KEGG   PATHWAY: rro05169
Entry
rro05169                    Pathway                                
Name
Epstein-Barr virus infection - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
rro05169  Epstein-Barr virus infection
rro05169

Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104664178  CR2; complement receptor type 2 isoform X1 [KO:K04012]
104682142  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
104657986  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
104657985  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
104673877  HLA class II histocompatibility antigen, DRB1-1 beta chain [KO:K06752]
104673884  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
104673840  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
104673850  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
104673860  HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752]
104673868  HLA class II histocompatibility antigen, DRB1-10 beta chain [KO:K06752]
104666619  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
104666621  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
104666623  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
104677747  TLR2; toll-like receptor 2 [KO:K10159]
104657448  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
104677388  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
104662981  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
104658364  TRAF6; LOW QUALITY PROTEIN: TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104682560  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
104676257  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
115899261  LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404]
104657888  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104656469  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104666046  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
104667046  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
104679802  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104662315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104664815  RELA; transcription factor p65 [KO:K04735]
104661913  TNF; tumor necrosis factor isoform X1 [KO:K03156]
104675233  IL6; interleukin-6 isoform X1 [KO:K05405]
104655060  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
104674592  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
104654431  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
104680828  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
104661734  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
104682894  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
104667206  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
104670273  interferon alpha-1/13 [KO:K05414]
104670275  IFNA8; interferon alpha-8 [KO:K05414]
104670276  interferon alpha-1/13-like [KO:K05414]
104670278  IFNA6; interferon alpha-6 [KO:K05414]
104670280  interferon alpha-14 [KO:K05414]
104670290  interferon alpha-4 [KO:K05414]
104670292  interferon alpha-10-like [KO:K05414]
104680728  interferon alpha-10 [KO:K05414]
115893964  interferon alpha-4 [KO:K05414]
115893973  interferon alpha-10-like [KO:K05414]
104670295  IFNB1; interferon beta [KO:K05415]
104658750  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
104658748  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
104668074  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
104670479  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
104675282  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
104673676  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
104662694  IRF9; interferon regulatory factor 9 [KO:K04693]
115897716  interferon regulatory factor 9 [KO:K04693]
104669977  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
104666641  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
104666642  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
104666645  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
104673151  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
104673206  ISG15; LOW QUALITY PROTEIN: ubiquitin-like protein ISG15 [KO:K12159]
104675147  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
104677132  FADD; FAS-associated death domain protein [KO:K02373]
104671864  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
104676299  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
104680402  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
104682248  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
104666540  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
104658958  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
104661761  cytochrome c-like [KO:K08738]
104679886  cytochrome c [KO:K08738]
104672188  cytochrome c [KO:K08738]
104681924  cytochrome c-like [KO:K08738]
115898126  cytochrome c-like [KO:K08738]
115894533  cytochrome c-like [KO:K08738]
115893266  cytochrome c-like [KO:K08738]
115893541  cytochrome c-like [KO:K08738]
115899152  cytochrome c-like [KO:K08738]
104656342  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
104677696  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
104666783  caspase-3-like [KO:K02187] [EC:3.4.22.56]
104673791  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104681408  uncharacterized protein LOC104681408 [KO:K10785]
104681410  uncharacterized protein LOC104681410 [KO:K10785]
104665572  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
104665573  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
104665574  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
104668979  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X3 [KO:K06453]
104673545  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
104662043  26S proteasome regulatory subunit 4 [KO:K03062]
104670546  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
104682317  26S proteasome regulatory subunit 4 [KO:K03062]
104658905  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4 [KO:K03062]
104676129  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
104669166  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
104668413  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
104675461  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
104664628  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
104661392  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
104671873  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
104675424  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
104669328  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
104653845  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
104655883  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
104672642  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
104681047  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
104666029  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
104679956  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
104663820  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X5 [KO:K06691]
104656595  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
115893294  26S proteasome complex subunit SEM1 [KO:K10881]
104666626  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
104666628  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
104657970  TAPBP; tapasin isoform X2 [KO:K08058]
104679628  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
104661079  CALR; calreticulin isoform X1 [KO:K08057]
104667845  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
104670209  patr class I histocompatibility antigen, B-2 alpha chain isoform X1 [KO:K06751]
104668193  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-42 alpha chain-like [KO:K06751]
104674706  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
104661905  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
115897009  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
104676771  mamu class I histocompatibility antigen, alpha chain F [KO:K06751]
104678084  HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751]
104668434  HLA class I histocompatibility antigen, A-30 alpha chain isoform X1 [KO:K06751]
104677089  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
104673193  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-14 alpha chain [KO:K06751]
104676774  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
104666183  popy class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
104678248  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
104679609  B2M; beta-2-microglobulin isoform X1 [KO:K08055]
104677625  SNW1; SNW domain-containing protein 1 isoform X2 [KO:K06063]
104676998  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
104654770  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
104677352  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
104657112  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
104666335  NCOR2; LOW QUALITY PROTEIN: nuclear receptor corepressor 2 [KO:K06065]
104660240  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
104662883  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
104658417  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
104678850  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
104666019  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
104669884  HES1; transcription factor HES-1 [KO:K06054]
104679477  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
104656102  RUNX3; runt-related transcription factor 3 isoform X1 [KO:K09279]
104674798  MYC; myc proto-oncogene protein [KO:K04377]
104678381  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
104658667  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
104661662  TP53; cellular tumor antigen p53 [KO:K04451]
104682880  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
104671382  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
104657306  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
104656307  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
104668405  DDB2; DNA damage-binding protein 2 [KO:K10140]
104653753  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
104669508  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
104663050  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104665061  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104670605  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104662124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104675620  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104680672  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104673041  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104676121  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104654186  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115893905  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104678377  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104673504  RELB; transcription factor RelB isoform X1 [KO:K09253]
104656517  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X3 [KO:K04469]
104655653  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
104676171  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
104667375  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
104672345  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
104679497  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
104676194  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104678447  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104668007  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104669650  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
104661228  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
104678467  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X3 [KO:K04432] [EC:2.7.12.2]
104654038  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
104660767  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104660769  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104682867  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
104682868  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
104664278  JUN; transcription factor AP-1 [KO:K04448]
104659869  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X2 [KO:K01510] [EC:3.6.1.5]
104664681  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X2 [KO:K01510] [EC:3.6.1.5]
104669616  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X2 [KO:K01510] [EC:3.6.1.5]
115900420  ectonucleoside triphosphate diphosphohydrolase 1-like [KO:K01510] [EC:3.6.1.5]
104678812  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
104658356  CD44; CD44 antigen isoform X1 [KO:K06256]
104681602  ITGAL; LOW QUALITY PROTEIN: integrin alpha-L [KO:K05718]
104665931  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
104670485  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
104655336  VIM; vimentin [KO:K07606]
104675026  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
104660959  JAK3; tyrosine-protein kinase JAK3 isoform X2 [KO:K11218] [EC:2.7.10.2]
104680286  STAT3; signal transducer and activator of transcription 3 isoform X3 [KO:K04692]
104661780  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
104662008  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
104663342  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
104665823  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104664696  LOW QUALITY PROTEIN: uncharacterized protein LOC104664696 [KO:K06856]
104674294  LOW QUALITY PROTEIN: uncharacterized protein LOC104674294 [KO:K06856]
104677074  uncharacterized protein LOC104677074 [KO:K06856]
104659579  BTK; tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
104682830  BLNK; B-cell linker protein isoform X1 [KO:K07371]
104671624  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
104662024  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
104668343  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
104677168  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104658979  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
104667309  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
104682344  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
104682750  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
104661791  CCNA2; cyclin-A2 [KO:K06627]
104677942  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
104660331  CCNE2; G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
104656155  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
104673700  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
104662760  RB1; retinoblastoma-associated protein [KO:K06618]
104660298  E2F1; transcription factor E2F1 [KO:K17454]
104656129  E2F2; LOW QUALITY PROTEIN: transcription factor E2F2 [KO:K09389]
104654803  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
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PMID:29116588
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Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
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The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
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Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
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Melchjorsen J
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Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
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Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
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PMID:19498380
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Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
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Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
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PMID:21146386
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Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
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Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
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PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
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Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
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PMID:25613730
  Authors
Cai Q, Chen K, Young KH
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Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
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Exp Mol Med 47:e133 (2015)
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PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
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Cell Mol Immunol 4:185-96 (2007)
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PMID:23793113
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Ersing I, Bernhardt K, Gewurz BE
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NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
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Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
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PMID:28835489
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Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
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J Virol 91:e01718-16 (2017)
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PMID:12740915
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Mori N, Morishita M, Tsukazaki T, Yamamoto N
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Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
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Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
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Edwards RH, Marquitz AR, Raab-Traub N
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Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
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MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
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PMID:11905817
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Thorley-Lawson DA
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Epstein-Barr virus: exploiting the immune system.
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Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
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Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
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Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
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Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
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Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
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J Biol Chem 278:47753-61 (2003)
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PMID:25403939
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Kang H, Kiess A, Chung CH
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Emerging biomarkers in head and neck cancer in the era of genomics.
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Nat Rev Clin Oncol 12:11-26 (2015)
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Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
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Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
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Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
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PMID:19649319
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Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
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Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
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PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
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Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
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Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
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Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
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Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
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Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
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Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
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El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
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Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
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Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
rro03050  Proteasome
rro04010  MAPK signaling pathway
rro04020  Calcium signaling pathway
rro04064  NF-kappa B signaling pathway
rro04110  Cell cycle
rro04115  p53 signaling pathway
rro04210  Apoptosis
rro04612  Antigen processing and presentation
rro04620  Toll-like receptor signaling pathway
rro04622  RIG-I-like receptor signaling pathway
rro04630  JAK-STAT signaling pathway
rro04662  B cell receptor signaling pathway
KO pathway
ko05169   
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