Entry
Name
PI3K-Akt signaling pathway - Moschus berezovskii (Chinese forest musk deer)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:
mbez ]
Gene
129561712 EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357 ]
129542296 FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497 ]
129541681 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
129546548 FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454 ]
129548822 VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858 ]
129564310 VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449 ]
129553310 GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452 ]
129544277 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
129545763 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
129543305 LOW QUALITY PROTEIN: chorionic somatomammotropin hormone 2-like [KO:K05439 ]
129543400 LOW QUALITY PROTEIN: placental prolactin-related protein 3-like [KO:K05439 ]
129543476 LOW QUALITY PROTEIN: placental prolactin-related protein 4-like [KO:K05439 ]
129537423 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
129553307 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
129556783 IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
129553320 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
129540790 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
129551508 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
129547146 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
129559156 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
129553207 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
129540801 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
129551433 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
129545675 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
129536555 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
129562435 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
129548858 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
129555099 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
129558470 GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
129552025 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548 ]
129552393 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289 ] [EC:2.7.1.153 ]
129543633 PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290 ]
129543654 PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290 ]
129545267 MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266 ]
129544632 RPTOR; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204 ]
129549398 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
129555980 eukaryotic translation initiation factor 4E type 1B-like [KO:K03259 ]
129537884 EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259 ]
129558881 EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259 ]
129561564 EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259 ]
129537152 EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258 ]
129547993 MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631 ]
129552348 MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629 ]
129558414 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
129563803 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456 ]
129563804 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456 ]
129546445 PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
129554318 PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456 ]
129542474 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354 ]
129556913 PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354 ]
129559074 PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354 ]
129562057 PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354 ]
129564509 PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583 ]
129550514 PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583 ]
129547508 PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583 ]
129548796 PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584 ]
129563521 PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584 ]
129543513 PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584 ]
129550662 PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584 ]
129551253 PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584 ]
129549628 LOW QUALITY PROTEIN: uncharacterized protein LOC129549628 [KO:K04079 ]
129550661 LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079 ]
129535215 LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079 ]
129540563 CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333 ]
129546934 PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340 ] [EC:3.1.3.16 ]
129551094 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
129538457 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
129537505 ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
129536687 ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
129540547 LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374 ]
129556793 CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048 ]
129559023 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048 ]
129552685 CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048 ]
129540564 CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048 ]
129554794 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048 ]
129552502 CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
129543841 ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049 ]
129541406 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539 ]
129562101 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
Compound
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Engelman JA, Luo J, Cantley LC
Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
Journal
Reference
Authors
Song G, Ouyang G, Bao S
Title
The activation of Akt/PKB signaling pathway and cell survival.
Journal
Reference
Authors
Hers I, Vincent EE, Tavare JM
Title
Akt signalling in health and disease.
Journal
Reference
Authors
Duronio V
Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
Journal
Reference
Authors
Kim D, Chung J.
Title
Akt: versatile mediator of cell survival and beyond.
Journal
Reference
Authors
Koyasu S
Title
The role of PI3K in immune cells.
Journal
Reference
Authors
Okkenhaug K, Vanhaesebroeck B.
Title
PI3K in lymphocyte development, differentiation and activation.
Journal
Reference
Authors
Richardson CJ, Schalm SS, Blenis J
Title
PI3-kinase and TOR: PIKTORing cell growth.
Journal
Reference
Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
Title
Akt, FoxO and regulation of apoptosis.
Journal
Reference
Authors
Georgescu MM
Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
Journal
Reference
Authors
West KA, Castillo SS, Dennis PA
Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
Journal
Reference
Authors
Wymann MP, Pirola L
Title
Structure and function of phosphoinositide 3-kinases.
Journal
Reference
Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
Title
Regulation of Raf-Akt Cross-talk.
Journal
Reference
Authors
Kikani CK, Dong LQ, Liu F
Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
Journal
Reference
Authors
Blume-Jensen P, Hunter T
Title
Oncogenic kinase signalling.
Journal
Reference
Authors
Osaki M, Oshimura M, Ito H
Title
PI3K-Akt pathway: its functions and alterations in human cancer.
Journal
Reference
Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Related pathway
mbez04620 Toll-like receptor signaling pathway
KO pathway
LinkDB
All DBs