KEGG   PATHWAY: rro04062
Entry
rro04062                    Pathway                                
Name
Chemokine signaling pathway - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
rro04062  Chemokine signaling pathway
rro04062

Other DBs
GO: 0070098
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104653553  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
104653559  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
104653712  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
104654186  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104654600  HRAS; GTPase HRas isoform X1 [KO:K02833]
104654807  [KO:K05505]
104654808  [KO:K05506]
104654871  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
104654979  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
104655463  ROCK1; LOW QUALITY PROTEIN: rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
104655777  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
104655840  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
104655987  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
104656469  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104656866  CCR6; C-C chemokine receptor type 6 [KO:K04181]
104656971  ELMO1; engulfment and cell motility protein 1 [KO:K12366]
104657305  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104657941  SHC4; SHC-transforming protein 4 [KO:K17449]
104658283  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
104658296  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
104658457  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
104658672  RAP1B; ras-related protein Rap-1b [KO:K07836]
104658796  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
104658873  CXCL8; LOW QUALITY PROTEIN: interleukin-8 [KO:K10030]
104658874  CXCL6; C-X-C motif chemokine 6 [KO:K05506]
104658875  PF4V1; LOW QUALITY PROTEIN: platelet factor 4 variant [KO:K05407]
104658876  CXCL1; growth-regulated alpha protein [KO:K05505]
104658878  PF4; platelet factor 4 isoform X2 [KO:K05407]
104658879  PPBP; platelet basic protein [KO:K10029]
104658880  [KO:K05506]
104658882  [KO:K05505]
104658883  [KO:K05506]
104658884  [KO:K05505]
104658932  RAP1A; ras-related protein Rap-1A [KO:K04353]
104659669  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
104659700  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
104659743  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
104660011  [KO:K05050]
104660012  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
104660661  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
104660849  [KO:K04542]
104660869  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
104660908  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
104660959  JAK3; tyrosine-protein kinase JAK3 isoform X2 [KO:K11218] [EC:2.7.10.2]
104661051  [KO:K04345] [EC:2.7.11.11]
104661201  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
104661780  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
104662061  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
104662124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104662176  CCL28; C-C motif chemokine 28 isoform X1 [KO:K05513]
104662315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104662403  ITK; tyrosine-protein kinase ITK/TSK isoform X1 [KO:K07363] [EC:2.7.10.2]
104662575  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104662674  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
104663024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
104663050  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104663093  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
104663095  ARRB2; beta-arrestin-2 isoform X4 [KO:K04439]
104663221  CDC42; cell division control protein 42 homolog [KO:K04393]
104663314  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
104663483  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
104663613  DOCK2; dedicator of cytokinesis protein 2 isoform X1 [KO:K12367]
104664050  CCL22; C-C motif chemokine 22 [KO:K21095]
104664051  CX3CL1; fractalkine [KO:K05508]
104664052  CCL17; C-C motif chemokine 17 [KO:K21083]
104664204  [KO:K12964]
104664316  PAK1; serine/threonine-protein kinase PAK 1 isoform X5 [KO:K04409] [EC:2.7.11.1]
104664320  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
104664497  [KO:K05408]
104664652  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
104664749  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
104664815  RELA; transcription factor p65 [KO:K04735]
104664906  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
104665061  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104665104  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
104665356  VAV1; proto-oncogene vav [KO:K05730]
104665700  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
104665823  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104665907  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
104666046  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
104666247  PXN; paxillin isoform X1 [KO:K05760]
104666852  CRKL; crk-like protein [KO:K04438]
104667046  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
104667102  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
104667372  RHOA; transforming protein RhoA [KO:K04513]
104668142  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
104668296  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
104668515  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
104668741  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
104668742  CCR8; C-C chemokine receptor type 8 [KO:K04183]
104668781  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104668961  XCL1; lymphotactin [KO:K05507]
104668962  [KO:K05507]
104669078  NRAS; GTPase NRas [KO:K07828]
104669784  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
104669848  CCR4; C-C chemokine receptor type 4 [KO:K04179]
104670041  KRAS; GTPase KRas isoform X1 [KO:K07827]
104670311  CRK; adapter molecule crk isoform X1 [KO:K04438]
104670580  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
104670605  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104671165  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
104671328  CCR5; C-C chemokine receptor type 5 [KO:K04180]
104671329  CCR2; C-C chemokine receptor type 2 [KO:K04177]
104671330  CCR3; C-C chemokine receptor type 3 isoform X2 [KO:K04178]
104671331  CCR1; C-C chemokine receptor type 1 [KO:K04176]
104671334  XCR1; chemokine XC receptor 1 [KO:K04193]
104671335  CXCR6; C-X-C chemokine receptor type 6 isoform X1 [KO:K04191]
104671337  CCR9; C-C chemokine receptor type 9 [KO:K04184]
104671354  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
104671367  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
104671381  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
104671624  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
104671949  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
104671957  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
104672220  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
104672234  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
104672288  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
104672393  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
104672569  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
104672906  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
104673041  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104673127  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
104673141  BAD; bcl2-associated agonist of cell death [KO:K02158]
104673151  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
104673153  CXCL11; C-X-C motif chemokine 11 isoform X1 [KO:K12672]
104673156  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
104673274  RASGRP2; RAS guanyl-releasing protein 2 isoform X3 [KO:K12361]
104673299  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
104673307  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
104673624  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
104673676  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
104673947  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
104674059  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
104674083  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
104675108  CCL1; C-C motif chemokine 1 [KO:K05514]
104675109  CCL13; C-C motif chemokine 13 [KO:K16595]
104675110  CCL8; C-C motif chemokine 8 [KO:K16596]
104675111  [KO:K05509]
104675191  ROCK2; rho-associated protein kinase 2 isoform X5 [KO:K17388] [EC:2.7.11.39]
104675282  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
104675620  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104675683  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
104675721  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
104676121  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104676171  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
104676897  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104677402  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
104677475  FOXO3; forkhead box protein O3 [KO:K09408]
104677489  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104677497  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
104677838  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
104678227  CCL15; C-C motif chemokine 15 [KO:K05511]
104678228  [KO:K05511]
104678229  CCL18; C-C motif chemokine 18 [KO:K21094]
104678230  CCL16; LOW QUALITY PROTEIN: C-C motif chemokine 16 [KO:K21093]
104678231  CCL14; C-C motif chemokine 14 [KO:K21092]
104678511  [KO:K12964]
104678544  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
104678955  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
104679097  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
104679173  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
104679339  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
104679461  CCL25; C-C motif chemokine 25 [KO:K13072]
104679596  CCL5; C-C motif chemokine 5 [KO:K12499]
104679749  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104679802  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104680014  CCL27; C-C motif chemokine 27 [KO:K16598]
104680017  [KO:K16598]
104680018  CCL19; C-C motif chemokine 19 [KO:K05512]
104680019  CCL21; C-C motif chemokine 21 [KO:K16062]
104680094  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
104680156  CCR10; C-C chemokine receptor type 10 [KO:K04185]
104680286  STAT3; signal transducer and activator of transcription 3 isoform X3 [KO:K04692]
104680321  [KO:K11224]
104680460  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
104680672  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104680990  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104681150  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104681221  CCL24; C-C motif chemokine 24 [KO:K21097]
104681222  CCL26; C-C motif chemokine 26 [KO:K21096]
104681251  NCF1; neutrophil cytosol factor 1 isoform X2 [KO:K08011]
104681311  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
104682036  CCR7; C-C chemokine receptor type 7 [KO:K04182]
104682502  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104682620  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
104682751  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
104682787  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
104682791  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
115892187  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
115893905  [KO:K04456] [EC:2.7.11.1]
115894708  [KO:K05408]
115894723  [KO:K05408]
115894851  [KO:K12964]
115894852  [KO:K05408]
115894914  [KO:K12964]
115894930  [KO:K21094]
115895307  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
115895854  [KO:K05704] [EC:2.7.10.2]
115898383  [KO:K04540]
115900349  [KO:K04542]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
rro04010  MAPK signaling pathway
rro04060  Cytokine-cytokine receptor interaction
rro04120  Ubiquitin mediated proteolysis
rro04630  JAK-STAT signaling pathway
rro04670  Leukocyte transendothelial migration
rro04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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