KEGG   PATHWAY: etf04060
Entry
etf04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Echinops telfairi (small Madagascar hedgehog)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
etf04060  Cytokine-cytokine receptor interaction
etf04060

Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101637996  BMP5; bone morphogenetic protein 5 [KO:K04663]
101638057  [KO:K05506]
101638132  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
101638351  OSM; oncostatin-M [KO:K05418]
101638625  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
101638698  IL1A; interleukin-1 alpha [KO:K04383]
101638886  INHA; inhibin alpha chain [KO:K05500]
101638943  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
101639189  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
101639333  IL1B; interleukin-1 beta [KO:K04519]
101639566  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
101639659  IL37; interleukin-37 [KO:K05485]
101639677  [KO:K22673]
101639819  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
101639885  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
101640062  CCL16; C-C motif chemokine 16 [KO:K21093]
101640088  ACVRL1; serine/threonine-protein kinase receptor R3 isoform X1 [KO:K13594] [EC:2.7.11.30]
101640105  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
101640190  IL36RN; interleukin-36 receptor antagonist protein [KO:K05483]
101640204  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101640227  CD70; CD70 antigen [KO:K05470]
101640272  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
101640287  [KO:K05484]
101640373  [KO:K21092]
101640427  AMH; muellerian-inhibiting factor [KO:K04665]
101640505  IL1F10; interleukin-1 family member 10 [KO:K05488]
101640576  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101640596  TNFRSF10B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 10B [KO:K04722]
101640597  IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481]
101640724  IL9; interleukin-9 [KO:K05432]
101640830  IFNGR2; interferon gamma receptor 2 [KO:K05133]
101640854  TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472]
101640890  CXCL11; C-X-C motif chemokine 11 isoform X1 [KO:K12672]
101641002  [KO:K14624]
101641110  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
101641282  GDF11; growth/differentiation factor 11 [KO:K22679]
101641411  ACVR2A; activin receptor type-2A isoform X2 [KO:K04670] [EC:2.7.11.30]
101641418  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
101641503  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
101641618  IL12A; interleukin-12 subunit alpha [KO:K05406]
101641745  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
101641973  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
101642049  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
101642172  [KO:K22669]
101642285  CCL27; C-C motif chemokine 27 [KO:K16598]
101642366  TNFSF18; tumor necrosis factor ligand superfamily member 18 isoform X1 [KO:K05479]
101642513  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101642657  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101642724  IL12RB1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063]
101642813  IL7; interleukin-7 [KO:K05431]
101642906  CCL19; C-C motif chemokine 19 [KO:K05512]
101643222  CCL21; C-C motif chemokine 21 [KO:K16062]
101643421  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
101643462  IL23R; interleukin-23 receptor [KO:K05065]
101643592  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
101643760  [KO:K05157]
101643882  CXCL12; stromal cell-derived factor 1 [KO:K10031]
101644009  IL26; interleukin-26 [KO:K05446]
101644043  IL27; interleukin-27 subunit alpha [KO:K22629]
101644240  IL6; interleukin-6 [KO:K05405]
101644318  MPL; thrombopoietin receptor [KO:K05082]
101644328  IFNG; interferon gamma [KO:K04687]
101644374  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
101644567  [KO:K04177]
101644890  CCR3; C-C chemokine receptor type 3 [KO:K04178]
101645004  CCR7; C-C chemokine receptor type 7 [KO:K04182]
101645205  [KO:K04176]
101645451  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
101645526  IL9R; interleukin-9 receptor [KO:K05073]
101645531  CCL5; C-C motif chemokine 5 [KO:K12499]
101645663  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
101645851  [KO:K05408]
101645913  AMHR2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
101646118  LEPR; leptin receptor isoform X1 [KO:K05062]
101646163  [KO:K12964]
101646200  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
101646517  THPO; thrombopoietin isoform X1 [KO:K06854]
101646613  TNFSF15; tumor necrosis factor ligand superfamily member 15 isoform X1 [KO:K05478]
101646673  BMP3; bone morphogenetic protein 3 [KO:K05496]
101646676  IL6ST; interleukin-6 receptor subunit beta isoform X2 [KO:K05060]
101646902  [KO:K05440]
101647050  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
101647092  [KO:K10029]
101647294  GDF2; growth/differentiation factor 2 [KO:K05503]
101647370  PRLR; prolactin receptor [KO:K05081]
101647415  [KO:K05407]
101647416  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
101647537  IL21R; interleukin-21 receptor [KO:K05075]
101647541  [KO:K05440]
101647560  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
101647727  [KO:K05505]
101647853  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
101647857  [KO:K05440]
101647885  IL17B; interleukin-17B [KO:K05490]
101647944  CCL24; C-C motif chemokine 24 isoform X1 [KO:K21097]
101648039  [KO:K05505]
101648172  IFNE; interferon epsilon [KO:K05442]
101648240  MSTN; growth/differentiation factor 8 [KO:K05497]
101648361  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
101648502  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
101648616  BMP2; bone morphogenetic protein 2 [KO:K21283]
101648773  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
101648880  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
101649395  [KO:K04180]
101649734  CSF3; granulocyte colony-stimulating factor [KO:K05423]
101650070  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101650414  IL10; interleukin-10 [KO:K05443]
101650420  GDF3; growth/differentiation factor 3 [KO:K22672]
101650484  IL12B; interleukin-12 subunit beta [KO:K05425]
101650492  GDF6; growth/differentiation factor 6 [KO:K20012]
101650550  IFNB1; interferon beta [KO:K05415]
101650665  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
101650705  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
101650709  IL17RB; interleukin-17 receptor B [KO:K05165]
101650718  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
101650725  IL19; interleukin-19 [KO:K05444]
101650862  [KO:K05414]
101650865  [KO:K05507]
101650957  XCR1; chemokine XC receptor 1 [KO:K04193]
101650988  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
101651033  IL20; interleukin-20 [KO:K22667]
101651333  IL24; interleukin-24 [KO:K22668]
101651474  RELL1; RELT-like protein 1 [KO:K26541]
101651571  CCR9; C-C chemokine receptor type 9 [KO:K04184]
101651579  TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
101651733  IL11; interleukin-11 [KO:K05417]
101651757  IL17RC; interleukin-17 receptor C [KO:K05166]
101651949  LIF; leukemia inhibitory factor [KO:K05419]
101652010  IL15; interleukin-15 isoform X3 [KO:K05433]
101652069  IL17RE; interleukin-17 receptor E [KO:K05168]
101652427  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101652439  TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
101652441  RELL2; RELT-like protein 2 [KO:K26541]
101652711  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
101652788  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
101653603  CD40LG; CD40 ligand [KO:K03161]
101653636  INHBE; inhibin beta E chain [KO:K22689]
101653663  IL34; interleukin-34 isoform X1 [KO:K22633]
101653709  IL4; interleukin-4 [KO:K05430]
101653730  BMP4; bone morphogenetic protein 4 [KO:K04662]
101653795  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
101653828  IL17D; interleukin-17D [KO:K05492]
101653943  INHBC; inhibin beta C chain [KO:K22688]
101653945  BMP7; bone morphogenetic protein 7 [KO:K16621]
101654019  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
101654036  EBI3; interleukin-27 subunit beta [KO:K24476]
101654279  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
101654325  LTA; lymphotoxin-alpha [KO:K05468]
101654642  TNF; tumor necrosis factor [KO:K03156]
101654643  BMP6; bone morphogenetic protein 6 [KO:K16620]
101654851  GDF9; growth/differentiation factor 9 [KO:K22673]
101655034  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
101655233  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
101655373  CXCL17; C-X-C motif chemokine 17 [KO:K22627]
101655661  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
101655814  CNTF; LOW QUALITY PROTEIN: ciliary neurotrophic factor [KO:K05420]
101656476  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
101656998  CCL17; C-C motif chemokine 17 [KO:K21083]
101657191  [KO:K05050]
101657280  IL2RG; LOW QUALITY PROTEIN: cytokine receptor common subunit gamma [KO:K05070]
101657308  CX3CL1; fractalkine [KO:K05508]
101657422  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101657479  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
101657488  GHR; growth hormone receptor [KO:K05080]
101657613  CCL22; C-C motif chemokine 22 [KO:K21095]
101657649  BMP15; bone morphogenetic protein 15 [KO:K05498]
101657801  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
101657861  PRL; prolactin [KO:K05439]
101658019  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
101658040  CCR10; C-C chemokine receptor type 10 [KO:K04185]
101658048  LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159]
101658132  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
101658181  IL2; interleukin-2 [KO:K05429]
101658298  NGF; beta-nerve growth factor [KO:K02582]
101658362  INHBA; inhibin beta A chain [KO:K04667]
101658364  CD27; CD27 antigen [KO:K05144]
101658394  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
101658397  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
101658420  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
101658450  [KO:K05050]
101658470  IL17C; interleukin-17C [KO:K05491]
101658502  IL21; interleukin-21 [KO:K05434]
101658811  CCR8; C-C chemokine receptor type 8 [KO:K04183]
101658890  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101658950  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
101658987  IFNLR1; interferon lambda receptor 1 [KO:K05140]
101659041  IL17F; interleukin-17F [KO:K05494]
101659058  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
101659067  LIFR; leukemia inhibitory factor receptor [KO:K05058]
101659086  EPOR; erythropoietin receptor [KO:K05079]
101659300  [KO:K05174]
101659305  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
101659356  IL17A; interleukin-17A [KO:K05489]
101659532  [KO:K05438]
101659612  IL18R1; interleukin-18 receptor 1 [KO:K05173]
101659751  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
101659926  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
101659959  BMP10; bone morphogenetic protein 10 [KO:K22670]
101660100  GDF5; growth/differentiation factor 5 [KO:K04664]
101660111  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
101660173  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
101660295  IL5; interleukin-5 [KO:K05428]
101660332  IL22; interleukin-22 [KO:K05445]
101660471  [KO:K05424]
101660515  IL25; interleukin-25 [KO:K05493]
101660553  IL1RL2; interleukin-1 receptor-like 2 [KO:K05172]
101660774  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101660798  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
101660872  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
101661183  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
101661201  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
101661380  IL23A; interleukin-23 subunit alpha [KO:K05426]
101661401  BMPR1B; bone morphogenetic protein receptor type-1B isoform X2 [KO:K13578] [EC:2.7.11.30]
101661409  CTF1; cardiotrophin-1 [KO:K24382]
101661569  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
101661680  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101661706  ACKR3; atypical chemokine receptor 3 [KO:K04304]
101661739  IL17RA; interleukin-17 receptor A [KO:K05164]
101662141  [KO:K14624]
101662149  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
101662341  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
101662350  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101662370  INHBB; inhibin beta B chain [KO:K22687]
101662451  [KO:K16597]
101662465  IL31; interleukin-31 [KO:K22631]
101662753  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
101662772  CCL1; C-C motif chemokine 1 [KO:K05514]
101662924  [KO:K04723]
101662977  CCR4; C-C chemokine receptor type 4 [KO:K04179]
101663170  EDA; ectodysplasin-A [KO:K05480]
101663291  CCR6; C-C chemokine receptor type 6 [KO:K04181]
101663598  NODAL; nodal homolog [KO:K04666]
101663716  EPO; erythropoietin [KO:K05437]
101664105  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101664241  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
101664359  [KO:K22669]
101664548  CXCL8; interleukin-8 [KO:K10030]
101664616  ACKR4; atypical chemokine receptor 4 [KO:K04186]
101664677  [KO:K22669]
105978190  [KO:K05475]
105978242  IL18; interleukin-18 [KO:K05482]
105978770  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
105978860  [KO:K16622]
115869391  [KO:K16598]
115872746  [KO:K16622]
123521347  IL36G; interleukin-36 gamma isoform X1 [KO:K05487]
123522305  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
123522472  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
123522712  [KO:K05405]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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