KEGG   PATHWAY: pps04934
Entry
pps04934                    Pathway                                
Name
Cushing syndrome - Pan paniscus (bonobo)
Description
Cushing syndrome (CS) is a rare disorder resulting from prolonged exposure to excess glucocorticoids via exogenous and endogenous sources. The typical clinical features of CS are related to hypercortisolism and include accumulation of central fat, moon facies, neuromuscular weakness, osteoporosis or bone fractures, metabolic complications, and mood changes. Traditionally, endogenous CS is classified as adrenocorticotropic hormone (ACTH)-dependent (about 80%) or ACTH- independent (about 20%). Among ACTH-dependent forms, pituitary corticotroph adenoma (Cushing's disease) is most common. Most pituitary tumors are sporadic, resulting from monoclonal expansion of a single mutated cell. Recently recurrent activating somatic driver mutations in the ubiquitin-specific protease 8 gene (USP8) were identified in almost half of corticotroph adenoma. Germline mutations in MEN1 (encoding menin), AIP (encoding aryl-hydrocarbon receptor-interacting protein), PRKAR1A (encoding cAMP-dependent protein kinase type I alpha regulatory subunit) and CDKN1B (encoding cyclin-dependent kinase inhibitor 1B; also known as p27 Kip1) have been identified in familial forms of pituitary adenomas. However, the frequency of familial pituitary adenomas is less than 5% in patients with pituitary adenomas. Among ACTH-independent CS, adrenal adenoma is most common. Rare adrenal causes of CS include primary bilateral macronodular adrenal hyperplasia (BMAH) or primary pigmented nodular adrenocortical disease (PPNAD).
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
pps04934  Cushing syndrome
pps04934

Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100992287  CRH; corticoliberin [KO:K05256]
100986244  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
100985319  CRHR2; corticotropin-releasing factor receptor 2 isoform X2 [KO:K04579]
100990650  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X2 [KO:K04632]
117974231  neuroendocrine secretory protein 55 [KO:K04632]
100984585  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
100992014  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100995134  ADCY3; adenylate cyclase type 3 isoform X4 [KO:K08043] [EC:4.6.1.1]
100978200  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
100989177  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100991116  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100984225  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100994715  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100972356  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100982589  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100970917  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100968237  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100974672  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
100985706  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100980724  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
100988487  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100986194  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
100981063  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100977804  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100989680  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100977358  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
100973232  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
100993334  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100995950  MEN1; menin [KO:K14970]
100991595  ASH2L; set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2 [KO:K14964]
100977836  RBBP5; retinoblastoma-binding protein 5 isoform X2 [KO:K14961]
103782718  WDR5B; WD repeat-containing protein 5B [KO:K14963]
100988935  WDR5; WD repeat-containing protein 5 isoform X3 [KO:K14963]
100984332  KMT2A; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
100995808  KMT2D; histone-lysine N-methyltransferase 2D isoform X6 [KO:K09187] [EC:2.1.1.354]
100992391  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
100976219  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100975637  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100976294  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
100981258  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100995605  CCND1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
100973837  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100983073  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
100984393  E2F2; transcription factor E2F2 [KO:K09389]
100986032  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
100971865  RASD1; dexamethasone-induced Ras-related protein 1 isoform X1 [KO:K07843]
100968961  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
100974334  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100985590  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X3 [KO:K04630]
100994782  AHR; aryl hydrocarbon receptor [KO:K09093]
100970167  AIPL1; aryl-hydrocarbon-interacting protein-like 1 [KO:K17767]
100987419  AIP; AH receptor-interacting protein isoform X1 [KO:K17767]
100973177  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X2 [KO:K09097]
100985362  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100981695  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
100982783  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100972365  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100977916  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100971701  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X6 [KO:K04850]
100975108  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X4 [KO:K04851]
100988624  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100982136  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100973727  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X3 [KO:K04515] [EC:2.7.11.17]
100983859  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X24 [KO:K04515] [EC:2.7.11.17]
100982179  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100986246  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100980934  RAP1A; ras-related protein Rap-1A [KO:K04353]
100995578  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
100971666  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100988422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100988437  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
100977025  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X3 [KO:K04369] [EC:2.7.12.2]
100979542  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100995567  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100976569  NR4A1; nuclear receptor subfamily 4immunitygroup A member 1 isoform X4 [KO:K04465]
100974885  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100981716  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
100971970  POMC; pro-opiomelanocortin [KO:K05228]
100987960  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
100972630  MRAP; melanocortin-2 receptor accessory protein [KO:K22398]
100972757  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
100973493  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4 [KO:K18437] [EC:3.1.4.53]
100982736  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
100993289  NR5A1; steroidogenic factor 1 [KO:K08560]
100985203  SP1; transcription factor Sp1 isoform X2 [KO:K04684]
100990886  PBX1; pre-B-cell leukemia transcription factor 1 isoform X3 [KO:K09355]
100971586  CYP11B1; cytochrome P450 11B1, mitochondrial isoform X2 [KO:K00497] [EC:1.14.15.4]
100989182  CYP17A1; steroid 17-alpha-hydroxylase/17,20 lyase [KO:K00512] [EC:1.14.14.19 1.14.14.32]
100971895  STAR; steroidogenic acute regulatory protein, mitochondrial [KO:K16931]
100988456  NCEH1; neutral cholesterol ester hydrolase 1 isoform X1 [KO:K14349] [EC:3.1.1.-]
100974370  ARMC5; armadillo repeat-containing protein 5 isoform X1 [KO:K22499]
100990550  AGT; angiotensinogen [KO:K09821]
100992718  AGTR1; type-1 angiotensin II receptor isoform X3 [KO:K04166]
100986730  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100972605  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100969660  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
100987524  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100969344  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X8 [KO:K05858] [EC:3.1.4.11]
100978643  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100984884  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100980378  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100982024  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X5 [KO:K04960]
100991720  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
100983419  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
100983134  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X9 [KO:K04855]
100972510  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
100987781  calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
100981177  KCNA4; potassium voltage-gated channel subfamily A member 4 [KO:K04877]
100974508  KCNK3; potassium channel subfamily K member 3 [KO:K04914]
100974202  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
100985228  SCARB1; scavenger receptor class B member 1 isoform X3 [KO:K13885]
100979902  CYP11A1; cholesterol side-chain cleavage enzyme, mitochondrial isoform X1 [KO:K00498] [EC:1.14.15.6]
100983009  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 [KO:K00070] [EC:1.1.1.145 5.3.3.1]
100982464  HSD3B2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 [KO:K00070] [EC:1.1.1.145 5.3.3.1]
100990187  LOW QUALITY PROTEIN: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1-like [KO:K00070] [EC:1.1.1.145 5.3.3.1]
117980568  steroid 21-hydroxylase-like [KO:K00513] [EC:1.14.14.16]
117980569  steroid 21-hydroxylase [KO:K00513] [EC:1.14.14.16]
100992582  FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
100995465  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100990322  WNT2; protein Wnt-2 [KO:K00182]
100983371  WNT2B; protein Wnt-2b [KO:K00182]
100992553  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100977143  WNT3A; protein Wnt-3a [KO:K00312]
100992168  WNT4; protein Wnt-4 [KO:K00408]
100990957  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100975676  WNT5B; protein Wnt-5b isoform X2 [KO:K00444]
100987794  WNT6; protein Wnt-6 [KO:K00445]
100995012  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
100993563  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
100993261  WNT9B; protein Wnt-9b isoform X1 [KO:K01064]
100986204  WNT9A; protein Wnt-9a [KO:K01064]
100995123  WNT10B; protein Wnt-10b [KO:K01357]
100988140  WNT10A; protein Wnt-10a [KO:K01357]
100989115  WNT11; protein Wnt-11 [KO:K01384]
100985948  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
100983788  FZD7; frizzled-7 [KO:K02432]
103784670  FZD1; frizzled-1 [KO:K02432]
100994538  FZD2; frizzled-2 [KO:K02235]
100984879  FZD3; frizzled-3 isoform X1 [KO:K02329]
100984214  FZD4; frizzled-4 [KO:K02354]
100977034  FZD5; frizzled-5 [KO:K02375]
117974549  FZD8; frizzled-8 [KO:K02375]
100980889  FZD6; frizzled-6 [KO:K02376]
100977692  FZD10; frizzled-10 [KO:K02842]
100977837  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100986952  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100991559  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
100972306  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100986279  AXIN1; axin-1 isoform X1 [KO:K02157]
100990800  AXIN2; axin-2 isoform X1 [KO:K04385]
100982035  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100992823  APC; adenomatous polyposis coli protein isoform X9 [KO:K02085]
100980839  TCF7; transcription factor 7 isoform X2 [KO:K02620]
100968002  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
100978424  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
100995847  LEF1; lymphoid enhancer-binding factor 1 isoform X2 [KO:K04492]
Compound
C00020  AMP
C00076  Calcium cation
C00187  Cholesterol
C00238  Potassium cation
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C00735  Cortisol
C01176  17alpha-Hydroxyprogesterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01953  Pregnenolone
C05138  17alpha-Hydroxypregnenolone
C05488  11-Deoxycortisol
C07557  2,3,7,8-Tetrachlorodibenzodioxin
Reference
PMID:26004339
  Authors
Lacroix A, Feelders RA, Stratakis CA, Nieman LK
  Title
Cushing's syndrome.
  Journal
Lancet 386:913-27 (2015)
DOI:10.1016/S0140-6736(14)61375-1
Reference
PMID:27588171
  Authors
Xiong Q, Ge W
  Title
Gene mutations in Cushing's disease.
  Journal
Biomed Rep 5:277-282 (2016)
DOI:10.3892/br.2016.729
Reference
PMID:25877147
  Authors
Fukuoka H, Takahashi Y
  Title
The role of genetic and epigenetic changes in pituitary tumorigenesis.
  Journal
Neurol Med Chir (Tokyo) 54 Suppl 3:943-57 (2014)
DOI:10.2176/nmc.suppl.2014-3
Reference
PMID:18987159
  Authors
Quereda V, Malumbres M
  Title
Cell cycle control of pituitary development and disease.
  Journal
J Mol Endocrinol 42:75-86 (2009)
DOI:10.1677/JME-08-0146
Reference
PMID:27742789
  Authors
Caimari F, Korbonits M
  Title
Novel Genetic Causes of Pituitary Adenomas.
  Journal
Clin Cancer Res 22:5030-5042 (2016)
DOI:10.1158/1078-0432.CCR-16-0452
Reference
PMID:25350067
  Authors
Lecoq AL, Kamenicky P, Guiochon-Mantel A, Chanson P
  Title
Genetic mutations in sporadic pituitary adenomas--what to screen for?
  Journal
Nat Rev Endocrinol 11:43-54 (2015)
DOI:10.1038/nrendo.2014.181
Reference
PMID:27625633
  Authors
Hannah-Shmouni F, Faucz FR, Stratakis CA
  Title
Alterations of Phosphodiesterases in Adrenocortical Tumors.
  Journal
Front Endocrinol (Lausanne) 7:111 (2016)
DOI:10.3389/fendo.2016.00111
Reference
PMID:21423242
  Authors
Melmed S
  Title
Pathogenesis of pituitary tumors.
  Journal
Nat Rev Endocrinol 7:257-66 (2011)
DOI:10.1038/nrendo.2011.40
Reference
PMID:19407507
  Authors
Daly AF, Tichomirowa MA, Beckers A
  Title
Genetic, molecular and clinical features of familial isolated pituitary adenomas.
  Journal
Horm Res 71 Suppl 2:116-22 (2009)
DOI:10.1159/000192448
Reference
PMID:28850717
  Authors
Albani A, Theodoropoulou M, Reincke M
  Title
Genetics of Cushing's disease.
  Journal
Clin Endocrinol (Oxf) 88:3-12 (2018)
DOI:10.1111/cen.13457
Reference
PMID:26045561
  Authors
Duan K, Hernandez KG, Mete O
  Title
Clinicopathological correlates of adrenal Cushing's syndrome.
  Journal
Postgrad Med J 91:331-42 (2015)
DOI:10.1136/postgradmedj-2014-202612rep
Reference
PMID:26264719
  Authors
Drougat L, Espiard S, Bertherat J
  Title
Genetics of primary bilateral macronodular adrenal hyperplasia: a model for early diagnosis of Cushing's syndrome?
  Journal
Eur J Endocrinol 173:M121-31 (2015)
DOI:10.1530/EJE-15-0532
Reference
PMID:17955016
  Authors
Stratakis CA, Boikos SA
  Title
Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias.
  Journal
Nat Clin Pract Endocrinol Metab 3:748-57 (2007)
DOI:10.1038/ncpendmet0648
Reference
PMID:19906235
  Authors
Refojo D, Holsboer F
  Title
CRH signaling. Molecular specificity for drug targeting in the CNS.
  Journal
Ann N Y Acad Sci 1179:106-19 (2009)
DOI:10.1111/j.1749-6632.2009.04983.x
Reference
PMID:12089357
  Authors
Kovalovsky D, Refojo D, Liberman AC, Hochbaum D, Pereda MP, Coso OA, Stalla GK, Holsboer F, Arzt E
  Title
Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways.
  Journal
Mol Endocrinol 16:1638-51 (2002)
DOI:10.1210/mend.16.7.0863
Reference
PMID:15380809
  Authors
Lacroix A, Baldacchino V, Bourdeau I, Hamet P, Tremblay J
  Title
Cushing's syndrome variants secondary to aberrant hormone receptors.
  Journal
Trends Endocrinol Metab 15:375-82 (2004)
DOI:10.1016/j.tem.2004.08.007
Reference
PMID:25485838
  Authors
Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M, Komada M
  Title
Mutations in the deubiquitinase gene USP8 cause Cushing's disease.
  Journal
Nat Genet 47:31-8 (2015)
DOI:10.1038/ng.3166
Reference
PMID:25930709
  Authors
Kaiser UB
  Title
Cushing's disease: towards precision medicine.
  Journal
Cell Res 25:649-50 (2015)
DOI:10.1038/cr.2015.53
Reference
PMID:28487882
  Authors
Uzilov AV, Cheesman KC, Fink MY, Newman LC, Pandya C, Lalazar Y, Hefti M, Fowkes M, Deikus G, Lau CY, Moe AS, Kinoshita Y, Kasai Y, Zweig M, Gupta A, Starcevic D, Mahajan M, Schadt EE, Post KD, Donovan MJ, Sebra R, Chen R, Geer EB
  Title
Identification of a novel RASD1 somatic mutation in a USP8-mutated corticotroph adenoma.
  Journal
Cold Spring Harb Mol Case Stud 3:a001602 (2017)
DOI:10.1101/mcs.a001602
Reference
PMID:26285834
  Authors
Huang C, Shi Y, Zhao Y
  Title
USP8 mutation in Cushing's disease.
  Journal
Oncotarget 6:18240-1 (2015)
DOI:10.18632/oncotarget.4856
Reference
PMID:26012588
  Authors
Theodoropoulou M, Reincke M, Fassnacht M, Komada M
  Title
Decoding the genetic basis of Cushing's disease: USP8 in the spotlight.
  Journal
Eur J Endocrinol 173:M73-83 (2015)
DOI:10.1530/EJE-15-0320
Reference
PMID:29370219
  Authors
Yu L, Zhang J, Guo X, Chen X, He Z, He Q
  Title
ARMC5 mutations in familial and sporadic primary bilateral macronodular adrenal hyperplasia.
  Journal
PLoS One 13:e0191602 (2018)
DOI:10.1371/journal.pone.0191602
Reference
PMID:19075677
  Authors
Wu X, Hua X
  Title
Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
  Journal
Curr Mol Med 8:805-15 (2008)
DOI:10.2174/156652408786733702
Reference
PMID:20457215
  Authors
Ozfirat Z, Korbonits M
  Title
AIP gene and familial isolated pituitary adenomas.
  Journal
Mol Cell Endocrinol 326:71-9 (2010)
DOI:10.1016/j.mce.2010.05.001
Related
pathway
pps00020  Citrate cycle (TCA cycle)
pps00140  Steroid hormone biosynthesis
pps04020  Calcium signaling pathway
pps04024  cAMP signaling pathway
pps04110  Cell cycle
pps04310  Wnt signaling pathway
pps04927  Cortisol synthesis and secretion
pps04960  Aldosterone-regulated sodium reabsorption
KO pathway
ko04934   
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