KEGG   PATHWAY: acun05132
Entry
acun05132                   Pathway                                
Name
Salmonella infection - Athene cunicularia (burrowing owl)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
acun05132  Salmonella infection
acun05132

Organism
Athene cunicularia (burrowing owl) [GN:acun]
Gene
113491322  PODXL; podocalyxin isoform X1 [KO:K06817]
113482598  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
113476514  RAB5A; ras-related protein Rab-5A [KO:K07887]
113489175  RAB5C; ras-related protein Rab-5C [KO:K07889]
113489677  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
113484813  RAB7A; ras-related protein Rab-7a [KO:K07897]
113489212  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
113488602  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
113490539  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
113480650  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
113486149  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
113480783  VPS39; vam6/Vps39-like protein [KO:K20183]
113477537  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
113487331  RILP; rab-interacting lysosomal protein [KO:K13883]
113480917  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
113477551  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
113482422  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
113477094  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
113484259  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
113476395  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
113477770  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
113487184  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
113486066  dynein light chain 1, cytoplasmic [KO:K10418]
113486067  dynein light chain 1, cytoplasmic-like [KO:K10418]
113487430  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
113484515  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
113484391  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
113477866  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
113489586  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
113485065  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
113485907  DCTN5; dynactin subunit 5 [KO:K10427]
113479650  DCTN6; dynactin subunit 6 [KO:K10428]
113476863  dynactin subunit 6-like [KO:K10428]
113481393  ACTR1A; alpha-centractin [KO:K16575]
113480516  ACTR10; actin-related protein 10 [KO:K16576]
113483531  tubulin alpha-3 chain [KO:K07374]
113488980  tubulin alpha-8 chain [KO:K07374]
113481974  tubulin alpha-5 chain-like [KO:K07374]
113481975  tubulin alpha-5 chain [KO:K07374]
113487814  tubulin alpha-3 chain [KO:K07374]
113487816  tubulin alpha-3 chain-like [KO:K07374]
113491097  TUBA8; tubulin alpha-8 chain [KO:K07374]
113487546  TUBB1; tubulin beta-1 chain [KO:K07375]
113490939  tubulin beta chain isoform X1 [KO:K07375]
113486443  TUBB4B; tubulin beta-4B chain [KO:K07375]
113477199  TUBB6; tubulin beta-6 chain [KO:K07375]
113476300  tubulin beta-2 chain [KO:K07375]
113476258  FYCO1; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
113491233  ADP-ribosylation factor-like protein 8B-A [KO:K07955]
113488960  ARL8A; ADP-ribosylation factor-like protein 8A [KO:K07955]
113484812  ARL8B; ADP-ribosylation factor-like protein 8B [KO:K07955]
113487822  PLEKHM2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
113482170  KIF5C; kinesin heavy chain [KO:K10396]
113476642  KIF5B; kinesin-1 heavy chain [KO:K10396]
113477707  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
113480802  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
113477961  ACBD3; Golgi resident protein GCP60 [KO:K23935]
113485019  RHOA; transforming protein RhoA [KO:K04513]
113491072  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
113491307  RAB9A; ras-related protein Rab-9A [KO:K07899]
113479937  RAB9B; ras-related protein Rab-9B [KO:K07900]
113476205  GCC2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
113477950  PFN3; LOW QUALITY PROTEIN: profilin-3 [KO:K05759]
113483406  PFN2; profilin-2 [KO:K05759]
113486852  EXOC7; exocyst complex component 7 isoform X1 [KO:K07195]
113480609  EXOC5; exocyst complex component 5 [KO:K19984]
113491431  EXOC4; exocyst complex component 4 [KO:K06111]
113476784  EXOC2; exocyst complex component 2 [KO:K17637]
113477514  RALA; ras-related protein Ral-A [KO:K07834]
113483859  actin, cytoplasmic type 5 [KO:K05692]
113485595  ACTB; actin, cytoplasmic 1 [KO:K05692]
113484112  ANXA2; annexin A2 [KO:K17092]
113480415  AHNAK2; protein AHNAK2 [KO:K23934]
113490635  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
113480594  RHOJ; rho-related GTP-binding protein RhoJ [KO:K07864]
113483227  ARHGEF26; rho guanine nucleotide exchange factor 26 [KO:K13744]
113479888  RHOG; rho-related GTP-binding protein RhoG [KO:K07863]
113477532  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
113487693  ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
113477643  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
113486078  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
113490665  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
113487097  MYL10; myosin regulatory light chain 10 [KO:K12756]
113476325  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
113476326  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
113484489  FHOD1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
113487836  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
113485871  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113482076  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
113476269  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
113485074  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
113476461  ABI1; abl interactor 1 [KO:K23649]
113479945  wiskott-Aldrich syndrome protein family member 3-like isoform X1 [KO:K06083]
113479757  WASF3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
113478064  ACTR2; actin-related protein 2 [KO:K17260]
113477058  ACTR3B; actin-related protein 3B [KO:K18584]
113482250  ACTR3; actin-related protein 3 [KO:K18584]
113485601  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
113485470  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
113482136  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
113486169  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
113482921  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
113482214  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
113479919  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
113478216  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
113487938  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113483286  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113483483  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
113490925  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
113488343  PIK3C2G; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
113488786  PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
113481213  PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923] [EC:2.7.1.154]
113485753  CYTH3; cytohesin-3 [KO:K18441]
113487931  CYTH4; LOW QUALITY PROTEIN: cytohesin-4 [KO:K18441]
113480759  ARF6; ADP-ribosylation factor 6 [KO:K07941]
113476357  ARF1; ADP-ribosylation factor 1 [KO:K07937]
113484152  SNX33; sorting nexin-33 [KO:K17923]
113489775  SNX18; sorting nexin-18 [KO:K17923]
113478446  SNX9; sorting nexin-9 isoform X1 [KO:K17923]
113491197  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
113490501  DNM2; dynamin-2 [KO:K23484] [EC:3.6.5.5]
113479337  toll-like receptor 1 [KO:K10169]
113479805  toll-like receptor 2 type-1 [KO:K10159]
113479806  TLR2; toll-like receptor 2 [KO:K10159]
113488468  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
113476914  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
113486459  TLR4; LOW QUALITY PROTEIN: toll-like receptor 4 [KO:K10160]
113476923  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
113477685  TLR5; toll-like receptor 5 [KO:K10168]
113475900  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
113481145  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113478050  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
113487745  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
113478283  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
113480051  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
113481883  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
113488090  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113480478  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
113479867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113476945  NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
113480494  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
113477670  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
113488626  HSP90B1; endoplasmin [KO:K09487]
113476158  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
113484502  receptor-interacting serine/threonine-protein kinase 2-like isoform X1 [KO:K08846] [EC:2.7.11.1]
113487470  CSE1L; exportin-2 [KO:K18423]
113486715  KPNA1; importin subunit alpha-5 [KO:K23940]
113483277  KPNA4; importin subunit alpha-3 [KO:K23583]
113480129  KPNA3; importin subunit alpha-4 [KO:K23583]
113477379  RPS3; 40S ribosomal protein S3 [KO:K02985]
113481169  HRAS; GTPase HRas [KO:K02833]
113484728  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113484193  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113489457  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113486052  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113485588  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
113486793  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
113491236  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
113491286  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
113488967  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
113488974  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
113486906  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
113485089  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113481395  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113479790  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113480870  FOS; proto-oncogene c-Fos [KO:K04379]
113482645  JUN; transcription factor AP-1 [KO:K04448]
113488139  interleukin-1 beta-like [KO:K04519]
113476314  IL6; interleukin-6 [KO:K05405]
113479570  interleukin-8-like [KO:K10030]
113479571  interleukin-8-like [KO:K10030]
113479572  interleukin-8-like [KO:K10030]
113476513  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
113485114  TCF7; transcription factor 7 [KO:K02620]
113481635  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
113479673  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
113476188  MYC; myc proto-oncogene protein [KO:K04377]
113483941  FBXO22; F-box only protein 22 [KO:K10302]
113485113  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
113480530  LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
113486502  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
113484484  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
113491430  inhibitor of apoptosis protein [KO:K16060]
113477033  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
113479368  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
113483422  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
113488038  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
113481356  FADD; FAS-associated death domain protein [KO:K02373]
113482526  caspase-8-like [KO:K04398] [EC:3.4.22.61]
113482527  caspase-8-like [KO:K04398] [EC:3.4.22.61]
113489021  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
113476288  cytochrome c [KO:K08738]
113476058  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
113479376  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
113481788  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
113490234  caspase-3-like [KO:K04397] [EC:3.4.22.60]
113478531  RHOB; rho-related GTP-binding protein RhoB [KO:K07856]
113479279  RHOH; rho-related GTP-binding protein RhoH [KO:K07873]
113477826  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113490822  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113480539  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113484312  MLKL; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
113491413  TXN2; thioredoxin, mitochondrial [KO:K03671]
113490229  TXN; thioredoxin [KO:K03671]
113480957  NLRP6; LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6 [KO:K12800]
113490195  NAIP; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1 [KO:K12807]
113487354  caspase-1-like [KO:K01370] [EC:3.4.22.36]
113488534  IL18; interleukin-18 [KO:K05482]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
acun04010  MAPK signaling pathway
acun04210  Apoptosis
acun04217  Necroptosis
acun04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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