Entry Name Yersinia infection - Trichechus manatus latirostris (Florida manatee)
Description Pathogenic Yersinia injects virulent Yersinia outer proteins (Yops) into the host cell through a type three secretion system (T3SS) to express its pathogenicity. Through inactivation of small GTPases by YopT protease, YopE GTPase-activating protein, and YpkA/YopO sequestration of GDP-bound small GTPases, Yersinia prevents its uptake by phagocytic cells and disrupts the actin cytoskeleton. YopH phosphatase shuts down phagocytosis by dephosphorylating key host proteins as well as suppresses T cell activation. Yersinia induces macrophage pyroptosis via YopB/YopD activation of canonical and noncanonical inflammasomes and YopT/YopE-mediated activation of pyrin. These effects are counteracted by YopK and YopM. YopP/J is a member of an ubiquitin-like protein cysteine protease family and simultaneously targets signaling components of the MAPK and NF-kappaB signaling pathways following activation of Toll-like receptor4 to inhibit production of proinflammatory cytokines.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map Ortholog table Organism Trichechus manatus latirostris (Florida manatee) [GN:
tmu ]
Gene 111820845 LOW QUALITY PROTEIN: uncharacterized protein LOC111820845 [KO:K06856 ]
101350744 low affinity immunoglobulin gamma Fc region receptor III-like isoform X1 [KO:K06472 ]
101355428 ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
101354182 actin-related protein 2/3 complex subunit 3 isoform X3 [KO:K05756 ]
101360925 actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
101345102 brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627 ]
101350066 LOW QUALITY PROTEIN: ARF GTPase-activating protein GIT2 [KO:K12487 ]
101347192 guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634 ]
101343031 NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800 ]
101360631 NLR family CARD domain-containing protein 4 isoform X1 [KO:K12805 ]
101357919 apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
101341326 myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
101344618 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
101355146 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
101358678 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
101346849 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
101359658 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
101351035 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
101343804 phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
101347746 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
101343469 T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458 ]
101361451 LOW QUALITY PROTEIN: uncharacterized protein LOC101361451 [KO:K10785 ]
101356413 linker for activation of T-cells family member 1 isoform X2 [KO:K07362 ]
101359059 nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
101355751 nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332 ]
101352434 nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Pha K, Navarro L
Title Yersinia type III effectors perturb host innate immune responses.
Journal Reference Authors Pinaud L, Sansonetti PJ, Phalipon A
Title Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal Reference Authors Huveneers S, Danen EH
Title Adhesion signaling - crosstalk between integrins, Src and Rho.
Journal Reference Authors Angot A, Vergunst A, Genin S, Peeters N
Title Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systems.
Journal Reference Authors Bliska JB
Title Yop effectors of Yersinia spp. and actin rearrangements.
Journal Reference Authors Gustavsson A, Yuan M, Fallman M
Title Temporal dissection of beta1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation.
Journal Reference Authors Bruce-Staskal PJ, Weidow CL, Gibson JJ, Bouton AH
Title Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake.
Journal J Cell Sci 115:2689-700 (2002)
Reference Authors McGee K, Zettl M, Way M, Fallman M
Title A role for N-WASP in invasin-promoted internalisation.
Journal Reference Authors Pizarro-Cerda J, Cossart P
Title Subversion of phosphoinositide metabolism by intracellular bacterial pathogens.
Journal Reference Authors Chung LK, Park YH, Zheng Y, Brodsky IE, Hearing P, Kastner DL, Chae JJ, Bliska JB
Title The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome.
Journal Reference Authors Schotte P, Denecker G, Van Den Broeke A, Vandenabeele P, Cornelis GR, Beyaert R
Title Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta.
Journal Reference Authors Orth K, Palmer LE, Bao ZQ, Stewart S, Rudolph AE, Bliska JB, Dixon JE
Title Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector.
Journal Reference Authors Zhou H, Monack DM, Kayagaki N, Wertz I, Yin J, Wolf B, Dixit VM
Title Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation.
Journal Reference Authors Haase R, Richter K, Pfaffinger G, Courtois G, Ruckdeschel K
Title Yersinia outer protein P suppresses TGF-beta-activated kinase-1 activity to impair innate immune signaling in Yersinia enterocolitica-infected cells.
Journal Reference Authors Thiefes A, Wolf A, Doerrie A, Grassl GA, Matsumoto K, Autenrieth I, Bohn E, Sakurai H, Niedenthal R, Resch K, Kracht M
Title The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.
Journal Reference Authors Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC
Title A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4.
Journal Reference Authors Rolan HG, Durand EA, Mecsas J
Title Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection.
Journal Reference Authors Alonso A, Bottini N, Bruckner S, Rahmouni S, Williams S, Schoenberger SP, Mustelin T
Title Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH.
Journal Related tmu04620 Toll-like receptor signaling pathway
tmu04621 NOD-like receptor signaling pathway
tmu04660 T cell receptor signaling pathway
tmu04666 Fc gamma R-mediated phagocytosis
tmu04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
