KEGG   PATHWAY: vvp05165
Entry
vvp05165                    Pathway                                
Name
Human papillomavirus infection - Vulpes vulpes (red fox)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
vvp05165  Human papillomavirus infection
vvp05165

Organism
Vulpes vulpes (red fox) [GN:vvp]
Gene
112921098  WNT1; proto-oncogene Wnt-1 isoform X1 [KO:K03209]
112907938  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
112929869  WNT2; protein Wnt-2 [KO:K00182]
112911970  WNT3A; protein Wnt-3a [KO:K00312]
112920633  WNT3; proto-oncogene Wnt-3 [KO:K00312]
112929848  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
112909974  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
112917420  WNT5B; protein Wnt-5b [KO:K00444]
112922542  WNT6; protein Wnt-6 [KO:K00445]
112914456  WNT7A; protein Wnt-7a [KO:K00572]
112935842  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
112914893  WNT8B; protein Wnt-8b [KO:K00714]
112921902  WNT8A; protein Wnt-8a [KO:K00714]
112911976  WNT9A; protein Wnt-9a [KO:K01064]
112920632  WNT9B; protein Wnt-9b [KO:K01064]
112922477  WNT10A; protein Wnt-10a [KO:K01357]
112921097  WNT10B; protein Wnt-10b [KO:K01357]
112928634  WNT11; protein Wnt-11 [KO:K01384]
112910612  WNT16; protein Wnt-16 [KO:K01558]
112923874  FZD1; frizzled-1 [KO:K02432]
112922796  FZD7; frizzled-7 [KO:K02432]
112910678  FZD2; frizzled-2 [KO:K02235]
112926772  FZD3; frizzled-3 [KO:K02329]
112932336  FZD4; frizzled-4 [KO:K02354]
112922465  FZD5; frizzled-5 [KO:K02375]
112921504  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
112916996  FZD6; frizzled-6 [KO:K02376]
112933856  FZD10; frizzled-10 [KO:K02842]
112935737  FZD9; frizzled-9 [KO:K02842]
112926256  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
112924817  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
112926150  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
112913469  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112909128  AXIN1; axin-1 isoform X1 [KO:K02157]
112920730  AXIN2; axin-2 isoform X1 [KO:K04385]
112935524  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
112915436  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
112921625  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
112927455  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
112935454  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
112917059  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
112916685  TCF7L1; transcription factor 7-like 1 [KO:K04490]
112916157  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
112907083  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
112934769  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
112935599  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
112930285  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
112914364  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
112922304  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
112931284  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
112921940  IFNB1; interferon beta [KO:K05415]
112923265  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
112934069  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
112933734  TADA3; transcriptional adapter 3 [KO:K11315]
112924853  TP53; cellular tumor antigen p53 [KO:K04451]
112909211  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
112931976  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112921564  PARD3; partitioning defective 3 homolog [KO:K04237]
112919260  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
112929426  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
112931916  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
112926694  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
112926173  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
112929847  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112911155  SCRIB; protein scribble homolog [KO:K16175]
112913543  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
112932292  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
112907643  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
112920794  LLGL2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
112924955  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
112911837  CRB3; protein crumbs homolog 3 [KO:K06090]
112926080  PATJ; inaD-like protein isoform X1 [KO:K06092]
112927182  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
112917517  VWF; von Willebrand factor [KO:K03900]
112919933  THBS1; thrombospondin-1 [KO:K16857]
112919585  THBS4; thrombospondin-4 [KO:K04659]
112918914  THBS3; thrombospondin-3 [KO:K04659]
112913266  COMP; cartilage oligomeric matrix protein [KO:K04659]
112922696  THBS2; thrombospondin-2 [KO:K04659]
112922455  FN1; fibronectin [KO:K05717]
112923896  COL1A2; collagen alpha-2(I) chain [KO:K06236]
112917855  COL1A1; collagen alpha-1(I) chain [KO:K06236]
112921081  COL2A1; collagen alpha-1(II) chain [KO:K19719]
112925530  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
112925468  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
112927466  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
112927467  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
112932053  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
112932054  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
112932527  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
112932531  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
112932544  collagen alpha-4(VI) chain-like [KO:K06238]
112909516  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
112909551  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
112908780  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
112914112  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
112932157  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
112908232  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
112930944  LAMA2; laminin subunit alpha-2 [KO:K05637]
112925240  LAMA1; laminin subunit alpha-1 [KO:K05637]
112925720  LAMA3; laminin subunit alpha-3 [KO:K06240]
112932206  LAMA5; laminin subunit alpha-5 [KO:K06240]
112925190  LAMA4; laminin subunit alpha-4 [KO:K06241]
112908586  LAMB1; laminin subunit beta-1 [KO:K05636]
112911607  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
112907138  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
112908567  LAMB4; laminin subunit beta-4 [KO:K06245]
112921712  LAMC1; laminin subunit gamma-1 [KO:K05635]
112921807  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
112927828  LAMC3; laminin subunit gamma-3 [KO:K06247]
112917862  CHAD; chondroadherin [KO:K06248]
112925377  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
112919662  SPP1; osteopontin isoform X1 [KO:K06250]
112933126  VTN; vitronectin [KO:K06251]
112913632  TNXB; tenascin-X isoform X1 [KO:K06252]
112921730  TNN; tenascin-N [KO:K06252]
112921850  TNR; tenascin-R [KO:K06252]
112923095  TNC; tenascin isoform X1 [KO:K06252]
112919611  IBSP; bone sialoprotein 2 [KO:K06253]
112933765  ITGA1; integrin alpha-1 [KO:K06480]
112933797  ITGA2; integrin alpha-2 [KO:K06481]
112910659  ITGA2B; integrin alpha-IIb [KO:K06476]
112917850  ITGA3; integrin alpha-3 [KO:K06482]
112934860  ITGA4; integrin alpha-4 [KO:K06483]
112911311  ITGA5; integrin alpha-5 [KO:K06484]
112916402  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
112922416  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
112933056  ITGA8; integrin alpha-8 [KO:K06584]
112921662  ITGA9; integrin alpha-9 [KO:K06585]
112907711  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
112931099  ITGA11; integrin alpha-11 [KO:K06587]
112931084  ITGAV; integrin alpha-V [KO:K06487]
112921568  ITGB1; integrin beta-1 [KO:K05719]
112920636  ITGB3; integrin beta-3 [KO:K06493]
112920800  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
112913510  ITGB5; integrin beta-5 [KO:K06588]
112916473  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
112921264  ITGB7; integrin beta-7 [KO:K06590]
112915730  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
112909230  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
112932869  PXN; paxillin [KO:K05760]
112913803  TNF; tumor necrosis factor [KO:K03156]
112917515  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112929410  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
112921762  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112931965  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112924009  FADD; FAS-associated death domain protein [KO:K02373]
112922873  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
112934766  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112920772  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
112916103  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112917055  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112925972  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
112931417  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
112926797  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
112928797  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
112920859  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
112934990  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
112908961  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
112932510  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
112935323  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
112930274  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112924290  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
112921765  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
112913999  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
112921351  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
112928006  TSC1; hamartin isoform X1 [KO:K07206]
112909041  TSC2; tuberin isoform X1 [KO:K07207]
112916202  RHEB; GTP-binding protein Rheb [KO:K07208]
112929738  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
112916127  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112917940  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112924182  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
112913897  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
112924315  BAD; bcl2-associated agonist of cell death [KO:K02158]
112927357  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112924665  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112926217  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112934961  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112914774  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112913170  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112935820  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112928376  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112930303  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112923528  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112918703  FOXO1; forkhead box protein O1 [KO:K07201]
112917274  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
112913942  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112924157  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112917379  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112913983  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
112922331  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112923889  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112931227  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
112928464  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
112922404  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
112933932  RB1; retinoblastoma-associated protein [KO:K06618]
112928177  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
112929613  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112907372  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
112928157  E2F1; transcription factor E2F1 [KO:K17454]
112933633  CCNA2; cyclin-A2 [KO:K06627]
112918679  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
112925961  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
112934959  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
112914029  VEGFA; vascular endothelial growth factor A [KO:K05448]
112914804  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112916156  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112911512  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112908352  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112924254  RELA; transcription factor p65 isoform X1 [KO:K04735]
112922285  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
112927551  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
112925191  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
112931745  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
112917351  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
112917081  IRF1; interferon regulatory factor 1 [KO:K09444]
112919452  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
112925203  TBP; TATA-box-binding protein isoform X1 [KO:K03120]
112921404  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
112913580  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
112913584  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
112913586  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
112912180  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X1 [KO:K06751]
112913727  DLA class I histocompatibility antigen, A9/A9 alpha chain [KO:K06751]
112911474  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
112913438  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
112925545  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
112934393  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
112927715  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
112916989  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
112927183  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
112915335  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
112917436  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
112928913  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
112914591  V-type proton ATPase subunit G 1 [KO:K02152]
112913590  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
112922995  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
112934504  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
112929352  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
112933819  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
112910758  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
112907020  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
112924169  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
112929420  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
112932005  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
112916234  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
112926116  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
112909098  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
112914818  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
112911469  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
112934223  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112925820  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112920790  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112921310  SOS2; son of sevenless homolog 2 [KO:K03099]
112935267  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112914428  HRAS; GTPase HRas isoform X1 [KO:K02833]
112917213  KRAS; GTPase KRas isoform X1 [KO:K07827]
112916766  NRAS; GTPase NRas [KO:K07828]
112933694  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112935545  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112929340  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112907501  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112921830  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
112933537  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
112932168  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
112932169  neuroendocrine secretory protein 55 [KO:K04632]
112908063  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112924478  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112931372  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
112922611  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
112930843  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
112918871  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
112924095  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
112935546  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
112908881  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
112915694  cyclic AMP-responsive element-binding protein 5 [KO:K09047]
112929808  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
112910789  TUBG1; tubulin gamma-1 chain [KO:K10389]
112910811  tubulin gamma-2 chain-like [KO:K10389]
112934161  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
112911635  interferon alpha-1/2-like [KO:K05414]
112911642  interferon alpha-3-like [KO:K05414]
112911646  interferon alpha-1/2 [KO:K05414]
112911647  interferon alpha-1/2-like [KO:K05414]
112911648  interferon alpha-1/2 [KO:K05414]
112911649  interferon alpha-1/2-like [KO:K05414]
112921941  interferon alpha-1/2-like [KO:K05414]
112921942  interferon alpha-1/2-like [KO:K05414]
112921945  interferon alpha-2-like [KO:K05414]
112909256  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
112909270  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
112907887  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112909637  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
112922923  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
112922378  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
112926537  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
112935312  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
112932874  2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
112932875  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
112908032  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
112908009  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
112926136  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
112930044  JAG1; protein jagged-1 isoform X1 [KO:K06052]
112906921  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
112912052  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
112913198  NOTCH3; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3 [KO:K20995]
112913644  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
112927245  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
112920916  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
112929107  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
112929356  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
112934942  MAML3; LOW QUALITY PROTEIN: mastermind-like protein 3 [KO:K06061]
112915776  MAML2; mastermind-like protein 2 [KO:K06061]
112932413  MAML1; mastermind-like protein 1 [KO:K06061]
112919038  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
112920073  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
112925420  HES1; transcription factor HES-1 [KO:K06054]
112924560  HES2; transcription factor HES-2 [KO:K09087]
112908770  HES6; transcription cofactor HES-6 [KO:K09087]
112924562  HES3; transcription factor HES-3 [KO:K09088]
112926135  HES4; transcription factor HES-4 [KO:K09089]
112924578  HES5; transcription factor HES-5 [KO:K06055]
112930494  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
112908233  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Related
pathway
vvp04064  NF-kappa B signaling pathway
vvp04110  Cell cycle
vvp04115  p53 signaling pathway
vvp04150  mTOR signaling pathway
vvp04151  PI3K-Akt signaling pathway
vvp04210  Apoptosis
vvp04310  Wnt signaling pathway
vvp04330  Notch signaling pathway
vvp04510  Focal adhesion
vvp04520  Adherens junction
vvp04530  Tight junction
vvp04612  Antigen processing and presentation
vvp04620  Toll-like receptor signaling pathway
vvp04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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