KEGG   PATHWAY: ko05203
Entry
ko05203                     Pathway                                
Name
Viral carcinogenesis
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
ko05203  Viral carcinogenesis
ko05203

Drug
D06555  Amolimogene bepiplasmid (USAN)
D06666  Verpasep caltespen (USAN/INN)
D12744  Ravidasvir (USAN/INN)
D12745  Ravidasvir hydrochloride (USAN)
Orthology
K00873  PK, pyk; pyruvate kinase [EC:2.7.1.40]
K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02087  CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K02146  ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d
K02158  BAD; Bcl-2-antagonist of cell death
K02159  BAX; apoptosis regulator BAX
K02187  CASP3; caspase 3 [EC:3.4.22.56]
K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K02216  CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
K02330  POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02833  HRAS; GTPase HRas
K03062  PSMC1, RPT2; 26S proteasome regulatory subunit T2
K03120  TBP; transcription initiation factor TFIID TATA-box-binding protein
K03122  TFIIA1, GTF2A1, TOA1; transcription initiation factor TFIIA large subunit
K03123  TFIIA2, GTF2A2, TOA2; transcription initiation factor TFIIA small subunit
K03124  TFIIB, GTF2B, SUA7, tfb; transcription initiation factor TFIIB
K03136  TFIIE1, GTF2E1, TFA1, tfe; transcription initiation factor TFIIE subunit alpha
K03137  TFIIE2, GTF2E2, TFA2; transcription initiation factor TFIIE subunit beta
K03141  TFIIH1, GTF2H1, TFB1; transcription initiation factor TFIIH subunit 1
K03142  TFIIH2, GTF2H2, SSL1; transcription initiation factor TFIIH subunit 2
K03143  TFIIH3, GTF2H3, TFB4; transcription initiation factor TFIIH subunit 3
K03144  TFIIH4, GTF2H4, TFB2; transcription initiation factor TFIIH subunit 4
K03159  TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K03172  TRAF1; TNF receptor-associated factor 1
K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K03174  TRAF3; TNF receptor-associated factor 3
K03363  CDC20; cell division cycle 20, cofactor of APC complex
K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K03990  C3; complement component 3
K04178  CCR3, CD193; C-C chemokine receptor type 3
K04179  CCR4, CD194; C-C chemokine receptor type 4
K04180  CCR5, CD195; C-C chemokine receptor type 5
K04183  CCR8, CDw198; C-C chemokine receptor type 8
K04345  PKA; protein kinase A [EC:2.7.11.11]
K04364  GRB2; growth factor receptor-bound protein 2
K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K04378  SRF; serum response factor
K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
K04393  CDC42; cell division control protein 42
K04398  CASP8; caspase 8 [EC:3.4.22.61]
K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
K04448  JUN; transcription factor AP-1
K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
K04451  TP53, P53; tumor protein p53
K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K04503  CCND1; G1/S-specific cyclin-D1
K04513  RHOA; Ras homolog gene family, member A
K04681  RBL1; retinoblastoma-like protein 1
K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
K04692  STAT3; signal transducer and activator of transcription 3
K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
K04734  NFKBIA; NF-kappa-B inhibitor alpha
K04735  RELA; transcription factor p65
K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
K05411  IRF3; interferon regulatory factor 3
K05699  ACTN1_4; actinin alpha 1/4
K05704  SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
K05760  PXN; paxillin
K05768  GSN; gelsolin
K05854  LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
K05870  CREB1; cyclic AMP-responsive element-binding protein 1
K06053  RBPSUH, RBPJK; recombining binding protein suppressor of hairless
K06062  PCAF, KAT2, GCN5; histone acetyltransferase [EC:2.3.1.48]
K06063  SNW1, SKIIP, SKIP; SNW domain-containing protein 1
K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06618  RB1; retinoblastoma-associated protein
K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K06626  CCNE; G1/S-specific cyclin-E1
K06627  CCNA; cyclin-A
K06630  YWHAE; 14-3-3 protein epsilon
K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K06679  MAD1; mitotic spindle assembly checkpoint protein MAD1
K06751  MHC1; MHC class I antigen
K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07827  KRAS, KRAS2; GTPase KRas
K07828  NRAS; GTPase NRas
K08053  RASA2, GAP1M; Ras GTPase-activating protein 2
K08665  HPN; hepsin [EC:3.4.21.106]
K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
K09048  CREB3; cyclic AMP-responsive element-binding protein 3
K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
K09254  REL; c-Rel proto-oncogene protein
K09447  IRF7; interferon regulatory factor 7
K09504  DNAJA3; DnaJ homolog subfamily A member 3
K09849  TRAF5; TNF receptor-associated factor 5
K10131  PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1
K10151  CCND2; G1/S-specific cyclin-D2
K10152  CCND3; G1/S-specific cyclin-D3
K10587  UBE3A, E6AP; ubiquitin-protein ligase E3 A [EC:2.3.2.26]
K10610  DDB1; DNA damage-binding protein 1
K10691  UBR4, ZUBR1; E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27]
K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
K11223  STAT5A; signal transducer and activator of transcription 5A
K11224  STAT5B; signal transducer and activator of transcription 5B
K11252  H2B; histone H2B
K11254  H4; histone H4
K11404  HDAC3; histone deacetylase 3 [EC:3.5.1.98]
K11405  HDAC8; histone deacetylase 8 [EC:3.5.1.98]
K11406  HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]
K11407  HDAC6; histone deacetylase 6 [EC:3.5.1.98]
K11408  HDAC7; histone deacetylase 7 [EC:3.5.1.98]
K11409  HDAC9; histone deacetylase 9 [EC:3.5.1.98]
K11418  HDAC11; histone deacetylase 11 [EC:3.5.1.98]
K11594  DDX3X, bel; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
K11643  CHD4, MI2B; chromodomain-helicase-DNA-binding protein 4 [EC:5.6.2.-]
K11838  USP7, UBP15; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
K12076  DLG1; disks large protein 1
K12496  EGR2; early growth response protein 2
K12497  EGR3; early growth response protein 3
K12886  HNRNPK; heterogeneous nuclear ribonucleoprotein K
K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
K15041  VDAC3; voltage-dependent anion channel protein 3
K15305  VAC14, TAX1BP2; vacuole morphology and inheritance protein 14
K15306  RANBP1; Ran-binding protein 1
K15413  SP100; nuclear body protein Sp100
K15979  SND1; staphylococcal nuclease domain-containing protein 1
K16174  MRPS18B, MRPS18-2; small subunit ribosomal protein S18b, mitochondrial
K16175  SCRIB; protein scribble
K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
K16197  YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16198  YWHAG_H; 14-3-3 protein gamma/eta
K16332  RBL2; retinoblastoma-like protein 2
K18671  HDAC10; histone deacetylase 10 [EC:3.5.1.98]
K19456  EBNALP; Lymphocryptovirus nuclear antigen leader protein
K19457  EBNA2; Lymphocryptovirus nuclear antigen 2
K19458  EBNA6, EBNA3C; Lymphocryptovirus nuclear antigen 6
K19459  LMP1; Lymphocryptovirus latent membrane protein 1
K19460  LMP2A; Lymphocryptovirus latent membrane protein 2A
K19461  EBNA1, BKRF1; Lymphocryptovirus nuclear antigen 1
K21649  ORF4; KSHV complement control protein
K21650  KIE1, ORF50; KSHV transcription activator ORF50
K21651  K15; KSHV signal transducing membrane protein
K21652  vIRF3; KSHV interferon regulatory factor-like protein 3
K21653  vIRF1, K9; KSHV interferon regulatory factor-like protein 1
K21654  vIRF2, K11; KSHV interferon regulatory factor-like protein 2
K21656  K12; KSHV protein K12
K21657  K4; KSHV macrophage inflammatory protein 2
K21658  K4.1; KSHV protein vCCL3
K21659  K6; KSHV protein K6
K21660  vBCL2, ORF16; KSHV apoptosis regulator BCL2 homolog
K21661  vIAP, K7; KSHV inhibitor of apoptosis protein
K21662  vFLIP, K13, ORF71; KSHV FLICE inhibitory protein
K21663  vCyclin, ORF72; KSHV cyclin homolog
K21664  vLANA, ORF73; KSHV latency-associated nuclear antigen
K21665  MIR1, K3; KSHV E3 ubiquitin-protein ligase MIR1 [EC:2.3.2.36]
K21666  MIR2, K5; KSHV E3 ubiquitin-protein ligase MIR2 [EC:2.3.2.36]
K21667  vGPCR; KSHV G-protein coupled receptor
K21669  K1; KSHV protein K1
K21670  vIL6, K2; KSHV interleukin 6
K21807  E6; Alphapapillomavirus protein E6
K21809  E7; Alphapapillomavirus protein E7
K21812  E5; Alphapapillomavirus protein E5
K21854  X; Orthohepadnavirus protein X
K21855  EBNA3, EBNA3A; Lymphocryptovirus nuclear antigen 3
K21856  EBNA4, EBNA3B; Lymphocryptovirus nuclear antigen 4
K21857  tax; Deltaretrovirus protein Tax-1
K21858  vIRF4, K10; KSHV interferon regulatory factor-like protein 4
K21859  KIE2, ORF45; KSHV transcription activator ORF45
K21860  K14; KSHV OX-2 membrane glycoprotein
K21861  ORF35; KSHV protein ORF35
K22271  Core; Hepatitis C virus core protein
K22273  NS3; Hepatitis C virus serine protease / helicase NS3 [EC:3.4.21.98 3.6.1.15 5.6.2.6]
K22275  NS5A; Hepatitis C virus non-structural protein 5A
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  Title
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Reference
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Reference
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HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
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Reference
PMID:12925958
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  Title
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Reference
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  Title
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Related
pathway
ko03022  Basal transcription factors
ko03320  PPAR signaling pathway
ko04010  MAPK signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04142  Lysosome
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04630  JAK-STAT signaling pathway
ko04662  B cell receptor signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection

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