KEGG   PATHWAY: mbez04510
Entry
mbez04510                   Pathway                                
Name
Focal adhesion - Moschus berezovskii (Chinese forest musk deer)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mbez04510  Focal adhesion
mbez04510

Other DBs
GO: 0005925
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129535252  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
129535668  VWF; von Willebrand factor [KO:K03900]
129535732  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
129535790  PARVB; beta-parvin [KO:K06275]
129535852  ITGA5; integrin alpha-5 [KO:K06484]
129535856  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
129536162  COL2A1; collagen alpha-1(II) chain [KO:K19719]
129536177  EMP1; epithelial membrane protein 1 [KO:K26255]
129536369  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
129536390  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
129536404  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
129536703  PARVG; gamma-parvin isoform X1 [KO:K06275]
129536787  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
129536806  VTN; vitronectin [KO:K06251]
129536830  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
129537242  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
129537257  RAP1B; ras-related protein Rap-1b [KO:K07836]
129537587  ITGB5; integrin beta-5 [KO:K06588]
129537610  FN1; fibronectin isoform X1 [KO:K05717]
129537845  [KO:K06269] [EC:3.1.3.16]
129538089  ITGA4; integrin alpha-4 [KO:K06483]
129538374  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
129538376  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
129538496  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
129538654  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
129538673  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
129539448  [KO:K04513]
129539573  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
129539650  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
129539680  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
129539810  [KO:K04392]
129539892  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
129539931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129539945  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
129540534  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
129540610  JUN; transcription factor Jun [KO:K04448]
129540618  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
129540703  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
129540801  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129540831  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
129541258  CRK; adapter molecule crk isoform X1 [KO:K04438]
129541434  [KO:K04353]
129541489  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
129541813  RAP1A; ras-related protein Rap-1A [KO:K04353]
129541824  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
129541834  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
129542185  PXN; paxillin isoform X1 [KO:K05760]
129542485  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129542494  CRKL; crk-like protein [KO:K04438]
129542500  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
129542695  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
129542802  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
129542873  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
129543220  VEGFA; vascular endothelial growth factor A [KO:K05448]
129543225  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
129543836  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
129543838  TNXB; tenascin-X isoform X1 [KO:K06252]
129544261  CHAD; chondroadherin [KO:K06248]
129544266  COL1A1; collagen alpha-1(I) chain [KO:K06236]
129544270  ITGA3; integrin alpha-3 [KO:K06482]
129544356  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
129544365  CDC42; cell division control protein 42 homolog [KO:K04393]
129544490  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
129544525  ITGB3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
129544591  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
129544620  ACTG1; actin, cytoplasmic 2 [KO:K05692]
129544714  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
129544725  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129544793  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
129545141  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
129545284  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
129545370  EMP2; epithelial membrane protein 2 [KO:K26256]
129545462  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129545501  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129545529  MYL11; myosin regulatory light chain 11 [KO:K12758]
129545763  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129545772  ACTB; actin, cytoplasmic 1 [KO:K05692]
129545815  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
129545961  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
129546400  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
129546625  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
129546665  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
129546814  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129546841  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
129546857  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
129547136  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
129547146  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129547261  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
129547527  [KO:K06243]
129547721  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129547827  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
129547838  RHOA; transforming protein RhoA [KO:K04513]
129547960  FLNB; filamin-B isoform X1 [KO:K27392]
129548045  CAV3; caveolin-3 [KO:K12959]
129548107  CTNNB1; catenin beta-1 [KO:K02105]
129548149  ITGA9; integrin alpha-9 [KO:K06585]
129548207  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129548597  HRAS; GTPase HRas isoform X1 [KO:K02833]
129548664  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
129548700  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
129548784  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
129548816  BAD; bcl2-associated agonist of cell death [KO:K02158]
129548822  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
129548841  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
129549029  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
129549287  VEGFC; vascular endothelial growth factor C [KO:K05449]
129549388  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
129549397  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
129549633  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
129549727  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
129549745  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
129549761  [KO:K12757]
129549763  [KO:K12757]
129549902  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129550230  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
129550347  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
129550501  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
129550706  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129551066  TNR; tenascin-R [KO:K06252]
129551067  TNN; tenascin-N [KO:K06252]
129551173  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
129551233  LAMB3; laminin subunit beta-3 [KO:K06244]
129551301  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
129551306  LAMC1; laminin subunit gamma-1 [KO:K05635]
129551508  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129551602  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129551654  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
129552089  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
129552228  COL1A2; collagen alpha-2(I) chain [KO:K06236]
129552289  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
129552336  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
129552370  RELN; reelin [KO:K06249] [EC:3.4.21.-]
129552404  LAMB1; laminin subunit beta-1 [KO:K05636]
129552406  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
129552423  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129552427  CAV1; caveolin-1 isoform X1 [KO:K06278]
129552428  CAV2; caveolin-2 [KO:K12958]
129552712  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129552737  ZYX; zyxin [KO:K06273]
129553207  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
129553269  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
129553271  ITGA1; integrin alpha-1 [KO:K06480]
129554238  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
129554248  [KO:K16060]
129554250  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
129554502  PARVA; alpha-parvin [KO:K06275]
129554581  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
129554914  [KO:K04392]
129555249  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
129555578  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
129555633  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129555693  VCL; vinculin isoform X1 [KO:K05700]
129556249  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
129556364  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
129556509  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
129556510  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
129556790  TLN1; talin-1 isoform X1 [KO:K06271]
129557186  SHC3; SHC-transforming protein 3 [KO:K17448]
129557201  TNC; tenascin isoform X1 [KO:K06252]
129557511  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
129557632  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
129558012  COMP; cartilage oligomeric matrix protein [KO:K04659]
129558269  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
129558379  SHC2; SHC-transforming protein 2 [KO:K17447]
129558396  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
129558488  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
129558539  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
129559031  VAV1; proto-oncogene vav [KO:K05730]
129559156  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129559190  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
129559467  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129559901  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
129560680  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
129560944  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
129561006  THBS2; thrombospondin-2 [KO:K04659]
129561134  [KO:K02105]
129561184  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
129561261  LAMA2; laminin subunit alpha-2 [KO:K05637]
129561272  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
129561305  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
129561563  IBSP; bone sialoprotein 2 [KO:K06253]
129561625  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
129561712  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
129561762  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
129561928  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
129562034  SPP1; osteopontin [KO:K06250]
129562088  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
129562134  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
129562363  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
129562372  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
129562490  TLN2; talin-2 isoform X1 [KO:K06271]
129562544  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
129562678  SOS2; son of sevenless homolog 2 [KO:K03099]
129562886  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
129562932  SHC4; SHC-transforming protein 4 [KO:K17449]
129563114  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
129563157  PGF; placenta growth factor isoform X1 [KO:K16859]
129563190  ITGA11; integrin alpha-11 [KO:K06587]
129563285  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
129563548  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
129564230  FLNA; filamin-A isoform X1 [KO:K04437]
129564249  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
129564296  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
129564305  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
129564310  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
129564349  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
129564389  [KO:K16060]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mbez04010  MAPK signaling pathway
mbez04060  Cytokine-cytokine receptor interaction
mbez04070  Phosphatidylinositol signaling system
mbez04110  Cell cycle
mbez04151  PI3K-Akt signaling pathway
mbez04310  Wnt signaling pathway
mbez04512  ECM-receptor interaction
mbez04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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