KEGG   PATHWAY: fch04510
Entry
fch04510                    Pathway                                
Name
Focal adhesion - Falco cherrug (Saker falcon)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
fch04510  Focal adhesion
fch04510

Other DBs
GO: 0005925
Organism
Falco cherrug (Saker falcon) [GN:fch]
Gene
102045918  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
102045976  CAV1; caveolin-1 [KO:K06278]
102046031  [KO:K06476]
102046128  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102046148  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102046174  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
102046242  LAMB2; laminin subunit beta-2 [KO:K06243]
102046312  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
102046374  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
102046521  THBS3; thrombospondin-3 [KO:K04659]
102046529  MYL2; LOW QUALITY PROTEIN: myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102046549  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
102046717  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
102046730  ITGA9; integrin alpha-9 [KO:K06585]
102046818  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102047033  COL1A2; collagen alpha-2(I) chain [KO:K06236]
102047228  [KO:K05734] [EC:2.7.11.1]
102047370  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102047380  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102047594  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
102047737  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
102047752  PIP5K1A; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
102047845  ITGA5; integrin alpha-5 [KO:K06484]
102047995  RAP1B; ras-related protein Rap-1b [KO:K07836]
102048020  PDGFC; platelet-derived growth factor C [KO:K05450]
102048076  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
102048115  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
102048204  EMP2; epithelial membrane protein 2 isoform X1 [KO:K26256]
102048216  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
102048221  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102048431  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
102048471  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102048492  CRK; adapter molecule crk [KO:K04438]
102048525  ZYX; zyxin isoform X4 [KO:K06273]
102048570  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
102048669  ACTN1; alpha-actinin-1 [KO:K05699]
102048772  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
102048929  SHC1; SHC-transforming protein 1 [KO:K06279]
102049085  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
102049160  RHOA; transforming protein RhoA [KO:K04513]
102049197  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102049265  EGF; pro-epidermal growth factor [KO:K04357]
102049277  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
102049349  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
102049446  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
102049450  [KO:K04659]
102049511  [KO:K19663] [EC:2.7.11.13]
102049812  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102049998  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
102050025  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
102050094  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102050186  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
102050194  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102050239  CAV2; caveolin-2 [KO:K12958]
102050353  ITGA10; integrin alpha-10 [KO:K06586]
102050406  JUN; transcription factor AP-1 [KO:K04448]
102050584  ITGB6; integrin beta-6 [KO:K06589]
102050643  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102050744  [KO:K12757]
102050787  ACTB; actin, cytoplasmic 1 [KO:K05692]
102051042  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102051053  [KO:K00907] [EC:2.7.11.18]
102051119  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
102051137  [KO:K12757]
102051164  CRKL; crk-like protein [KO:K04438]
102051437  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X7 [KO:K06277]
102051465  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102051466  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
102051485  VTN; vitronectin [KO:K06251]
102051492  [KO:K05096] [EC:2.7.10.1]
102051503  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102051620  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
102051664  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
102051757  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
102051835  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102051891  CAV3; caveolin-3 [KO:K12959]
102052167  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102052258  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
102052286  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102052290  PDGFD; platelet-derived growth factor D [KO:K05450]
102052372  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
102052384  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
102052422  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102052429  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
102052513  VWF; von Willebrand factor [KO:K03900]
102052718  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102052801  RAP1A; ras-related protein Rap-1A [KO:K04353]
102052902  PARVA; alpha-parvin isoform X1 [KO:K06275]
102053036  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102053069  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102053143  LAMB3; laminin subunit beta-3 [KO:K06244]
102053170  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102053189  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
102053357  EMP1; epithelial membrane protein 1 [KO:K26255]
102053397  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102053453  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
102053549  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102053577  VEGFA; vascular endothelial growth factor A [KO:K05448]
102053583  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102053624  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
102053780  LAMB4; laminin subunit beta-4 [KO:K06245]
102053816  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102053889  RELN; reelin [KO:K06249] [EC:3.4.21.-]
102053908  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
102053954  LAMB1; laminin subunit beta-1 [KO:K05636]
102054066  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X4 [KO:K06276] [EC:2.7.11.1]
102054080  CHAD; chondroadherin isoform X1 [KO:K06248]
102054093  [KO:K06269] [EC:3.1.3.16]
102054173  TNR; tenascin-R isoform X1 [KO:K06252]
102054176  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102054246  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
102054264  FN1; fibronectin [KO:K05717]
102054310  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102054322  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102054866  THBS1; thrombospondin-1 [KO:K16857]
102054986  SPP1; osteopontin [KO:K06250]
102055031  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
102055120  TLN2; talin-2 [KO:K06271]
102055425  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102055444  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
102055449  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
102055506  HRAS; GTPase HRas [KO:K02833]
102055526  PARVB; beta-parvin isoform X1 [KO:K06275]
102055583  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
102055640  FLNB; filamin-B isoform X1 [KO:K27392]
102055660  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
102055806  PARVG; gamma-parvin isoform X2 [KO:K06275]
102055811  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102055848  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
102055927  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102056115  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
102056135  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102056164  LAMC2; laminin subunit gamma-2 [KO:K06246]
102056264  LAMA1; laminin subunit alpha-1 [KO:K05637]
102056280  TNC; tenascin isoform X1 [KO:K06252]
102056333  LAMC1; laminin subunit gamma-1 [KO:K05635]
102056424  SOS2; son of sevenless homolog 2 [KO:K03099]
102056589  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102056680  ITGA2; integrin alpha-2 [KO:K06481]
102056732  ITGA4; integrin alpha-4 [KO:K06483]
102056825  [KO:K05692]
102056851  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
102056852  IBSP; bone sialoprotein 2 isoform X1 [KO:K06253]
102056938  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102057018  TNN; LOW QUALITY PROTEIN: tenascin-N [KO:K06252]
102057028  PXN; paxillin [KO:K05760]
102057083  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102057209  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102057369  COL9A3; LOW QUALITY PROTEIN: collagen alpha-3(IX) chain [KO:K08131]
102057374  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
102057414  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102057542  FYN; tyrosine-protein kinase Fyn isoform X2 [KO:K05703] [EC:2.7.10.2]
102057575  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102057654  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
102057992  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
102057999  VCL; vinculin isoform X3 [KO:K05700]
102058260  MYL10; myosin regulatory light chain 10 isoform X2 [KO:K12756]
102058347  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
102058399  LAMA5; laminin subunit alpha-5 [KO:K06240]
102058478  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102058509  COMP; cartilage oligomeric matrix protein [KO:K04659]
102058683  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102058744  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
102058848  LAMC3; laminin subunit gamma-3 [KO:K06247]
102058984  ITGA8; integrin alpha-8 [KO:K06584]
102059098  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
102059103  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
102059158  PTK2; focal adhesion kinase 1 isoform X9 [KO:K05725] [EC:2.7.10.2]
102059161  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
102059263  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102059271  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102059378  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X3 [KO:K12329]
102059472  THBS2; thrombospondin-2 [KO:K04659]
102059514  TLN1; talin-1 isoform X2 [KO:K06271]
102059517  [KO:K02649]
102059520  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102059641  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
102059714  ITGB8; integrin beta-8 isoform X4 [KO:K06591]
102059725  [KO:K05699]
102059828  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102059900  COL2A1; LOW QUALITY PROTEIN: collagen alpha-1(II) chain [KO:K19719]
102059983  PGF; placenta growth factor [KO:K16859]
102060018  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102060062  IGF1; insulin-like growth factor I [KO:K05459]
102060179  ITGAV; integrin alpha-V [KO:K06487]
102060261  VEGFD; vascular endothelial growth factor D [KO:K05449]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
fch04010  MAPK signaling pathway
fch04060  Cytokine-cytokine receptor interaction
fch04070  Phosphatidylinositol signaling system
fch04110  Cell cycle
fch04310  Wnt signaling pathway
fch04512  ECM-receptor interaction
fch04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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