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Entry |
Name |
Definition |
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N00121
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LMO2-rearrangement to transcriptional activation
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(LMO2*+LDB1) == (LYL1+TCF3) ⇒ HHEX
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N00122
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LMO2-rearrangement to transcriptional repression
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(LMO2*+LDB1) == (LYL1+TCF3) ⫤ PTCRA
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N00123
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Amplified REL to transcription
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REL* ⇒ (CCND2,BCL2A1,BIRC3,TRAF1,BCL2L1,CD86,CD40)
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N00124
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IGH-MAF fusion to transcriptional activation
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IGH-MAF ⇒ (CCND2,ITGB7)
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N00125
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IGH-MMSET fusion to transcriptional activation
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IGH-MMSET → H3 ⇒ CCND2
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N00126
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PAX8-PPARG fusion to PPARG-mediated transcription
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PAX8-PPARG ⊣ (RXR+PPARG)
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N00127
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PRCC-TFE3 fusion to transcriptional activation
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PRCC-TFE3 ⇒ CDKN1A
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N00128
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TMPRSS2-ERG fusion to transcriptional activation
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TMPRSS2-ERG ⇒ (PLAU,PLAT,MMP3,MMP9,ZEB1,IL1R2)
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N00129
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TMPRSS2-ERG fusion to transcriptional repression
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TMPRSS2-ERG ⫤ SPINT1
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N00130
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TMPRSS2-ETV5 fusion to transcriptional activation
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TMPRSS2-ETV5 ⇒ (PLAU,MMP9)
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N00131
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Amplified MYCN to transcriptional activation
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MYCN* == MAX ⇒ (MDM2,PTK2,TP53,BMI1)
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N00132
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Amplified MYCN to transcriptional repression
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MYCN* == MAX == (SP1+ZBTB17) ⇒ (NTRK1,NGFR)
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N00133
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EWSR1-FLI1 fusion to transcriptional activation
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EWSR1-FLI1 ⇒ (IGF1,MYC,ID2)
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N00134
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EWSR1-FLI1 fusion to transcriptional repression
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EWSR1-FLI1 ⫤ (CDKN1A,TGFBR2,IGFBP3)
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N00135
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EWSR1-ERG fusion to transcriptional activation
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EWSR1-ERG ⇒ IGF1
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N00136
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EWSR1-ATF1 fusion to transcriptional activation
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EWSR1-ATF1 ⇒ (ARNT2,ATM,MITF)
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N00137
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EWSR1-WT1 fusion to transcriptional activation
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EWSR1-WT1 ⇒ (PDGFA,IL2RB,BAIAP3,TSPAN7,MLF1)
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N00138
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EWSR1-NR4A3
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EWSR-NR4A3 ⇒ PPARG
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N00139
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FUS-DDIT3 fusion to CEBPB-mediated transcription
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FUS-DDIT3 == CEBPB ⇒ IL6
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N00140
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FUS-DDIT3 fusion to NFKB-mediated transcription
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FUS-DDIT3 == (NFKBIZ+NFKB) ⇒ CXCL8
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N00141
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PAX3-FOXO1 fusion to transcriptional activation
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PAX3-FOXO1 ⇒ FLT1
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N00142
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SYT-SSX fusion to transcriptional repression
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SYT-SSX ⫤ NUPR1
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N00143
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ASPL-TFE3 fusion to transcriptional activation
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ASPL-TFE3 ⇒ MET
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N00144
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TLX1 rearrangement to transcriptional repression
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TLX1* ⫤ BCL11B
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N00145
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Extrinsic apoptotic pathway
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TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2/5) → FADD → CASP8 → (CASP3,CASP7)
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N00146
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Crosstalk between extrinsic and intrinsic apoptotic pathways
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(FASLG,TNFSF10) → (FAS,TNFRSF10B) → FADD → (CASP8,CASP10) → BID → (BAX,BAK1) → CYCS == APAF1 → CASP9 → (CASP3,CASP7)
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N00147
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EGF-EGFR-PLCG-calcineurin signaling pathway
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EGF → EGFR → PLCG → IP3 → Ca2+ → CALM == CN → NFAT
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N00148
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TLR3-IRF7 signaling pathway
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TLR3 → TICAM1 → TRAF3 → (IKBKE+TBK1) → IRF7 ⇒ IFNA
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N00149
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TLR3-IRF3 signaling pathway
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TLR3 → TICAM1 → TRAF3 → (IKBKE+TBK1) → IRF3 → (CREBBP,EP300) ⇒ IFNB1
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N00150
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Type I IFN signaling pathway
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(IFNA,IFNB1) → (IFNAR1+IFNAR2) → (JAK1,TYK2) → (STAT1+STAT2+IRF9) ⇒ (IRF7,EIF2AK2)
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N00151
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TNF-NFKB signaling pathway
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TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2/5) → (TAB1/2/3+TAK1) → IKK → NFKBIA → NFKB
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N00152
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CXCR-GNB/G-ERK signaling pathway
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CXCL8 → CXCR2 → GNB/G → RAS → RAF1 → MEK → ERK
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N00153
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CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
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(CC,CXC) → (CCR,CXCR) → GNB/G → PI3Kgamma → PREX1 → RAC1
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N00154
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CXCR-GNB/G-PI3K-AKT signaling pathway
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CXCL8 → CXCR2 → GNB/G → PI3Kgamma → PIP3 → AKT → MTOR
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N00155
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Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
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mTORC1 → ULK1_complex → PI3KC3-C1
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N00156
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Autophagy-vesicle nucleation/elongation/maturation, LC3-II formation
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LC3 — ATG4 ⇛ ATG7 ⇛ ATG3 ⇛ (ATG12+ATG5+ATG16L1) → LC3-II
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N00157
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KSHV vGPCR to GNB/G-ERK signaling pathway
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vGPCR → GNB/G
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N00158
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KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
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vGPCR → GNB/G
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N00159
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KSHV K1 to PI3K signaling pathway
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K1 → PI3K
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N00160
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KSHV K1 to RAS-ERK signaling pathway
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K1 → RAS
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