KEGG   PATHWAY: slal04148
Entry
slal04148                   Pathway                                
Name
Efferocytosis - Seriola lalandi dorsalis (Yellowtail amberjack)
Class
Cellular Processes; Transport and catabolism
Pathway map
slal04148  Efferocytosis
slal04148

Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111663309  caspase-3-like [KO:K02187] [EC:3.4.22.56]
111667597  caspase-3-like [KO:K02187] [EC:3.4.22.56]
111664455  caspase-3-like [KO:K04397] [EC:3.4.22.60]
111669656  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
111654143  caspase-1-A-like isoform X1 [KO:K01370] [EC:3.4.22.36]
111666650  panx1; pannexin-1 [KO:K03443]
111647557  pannexin-1-like isoform X1 [KO:K03443]
111648978  P2Y purinoceptor 2-like [KO:K04269]
111648825  p2ry6; P2Y purinoceptor 6 [KO:K04272]
111655153  P2Y purinoceptor 12-like [KO:K04298]
111659689  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
111647507  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
111652178  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
111668245  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
111673436  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
111659723  ATP-binding cassette sub-family A member 1-like isoform X1 [KO:K05641]
111665601  ATP-binding cassette sub-family A member 1-like isoform X1 [KO:K05641]
111669992  ATP-binding cassette sub-family A member 1-like [KO:K05641]
111665943  ATP-binding cassette sub-family A member 1-like isoform X1 [KO:K05641]
111646979  probable G-protein coupled receptor 132 [KO:K08426]
111645972  probable G-protein coupled receptor 132 [KO:K08426]
111644771  adam17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
111672592  disintegrin and metalloproteinase domain-containing protein 17-like [KO:K06059] [EC:3.4.24.86]
111666982  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
111655135  adam10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
111654257  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
111660684  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
111644232  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
111658107  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111645629  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
111659127  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111654253  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
111668383  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
111655237  epas1; endothelial PAS domain-containing protein 1 isoform X1 [KO:K08268]
111651106  hif1a; hypoxia-inducible factor 1-alpha [KO:K08268]
111657960  hypoxia-inducible factor 3-alpha-like isoform X1 [KO:K08268]
111652194  aryl hydrocarbon receptor nuclear translocator-like isoform X1 [KO:K09097]
111646990  epo; erythropoietin [KO:K05437]
111662520  erythropoietin receptor-like [KO:K05079]
111665981  jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
111651535  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
111657703  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111660943  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111661872  CCAAT/enhancer-binding protein beta-like [KO:K10048]
111658805  peroxisome proliferator-activated receptor gamma-like [KO:K08530]
111670200  pparg; peroxisome proliferator-activated receptor gamma [KO:K08530]
111667647  peroxisome proliferator-activated receptor gamma-like [KO:K08530]
111655951  rxra; retinoic acid receptor RXR-alpha [KO:K08524]
111668805  retinoic acid receptor RXR-beta-A-like [KO:K08524]
111661160  lactadherin-like isoform X1 [KO:K17253]
111650402  lactadherin-like isoform X1 [KO:K17253]
111668324  gas6; growth arrest-specific protein 6 [KO:K05464]
111658974  tyrosine-protein kinase Mer-like [KO:K05117] [EC:2.7.10.1]
111660053  cd36; platelet glycoprotein 4 [KO:K06259]
111661462  thrombospondin-1-like [KO:K16857]
111663195  thrombospondin-1-like [KO:K16857]
111667016  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
111652614  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
111656372  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111645378  ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
111646041  prostaglandin E2 receptor EP2 subtype-like [KO:K04259]
111667910  prostaglandin E2 receptor EP2 subtype-like [KO:K04259]
111671080  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
111645129  prostaglandin E2 receptor EP4 subtype-like isoform X1 [KO:K04261]
111669979  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
111668043  ptger4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
111661597  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
111673100  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
111673158  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
111665325  cyclic AMP-responsive element-binding protein 1 [KO:K05870]
111652073  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
111662255  transforming growth factor beta-1-like [KO:K13375]
111657700  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
111663974  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like isoform X1 [KO:K05853] [EC:7.2.2.10]
111647600  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
111652250  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
111652995  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
111647980  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
111645319  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
111663086  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
111664493  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
111673541  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
111669788  calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
111659482  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
111667982  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
111650024  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
111670673  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111667674  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111667284  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111653210  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
111661800  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111667336  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
111667810  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
111667188  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04443] [EC:2.7.11.1]
111654678  alox5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
111655609  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111655750  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111670187  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111668520  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111661802  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111672175  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111656020  dusp16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111660999  dual specificity protein phosphatase 2-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111663683  ano6; anoctamin-6 isoform X1 [KO:K19500]
111666886  ano3; anoctamin-3 isoform X1 [KO:K19498]
111654772  ano4; anoctamin-4 isoform X1 [KO:K19499]
111668327  anoctamin-5-like [KO:K19480]
111666887  ano5; anoctamin-5 isoform X1 [KO:K19480]
111663336  ano7; anoctamin-7 [KO:K19501]
111656214  anoctamin-7-like isoform X1 [KO:K19501]
111666873  anoctamin-9-like isoform X1 [KO:K19503]
111669313  anoctamin-9-like [KO:K19503]
111657470  bsg; basigin isoform X1 [KO:K06535]
111655029  XK-related protein 8-like [KO:K26813]
111655031  XK-related protein 8-like [KO:K26813]
111662874  xkr9; XK-related protein 9 [KO:K26814]
111644257  XK-related protein 7-like [KO:K26811]
111661860  XK-related protein 7-like [KO:K26811]
111648356  xkr4; XK-related protein 4 [KO:K26811]
111645996  XK-related protein 6-like [KO:K26811]
111665221  xkr6; XK-related protein 6 [KO:K26811]
111662997  atp8a2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
111648157  atp8a1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
111671671  atp11b; probable phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
111654355  probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
111665308  probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
111651638  cell cycle control protein 50A-like [KO:K26935]
111645243  cell cycle control protein 50A-like [KO:K26935]
111668353  pros1; vitamin K-dependent protein S isoform X1 [KO:K03908]
111659520  itgav; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
111657078  itgb3; integrin beta-3 isoform X1 [KO:K06493]
111658453  integrin beta-3-like [KO:K06493]
111654088  itgb5; integrin beta-5 [KO:K06588]
111662207  axl; tyrosine-protein kinase receptor UFO [KO:K05115] [EC:2.7.10.1]
111672844  tyro3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
111664426  adgrb1; adhesion G protein-coupled receptor B1 [KO:K04596]
111657633  adhesion G protein-coupled receptor B1-like isoform X1 [KO:K04596]
111662318  stab1; stabilin-1 [KO:K19020]
111647799  stab2; stabilin-2 [KO:K19013]
111657213  focal adhesion kinase 1-like [KO:K05725] [EC:2.7.10.2]
111662376  ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111647742  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
111671297  adapter molecule crk-like [KO:K04438]
111655640  crkl; crk-like protein [KO:K04438]
111656071  adapter molecule crk-like [KO:K04438]
111659257  engulfment and cell motility protein 1 isoform X1 [KO:K12366]
111655245  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
111667536  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
111672005  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111649397  adam9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
111660188  disintegrin and metalloproteinase domain-containing protein 9-like isoform X1 [KO:K06834] [EC:3.4.24.-]
111651878  calreticulin-like [KO:K08057]
111669159  calreticulin-like [KO:K08057]
111671697  calreticulin-like [KO:K08057]
111657333  complement C1q subcomponent subunit B-like [KO:K03987]
111650554  complement C1q subcomponent subunit B-like [KO:K03987]
111657321  complement C1q subcomponent subunit C-like [KO:K03988]
111657322  LOW QUALITY PROTEIN: complement C1q subcomponent subunit C-like [KO:K03988]
111667743  low-density lipoprotein receptor-related protein 1-like [KO:K04550]
111668950  low-density lipoprotein receptor-related protein 1-like [KO:K04550]
111666916  multiple epidermal growth factor-like domains protein 11 [KO:K24068]
111648056  megf10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
111656885  multiple epidermal growth factor-like domains protein 11 [KO:K24068]
111668126  scarf1; scavenger receptor class F member 1 [KO:K24318]
111667447  gulp1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
111653225  PTB domain-containing engulfment adapter protein 1-like [KO:K23285]
111657159  ras-related protein Rab-17-like [KO:K07909]
111659338  ras-related protein Rab-5A [KO:K07887]
111652636  ras-related protein Rab-5A [KO:K07887]
111659545  ras-related protein Rab-5B-like [KO:K07888]
111652822  rab5c; ras-related protein Rab-5C [KO:K07889]
111665760  ras-related protein Rab-5C-like [KO:K07889]
111657106  ras-related protein Rab-5C-like [KO:K07889]
111668342  tgfbrap1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
111651005  transforming growth factor-beta receptor-associated protein 1-like [KO:K20177]
111672943  vps8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
111654021  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
111669699  vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
111672717  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
111644891  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
111664731  rab14; ras-related protein Rab-14 [KO:K07881]
111653115  ras-related protein Rab-14-like [KO:K07881]
111646808  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
111656603  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
111670680  ras-related protein Rab-7a-like [KO:K07897]
111649239  ras-related protein rab7-like [KO:K07897]
111667766  ras-related protein rab7-like [KO:K07897]
111670952  ras-related protein rab7 [KO:K07897]
111650008  pqlc2; lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
111652643  lysosomal amino acid transporter 1 homolog [KO:K23678]
111657045  arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
111670607  arginase-2, mitochondrial-like [KO:K01476] [EC:3.5.3.1]
111646803  arg2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
111645548  odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
111647921  cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
111666783  cholesterol 25-hydroxylase-like protein 2 [KO:K10223] [EC:1.14.99.38]
111670054  cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
111657183  ch25h; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
111667029  cholesterol 25-hydroxylase-like protein 1, member 2 [KO:K10223] [EC:1.14.99.38]
111667050  cholesterol 25-hydroxylase-like protein 1, member 1 [KO:K10223] [EC:1.14.99.38]
111644318  nr1h3; oxysterols receptor LXR-alpha [KO:K08536]
111658709  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
111671246  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
111662452  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
111661771  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
111661846  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
111669311  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
111669537  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
111653533  pre-B-cell leukemia transcription factor 1-like isoform X1 [KO:K09355]
111662587  pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
111667880  il10; interleukin-10 [KO:K05443]
111655119  lipa; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
111658751  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
111670756  ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
111657929  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
111658845  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
111646791  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
111644188  monocarboxylate transporter 1-like [KO:K08179]
111662369  slc16a1; monocarboxylate transporter 1 [KO:K08179]
111650865  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
111655039  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
111651204  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
111647527  LOW QUALITY PROTEIN: platelet endothelial cell adhesion molecule-like [KO:K06471]
111655472  platelet endothelial cell adhesion molecule-like isoform X1 [KO:K06471]
111657449  sialic acid-binding Ig-like lectin 10 [KO:K06749]
111668724  uncharacterized protein LOC111668724 [KO:K06551]
111649494  V-set domain-containing T-cell activation inhibitor 1-like [KO:K06551]
111669899  ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
111666017  ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
111656118  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
slal00010  Glycolysis / Gluconeogenesis
slal04140  Autophagy - animal
slal04145  Phagosome
KO pathway
ko04148   
LinkDB

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