KEGG   PATHWAY: sbq05167
Entry
sbq05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
sbq05167  Kaposi sarcoma-associated herpesvirus infection
sbq05167

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101044671  C3; complement C3 [KO:K03990]
101049918  TLR3; toll-like receptor 3 [KO:K05401]
101041287  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101043245  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
101027871  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101053608  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101034616  IRF7; interferon regulatory factor 7 [KO:K09447]
101032308  interferon alpha-8-like [KO:K05414]
101032622  interferon alpha-2-like [KO:K05414]
101032943  IFNA13; interferon alpha-1/13 [KO:K05414]
104649849  interferon alpha-5-like [KO:K05414]
101034105  interferon alpha-8-like [KO:K05414]
101034416  interferon alpha-5-like [KO:K05414]
101034728  IFNA21; interferon alpha-21 [KO:K05414]
101033122  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
101033803  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101050224  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
101035681  IFNB1; interferon beta [KO:K05415]
101035044  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101031615  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101028662  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
101030811  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101029836  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
101051991  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
101053943  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
101037444  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101044137  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101040899  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101052690  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101052249  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101030219  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101034302  ZFP36; tristetraprolin [KO:K15308]
101034757  IL6; interleukin-6 [KO:K05405]
101043583  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
101054252  CCR3; C-C chemokine receptor type 3 [KO:K04178]
101029550  CCR5; C-C chemokine receptor type 5 [KO:K04180]
101037693  CCR1; C-C chemokine receptor type 1 [KO:K04176]
101034328  CCR4; C-C chemokine receptor type 4 [KO:K04179]
101047374  CCR8; C-C chemokine receptor type 8 isoform X1 [KO:K04183]
101035635  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101046905  FADD; FAS-associated death domain protein [KO:K02373]
101053601  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101040331  BID; BH3-interacting domain death agonist [KO:K04726]
101050177  BAX; apoptosis regulator BAX [KO:K02159]
101041291  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101033270  cytochrome c [KO:K08738]
101034412  cytochrome c-like [KO:K08738]
101051525  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101029697  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
104649955  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
101050794  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
101035434  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101044006  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101052971  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101043425  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101048714  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101035787  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101035406  RELA; transcription factor p65 [KO:K04735]
101043647  TP53; cellular tumor antigen p53 [KO:K04451]
101041919  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
101040767  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101040507  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101038309  RB1; retinoblastoma-associated protein [KO:K06618]
101029045  E2F1; transcription factor E2F1 [KO:K17454]
101042612  E2F2; transcription factor E2F2 [KO:K09389]
101034207  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
101042893  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101043856  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101046108  HLA class I histocompatibility antigen, B-27 alpha chain-like [KO:K06751]
104650390  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
104650398  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
101032412  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101040674  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101041111  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101033054  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
101040568  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101040877  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
101044935  LOW QUALITY PROTEIN: popy class I histocompatibility antigen, alpha chain E [KO:K06751]
101050220  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101050865  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101054160  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
101054438  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
101043934  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
101033901  MICB; MHC class I polypeptide-related sequence B [KO:K07985]
101028387  MHC class I polypeptide-related sequence A-like [KO:K07985]
101038332  MHC class I polypeptide-related sequence A-like [KO:K07985]
101041254  CLEC2B; C-type lectin domain family 2 member B isoform X1 [KO:K10071]
101035967  ubiquitin-like [KO:K02927]
101039776  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
101029100  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
101031040  ubiquitin-like [KO:K02977]
101040915  beclin-2-like [KO:K08334]
101034503  BECN1; beclin-1 isoform X2 [KO:K08334]
101032849  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
101045444  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101046033  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
101049912  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
101047075  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
101028665  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
101041488  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101050677  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101030203  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101030409  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
101038619  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101041345  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101030348  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101037908  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101030524  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101044875  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101051683  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101046368  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101044114  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101047663  HRAS; GTPase HRas isoform X2 [KO:K02833]
101047035  KRAS; GTPase KRas isoform X1 [KO:K07827]
101036877  NRAS; GTPase NRas [KO:K07828]
101054052  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101040361  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101036151  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101038546  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101043202  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101044689  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
101043809  JUN; transcription factor AP-1 [KO:K04448]
101046701  FOS; proto-oncogene c-Fos [KO:K04379]
101028650  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101031169  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
101033790  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
101029768  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101052779  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101027982  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101032496  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101033359  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101050592  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101034861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101045714  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101040766  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101047083  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101033919  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X2 [KO:K12365]
101042808  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101039160  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101027742  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
101048066  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101044972  cell surface glycoprotein CD200 receptor 2 isoform X1 [KO:K21668]
101031617  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
101051959  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101032860  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
101036887  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
101037589  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101047840  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101030999  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101046976  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101029556  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101049881  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101048916  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101036413  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101031785  calmodulin-alpha-like [KO:K02183]
101041174  CALML6; calmodulin-like protein 6 isoform X2 [KO:K02183]
101029957  CALM3; calmodulin [KO:K02183]
101047982  CALM2; calmodulin [KO:K02183]
101039332  CALML3; calmodulin-like protein 3 [KO:K02183]
101039863  CALML5; calmodulin-like protein 5 [KO:K02183]
101049022  CALM1; LOW QUALITY PROTEIN: calmodulin [KO:K02183]
101045514  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101035788  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101032266  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101039659  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
104650539  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101049490  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101040060  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101043069  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101049298  CXCL8; interleukin-8 [KO:K10030]
101027603  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101048540  C-X-C motif chemokine 2 [KO:K05505]
101028380  RCAN1; calcipressin-1 [KO:K17901]
101030554  FGF2; fibroblast growth factor 2 [KO:K18497]
101032691  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
101043776  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101044719  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
101029979  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
101049662  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
101051107  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101043327  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101029076  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
101033762  TCF7L1; transcription factor 7-like 1 [KO:K04490]
101037011  TCF7L2; transcription factor 7-like 2 [KO:K04491]
101047688  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
101034085  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101047858  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
101047066  MYC; myc proto-oncogene protein isoform X2 [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
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Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10799607
  Authors
Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
  Journal
J Virol 74:5300-9 (2000)
DOI:10.1128/JVI.74.11.5300-5309.2000
Reference
PMID:17166914
  Authors
Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
  Journal
J Virol 81:2117-27 (2007)
DOI:10.1128/JVI.01961-06
Reference
PMID:18230726
  Authors
Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
  Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
  Journal
Proc Natl Acad Sci U S A 105:1656-61 (2008)
DOI:10.1073/pnas.0707883105
Reference
PMID:11413168
  Authors
Coscoy L, Ganem D
  Title
A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
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J Clin Invest 107:1599-606 (2001)
DOI:10.1172/JCI12432
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PMID:24710493
  Authors
Pratt ZL, Sugden B
  Title
How human tumor viruses make use of autophagy.
  Journal
Cells 1:617-30 (2012)
DOI:10.3390/cells1030617
Reference
PMID:10354594
  Authors
Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
  Journal
Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
Reference
PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
  Journal
Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:12770701
  Authors
Verma SC, Robertson ES
  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
  Journal
FEMS Microbiol Lett 222:155-63 (2003)
DOI:10.1016/S0378-1097(03)00261-1
Reference
PMID:11960692
  Authors
Jenner RG, Boshoff C
  Title
The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
  Journal
Biochim Biophys Acta 1602:1-22 (2002)
DOI:10.1016/S0304-419X(01)00040-3
Reference
PMID:15220441
  Authors
Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN
  Title
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
  Journal
J Virol 78:7667-76 (2004)
DOI:10.1128/JVI.78.14.7667-7676.2004
Reference
PMID:10987301
  Authors
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
  Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
  Journal
Cancer Res 60:4873-80 (2000)
Reference
PMID:27518127
  Authors
Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
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Curr Opin Virol 20:11-19 (2016)
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Reference
PMID:15573137
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Sodhi A, Montaner S, Gutkind JS
  Title
Viral hijacking of G-protein-coupled-receptor signalling networks.
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Nat Rev Mol Cell Biol 5:998-1012 (2004)
DOI:10.1038/nrm1529
Reference
PMID:17329974
  Authors
Montaner S
  Title
Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
  Journal
Cell Cycle 6:438-43 (2007)
DOI:10.4161/cc.6.4.3843
Reference
PMID:23028325
  Authors
Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
  Journal
PLoS Pathog 8:e1002927 (2012)
DOI:10.1371/journal.ppat.1002927
Reference
PMID:10318948
  Authors
Lagunoff M, Majeti R, Weiss A, Ganem D
  Title
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
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Proc Natl Acad Sci U S A 96:5704-9 (1999)
DOI:10.1073/pnas.96.10.5704
Reference
PMID:26192396
  Authors
Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D
  Title
Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
  Journal
Rev Med Virol 25:273-85 (2015)
DOI:10.1002/rmv.1843
Reference
PMID:25187543
  Authors
Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
  Title
Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
  Journal
J Virol 88:13161-72 (2014)
DOI:10.1128/JVI.01766-14
Reference
PMID:17050609
  Authors
Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
J Virol 81:42-58 (2007)
DOI:10.1128/JVI.00648-06
Reference
PMID:16585191
  Authors
Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
  Title
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
Cancer Res 66:3658-66 (2006)
DOI:10.1158/0008-5472.CAN-05-3680
Reference
PMID:22521915
  Authors
Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
  Title
The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
  Journal
Virology 428:112-20 (2012)
DOI:10.1016/j.virol.2012.03.013
Reference
PMID:25594835
  Authors
Purushothaman P, Uppal T, Verma SC
  Title
Molecular biology of KSHV lytic reactivation.
  Journal
Viruses 7:116-53 (2015)
DOI:10.3390/v7010116
Reference
PMID:14991150
  Authors
Fujimuro M, Hayward SD
  Title
Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
  Journal
J Mol Med (Berl) 82:223-31 (2004)
DOI:10.1007/s00109-003-0519-7
Reference
PMID:26870016
  Authors
Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
  Title
KSHV Genome Replication and Maintenance.
  Journal
Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
Related
pathway
sbq04010  MAPK signaling pathway
sbq04064  NF-kappa B signaling pathway
sbq04110  Cell cycle
sbq04115  p53 signaling pathway
sbq04140  Autophagy - animal
sbq04144  Endocytosis
sbq04151  PI3K-Akt signaling pathway
sbq04210  Apoptosis
sbq04310  Wnt signaling pathway
sbq04610  Complement and coagulation cascades
sbq04620  Toll-like receptor signaling pathway
sbq04630  JAK-STAT signaling pathway
sbq04650  Natural killer cell mediated cytotoxicity
sbq04668  TNF signaling pathway
KO pathway
ko05167   
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