Entry Name Necroptosis - Castor canadensis (American beaver)
Description Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class Cellular Processes; Cell growth and deathBRITE hierarchy
Pathway map Ortholog table Organism Castor canadensis (American beaver) [GN:
ccan ]
Gene 109682791 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
109694060 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
109689097 Birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060 ]
109692755 Spata2l; LOW QUALITY PROTEIN: spermatogenesis-associated protein 2-like protein [KO:K17595 ]
109688488 Cflar; LOW QUALITY PROTEIN: CASP8 and FADD-like apoptosis regulator [KO:K04724 ]
109685840 Ripk3; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3 [KO:K08847 ] [EC:2.7.11.1 ]
109690704 Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
109697584 Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862 ]
109693642 Vdac2; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2 [KO:K15040 ]
109696398 Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041 ]
109687959 Nlrp3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800 ]
109682713 Pycard; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799 ]
109693755 Vps4b; vacuolar protein sorting-associated protein 4B [KO:K12196 ]
109693768 Vps4a; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196 ]
109692754 Chmp1a; charged multivesicular body protein 1a isoform X1 [KO:K12197 ]
109683456 tumor necrosis factor ligand superfamily member 10-like [KO:K04721 ]
109689125 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
109691142 Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
109697033 Ifngr1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132 ]
109679865 LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220 ]
109682738 Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
109686120 Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
109687324 Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
109682739 Stat4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222 ]
109687323 Stat5a; signal transducer and activator of transcription 5A [KO:K11223 ]
109686109 Stat6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225 ]
109687793 Ticam1; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1 [KO:K05842 ]
109687400 Aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727 ] [EC:1.-.-.-]
Compound C14592 N-Methyl-N'-nitro-N-nitrosoguanidine
Reference Authors Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
Title Molecular mechanisms of necroptosis: an ordered cellular explosion.
Journal Reference Authors Brenner D, Blaser H, Mak TW
Title Regulation of tumour necrosis factor signalling: live or let die.
Journal Reference Authors Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
Title Regulated necrosis: disease relevance and therapeutic opportunities.
Journal Reference Authors Ofengeim D, Yuan J
Title Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
Journal Reference Authors Murphy JM, Vince JE
Title Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
Journal Reference Authors Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
Title Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
Journal Reference Authors Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
Title An evolutionary perspective on the necroptotic pathway.
Journal Reference Authors Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
Title DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
Journal Reference Authors Yuan J, Najafov A, Py BF
Title Roles of Caspases in Necrotic Cell Death.
Journal Reference Authors Jorgensen I, Rayamajhi M, Miao EA
Title Programmed cell death as a defence against infection.
Journal Reference Authors Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
Title The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
Journal Reference Authors Vanlangenakker N, Vanden Berghe T, Vandenabeele P
Title Many stimuli pull the necrotic trigger, an overview.
Journal Reference Authors Moriwaki K, Chan FK
Title RIP3: a molecular switch for necrosis and inflammation.
Journal Reference Authors Humphries F, Yang S, Wang B, Moynagh PN
Title RIP kinases: key decision makers in cell death and innate immunity.
Journal Reference Authors Wegner KW, Saleh D, Degterev A
Title Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
Journal Reference Authors Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
Title SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
Journal Reference Authors Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
Title The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
Journal Reference Authors Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
Title Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
Journal Reference Authors Jacobsen AV, Silke J
Title The importance of being chaperoned: HSP90 and necroptosis.
Journal Reference Authors Gurung P, Man SM, Kanneganti TD
Title A20 is a regulator of necroptosis.
Journal Reference Authors Feng N, Anderson ME
Title CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
Journal Reference Authors Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
Title Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
Journal Reference Authors Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
Title Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
Journal Reference Authors Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
Title NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
Journal Reference Authors Sridharan H, Upton JW
Title Programmed necrosis in microbial pathogenesis.
Journal Reference Authors Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
Title BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
Journal Reference Authors Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
Title Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
Journal Reference Authors Upton JW, Kaiser WJ
Title DAI Another Way: Necroptotic Control of Viral Infection.
Journal Reference Authors Silke J, Rickard JA, Gerlic M
Title The diverse role of RIP kinases in necroptosis and inflammation.
Journal Reference Authors Guo H, Kaiser WJ
Title ESCRTing Necroptosis.
Journal Reference Authors Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
Title ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
Journal Reference Authors Petrie EJ, Hildebrand JM, Murphy JM
Title Insane in the membrane: a structural perspective of MLKL function in necroptosis.
Journal Reference Authors Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
Title Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
Journal Reference Authors Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
Title RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
Journal Reference Authors Shlomovitz I, Zargrian S, Gerlic M
Title Mechanisms of RIPK3-induced inflammation.
Journal Related ccan00250 Alanine, aspartate and glutamate metabolism
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