KEGG   PATHWAY: mcf05202
Entry
mcf05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Macaca fascicularis (crab-eating macaque)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
mcf05202  Transcriptional misregulation in cancer
mcf05202

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101864810  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
101865056  BMI1; polycomb complex protein BMI-1 [KO:K11459]
101865178  ETV5; ETS translocation variant 5 [KO:K15593]
101865484  FUT8; alpha-(1,6)-fucosyltransferase isoform X1 [KO:K00717] [EC:2.4.1.68]
101865661  PROM1; prominin-1 isoform X1 [KO:K06532]
101865995  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
101866035  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
101866174  SS18; protein SSXT isoform X1 [KO:K15623]
101866311  KMT2A; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
101866398  CDK14; cyclin-dependent kinase 14 isoform X2 [KO:K08821] [EC:2.7.11.22]
101866471  MAX; protein max isoform X1 [KO:K04453]
101866775  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
101867066  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
101867139  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
101867480  PAX3; paired box protein Pax-3 isoform X1 [KO:K09381]
101925142  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
101925178  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
101925549  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
101925550  PTK2; focal adhesion kinase 1 isoform X3 [KO:K05725] [EC:2.7.10.2]
101925561  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
101926276  [KO:K11253]
101926297  EYA1; eyes absent homolog 1 isoform X2 [KO:K15616] [EC:3.1.3.48]
101926502  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3 [KO:K11427] [EC:2.1.1.360]
101926559  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
101926602  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X2 [KO:K12823] [EC:5.6.2.7]
101926617  LMO2; rhombotin-2 isoform X1 [KO:K15612]
101926722  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102114944  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
102114968  CCNT1; cyclin-T1 isoform X1 [KO:K15188]
102115080  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102115279  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102115299  DEFA6; defensin-6 [KO:K05230]
102115306  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102115311  BCL6; B-cell lymphoma 6 protein [KO:K15618]
102115442  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102115659  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
102115676  DEFA4; LOW QUALITY PROTEIN: defensin alpha 4 [KO:K05230]
102115996  SP1; transcription factor Sp1 isoform X3 [KO:K04684]
102116432  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
102116444  [KO:K05230]
102116653  REL; proto-oncogene C-Rel isoform X3 [KO:K09254]
102116712  FOXO1; forkhead box protein O1 [KO:K07201]
102116857  EWSR1; RNA-binding protein EWS isoform X6 [KO:K13209]
102116893  BMP2K; BMP-2-inducible protein kinase isoform X1 [KO:K08854] [EC:2.7.11.1]
102117020  [KO:K11253]
102117042  MYCN; N-myc proto-oncogene protein isoform X1 [KO:K09109]
102117659  [KO:K05230]
102117693  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
102117786  PAX7; paired box protein Pax-7 [KO:K09381]
102117954  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X2 [KO:K06624]
102118074  HMGA2; high mobility group protein HMGI-C isoform X2 [KO:K09283]
102118362  IL3; interleukin-3 [KO:K04736]
102118388  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
102118526  RUNX1T1; LOW QUALITY PROTEIN: protein CBFA2T1 [KO:K10053]
102118641  [KO:K05230]
102118672  [KO:K11253]
102118696  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
102118747  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
102118903  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
102119140  MLLT3; protein AF-9 isoform X1 [KO:K15187]
102119204  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
102119223  [KO:K15624]
102119572  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102120453  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
102120697  NFKBIZ; NF-kappa-B inhibitor zeta isoform X1 [KO:K14242]
102120730  MAF; transcription factor Maf isoform X1 [KO:K09035]
102120735  [KO:K15624]
102121259  [KO:K15624]
102121325  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
102121356  [KO:K15624]
102121461  MLLT1; protein ENL isoform X1 [KO:K15187]
102121501  [KO:K06067] [EC:3.5.1.98]
102121884  SUPT3H; transcription initiation protein SPT3 homolog isoform X3 [KO:K11313]
102122019  [KO:K15624]
102122045  SPINT1; kunitz-type protease inhibitor 1 isoform X1 [KO:K15619]
102122434  CCNA2; cyclin-A2 [KO:K06627]
102122479  [KO:K13105]
102122532  [KO:K06856]
102122565  BCL2A1; bcl-2-related protein A1 [KO:K02162]
102122741  ERG; transcriptional regulator ERG isoform X5 [KO:K09435]
102122893  KDM6A; lysine-specific demethylase 6A isoform X4 [KO:K11447] [EC:1.14.11.68]
102122895  [KO:K15624]
102123260  [KO:K15624]
102123512  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102123638  [KO:K11253]
102124177  [KO:K15624]
102124214  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102124310  RUNX2; runt-related transcription factor 2 isoform X2 [KO:K09278]
102124623  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
102124814  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
102125039  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
102125546  [KO:K05230]
102125912  [KO:K05230]
102125981  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
102126352  LYL1; protein lyl-1 [KO:K15604]
102126620  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102126703  [KO:K05230]
102127195  ETV4; ETS translocation variant 4 isoform X3 [KO:K15592]
102127272  CXCL8; interleukin-8 [KO:K10030]
102127513  AFF1; AF4/FMR2 family member 1 isoform X2 [KO:K15184]
102127880  TSPAN7; tetraspanin-7 [KO:K06571]
102127956  TAF15; TATA-binding protein-associated factor 2N isoform X1 [KO:K14651]
102127966  MYC; myc proto-oncogene protein [KO:K04377]
102128018  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
102128083  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
102128204  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
102128485  SIX1; homeobox protein SIX1 [KO:K15614]
102128714  PAX8; paired box protein Pax-8 isoform X4 [KO:K09293]
102129342  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
102129364  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
102129537  TCF3; transcription factor E2-alpha isoform X2 [KO:K09063]
102129932  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
102130133  [KO:K11253]
102130142  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102130174  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
102130260  GZMB; granzyme B [KO:K01353] [EC:3.4.21.79]
102130410  MPO; myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
102131274  WT1; Wilms tumor protein isoform X3 [KO:K09234]
102131304  SIX4; homeobox protein SIX4 isoform X1 [KO:K15615]
102131470  HOXA11; homeobox protein Hox-A11 [KO:K21951]
102131632  DDIT3; DNA damage-inducible transcript 3 protein isoform X2 [KO:K04452]
102131929  PRCC; proline-rich protein PRCC isoform X1 [KO:K13105]
102132255  BAX; apoptosis regulator BAX isoform X6 [KO:K02159]
102132310  PBX1; pre-B-cell leukemia transcription factor 1 isoform X6 [KO:K09355]
102132397  [KO:K06067] [EC:3.5.1.98]
102132522  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
102132722  RARA; retinoic acid receptor alpha isoform X2 [KO:K08527]
102132881  HOXA9; homeobox protein Hox-A9 [KO:K21950]
102132914  NSD2; histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
102132944  FLI1; Friend leukemia integration 1 transcription factor isoform X2 [KO:K09436]
102132965  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
102133117  [KO:K11253]
102133330  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
102133638  HOXA10; homeobox protein Hox-A10 [KO:K17443]
102134273  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102134336  [KO:K11253]
102134847  MEN1; menin isoform X1 [KO:K14970]
102134887  TLX1; T-cell leukemia homeobox protein 1 [KO:K09340]
102135061  FEV; protein FEV [KO:K09437]
102135088  MEF2C; myocyte-specific enhancer factor 2C isoform X2 [KO:K04454]
102135480  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102135637  ELANE; neutrophil elastase isoform X1 [KO:K01327] [EC:3.4.21.37]
102135666  PTCRA; pre T-cell antigen receptor alpha isoform X2 [KO:K06056]
102135847  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
102135886  PLAU; urokinase-type plasminogen activator isoform X1 [KO:K01348] [EC:3.4.21.73]
102135944  [KO:K11253]
102135998  TP53; cellular tumor antigen P53 [KO:K04451]
102136063  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102136081  KLF3; Krueppel-like factor 3 isoform X3 [KO:K15605]
102136120  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
102136323  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102136550  JUP; junction plakoglobin [KO:K10056]
102137024  BCL11B; B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
102137082  ITGB7; integrin beta-7 isoform X3 [KO:K06590]
102137447  TMPRSS2; transmembrane protease serine 2 isoform X1 [KO:K09633] [EC:3.4.21.122]
102137525  ATM; serine-protein kinase ATM isoform X3 [KO:K04728] [EC:2.7.11.1]
102137780  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
102138168  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
102138231  SS18L1; calcium-responsive transactivator isoform X1 [KO:K15623]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
102138308  H3-4; histone H3.1t [KO:K11253]
102138714  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
102138940  MLF1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
102138971  IL6; interleukin-6 precursor [KO:K05405]
102139360  ETV7; transcription factor ETV7 isoform X2 [KO:K03211]
102139514  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
102140664  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
102140882  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
102140931  SPI1; transcription factor PU.1 isoform X3 [KO:K09438]
102141183  PER2; period circadian protein homolog 2 [KO:K02633]
102142272  NR4A3; nuclear receptor subfamily 4 group A member 3 isoform X1 [KO:K08559]
102142327  ETV6; transcription factor ETV6 isoform X1 [KO:K03211]
102142357  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
102142460  WNT16; protein Wnt-16 [KO:K01558]
102142651  MMP3; stromelysin-1 [KO:K01394] [EC:3.4.24.17]
102143079  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X3 [KO:K11449] [EC:1.14.11.-]
102143926  IL1R2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
102144139  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
102144336  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
102144470  SIN3A; paired amphipathic helix protein Sin3a isoform X3 [KO:K11644]
102144553  [KO:K11253]
102144652  TFE3; transcription factor E3 isoform X1 [KO:K09105]
102144988  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X4 [KO:K05092] [EC:2.7.10.1]
102145008  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
102145310  MEIS1; homeobox protein Meis1 isoform X2 [KO:K15613]
102145462  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
102145509  BAIAP3; BAI1-associated protein 3 [KO:K15621]
102145763  ETV1; ETS translocation variant 1 isoform X2 [KO:K09431]
102145856  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
102146338  [KO:K11253]
102146652  NUPR1; nuclear protein 1 isoform X1 [KO:K15626]
102146894  [KO:K11253]
102147067  [KO:K11253]
102147198  FCGR1A; LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
102147235  CD86; T-lymphocyte activation antigen CD86 isoform X6 [KO:K05413]
107126396  [KO:K15624]
107128638  [KO:K06856]
107130290  [KO:K06856]
123571056  [KO:K15624]
123571637  [KO:K11253]
123574606  [KO:K06856]
135964514  [KO:K05230]
135964515  [KO:K05230]
135964591  [KO:K05230]
135964874  [KO:K05230]
135965514  [KO:K15619]
135965565  [KO:K15619]
135971582  [KO:K06856]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
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Br J Haematol 145:140-3 (2009)
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Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
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Blood 101:3681-6 (2003)
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Blood 97:2798-807 (2001)
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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Curr Opin Genet Dev 19:82-91 (2009)
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Biochim Biophys Acta 1796:201-15 (2009)
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
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An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
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Cancer Cell 17:443-54 (2010)
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
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PLoS One 6:e21650 (2011)
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
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The MYCN oncogene and differentiation in neuroblastoma.
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MYCN oncoprotein targets and their therapeutic potential.
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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J Biol Chem 282:12503-16 (2007)
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Fusion oncogenes in tumor development.
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
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Cancer Res 69:7140-50 (2009)
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Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression.
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Int J Cancer 115:556-60 (2005)
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Oncogene 28:270-8 (2009)
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Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Cancer Lett 270:10-8 (2008)
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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PMID:17101797
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
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PMID:19472090
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Expression of MET in alveolar soft part sarcoma.
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Med Oncol 27:459-65 (2010)
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Genes Cancer 2:466-74 (2011)
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
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Related
pathway
mcf04115  p53 signaling pathway
mcf05211  Renal cell carcinoma
mcf05215  Prostate cancer
mcf05216  Thyroid cancer
mcf05221  Acute myeloid leukemia
KO pathway
ko05202   

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