KEGG   PATHWAY: rro05203
Entry
rro05203                    Pathway                                
Name
Viral carcinogenesis - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
rro05203  Viral carcinogenesis
rro05203

Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104655840  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
115895854  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
104654600  HRAS; GTPase HRas isoform X1 [KO:K02833]
104670041  KRAS; GTPase KRas isoform X1 [KO:K07827]
104669078  NRAS; GTPase NRas [KO:K07828]
104676897  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104681150  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104680220  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
104672399  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
104682563  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104672444  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
104663511  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
104665486  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
104668385  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
104656623  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
104681895  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
104674035  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
104679393  DDB1; DNA damage-binding protein 1 [KO:K10610]
104675211  YWHAQ; 14-3-3 protein theta [KO:K16197]
104678862  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
104670827  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
115893879  LOW QUALITY PROTEIN: uncharacterized protein LOC115893879 [KO:K16197]
104670310  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
104660365  YWHAH; 14-3-3 protein eta [KO:K16198]
104681212  YWHAG; 14-3-3 protein gamma [KO:K16198]
104668074  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
104680286  STAT3; signal transducer and activator of transcription 3 isoform X3 [KO:K04692]
104680310  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
104680321  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
104666783  caspase-3-like [KO:K02187] [EC:3.4.22.56]
104673791  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104667121  HPN; serine protease hepsin isoform X2 [KO:K08665] [EC:3.4.21.106]
104663050  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104665061  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104670605  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104662124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104675620  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104680672  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104664815  RELA; transcription factor p65 [KO:K04735]
104673457  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
104656517  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X3 [KO:K04469]
104662315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104661662  TP53; cellular tumor antigen p53 [KO:K04451]
104660331  CCNE2; G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
104656155  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
104673700  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
104655652  EGR2; E3 SUMO-protein ligase EGR2 [KO:K12496]
104663976  EGR3; early growth response protein 3 isoform X1 [KO:K12497]
104666042  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
104680124  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
104656168  SP100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
104678689  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
104682880  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
104666837  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
104669977  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
104662061  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
104677489  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104661051  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
104663440  histone H2B type 1 [KO:K11252]
104663458  histone H2B type 1 [KO:K11252]
104663499  histone H2B type 1-F/J/L-like [KO:K11252]
104663505  histone H2B type 1 [KO:K11252]
104663512  histone H2B type 1 [KO:K11252]
104663518  histone H2B type 1-M-like isoform X2 [KO:K11252]
104663549  histone H2B type 1 [KO:K11252]
104663594  histone H2B type 1-B [KO:K11252]
104670855  histone H2B type 1-O [KO:K11252]
104670892  histone H2B type 1-N [KO:K11252]
104670908  histone H2B type 1-M [KO:K11252]
104670933  histone H2B type 1-F/J/L [KO:K11252]
104671029  histone H2B type 1-K [KO:K11252]
104659773  histone H2B type W-T-like [KO:K11252]
104659774  histone H2B type F-M [KO:K11252]
104659775  LOW QUALITY PROTEIN: histone H2B type W-T-like [KO:K11252]
104675411  late histone H2B.L4 [KO:K11252]
104666728  histone H2B type 3-A-like [KO:K11252]
104666729  histone H2B type 3-B [KO:K11252]
104670099  histone H2B type 2-F isoform X2 [KO:K11252]
104659463  histone H2B type 1-A [KO:K11252]
104681099  histone H2B type 2-E [KO:K11252]
115898589  histone H2B type W-T-like [KO:K11252]
115898590  histone H2B type W-T-like [KO:K11252]
115898591  histone H2B type W-T-like [KO:K11252]
115898599  histone H2B type W-T-like [KO:K11252]
115898692  histone H2B type F-M [KO:K11252]
115898732  histone H2B type W-T [KO:K11252]
115899114  histone H2B type 2-E [KO:K11252]
115895877  histone H2B type 2-E [KO:K11252]
115891967  histone H2B type 1-J [KO:K11252]
104663570  histone H4 [KO:K11254]
104666383  histone H4 [KO:K11254]
104655509  histone H4 [KO:K11254]
115896855  histone H4 [KO:K11254]
104663636  histone H4 [KO:K11254]
115896857  histone H4 [KO:K11254]
115896899  histone H4 [KO:K11254]
104671053  histone H4 [KO:K11254]
104666540  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
104681311  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
104655653  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
104663679  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
104674401  TBP; TATA-box-binding protein [KO:K03120]
104669139  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
104678239  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
104678381  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
104658667  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
104678850  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
104666019  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
104677625  SNW1; SNW domain-containing protein 1 isoform X2 [KO:K06063]
104667646  GTF2H1; general transcription factor IIH subunit 1 [KO:K03141]
104675637  GTF2H2; general transcription factor IIH subunit 2 [KO:K03142]
104666327  GTF2H3; general transcription factor IIH subunit 3 isoform X1 [KO:K03143]
104666205  GTF2H4; general transcription factor IIH subunit 4 isoform X2 [KO:K03144]
104680976  GTF2E1; general transcription factor IIE subunit 1 [KO:K03136]
104668227  GTF2E2; transcription initiation factor IIE subunit beta [KO:K03137]
104674423  SND1; staphylococcal nuclease domain-containing protein 1 [KO:K15979]
104673260  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
104672289  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
104660431  GTF2B; transcription initiation factor IIB [KO:K03124]
104677168  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104658979  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
104667309  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
104682750  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
104661791  CCNA2; cyclin-A2 [KO:K06627]
104677942  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
104662024  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
104666189  MRPS18B; 28S ribosomal protein S18b, mitochondrial [KO:K16174]
104669131  TRAF1; TNF receptor-associated factor 1 isoform X1 [KO:K03172]
104669650  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
104654431  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
104669508  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
104660959  JAK3; tyrosine-protein kinase JAK3 isoform X2 [KO:K11218] [EC:2.7.10.2]
104661780  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
104662008  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
104671774  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
104655633  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
104656439  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
104676365  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
104671698  SCRIB; protein scribble homolog isoform X7 [KO:K16175]
104666247  PXN; paxillin isoform X1 [KO:K05760]
104658958  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
104667206  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
104662043  26S proteasome regulatory subunit 4 [KO:K03062]
104670546  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
104682317  26S proteasome regulatory subunit 4 [KO:K03062]
104658905  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4 [KO:K03062]
104662760  RB1; retinoblastoma-associated protein [KO:K06618]
104655806  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
104658250  RBL2; retinoblastoma-like protein 2 [KO:K16332]
104668343  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
104679837  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X5 [KO:K10691] [EC:2.3.2.27]
104664278  JUN; transcription factor AP-1 [KO:K04448]
104680111  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
104654770  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
104677352  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
104657112  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
104681822  HDAC3; histone deacetylase 3 isoform X1 [KO:K11404] [EC:3.5.1.98]
104654705  HDAC5; histone deacetylase 5 isoform X3 [KO:K11406] [EC:3.5.1.98]
104660448  HDAC4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
104660656  HDAC6; histone deacetylase 6 isoform X2 [KO:K11407] [EC:3.5.1.98]
104654835  HDAC7; LOW QUALITY PROTEIN: histone deacetylase 7 [KO:K11408] [EC:3.5.1.98]
104671474  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
104658630  HDAC9; histone deacetylase 9 isoform X15 [KO:K11409] [EC:3.5.1.98]
104660766  HDAC10; polyamine deacetylase HDAC10 isoform X1 [KO:K18671] [EC:3.5.1.98]
104679017  HDAC11; histone deacetylase 11 isoform X1 [KO:K11418] [EC:3.5.1.98]
104663550  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
104662694  IRF9; interferon regulatory factor 9 [KO:K04693]
115897716  interferon regulatory factor 9 [KO:K04693]
104654688  DNAJA3; dnaJ homolog subfamily A member 3, mitochondrial isoform X1 [KO:K09504]
104680633  KAT2A; histone acetyltransferase KAT2A [KO:K06062] [EC:2.3.1.48]
104665709  KAT2B; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
104663331  GTF2A1; transcription initiation factor IIA subunit 1 isoform X1 [KO:K03122]
104668944  GTF2A1L; TFIIA-alpha and beta-like factor isoform X1 [KO:K03122]
104670880  GTF2A2; transcription initiation factor IIA subunit 2 [KO:K03123]
104667339  SRF; serum response factor [KO:K04378]
104667046  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
104679802  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104674071  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
104663221  CDC42; cell division control protein 42 homolog [KO:K04393]
104665823  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104667372  RHOA; transforming protein RhoA [KO:K04513]
104655849  GSN; gelsolin isoform X1 [KO:K05768]
104676707  SCIN; adseverin [KO:K05768]
104679965  ACTN4; alpha-actinin-4 [KO:K05699]
104659630  ACTN1; LOW QUALITY PROTEIN: alpha-actinin-1 [KO:K05699]
104682344  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
104654275  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
104654271  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
104653937  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
104669028  CDC20; cell division cycle protein 20 homolog [KO:K03363]
104664955  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X2 [KO:K06679]
104677815  VAC14; protein VAC14 homolog isoform X2 [KO:K15305]
104681981  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
104668950  ran-specific GTPase-activating protein-like [KO:K15306]
104666045  POLB; DNA polymerase beta isoform X1 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
104682894  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
104680478  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
104671328  CCR5; C-C chemokine receptor type 5 [KO:K04180]
104668742  CCR8; C-C chemokine receptor type 8 [KO:K04183]
104671330  CCR3; C-C chemokine receptor type 3 isoform X2 [KO:K04178]
104669848  CCR4; C-C chemokine receptor type 4 [KO:K04179]
104661739  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104671864  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
104673141  BAD; bcl2-associated agonist of cell death [KO:K02158]
104673006  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
104665361  C3; complement C3 [KO:K03990]
104670209  patr class I histocompatibility antigen, B-2 alpha chain isoform X1 [KO:K06751]
104668193  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-42 alpha chain-like [KO:K06751]
104674706  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
104661905  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
115897009  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
104676771  mamu class I histocompatibility antigen, alpha chain F [KO:K06751]
104678084  HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751]
104668434  HLA class I histocompatibility antigen, A-30 alpha chain isoform X1 [KO:K06751]
104677089  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
104673193  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-14 alpha chain [KO:K06751]
104676774  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
104666183  popy class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
104678248  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
Reference
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  Title
Viruses associated with human cancer.
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Reference
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Cancer Biol Ther 10:961-78 (2010)
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  Title
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.
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Oncogene 27 Suppl 2:S31-42 (2008)
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Reference
PMID:16459163
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Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
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J Lab Clin Med 147:58-66 (2006)
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Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
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Reference
PMID:21647825
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Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
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J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:21966251
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Nishida N, Goel A
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Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
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Curr Genomics 12:130-7 (2011)
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Reference
PMID:19854353
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Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
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Adv Cancer Res 103:75-109 (2009)
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Reference
PMID:18251977
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Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
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Reference
PMID:9343405
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Klein NP, Schneider RJ
  Title
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
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Mol Cell Biol 17:6427-36 (1997)
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The Viral Interferon Regulatory Factors of KSHV: Immunosuppressors or Oncogenes?
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Front Immunol 2:19 (2011)
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Trends Mol Med 11:309-12 (2005)
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Related
pathway
rro03022  Basal transcription factors
rro03320  PPAR signaling pathway
rro04010  MAPK signaling pathway
rro04062  Chemokine signaling pathway
rro04064  NF-kappa B signaling pathway
rro04110  Cell cycle
rro04115  p53 signaling pathway
rro04142  Lysosome
rro04151  PI3K-Akt signaling pathway
rro04210  Apoptosis
rro04630  JAK-STAT signaling pathway
rro04662  B cell receptor signaling pathway
rro04810  Regulation of actin cytoskeleton
rro05160  Hepatitis C
rro05161  Hepatitis B
rro05165  Human papillomavirus infection
rro05166  Human T-cell leukemia virus 1 infection
rro05167  Kaposi sarcoma-associated herpesvirus infection
rro05169  Epstein-Barr virus infection
KO pathway
ko05203   
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