KEGG   PATHWAY: one00310
Entry
one00310                    Pathway                                
Name
Lysine degradation - Oncorhynchus nerka (sockeye salmon)
Class
Metabolism; Amino acid metabolism
Pathway map
one00310  Lysine degradation
one00310

Module
one_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:one00310]
Other DBs
GO: 0006554
Organism
Oncorhynchus nerka (sockeye salmon) [GN:one]
Gene
115101199  [KO:K11426] [EC:2.1.1.354 2.1.1.357]
115101297  tmlhe; trimethyllysine dioxygenase, mitochondrial isoform X1 [KO:K00474] [EC:1.14.11.8]
115101452  [KO:K14959] [EC:2.1.1.354]
115101596  [KO:K11703] [EC:2.4.1.50]
115102224  [KO:K11419] [EC:2.1.1.355]
115102563  [KO:K00128] [EC:1.2.1.3]
115102572  kmt2d; histone-lysine N-methyltransferase 2D [KO:K09187] [EC:2.1.1.354]
115102664  [KO:K00128] [EC:1.2.1.3]
115103015  [KO:K09188] [EC:2.1.1.354]
115103999  [KO:K11703] [EC:2.4.1.50]
115104148  [KO:K17451] [EC:2.1.1.356]
115104488  [KO:K09188] [EC:2.1.1.354]
115105003  ezh2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
115105497  [KO:K15588] [EC:2.1.1.357]
115105818  [KO:K11422] [EC:2.1.1.354]
115105910  kmt5a; N-lysine methyltransferase KMT5A isoform X1 [KO:K11428] [EC:2.1.1.361]
115106814  [KO:K00128] [EC:1.2.1.3]
115108316  [KO:K11427] [EC:2.1.1.360]
115108364  [KO:K11703] [EC:2.4.1.50]
115108629  aldh9a1; 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
115109021  hykk; hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
115109400  [KO:K11429] [EC:2.1.1.362]
115109716  [KO:K15791] [EC:1.2.4.-]
115110049  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
115110086  [KO:K11703] [EC:2.4.1.50]
115110290  [KO:K17451] [EC:2.1.1.356]
115110447  [KO:K00252] [EC:1.3.8.6]
115110747  [KO:K11429] [EC:2.1.1.362]
115110761  [KO:K11422] [EC:2.1.1.354]
115110921  [KO:K11429] [EC:2.1.1.362]
115111191  [KO:K11422] [EC:2.1.1.354]
115111441  [KO:K11420] [EC:2.1.1.355]
115111631  [KO:K11428] [EC:2.1.1.361]
115111712  [KO:K11425] [EC:2.1.1.370 2.1.1.371]
115112017  prdm6; putative histone-lysine N-methyltransferase PRDM6 isoform X1 [KO:K20795] [EC:2.1.1.361]
115112061  [KO:K00471] [EC:1.14.11.1]
115113476  [KO:K00471] [EC:1.14.11.1]
115113782  [KO:K11421] [EC:2.1.1.366]
115114491  [KO:K09188] [EC:2.1.1.354]
115114631  [KO:K00149] [EC:1.2.1.47 1.2.1.3]
115115571  [KO:K11423] [EC:2.1.1.359]
115115615  [KO:K11429] [EC:2.1.1.362]
115116302  [KO:K11430] [EC:2.1.1.356]
115117565  [KO:K11432] [EC:2.1.1.355]
115117608  [KO:K00252] [EC:1.3.8.6]
115118053  [KO:K20796] [EC:2.1.1.354]
115118459  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
115119422  [KO:K11703] [EC:2.4.1.50]
115120485  [KO:K15588] [EC:2.1.1.357]
115120562  [KO:K22410] [EC:2.1.1.367]
115121181  [KO:K20796] [EC:2.1.1.354]
115121652  [KO:K11420] [EC:2.1.1.355]
115121742  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
115123272  [KO:K11426] [EC:2.1.1.354 2.1.1.357]
115123402  [KO:K18494] [EC:2.1.1.355]
115123820  [KO:K11421] [EC:2.1.1.366]
115124051  [KO:K20796] [EC:2.1.1.354]
115124052  [KO:K20796] [EC:2.1.1.354]
115124511  [KO:K13645] [EC:1.14.11.4]
115124735  setd1b; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase SETD1B [KO:K11422] [EC:2.1.1.354]
115124881  [KO:K00128] [EC:1.2.1.3]
115125326  [KO:K00128] [EC:1.2.1.3]
115126209  [KO:K11424] [EC:2.1.1.357]
115126486  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
115127516  [KO:K11703] [EC:2.4.1.50]
115127850  [KO:K11428] [EC:2.1.1.361]
115128210  [KO:K06101] [EC:2.1.1.354]
115128219  [KO:K11421] [EC:2.1.1.366]
115128277  [KO:K14959] [EC:2.1.1.354]
115128285  [KO:K11420] [EC:2.1.1.355]
115129191  [KO:K15588] [EC:2.1.1.357]
115129275  [KO:K00128] [EC:1.2.1.3]
115130171  [KO:K09188] [EC:2.1.1.354]
115130512  phykpl; 5-phosphohydroxy-L-lysine phospho-lyase isoform X1 [KO:K18202] [EC:4.2.3.134]
115130681  setd7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
115131723  [KO:K11420] [EC:2.1.1.355]
115131772  [KO:K06101] [EC:2.1.1.354]
115131800  [KO:K14959] [EC:2.1.1.354]
115132021  [KO:K11419] [EC:2.1.1.355]
115132052  prdm16; histone-lysine N-methyltransferase PRDM16 isoform X1 [KO:K22410] [EC:2.1.1.367]
115132054  plod1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform X1 [KO:K00473] [EC:1.14.11.4]
115132107  [KO:K11432] [EC:2.1.1.355]
115132329  [KO:K11419] [EC:2.1.1.355]
115132488  [KO:K09187] [EC:2.1.1.354]
115132988  [KO:K09189] [EC:2.1.1.354]
115133410  aadat; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [KO:K00825] [EC:2.6.1.7 2.6.1.39]
115133925  [KO:K15791] [EC:1.2.4.-]
115134271  [KO:K11429] [EC:2.1.1.362]
115134466  [KO:K00382] [EC:1.8.1.4]
115135357  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
115135673  [KO:K00474] [EC:1.14.11.8]
115135873  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
115135948  [KO:K15588] [EC:2.1.1.357]
115136683  [KO:K11432] [EC:2.1.1.355]
115136895  [KO:K04462] [EC:2.1.1.367]
115137115  [KO:K09186] [EC:2.1.1.354]
115138342  smyd3; histone-lysine N-methyltransferase SMYD3 isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
115138501  [KO:K00658] [EC:2.3.1.61]
115138738  [KO:K07515] [EC:4.2.1.17 1.1.1.211]
115139140  [KO:K00658] [EC:2.3.1.61]
115139304  smyd2; N-lysine methyltransferase SMYD2 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
115139309  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
115140198  [KO:K11425] [EC:2.1.1.370 2.1.1.371]
115140308  [KO:K11426] [EC:2.1.1.354 2.1.1.357]
115140822  [KO:K14959] [EC:2.1.1.354]
115141498  [KO:K09186] [EC:2.1.1.354]
115141695  [KO:K04462] [EC:2.1.1.367]
115141925  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
115143395  [KO:K11433] [EC:2.1.1.357]
115144283  [KO:K20796] [EC:2.1.1.354]
115144356  camkmt; calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
115144791  [KO:K14157] [EC:1.5.1.8 1.5.1.9]
115144793  [KO:K00382] [EC:1.8.1.4]
115144895  [KO:K11427] [EC:2.1.1.360]
115144941  [KO:K11703] [EC:2.4.1.50]
115145942  [KO:K07515] [EC:4.2.1.17 1.1.1.211]
115146233  [KO:K00658] [EC:2.3.1.61]
115147148  [KO:K11420] [EC:2.1.1.355]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
one00020  Citrate cycle (TCA cycle)
one00780  Biotin metabolism
KO pathway
ko00310   

DBGET integrated database retrieval system