KEGG   PATHWAY: gvr05207
Entry
gvr05207                    Pathway                                
Name
Chemical carcinogenesis - receptor activation - Galeopterus variegatus (Sunda flying lemur)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
gvr05207  Chemical carcinogenesis - receptor activation
gvr05207

Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103583204  [KO:K08047] [EC:4.6.1.1]
103583388  [KO:K19663] [EC:2.7.11.13]
103583638  [KO:K00799] [EC:2.5.1.18]
103583848  [KO:K15730] [EC:5.3.99.3]
103584009  [KO:K09048]
103585066  CHRNA9; neuronal acetylcholine receptor subunit alpha-9 [KO:K04810]
103585135  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103585172  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
103585217  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
103585251  [KO:K04809]
103585324  ESR2; estrogen receptor beta [KO:K08551]
103585463  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103585491  KPNA2; LOW QUALITY PROTEIN: importin subunit alpha-1 [KO:K15043]
103585560  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
103585612  [KO:K00799] [EC:2.5.1.18]
103585621  [KO:K00799] [EC:2.5.1.18]
103585630  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
103585760  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
103586204  BAD; bcl2 antagonist of cell death [KO:K02158]
103586304  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
103586347  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
103586462  KPNA5; importin subunit alpha-6 [KO:K15042]
103586572  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103586701  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103586784  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103586861  E2F1; transcription factor E2F1 [KO:K17454]
103587154  [KO:K00799] [EC:2.5.1.18]
103587155  [KO:K00799] [EC:2.5.1.18]
103587156  [KO:K00799] [EC:2.5.1.18]
103587157  [KO:K00799] [EC:2.5.1.18]
103587459  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103587634  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
103587820  MYC; myc proto-oncogene protein [KO:K04377]
103587883  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103588056  [KO:K07409] [EC:1.14.14.1]
103588057  [KO:K07408] [EC:1.14.14.1]
103588331  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
103588342  [KO:K04079]
103588410  ARRB2; beta-arrestin-2 [KO:K04439]
103588497  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103588543  DLL4; delta-like protein 4 [KO:K06051]
103588567  HSP90B1; endoplasmin [KO:K09487]
103588664  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103588673  FGF7; fibroblast growth factor 7 [KO:K04358]
103588716  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103588746  FGF20; fibroblast growth factor 20 [KO:K04358]
103588815  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103588854  WNT1; proto-oncogene Wnt-1 [KO:K03209]
103588863  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103589107  KPNB1; importin subunit beta-1 [KO:K14293]
103589135  ADRB1; beta-1 adrenergic receptor [KO:K04141]
103589329  NRAS; GTPase NRas [KO:K07828]
103589434  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103589593  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
103589982  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
103589988  AIP; AH receptor-interacting protein [KO:K17767]
103590053  PAQR7; membrane progestin receptor alpha [KO:K25039]
103590113  UGT1A6; UDP-glucuronosyltransferase 1-6 isoform X1 [KO:K00699] [EC:2.4.1.17]
103590144  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
103590279  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103590414  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
103590618  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103590768  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
103590810  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
103591384  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103591489  [KO:K09093]
103591612  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
103591675  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
103591744  FGF9; fibroblast growth factor 9 [KO:K04358]
103591872  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103591959  CHRNB4; neuronal acetylcholine receptor subunit beta-4 [KO:K04815]
103591961  CHRNA3; neuronal acetylcholine receptor subunit alpha-3 [KO:K04805]
103592192  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103592390  JUN; transcription factor AP-1 [KO:K04448]
103592574  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103592660  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
103592681  PTGES3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
103592952  PAQR5; membrane progestin receptor gamma isoform X1 [KO:K25041]
103593080  JAG1; protein jagged-1 [KO:K06052]
103593419  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
103593663  RB1; retinoblastoma-associated protein [KO:K06618]
103593683  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103593713  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
103593805  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
103593962  FGF17; fibroblast growth factor 17 [KO:K04358]
103594351  FGF18; fibroblast growth factor 18 [KO:K04358]
103594556  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
103594579  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
103594939  KPNA6; importin subunit alpha-7 [KO:K15042]
103594947  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103595029  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
103595172  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
103595295  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103595313  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
103595334  RELA; transcription factor p65 [KO:K04735]
103595352  [KO:K11224]
103595355  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
103595356  [KO:K04692]
103595380  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103595413  FGF8; fibroblast growth factor 8 [KO:K04358]
103595446  VDR; vitamin D3 receptor isoform X1 [KO:K08539]
103595468  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
103595819  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
103595967  BIRC5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
103596129  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103596252  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 isoform X1 [KO:K04806]
103596384  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103596428  BCL6; B-cell lymphoma 6 protein [KO:K15618]
103596549  NR1I3; nuclear receptor subfamily 1 group I member 3 [KO:K08541]
103597025  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103597068  FGF16; fibroblast growth factor 16 [KO:K04358]
103597103  AR; androgen receptor [KO:K08557]
103597229  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103597297  AIPL1; aryl-hydrocarbon-interacting protein-like 1 isoform X1 [KO:K17767]
103597918  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103597936  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
103598325  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103598337  [KO:K04373] [EC:2.7.11.1]
103598410  ARRB1; beta-arrestin-1 [KO:K04439]
103598510  DLL3; delta-like protein 3 [KO:K06051]
103598524  UGT2A3; UDP-glucuronosyltransferase 2A3 isoform X1 [KO:K00699] [EC:2.4.1.17]
103598534  [KO:K20994]
103599238  KPNA7; importin subunit alpha-8 [KO:K15043]
103599295  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103599501  KRAS; GTPase KRas [KO:K07827]
103599555  KLF4; Krueppel-like factor 4 isoform X1 [KO:K17846]
103599611  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103599669  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103599847  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103599869  [KO:K00699] [EC:2.4.1.17]
103599871  [KO:K00699] [EC:2.4.1.17]
103599872  [KO:K00699] [EC:2.4.1.17]
103599873  [KO:K00699] [EC:2.4.1.17]
103599965  KLF5; Krueppel-like factor 5 [KO:K09206]
103600115  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
103600170  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
103600172  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
103600278  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
103600324  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103600371  PGR; progesterone receptor [KO:K08556]
103600497  [KO:K07412] [EC:1.14.14.1]
103600797  [KO:K07410] [EC:1.14.14.1]
103601062  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
103601216  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
103601359  DLL1; delta-like protein 1 [KO:K06051]
103601761  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
103601973  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
103602127  KPNA3; importin subunit alpha-4 [KO:K23583]
103602136  FGF10; fibroblast growth factor 10 isoform X1 [KO:K04358]
103602483  KPNA1; importin subunit alpha-5 [KO:K23940]
103602586  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
103602700  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
103603077  [KO:K04851]
103603414  ADRB2; beta-2 adrenergic receptor [KO:K04142]
103603638  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
103604574  [KO:K04849]
103604776  [KO:K04361] [EC:2.7.10.1]
103604998  [KO:K04358]
103604999  FGF3; fibroblast growth factor 3 [KO:K04358]
103605275  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103605422  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
103605424  [KO:K00799] [EC:2.5.1.18]
103605698  [KO:K04456] [EC:2.7.11.1]
103605891  FOS; proto-oncogene c-Fos [KO:K04379]
103605899  KPNA4; importin subunit alpha-3 [KO:K23583]
103606115  AHR; aryl hydrocarbon receptor [KO:K09093]
103606198  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
103606211  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
103606316  [KO:K07424] [EC:1.14.14.1]
103606317  [KO:K07424] [EC:1.14.14.1]
103606686  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
103606837  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
103607082  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103607349  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
103607736  CDC6; cell division control protein 6 homolog isoform X1 [KO:K02213]
103608053  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
103608112  CHRNB2; LOW QUALITY PROTEIN: neuronal acetylcholine receptor subunit beta-2 [KO:K04813]
103608454  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103608810  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
103608866  [KO:K04632]
103608964  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
103609025  [KO:K00799] [EC:2.5.1.18]
103609252  GSTA4; glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
103609408  FGF6; fibroblast growth factor 6 [KO:K04358]
103609494  [KO:K00699] [EC:2.4.1.17]
103609495  [KO:K00699] [EC:2.4.1.17]
103609500  [KO:K00699] [EC:2.4.1.17]
103610024  PAQR8; membrane progestin receptor beta isoform X1 [KO:K25040]
103610085  FGF22; fibroblast growth factor 22 [KO:K04358]
103610440  [KO:K00699] [EC:2.4.1.17]
103610513  HRAS; GTPase HRas isoform X1 [KO:K02833]
103610749  [KO:K04725] [EC:2.3.2.27]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:19631282
  Authors
Hernandez LG, van Steeg H, Luijten M, van Benthem J
  Title
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
  Journal
Mutat Res 682:94-109 (2009)
DOI:10.1016/j.mrrev.2009.07.002
Reference
PMID:21444681
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Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
Reference
PMID:19194381
  Authors
Schuller HM
  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
  Journal
Nat Rev Cancer 9:195-205 (2009)
DOI:10.1038/nrc2590
Reference
PMID:21541211
  Authors
Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
  Journal
J Oncol 2011:456743 (2011)
DOI:10.1155/2011/456743
Reference
PMID:31956359
  Authors
Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
  Title
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
  Journal
J Cancer 11:1125-1140 (2020)
DOI:10.7150/jca.36359
Reference
PMID:24827506
  Authors
Grando SA
  Title
Connections of nicotine to cancer.
  Journal
Nat Rev Cancer 14:419-29 (2014)
DOI:10.1038/nrc3725
Reference
PMID:24398389
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
Reference
PMID:21640716
  Authors
Improgo MR, Tapper AR, Gardner PD
  Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
  Journal
Biochem Pharmacol 82:1015-21 (2011)
DOI:10.1016/j.bcp.2011.05.020
Reference
PMID:18262664
  Authors
Egleton RD, Brown KC, Dasgupta P
  Title
Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.
  Journal
Trends Pharmacol Sci 29:151-8 (2008)
DOI:10.1016/j.tips.2007.12.006
Reference
PMID:24830349
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Xue J, Yang S, Seng S
  Title
Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN.
  Journal
Cancers (Basel) 6:1138-56 (2014)
DOI:10.3390/cancers6021138
Reference
PMID:21801603
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Wen J, Fu JH, Zhang W, Guo M
  Title
Lung carcinoma signaling pathways activated by smoking.
  Journal
Chin J Cancer 30:551-8 (2011)
DOI:10.5732/cjc.011.10059
Reference
PMID:28664511
  Authors
Gankhuyag N, Lee KH, Cho JY
  Title
The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis.
  Journal
J Mammary Gland Biol Neoplasia 22:159-170 (2017)
DOI:10.1007/s10911-017-9381-z
Reference
PMID:22330135
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Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ
  Title
IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer.
  Journal
Oncogene 32:151-9 (2013)
DOI:10.1038/onc.2012.39
Reference
PMID:20106947
  Authors
Chen RJ, Ho YS, Guo HR, Wang YJ
  Title
Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells.
  Journal
Toxicol Sci 115:118-30 (2010)
DOI:10.1093/toxsci/kfq028
Reference
PMID:20953833
  Authors
Lee CH, Chang YC, Chen CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Chang HW, Chang CH, Huang CS, Wu CH, Ho YS
  Title
Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces alpha9-nicotinic acetylcholine receptor expression in human breast cancer cells.
  Journal
Breast Cancer Res Treat 129:331-45 (2011)
DOI:10.1007/s10549-010-1209-0
Reference
PMID:16421368
  Authors
Yager JD, Davidson NE
  Title
Estrogen carcinogenesis in breast cancer.
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N Engl J Med 354:270-82 (2006)
DOI:10.1056/NEJMra050776
Reference
PMID:29229539
  Authors
Murata M, Kang JH
  Title
Bisphenol A (BPA) and cell signaling pathways.
  Journal
Biotechnol Adv 36:311-327 (2018)
DOI:10.1016/j.biotechadv.2017.12.002
Reference
PMID:28251049
  Authors
Wang Z, Liu H, Liu S
  Title
Low-Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer.
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Related
pathway
gvr00980  Metabolism of xenobiotics by cytochrome P450
gvr03320  PPAR signaling pathway
gvr04010  MAPK signaling pathway
gvr04024  cAMP signaling pathway
gvr04150  mTOR signaling pathway
gvr04151  PI3K-Akt signaling pathway
gvr04370  VEGF signaling pathway
gvr04915  Estrogen signaling pathway
gvr05204  Chemical carcinogenesis - DNA adducts
gvr05206  MicroRNAs in cancer
gvr05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   

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