KEGG   PATHWAY: srx04512
Entry
srx04512                    Pathway                                
Name
ECM-receptor interaction - Sinocyclocheilus rhinocerous
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
srx04512  ECM-receptor interaction
srx04512

Other DBs
GO: 0005201
Organism
Sinocyclocheilus rhinocerous [GN:srx]
Gene
107722140  collagen alpha-2(I) chain-like [KO:K06236]
107708989  collagen alpha-1(I) chain-like isoform X1 [KO:K06236]
107717204  collagen alpha-1(I) chain-like [KO:K06236]
107720033  collagen alpha-1(I) chain-like [KO:K06236]
107731699  collagen alpha-2(I) chain-like [KO:K06236]
107740634  collagen alpha-1(I) chain-like isoform X1 [KO:K06236]
107731244  collagen alpha-1(II) chain-like [KO:K19719]
107742021  collagen alpha-1(II) chain isoform X1 [KO:K19719]
107715436  collagen alpha-1(II) chain-like isoform X1 [KO:K19719]
107730819  LOW QUALITY PROTEIN: collagen alpha-4(IV) chain-like [KO:K06237]
107711567  col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
107711551  collagen alpha-6(IV) chain-like [KO:K06237]
107715897  collagen alpha-2(IV) chain-like [KO:K06237]
107715912  collagen alpha-1(IV) chain-like isoform X1 [KO:K06237]
107721566  collagen alpha-2(IV) chain-like [KO:K06237]
107721605  collagen alpha-1(IV) chain-like isoform X1 [KO:K06237]
107707901  collagen alpha-5(IV) chain-like [KO:K06237]
107739767  collagen alpha-5(IV) chain-like [KO:K06237]
107750310  collagen alpha-6(IV) chain-like [KO:K06237]
107755689  collagen alpha-6(VI) chain-like [KO:K06238]
107725234  collagen alpha-3(VI) chain-like [KO:K06238]
107723650  collagen alpha-3(VI) chain-like [KO:K06238]
107705786  collagen alpha-6(VI) chain-like [KO:K06238]
107715812  collagen alpha-1(VI) chain-like [KO:K06238]
107715814  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
107718214  collagen alpha-1(VI) chain-like isoform X1 [KO:K06238]
107718216  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
107734282  collagen alpha-6(VI) chain-like [KO:K06238]
107734283  collagen alpha-6(VI) chain-like [KO:K06238]
107722164  collagen alpha-2(IX) chain-like [KO:K08131]
107718896  collagen alpha-1(IX) chain-like [KO:K08131]
107719903  collagen alpha-3(IX) chain-like [KO:K08131]
107713563  collagen alpha-3(IX) chain-like isoform X1 [KO:K08131]
107712764  collagen alpha-2(IX) chain-like [KO:K08131]
107753862  collagen alpha-1(IX) chain-like [KO:K08131]
107747272  collagen alpha-1(IX) chain-like [KO:K08131]
107736861  collagen alpha-1(IX) chain-like [KO:K08131]
107727315  collagen alpha-2(IX) chain-like [KO:K08131]
107711612  lama2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
107740527  LOW QUALITY PROTEIN: laminin subunit alpha-2-like [KO:K05637]
107747483  laminin subunit alpha-1-like [KO:K05637]
107743991  laminin subunit alpha-1-like [KO:K05637]
107705144  laminin subunit alpha-3-like [KO:K06240]
107708592  laminin subunit alpha-3-like [KO:K06240]
107727012  LOW QUALITY PROTEIN: laminin subunit alpha-5-like [KO:K06240]
107705651  laminin subunit alpha-5-like [KO:K06240]
107715692  lama4; laminin subunit alpha-4 [KO:K06241]
107712496  lamb1; laminin subunit beta-1 [KO:K05636]
107739090  laminin subunit beta-1-like [KO:K05636]
107755155  laminin subunit beta-1-like [KO:K05636]
107737682  laminin subunit beta-2-like [KO:K06243]
107712697  laminin subunit beta-2-like [KO:K06243]
107737594  laminin subunit beta-2-like isoform X1 [KO:K06243]
107712713  laminin subunit beta-1-like [KO:K06243]
107710800  lamb3; laminin subunit beta-3 [KO:K06244]
107712510  laminin subunit beta-4-like [KO:K06245]
107722047  laminin subunit gamma-1 [KO:K05635]
107726890  laminin subunit gamma-1-like [KO:K05635]
107722066  laminin subunit gamma-2-like [KO:K06246]
107726891  LOW QUALITY PROTEIN: laminin subunit gamma-2-like [KO:K06246]
107757520  laminin subunit gamma-3-like [KO:K06247]
107718641  laminin subunit gamma-3-like [KO:K06247]
107706882  chondroadherin-like [KO:K06248]
107727306  chondroadherin-like [KO:K06248]
107728186  reelin-like [KO:K06249] [EC:3.4.21.-]
107711363  reln; reelin [KO:K06249] [EC:3.4.21.-]
107719693  thrombospondin-1-like [KO:K16857]
107721311  thrombospondin-1-like [KO:K16857]
107743901  thrombospondin-1-like isoform X1 [KO:K16857]
107756566  thrombospondin-1-like [KO:K16857]
107756306  thrombospondin-4-B-like isoform X1 [KO:K04659]
107755534  thrombospondin-2-like isoform X1 [KO:K04659]
107719129  thrombospondin-3a [KO:K04659]
107705413  thrombospondin-2-like [KO:K04659]
107720209  thrombospondin-4-B-like [KO:K04659]
107705968  thrombospondin-4-B-like [KO:K04659]
107714313  thrombospondin-3a-like [KO:K04659]
107731553  thrombospondin-3b-like [KO:K04659]
107707836  thrombospondin-2-like [KO:K04659]
107739867  thrombospondin-2-like isoform X1 [KO:K04659]
107747026  thrombospondin-4-like [KO:K04659]
107738600  thrombospondin-3b [KO:K04659]
107733073  thrombospondin-4-like [KO:K04659]
107737158  thrombospondin-4-B [KO:K04659]
107721590  fibronectin-like [KO:K05717]
107716781  fibronectin-like [KO:K05717]
107731971  vitronectin-like [KO:K06251]
107725145  LOW QUALITY PROTEIN: tenascin-like [KO:K06252]
107709842  tenascin-like [KO:K06252]
107715756  tenascin-like [KO:K06252]
107724633  tenascin-like [KO:K06252]
107722078  tenascin-N-like isoform X1 [KO:K06252]
107726886  LOW QUALITY PROTEIN: tenascin-R-like [KO:K06252]
107722042  tenascin-R-like [KO:K06252]
107726927  tenascin-N-like isoform X1 [KO:K06252]
107757727  tenascin-X-like isoform X1 [KO:K06252]
107715542  tenascin-like [KO:K06252]
107729354  nephronectin-like isoform X1 [KO:K06824]
107757009  nephronectin-like isoform X1 [KO:K06824]
107750194  nephronectin-like [KO:K06824]
107746850  extracellular matrix protein FRAS1-like [KO:K23379]
107752371  extracellular matrix protein FRAS1-like [KO:K23379]
107730863  FRAS1-related extracellular matrix protein 2-like [KO:K23380]
107715059  FRAS1-related extracellular matrix protein 1-like [KO:K23380]
107720635  FRAS1-related extracellular matrix protein 2-like isoform X1 [KO:K23380]
107728586  FRAS1-related extracellular matrix protein 1-like [KO:K23380]
107738332  frem1; FRAS1-related extracellular matrix protein 1 [KO:K23380]
107718779  FRAS1-related extracellular matrix protein 2-like [KO:K23380]
107752721  FRAS1-related extracellular matrix protein 2-like [KO:K23380]
107736173  vwf; von Willebrand factor [KO:K03900]
107716114  LOW QUALITY PROTEIN: agrin-like [KO:K06254]
107737670  agrin-like [KO:K06254]
107745451  basement membrane-specific heparan sulfate proteoglycan core protein-like [KO:K06255]
107716070  basement membrane-specific heparan sulfate proteoglycan core protein-like [KO:K06255]
107713335  itga1; integrin alpha-1 isoform X1 [KO:K06480]
107713336  integrin alpha-2-like [KO:K06481]
107713338  integrin alpha-2-like [KO:K06481]
107744091  integrin alpha-2-like [KO:K06481]
107744146  integrin alpha-2-like [KO:K06481]
107725055  integrin alpha-8-like [KO:K06476]
107708875  LOW QUALITY PROTEIN: integrin alpha-3-like [KO:K06482]
107709989  integrin alpha-3-like [KO:K06482]
107739753  itga3; integrin alpha-3 [KO:K06482]
107755364  itga4; integrin alpha-4 [KO:K06483]
107717001  integrin alpha-4-like isoform X1 [KO:K06483]
107756357  itga5; integrin alpha-5 [KO:K06484]
107723722  integrin alpha-5-like [KO:K06484]
107740164  integrin alpha-6-like isoform X1 [KO:K06485]
107738477  integrin alpha-6-like [KO:K06485]
107745248  LOW QUALITY PROTEIN: integrin alpha-6-like [KO:K06485]
107708686  integrin alpha-6-like [KO:K06485]
107742949  integrin alpha-6-like [KO:K06485]
107713863  integrin alpha-7-like [KO:K06583]
107713866  integrin alpha-7-like isoform X1 [KO:K06583]
107717802  integrin alpha-8-like [KO:K06584]
107738861  itga8; integrin alpha-8 [KO:K06584]
107733329  itga9; integrin alpha-9 [KO:K06585]
107754575  integrin alpha-9-like [KO:K06585]
107707172  integrin alpha-10-like [KO:K06586]
107743189  integrin alpha-10-like [KO:K06586]
107745098  integrin alpha-11-like isoform X1 [KO:K06587]
107738627  integrin alpha-11-like [KO:K06587]
107740496  integrin alpha-11-like [KO:K06587]
107755089  integrin alpha-11-like [KO:K06587]
107749889  itgav; integrin alpha-V [KO:K06487]
107752904  integrin alpha-V-like [KO:K06487]
107749113  integrin beta-1-A-like [KO:K05719]
107734314  integrin beta-1-like [KO:K05719]
107713907  integrin beta-1-like [KO:K05719]
107721734  integrin beta-1-like [KO:K05719]
107727289  integrin beta-3-like [KO:K06493]
107706862  integrin beta-3-like [KO:K06493]
107754700  integrin beta-3-like isoform X1 [KO:K06493]
107725294  LOW QUALITY PROTEIN: integrin beta-4-like [KO:K06525]
107758026  integrin beta-4-like isoform X1 [KO:K06525]
107725247  integrin beta-5-like isoform X1 [KO:K06588]
107723672  integrin beta-5-like [KO:K06588]
107718899  integrin beta-6-like [KO:K06589]
107747010  integrin beta-6-like [KO:K06589]
107711053  integrin beta-7-like [KO:K06590]
107740576  integrin beta-7-like [KO:K06590]
107709728  integrin beta-8-like [KO:K06591]
107755959  itgb8; integrin beta-8 isoform X1 [KO:K06591]
107749566  CD44 antigen-like [KO:K06256]
107740054  CD44 antigen-like [KO:K06256]
107708113  syndecan-4-like [KO:K16338]
107723923  syndecan-4-like [KO:K16338]
107755746  synaptic vesicle glycoprotein 2C-like isoform X1 [KO:K06258]
107720517  synaptic vesicle glycoprotein 2B-like [KO:K06258]
107731077  synaptic vesicle glycoprotein 2C-like [KO:K06258]
107728488  sv2a; LOW QUALITY PROTEIN: synaptic vesicle glycoprotein 2A [KO:K06258]
107714041  synaptic vesicle glycoprotein 2B-like [KO:K06258]
107726650  synaptic vesicle glycoprotein 2A-like [KO:K06258]
107713605  synaptic vesicle glycoprotein 2C-like [KO:K06258]
107738666  synaptic vesicle glycoprotein 2B-like [KO:K06258]
107748435  synaptic vesicle glycoprotein 2C-like [KO:K06258]
107710677  cd36; platelet glycoprotein 4 [KO:K06259]
107755879  platelet glycoprotein 4-like [KO:K06259]
107715693  platelet glycoprotein V-like [KO:K06260]
107741564  platelet glycoprotein V-like [KO:K06260]
107737937  platelet glycoprotein Ib alpha chain-like [KO:K06261]
107714586  platelet glycoprotein Ib beta chain-like [KO:K06262]
107713039  platelet glycoprotein Ib beta chain-like isoform X1 [KO:K06262]
107736950  platelet glycoprotein IX-like [KO:K06263]
107757307  dystroglycan-like [KO:K06265]
107708488  dystroglycan-like [KO:K06265]
107707212  hyaluronan-mediated motility receptor-like [KO:K06267]
107751923  hyaluronan mediated motility receptor-like isoform X1 [KO:K06267]
Compound
G10505  Hyaluronic acid
Reference
PMID:11572082
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
PMID:12921709
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
PMID:12125070
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
PMID:12796473
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
PMID:10617638
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
PMID:15036264
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
PMID:15381249
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
PMID:11331578
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
PMID:12736199
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
PMID:15229478
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
PMID:12845610
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
PMID:29079659
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
srx04510  Focal adhesion
KO pathway
ko04512   
LinkDB

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