transactivator [KO:K15623]
129078652  SS18; protein SSXT isoform X1 [KO:K15623]
129065032  protein SSX4-like [KO:K15624]
129078137  NUPR1; nuclear protein 1 [KO:K15626]
129086623  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
129063382  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129082291  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
129069921  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
129081112  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
129082924  BAX; apoptosis regulator BAX [KO:K02159]
129066993  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
129081434  DDB2; DNA damage-binding protein 2 [KO:K10140]
129074622  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
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Blood 97:2798-807 (2001)
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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Curr Opin Genet Dev 19:82-91 (2009)
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Biochim Biophys Acta 1796:201-15 (2009)
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Mol Endocrinol 21:1835-46 (2007)
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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The MYCN oncogene and differentiation in neuroblastoma.
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MYCN oncoprotein targets and their therapeutic potential.
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Recent advances in p53 research and cancer treatment.
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Related
pathway
ppam04115  p53 signaling pathway
ppam05211  Renal cell carcinoma
ppam05215  Prostate cancer
ppam05216  Thyroid cancer
ppam05221  Acute myeloid leukemia
KO pathway
ko05202   
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