KEGG   PATHWAY: pcoq04510
Entry
pcoq04510                   Pathway                                
Name
Focal adhesion - Propithecus coquereli (Coquerel's sifaka)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pcoq04510  Focal adhesion
pcoq04510

Other DBs
GO: 0005925
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105804941  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
105805087  VWF; von Willebrand factor [KO:K03900]
105805127  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105805131  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
105805188  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105805204  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105805467  LAMB3; laminin subunit beta-3 [KO:K06244]
105805556  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
105805749  FIGF; vascular endothelial growth factor D [KO:K05449]
105805953  ACTB; actin, cytoplasmic 1 [KO:K05692]
105805988  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105806045  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105806183  PAK7; serine/threonine-protein kinase PAK 7 isoform X1 [KO:K05736] [EC:2.7.11.1]
105806240  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105806347  JUN; transcription factor AP-1 [KO:K04448]
105806400  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
105806476  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
105806496  [KO:K26255]
105806551  LAMC3; laminin subunit gamma-3 [KO:K06247]
105806600  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105806663  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
105806762  LAMC2; laminin subunit gamma-2 [KO:K06246]
105806763  LAMC1; laminin subunit gamma-1 [KO:K05635]
105807480  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105807498  VEGFA; vascular endothelial growth factor A [KO:K05448]
105807665  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105807691  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105807739  TNC; tenascin isoform X1 [KO:K06252]
105808008  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
105808035  ITGB5; integrin beta-5 [KO:K06588]
105808062  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
105808407  RAP1B; ras-related protein Rap-1b [KO:K07836]
105808489  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105808525  ITGB1; integrin beta-1 [KO:K05719]
105808741  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105808765  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
105809043  [KO:K04353]
105809082  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
105809239  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
105809569  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105809606  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105809892  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105810138  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105810397  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105810615  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
105810725  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
105810783  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105810946  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105810968  TLN2; talin-2 [KO:K06271]
105811010  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
105811016  HGF; hepatocyte growth factor [KO:K05460]
105811099  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
105811149  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
105811228  SHC2; SHC-transforming protein 2 [KO:K17447]
105811507  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
105811544  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
105811845  VAV1; proto-oncogene vav [KO:K05730]
105811876  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
105812126  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
105812281  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
105812283  CAV3; caveolin-3 [KO:K12959]
105812474  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
105812606  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105812683  IBSP; bone sialoprotein 2 [KO:K06253]
105812700  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105812717  SPP1; osteopontin [KO:K06250]
105813090  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105813132  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105813169  EMP2; epithelial membrane protein 2 [KO:K26256]
105813240  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
105813423  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105813545  VTN; vitronectin [KO:K06251]
105813732  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
105813943  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105813968  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
105814034  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
105814042  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105814299  SHC4; SHC-transforming protein 4 [KO:K17449]
105814426  THBS1; thrombospondin-1 [KO:K16857]
105814454  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
105814677  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105815054  [KO:K05760]
105815122  IGF1; insulin-like growth factor I [KO:K05459]
105815161  RELN; reelin [KO:K06249] [EC:3.4.21.-]
105815168  LAMB4; laminin subunit beta-4 [KO:K06245]
105815196  LAMB1; laminin subunit beta-1 [KO:K05636]
105815438  ZYX; zyxin isoform X1 [KO:K06273]
105815600  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105815695  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105815884  ITGA4; integrin alpha-4 [KO:K06483]
105815999  [KO:K04440] [EC:2.7.11.24]
105816054  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
105816133  FN1; fibronectin [KO:K05717]
105816267  VEGFC; vascular endothelial growth factor C [KO:K05449]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105816588  LAMA1; laminin subunit alpha-1 [KO:K05637]
105816606  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
105816631  MYL12B; myosin regulatory light chain 12B [KO:K12757]
105816632  [KO:K12757]
105816821  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
105816940  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105816954  ITGA5; integrin alpha-5 [KO:K06484]
105817079  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
105817084  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
105817144  CAV1; caveolin-1 isoform X1 [KO:K06278]
105817145  CAV2; caveolin-2 isoform X1 [KO:K12958]
105817148  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105817164  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105817331  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105817361  CRK; adapter molecule crk isoform X1 [KO:K04438]
105817661  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
105817680  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
105817773  SHC3; SHC-transforming protein 3 [KO:K17448]
105817841  TNXB; tenascin-X [KO:K06252]
105817935  [KO:K06590]
105818006  SOS1; son of sevenless homolog 1 [KO:K03099]
105818088  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
105818166  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
105818191  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105818382  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
105818421  PARVA; alpha-parvin [KO:K06275]
105818530  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105818542  LAMA5; laminin subunit alpha-5 [KO:K06240]
105818935  EGF; pro-epidermal growth factor [KO:K04357]
105819002  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105819095  ITGA2; integrin alpha-2 [KO:K06481]
105819125  ITGA1; integrin alpha-1 [KO:K06480]
105819174  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
105819379  RHOA; transforming protein RhoA [KO:K04513]
105819518  EMP1; epithelial membrane protein 1 [KO:K26255]
105819557  ITGB6; integrin beta-6 [KO:K06589]
105819655  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
105819783  PGF; placenta growth factor isoform X1 [KO:K16859]
105819843  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
105819944  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
105819999  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105820004  TLN1; talin-1 isoform X1 [KO:K06271]
105820016  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105820421  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105820555  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
105820591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105820606  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
105821100  TNN; tenascin-N [KO:K06252]
105821582  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105821619  [KO:K06275]
105821635  PARVG; gamma-parvin [KO:K06275]
105821872  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
105821914  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
105821989  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105822028  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105822091  RAP1A; ras-related protein Rap-1A [KO:K04353]
105822120  ITGA2B; integrin alpha-IIb [KO:K06476]
105822163  [KO:K05450]
105822164  [KO:K05450]
105822276  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
105822279  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
105822386  CRKL; crk-like protein [KO:K04438]
105822435  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105822622  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105822640  [KO:K06493]
105822702  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105822757  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105823142  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
105823559  LAMA2; laminin subunit alpha-2 [KO:K05637]
105823643  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105823644  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105823658  ITGA8; integrin alpha-8 [KO:K06584]
105824021  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105824348  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105824525  FLNA; filamin-A isoform X1 [KO:K04437]
105824609  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105824713  ITGB4; integrin beta-4 [KO:K06525]
105824793  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105824947  CHAD; chondroadherin [KO:K06248]
105824997  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105825024  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
105825335  CTNNB1; catenin beta-1 [KO:K02105]
105825462  [KO:K06238]
105825470  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
105825476  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
105825489  VCL; vinculin isoform X1 [KO:K05700]
105825623  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105825660  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
105825770  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105825798  MYL5; myosin light chain 5 [KO:K12753]
105825853  SOS2; son of sevenless homolog 2 [KO:K03099]
105826023  MYL10; myosin regulatory light chain 10 [KO:K12756]
105826536  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
105826540  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105826612  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105826682  [KO:K05730]
105826784  THBS2; thrombospondin-2 [KO:K04659]
105826800  ITGA11; integrin alpha-11 [KO:K06587]
105826835  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
105827209  TNR; tenascin-R [KO:K06252]
105827296  BAD; bcl2-associated agonist of cell death [KO:K02158]
105827300  VEGFB; vascular endothelial growth factor B [KO:K16858]
105827311  LAMB2; laminin subunit beta-2 [KO:K06243]
105827321  FLNB; filamin-B isoform X1 [KO:K27392]
105827364  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105827423  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
105827543  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
105827561  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pcoq04010  MAPK signaling pathway
pcoq04060  Cytokine-cytokine receptor interaction
pcoq04070  Phosphatidylinositol signaling system
pcoq04110  Cell cycle
pcoq04151  PI3K-Akt signaling pathway
pcoq04310  Wnt signaling pathway
pcoq04512  ECM-receptor interaction
pcoq04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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