KEGG   PATHWAY: ko05165
Entry
ko05165                     Pathway                                
Name
Human papillomavirus infection
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
ko05165  Human papillomavirus infection
ko05165

Drug
D02783  Afovirsen sodium (USAN)
D06555  Amolimogene bepiplasmid (USAN)
D06666  Verpasep caltespen (USAN/INN)
Orthology
K00182  WNT2; wingless-type MMTV integration site family, member 2
K00312  WNT3; wingless-type MMTV integration site family, member 3
K00408  WNT4; wingless-type MMTV integration site family, member 4
K00444  WNT5; wingless-type MMTV integration site family, member 5
K00445  WNT6; wingless-type MMTV integration site family, member 6
K00572  WNT7; wingless-type MMTV integration site family, member 7
K00714  WNT8; wingless-type MMTV integration site family, member 8
K00873  PK, pyk; pyruvate kinase [EC:2.7.1.40]
K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K01064  WNT9; wingless-type MMTV integration site family, member 9
K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K01357  WNT10; wingless-type MMTV integration site family, member 10
K01384  WNT11; wingless-type MMTV integration site family, member 11
K01558  WNT16; wingless-type MMTV integration site family, member 16
K02085  APC; adenomatosis polyposis coli protein
K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K02105  CTNNB1; catenin beta 1
K02144  ATPeV1H; V-type H+-transporting ATPase subunit H
K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A [EC:7.1.2.2]
K02146  ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d
K02147  ATPeV1B, ATP6B; V-type H+-transporting ATPase subunit B
K02148  ATPeV1C, ATP6C; V-type H+-transporting ATPase subunit C
K02149  ATPeV1D, ATP6M; V-type H+-transporting ATPase subunit D
K02150  ATPeV1E, ATP6E; V-type H+-transporting ATPase subunit E
K02151  ATPeV1F, ATP6S14; V-type H+-transporting ATPase subunit F
K02152  ATPeV1G, ATP6G; V-type H+-transporting ATPase subunit G
K02153  ATPeV0E, ATP6H; V-type H+-transporting ATPase subunit e
K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
K02155  ATPeV0C, ATP6L; V-type H+-transporting ATPase 16kDa proteolipid subunit
K02157  AXIN1; axin 1
K02158  BAD; Bcl-2-antagonist of cell death
K02159  BAX; apoptosis regulator BAX
K02187  CASP3; caspase 3 [EC:3.4.22.56]
K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K02235  FZD2; frizzled 2
K02329  FZD3; frizzled 3
K02353  DVL; segment polarity protein dishevelled
K02354  FZD4, fz4, CD344; frizzled 4
K02373  FADD; FAS-associated death domain protein
K02375  FZD5_8, fz2; frizzled 5/8
K02376  FZD6; frizzled 6
K02432  FZD1_7, fz; frizzled 1/7
K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
K02599  NOTCH1; Notch 1
K02620  TCF7, TCF-1; transcription factor 7
K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02833  HRAS; GTPase HRas
K02842  FZD9_10, CD349_50; frizzled 9/10
K03062  PSMC1, RPT2; 26S proteasome regulatory subunit T2
K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K03099  SOS; son of sevenless
K03120  TBP; transcription initiation factor TFIID TATA-box-binding protein
K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K03174  TRAF3; TNF receptor-associated factor 3
K03209  WNT1; wingless-type MMTV integration site family, member 1
K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K03661  ATPeV0B, ATP6F; V-type H+-transporting ATPase 21kDa proteolipid subunit
K03662  ATPeVS1, ATP6S1; V-type H+-transporting ATPase S1 subunit
K03900  VWF; von Willebrand factor
K04237  PARD3; partitioning defective protein 3
K04261  PTGER4; prostaglandin E receptor 4
K04345  PKA; protein kinase A [EC:2.7.11.11]
K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04357  EGF; epidermal growth factor
K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K04364  GRB2; growth factor receptor-bound protein 2
K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K04385  AXIN2; axin 2
K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
K04393  CDC42; cell division control protein 42
K04398  CASP8; caspase 8 [EC:3.4.22.61]
K04451  TP53, P53; tumor protein p53
K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K04490  TCF7L1; transcription factor 7-like 1
K04491  TCF7L2; transcription factor 7-like 2
K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K04503  CCND1; G1/S-specific cyclin-D1
K04505  PSEN1, PS1; presenilin 1 [EC:3.4.23.-]
K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K04659  THBS2S; thrombospondin 2/3/4/5
K04681  RBL1; retinoblastoma-like protein 1
K04688  RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04693  IRF9, ISGF3G, P48; interferon regulatory factor 9
K04728  ATM, TEL1; serine-protein kinase ATM [EC:2.7.11.1]
K04735  RELA; transcription factor p65
K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05130  IFNAR1; interferon receptor 1
K05131  IFNAR2; interferon receptor 2
K05401  TLR3, CD283; toll-like receptor 3
K05410  TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
K05411  IRF3; interferon regulatory factor 3
K05414  IFNA; interferon alpha
K05415  IFNB; interferon beta
K05448  VEGFA; vascular endothelial growth factor A
K05631  AIP3, WWP3, BAIAP1; atrophin-1 interacting protein 3 (BAI1-associated protein 1)
K05635  LAMC1; laminin, gamma 1
K05636  LAMB1; laminin, beta 1
K05637  LAMA1_2; laminin, alpha 1/2
K05717  FN1; fibronectin 1
K05719  ITGB1, CD29; integrin beta 1
K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
K05760  PXN; paxillin
K05842  TRIF; toll-like receptor adapter molecule 1
K05870  CREB1; cyclic AMP-responsive element-binding protein 1
K05948  FNG; fringe [EC:2.4.1.222]
K06052  JAG1, CD339; jagged-1
K06053  RBPSUH, RBPJK; recombining binding protein suppressor of hairless
K06054  HES1; hairy and enhancer of split 1
K06055  HES5; hairy and enhancer of split 5
K06061  MAML; mastermind
K06067  HDAC1_2; histone deacetylase 1/2 [EC:3.5.1.98]
K06069  PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]
K06090  CRB3; crumbs 3
K06091  MPP5, PALS1; MAGUK p55 subfamily member 5
K06092  INADL, PATJ; InaD-like protein
K06093  PARD6; partitioning defective protein 6
K06094  LLGL; lethal(2) giant larvae protein
K06236  COL1A; collagen type I alpha
K06237  COL4A; collagen type IV alpha
K06238  COL6A; collagen type VI alpha
K06240  LAMA3_5; laminin, alpha 3/5
K06241  LAMA4; laminin, alpha 4
K06243  LAMB2; laminin, beta 2
K06244  LAMB3; laminin, beta 3
K06245  LAMB4; laminin, beta 4
K06246  LAMC2; laminin, gamma 2
K06247  LAMC3; laminin, gamma 3
K06248  CHAD; chondroadherin
K06249  RELN; reelin [EC:3.4.21.-]
K06250  SPP1, BNSP, OPN; secreted phosphoprotein 1
K06251  VTN; vitronectin
K06252  TN; tenascin
K06253  IBSP; integrin binding sialoprotein
K06476  ITGA2B, CD41; integrin alpha 2B
K06480  ITGA1, CD49a; integrin alpha 1
K06481  ITGA2, CD49b; integrin alpha 2
K06482  ITGA3, CD49c; integrin alpha 3
K06483  ITGA4, CD49d; integrin alpha 4
K06484  ITGA5, CD49e; integrin alpha 5
K06485  ITGA6, CD49f; integrin alpha 6
K06487  ITGAV, CD51; integrin alpha V
K06493  ITGB3, CD61; integrin beta 3
K06525  ITGB4, CD104; integrin beta 4
K06583  ITGA7; integrin alpha 7
K06584  ITGA8; integrin alpha 8
K06585  ITGA9; integrin alpha 9
K06586  ITGA10; integrin alpha 10
K06587  ITGA11; integrin alpha 11
K06588  ITGB5; integrin beta 5
K06589  ITGB6; integrin beta 6
K06590  ITGB7; integrin beta 7
K06591  ITGB8; integrin beta 8
K06618  RB1; retinoblastoma-associated protein
K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K06626  CCNE; G1/S-specific cyclin-E1
K06627  CCNA; cyclin-A
K06640  ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K06751  MHC1; MHC class I antigen
K07201  FOXO1; forkhead box protein O1
K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
K07206  TSC1; tuberous sclerosis 1
K07207  TSC2; tuberous sclerosis 2
K07208  RHEB; Ras homolog enriched in brain
K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07211  IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]
K07827  KRAS, KRAS2; GTPase KRas
K07828  NRAS; GTPase NRas
K08131  COL9A; collagen type IX alpha
K08957  CSNK1A; casein kinase 1, alpha [EC:2.7.11.1]
K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
K09048  CREB3; cyclic AMP-responsive element-binding protein 3
K09087  HES2_6_7; hairy and enhancer of split 2/6/7
K09088  HES3; hairy and enhancer of split 3
K09089  HES4; hairy and enhancer of split 4
K09091  HEY; hairy and enhancer of split related with YRPW motif
K09444  IRF1; interferon regulatory factor 1
K10151  CCND2; G1/S-specific cyclin-D2
K10152  CCND3; G1/S-specific cyclin-D3
K10389  TUBG; tubulin gamma
K10587  UBE3A, E6AP; ubiquitin-protein ligase E3 A [EC:2.3.2.26]
K10691  UBR4, ZUBR1; E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27]
K11126  TERT, EST2; telomerase reverse transcriptase [EC:2.7.7.49]
K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
K11219  TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
K11220  STAT1; signal transducer and activator of transcription 1
K11221  STAT2; signal transducer and activator of transcription 2
K11315  TADA3, ADA3, NGG1; transcriptional adapter 3
K11583  PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
K11584  PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K11643  CHD4, MI2B; chromodomain-helicase-DNA-binding protein 4 [EC:5.6.2.-]
K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K12075  DLG2; discs large protein 2
K12076  DLG1; disks large protein 1
K12159  ISG15; ubiquitin cross-reactive protein
K12236  NFX1; transcriptional repressor NF-X1
K13365  SLC9A3R1, NHERF1; sodium/hydrogen exchange regulatory cofactor NHE-RF1
K14009  BCAP31, BAP31; B-cell receptor-associated protein 31
K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
K14608  OASL; 2'-5'-oligoadenylate synthase-like protein
K14754  MX; interferon-induced GTP-binding protein Mx
K16175  SCRIB; protein scribble
K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
K16332  RBL2; retinoblastoma-like protein 2
K16857  THBS1; thrombospondin 1
K17454  E2F1; transcription factor E2F1
K18952  PRKCZ; atypical protein kinase C zeta type [EC:2.7.11.13]
K19260  L1; Papillomaviridae major capsid protein L1
K19719  COL2A; collagen type II alpha
K20994  NOTCH2; Notch 2
K20995  NOTCH3; Notch 3
K20996  NOTCH4; Notch 4
K21098  DLG3; discs large protein 3
K21807  E6; Alphapapillomavirus protein E6
K21808  L2; Alphapapillomavirus minor capsid protein L2
K21809  E7; Alphapapillomavirus protein E7
K21810  E1; Alphapapillomavirus replication protein E1 [EC:5.6.2.-]
K21811  E2; Alphapapillomavirus regulatory protein E2
K21812  E5; Alphapapillomavirus protein E5
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:20592731
  Authors
Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
  Journal
Nat Rev Cancer 10:550-60 (2010)
DOI:10.1038/nrc2886
Reference
PMID:25752815
  Authors
Chen J
  Title
Signaling pathways in HPV-associated cancers and therapeutic implications.
  Journal
Rev Med Virol 25 Suppl 1:24-53 (2015)
DOI:10.1002/rmv.1823
Reference
PMID:26008697
  Authors
Tummers B, Burg SH
  Title
High-risk human papillomavirus targets crossroads in immune signaling.
  Journal
Viruses 7:2485-506 (2015)
DOI:10.3390/v7052485
Reference
PMID:19684440
  Authors
Lehoux M, D'Abramo CM, Archambault J
  Title
Molecular mechanisms of human papillomavirus-induced carcinogenesis.
  Journal
Public Health Genomics 12:268-80 (2009)
DOI:10.1159/000214918
Reference
PMID:23164805
  Authors
Pang CL, Thierry F
  Title
Human papillomavirus proteins as prospective therapeutic targets.
  Journal
Microb Pathog 58:55-65 (2013)
DOI:10.1016/j.micpath.2012.11.002
Reference
PMID:19156753
  Authors
Yugawa T, Kiyono T
  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
  Journal
Rev Med Virol 19:97-113 (2009)
DOI:10.1002/rmv.605
Reference
PMID:17645777
  Authors
Narisawa-Saito M, Kiyono T
  Title
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
  Journal
Cancer Sci 98:1505-11 (2007)
DOI:10.1111/j.1349-7006.2007.00546.x
Reference
PMID:11486705
  Authors
Wolf JK, Ramirez PT.
  Title
The molecular biology of cervical cancer.
  Journal
Cancer Invest 19:621-9 (2001)
DOI:10.1081/CNV-100104290
Reference
PMID:10793105
  Authors
zur Hausen H
  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
  Journal
J Natl Cancer Inst 92:690-8 (2000)
DOI:10.1093/jnci/92.9.690
Reference
PMID:16259056
  Authors
Kim YT, Zhao M
  Title
Aberrant cell cycle regulation in cervical carcinoma.
  Journal
Yonsei Med J 46:597-613 (2005)
DOI:10.3349/ymj.2005.46.5.597
Reference
PMID:15956361
  Authors
McCance DJ
  Title
Human papillomaviruses and cell signaling.
  Journal
Sci STKE 2005:pe29 (2005)
DOI:10.1126/stke.2882005pe29
Reference
PMID:15342967
  Authors
Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
  Title
The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
  Journal
Kobe J Med Sci 50:9-19 (2004)
Reference
PMID:24316445
  Authors
Tommasino M
  Title
The human papillomavirus family and its role in carcinogenesis.
  Journal
Semin Cancer Biol 26:13-21 (2014)
DOI:10.1016/j.semcancer.2013.11.002
Reference
PMID:26295406
  Authors
Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
  Title
Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
  Journal
Viruses 7:4734-55 (2015)
DOI:10.3390/v7082842
Reference
PMID:26289783
  Authors
Shah M, Anwar MA, Park S, Jafri SS, Choi S
  Title
In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
  Journal
Sci Rep 5:13446 (2015)
DOI:10.1038/srep13446
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26147797
  Authors
Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
  Title
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
  Journal
Viruses 7:3530-51 (2015)
DOI:10.3390/v7072785
Reference
PMID:21954943
  Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
  Title
PDZ domains: the building blocks regulating tumorigenesis.
  Journal
Biochem J 439:195-205 (2011)
DOI:10.1042/BJ20110903
Reference
PMID:23175122
  Authors
Banks L, Pim D, Thomas M
  Title
Human tumour viruses and the deregulation of cell polarity in cancer.
  Journal
Nat Rev Cancer 12:877-86 (2012)
DOI:10.1038/nrc3400
Reference
PMID:19029942
  Authors
Thomas M, Narayan N, Pim D, Tomaic V, Massimi P, Nagasaka K, Kranjec C, Gammoh N, Banks L
  Title
Human papillomaviruses, cervical cancer and cell polarity.
  Journal
Oncogene 27:7018-30 (2008)
DOI:10.1038/onc.2008.351
Reference
PMID:19901438
  Authors
Jayshree RS, Sreenivas A, Tessy M, Krishna S
  Title
Cell intrinsic & extrinsic factors in cervical carcinogenesis.
  Journal
Indian J Med Res 130:286-95 (2009)
Reference
PMID:16862386
  Authors
Garnett TO, Duerksen-Hughes PJ
  Title
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
  Journal
Arch Virol 151:2321-35 (2006)
DOI:10.1007/s00705-006-0821-0
Reference
PMID:26022660
  Authors
Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
  Title
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
  Journal
Mol Cancer 14:87 (2015)
DOI:10.1186/s12943-015-0361-x
Reference
PMID:22078316
  Authors
Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G
  Title
Papillomavirus E5: the smallest oncoprotein with many functions.
  Journal
Mol Cancer 10:140 (2011)
DOI:10.1186/1476-4598-10-140
Reference
PMID:11753669
  Authors
DiMaio D, Mattoon D
  Title
Mechanisms of cell transformation by papillomavirus E5 proteins.
  Journal
Oncogene 20:7866-73 (2001)
DOI:10.1038/sj.onc.1204915
Reference
PMID:22262402
  Authors
Ganguly N
  Title
Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
  Journal
Cell Oncol (Dordr) 35:67-76 (2012)
DOI:10.1007/s13402-011-0069-x
Reference
PMID:23731971
  Authors
DiMaio D, Petti LM
  Title
The E5 proteins.
  Journal
Virology 445:99-114 (2013)
DOI:10.1016/j.virol.2013.05.006
Reference
PMID:23403708
  Authors
De Marco F
  Title
Oxidative stress and HPV carcinogenesis.
  Journal
Viruses 5:708-31 (2013)
DOI:10.3390/v5020708
Reference
PMID:26643553
  Authors
Wieringa HW, van der Zee AG, de Vries EG, van Vugt MA
  Title
Breaking the DNA damage response to improve cervical cancer treatment.
  Journal
Cancer Treat Rev 42:30-40 (2016)
DOI:10.1016/j.ctrv.2015.11.008
Reference
PMID:19861444
  Authors
Chung CH, Gillison ML
  Title
Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
  Journal
Clin Cancer Res 15:6758-62 (2009)
DOI:10.1158/1078-0432.CCR-09-0784
Reference
PMID:11325599
  Authors
Koromilas AE, Li S, Matlashewski G
  Title
Control of interferon signaling in human papillomavirus infection.
  Journal
Cytokine Growth Factor Rev 12:157-70 (2001)
DOI:10.1016/S1359-6101(00)00023-X
Reference
PMID:10702232
  Authors
Park JS, Kim EJ, Kwon HJ, Hwang ES, Namkoong SE, Um SJ
  Title
Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
  Journal
J Biol Chem 275:6764-9 (2000)
DOI:10.1074/jbc.275.10.6764
Reference
PMID:22499770
  Authors
Sandberg A, Lindell G, Kallstrom BN, Branca RM, Danielsson KG, Dahlberg M, Larson B, Forshed J, Lehtio J
  Title
Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
  Journal
Mol Cell Proteomics 11:M112.016998 (2012)
DOI:10.1074/mcp.M112.016998
Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
  Journal
Proc Natl Acad Sci U S A 96:1291-6 (1999)
DOI:10.1073/pnas.96.4.1291
Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
  Journal
J Biol Chem 279:35664-70 (2004)
DOI:10.1074/jbc.M403385200
Reference
PMID:18505829
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
  Journal
Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
ko04064  NF-kappa B signaling pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04310  Wnt signaling pathway
ko04330  Notch signaling pathway
ko04510  Focal adhesion
ko04520  Adherens junction
ko04530  Tight junction
ko04612  Antigen processing and presentation
ko04620  Toll-like receptor signaling pathway
ko04630  JAK-STAT signaling pathway

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