KEGG   PATHWAY: rro05167
Entry
rro05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
rro05167  Kaposi sarcoma-associated herpesvirus infection
rro05167

Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104665361  C3; complement C3 [KO:K03990]
104673812  TLR3; toll-like receptor 3 isoform X2 [KO:K05401]
104665406  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
104654431  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
104661734  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
104680828  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
104682894  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
104670273  interferon alpha-1/13 [KO:K05414]
104670275  IFNA8; interferon alpha-8 [KO:K05414]
104670276  interferon alpha-1/13-like [KO:K05414]
104670278  IFNA6; interferon alpha-6 [KO:K05414]
104670280  interferon alpha-14 [KO:K05414]
104670290  interferon alpha-4 [KO:K05414]
104670292  interferon alpha-10-like [KO:K05414]
104680728  interferon alpha-10 [KO:K05414]
115893964  interferon alpha-4 [KO:K05414]
115893973  interferon alpha-10-like [KO:K05414]
104667206  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
104673260  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
104672289  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
104670295  IFNB1; interferon beta [KO:K05415]
104658750  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
104658748  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
104668074  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
104670479  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
104675282  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
104673676  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
104662694  IRF9; interferon regulatory factor 9 [KO:K04693]
115897716  interferon regulatory factor 9 [KO:K04693]
104669977  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
104660767  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104660769  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104682867  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
104682868  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
104661739  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104654038  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
104676148  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
104675233  IL6; interleukin-6 isoform X1 [KO:K05405]
104659848  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
104671330  CCR3; C-C chemokine receptor type 3 isoform X2 [KO:K04178]
104671328  CCR5; C-C chemokine receptor type 5 [KO:K04180]
104671331  CCR1; C-C chemokine receptor type 1 [KO:K04176]
104669848  CCR4; C-C chemokine receptor type 4 [KO:K04179]
104668742  CCR8; C-C chemokine receptor type 8 [KO:K04183]
104675147  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
104677132  FADD; FAS-associated death domain protein [KO:K02373]
104671864  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
104676299  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
104666540  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
104658958  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
104661761  cytochrome c-like [KO:K08738]
104679886  cytochrome c [KO:K08738]
104672188  cytochrome c [KO:K08738]
104681924  cytochrome c-like [KO:K08738]
115898126  cytochrome c-like [KO:K08738]
115894533  cytochrome c-like [KO:K08738]
115893266  cytochrome c-like [KO:K08738]
115893541  cytochrome c-like [KO:K08738]
115899152  cytochrome c-like [KO:K08738]
104677696  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
104666783  caspase-3-like [KO:K02187] [EC:3.4.22.56]
104673791  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104680127  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104655653  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
104669650  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
104656469  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104666046  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
104667046  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
104679802  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104662315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104664815  RELA; transcription factor p65 [KO:K04735]
104661662  TP53; cellular tumor antigen p53 [KO:K04451]
104682880  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
104682344  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
104682750  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
104662760  RB1; retinoblastoma-associated protein [KO:K06618]
104660298  E2F1; transcription factor E2F1 [KO:K17454]
104656129  E2F2; LOW QUALITY PROTEIN: transcription factor E2F2 [KO:K09389]
104654803  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
104670209  patr class I histocompatibility antigen, B-2 alpha chain isoform X1 [KO:K06751]
104668193  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-42 alpha chain-like [KO:K06751]
104674706  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
104661905  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
115897009  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
104676771  mamu class I histocompatibility antigen, alpha chain F [KO:K06751]
104678084  HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751]
104668434  HLA class I histocompatibility antigen, A-30 alpha chain isoform X1 [KO:K06751]
104677089  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
104673193  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-14 alpha chain [KO:K06751]
104676774  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
104666183  popy class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
104678248  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
104675021  IFNGR1; interferon gamma receptor 1 [KO:K05132]
104670485  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
104667916  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
104661906  MHC class I polypeptide-related sequence B [KO:K07985]
104656725  MHC class I polypeptide-related sequence B-like [KO:K07985]
104672819  CLEC2B; C-type lectin domain family 2 member B [KO:K10071]
104680628  UBA52; ubiquitin-60S ribosomal protein L40 isoform X1 [KO:K02927]
104657521  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
115894892  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
104673976  ubiquitin-40S ribosomal protein S27a [KO:K02977]
104677290  RPS27A; LOW QUALITY PROTEIN: ubiquitin-40S ribosomal protein S27a [KO:K02977]
115894201  ubiquitin-40S ribosomal protein S27a [KO:K02977]
104681436  UBB; polyubiquitin-B [KO:K04551]
104666337  UBC; polyubiquitin-C [KO:K08770]
104680067  BECN1; beclin-1 isoform X1 [KO:K08334]
104679208  BECN2; beclin-2 [KO:K08334]
104669140  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
104658709  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
104660632  ATG3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
104665626  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
104679210  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
104680509  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
104656055  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
104653553  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
104673624  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
104680094  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
104670580  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
104660908  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
104672906  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
104679339  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
115898383  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
104679173  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
104660849  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
104677497  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
115900349  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
104671381  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
115892187  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
104660869  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
104682787  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
104657305  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
115895307  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
104682791  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
104659743  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
104654600  HRAS; GTPase HRas isoform X1 [KO:K02833]
104670041  KRAS; GTPase KRas isoform X1 [KO:K07827]
104669078  NRAS; GTPase NRas [KO:K07828]
104673299  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
104662575  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104665487  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104676897  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104681150  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104655242  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
104664278  JUN; transcription factor AP-1 [KO:K04448]
104677590  FOS; LOW QUALITY PROTEIN: proto-oncogene c-Fos [KO:K04379]
104677402  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
104658283  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
104658296  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
104663050  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104665061  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104670605  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104662124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104675620  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104680672  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104673041  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104676121  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104654186  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115893905  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104654362  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
104678544  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
104665823  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104676194  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104678447  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104668007  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104660629  CD200R1L; cell surface glycoprotein CD200 receptor 2 isoform X1 [KO:K21668]
104660628  CD200R1; cell surface glycoprotein CD200 receptor 1 isoform X1 [KO:K21668]
104662008  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
104655840  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
115895854  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
104653712  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
104661780  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
104672345  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
104679497  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
104671624  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
104672220  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
104664252  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
104675331  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
104658948  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104662055  calmodulin [KO:K02183]
104663170  CALM2; calmodulin-2 [KO:K02183]
104680741  calmodulin-alpha-like [KO:K02183]
104670544  CALM1; calmodulin-1 [KO:K02183]
104673406  CALM3; calmodulin-3 [KO:K02183]
104664834  CALML5; calmodulin-like protein 5 [KO:K02183]
104664835  CALML3; calmodulin-like protein 3 [KO:K02183]
104653554  CALML6; calmodulin-like protein 6 isoform X2 [KO:K02183]
104662590  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
104674211  calmodulin-alpha-like [KO:K02183]
104656871  calmodulin-like [KO:K02183]
104663969  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104663623  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104669965  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104675975  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
104670806  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
104653917  calcineurin subunit B type 1 [KO:K06268]
104667797  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104662367  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
104655599  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
104662672  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
104658873  CXCL8; LOW QUALITY PROTEIN: interleukin-8 [KO:K10030]
104664377  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
104658884  growth-regulated alpha protein-like [KO:K05505]
104658876  CXCL1; growth-regulated alpha protein [KO:K05505]
104654807  C-X-C motif chemokine 3 isoform X2 [KO:K05505]
104658882  C-X-C motif chemokine 3-like [KO:K05505]
104658768  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
104661758  FGF2; fibroblast growth factor 2 [KO:K18497]
104667362  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
104682558  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
104676532  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
104680478  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
104665700  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
104680286  STAT3; signal transducer and activator of transcription 3 isoform X3 [KO:K04692]
104680990  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104670934  CTNNB1; catenin beta-1 [KO:K02105]
104659811  TCF7; transcription factor 7 isoform X9 [KO:K02620]
104659731  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
104664436  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
104670045  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
104680220  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
104677168  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104674798  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
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Eur J Immunol 31:2458-66 (2001)
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J Virol 82:6501-13 (2008)
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Trends Mol Med 11:309-12 (2005)
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Biochim Biophys Acta 1766:140-58 (2006)
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Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
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EMBO J 21:2602-15 (2002)
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KSHV vFLIP binds to IKK-gamma to activate IKK.
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Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
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J Virol 74:5300-9 (2000)
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Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
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J Virol 81:2117-27 (2007)
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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
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Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
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Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
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Biochim Biophys Acta 1602:1-22 (2002)
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Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
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J Virol 78:7667-76 (2004)
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The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
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Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
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PLoS Pathog 8:e1002927 (2012)
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J Virol 81:42-58 (2007)
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Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
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Cancer Res 66:3658-66 (2006)
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
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Virology 428:112-20 (2012)
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Molecular biology of KSHV lytic reactivation.
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Viruses 7:116-53 (2015)
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
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J Mol Med (Berl) 82:223-31 (2004)
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KSHV Genome Replication and Maintenance.
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Front Microbiol 7:54 (2016)
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pathway
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rro04064  NF-kappa B signaling pathway
rro04110  Cell cycle
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rro04144  Endocytosis
rro04151  PI3K-Akt signaling pathway
rro04210  Apoptosis
rro04310  Wnt signaling pathway
rro04610  Complement and coagulation cascades
rro04620  Toll-like receptor signaling pathway
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KO pathway
ko05167   
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