KEGG   PATHWAY: arut04622
Entry
arut04622                   Pathway                                
Name
RIG-I-like receptor signaling pathway - Acipenser ruthenus (sterlet)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
arut04622  RIG-I-like receptor signaling pathway
arut04622

Organism
Acipenser ruthenus (sterlet) [GN:arut]
Gene
117403785  antiviral innate immune response receptor RIG-I-like [KO:K12646] [EC:5.6.2.6]
117970430  antiviral innate immune response receptor RIG-I-like [KO:K12646] [EC:5.6.2.6]
117409459  antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
117403804  antiviral innate immune response receptor RIG-I-like isoform X1 [KO:K12646] [EC:5.6.2.6]
117406696  LOW QUALITY PROTEIN: interferon-induced helicase C domain-containing protein 1-like [KO:K12647] [EC:5.6.2.6]
117426630  ifih1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
117394723  NFX1-type zinc finger-containing protein 1-like [KO:K27391]
117422257  LOW QUALITY PROTEIN: NFX1-type zinc finger-containing protein 1-like [KO:K27391]
117400386  NFX1-type zinc finger-containing protein 1-like [KO:K27391]
117408411  uncharacterized protein LOC117408411 isoform X1 [KO:K12648]
117420902  anther-specific proline-rich protein APG-like [KO:K12648]
117433262  probable ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:5.6.2.6]
117434584  dhx58; probable ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:5.6.2.6]
117962601  TNF receptor-associated factor 3-like isoform X1 [KO:K03174]
117410328  TNF receptor-associated factor 3-like isoform X2 [KO:K03174]
117426382  TRAF family member-associated NF-kappa-B activator-like isoform X1 [KO:K12650]
117403412  tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
117399259  5-azacytidine-induced protein 2-like [KO:K12651]
117435525  5-azacytidine-induced protein 2-like [KO:K12651]
117433286  LOW QUALITY PROTEIN: TANK-binding kinase 1-binding protein 1-like [KO:K12652]
117434715  TANK-binding kinase 1-binding protein 1-like [KO:K12652]
117962689  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
117404249  NF-kappa-B essential modulator [KO:K07210]
117401606  NF-kappa-B essential modulator-like [KO:K07210]
117419798  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
117397675  inhibitor of nuclear factor kappa-B kinase subunit epsilon-like [KO:K07211] [EC:2.7.11.10]
117431931  inhibitor of nuclear factor kappa-B kinase subunit epsilon-like [KO:K07211] [EC:2.7.11.10]
117435108  interferon regulatory factor 3-like [KO:K09447]
117432304  interferon regulatory factor 7-like [KO:K09447]
117969715  interferon alpha-1-like [KO:K05414]
117434868  interferon a3-like [KO:K05414]
117969716  interferon a3-like [KO:K05414]
117434859  interferon a3-like [KO:K05414]
117969717  interferon alpha-1-like [KO:K05414]
117964166  interferon alpha-1-like [KO:K05414]
117434834  interferon a3-like [KO:K05414]
117434857  interferon a3-like [KO:K05414]
117964173  interferon a3-like [KO:K05414]
117434482  interferon alpha-1-like [KO:K05414]
117434484  interferon alpha-1-like [KO:K05414]
117434485  interferon alpha-1-like [KO:K05414]
117434486  interferon a3-like [KO:K05414]
117434487  interferon a3-like [KO:K05414]
117434490  interferon a3-like [KO:K05414]
117434491  interferon beta-like [KO:K05414]
117434609  interferon a3-like [KO:K05414]
117434872  interferon a3-like [KO:K05414]
117425088  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
117424274  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
117435159  FAS-associated death domain protein-like [KO:K02373]
117431917  fadd; FAS-associated death domain protein [KO:K02373]
117394623  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
117426878  LOW QUALITY PROTEIN: caspase-8-like [KO:K04398] [EC:3.4.22.61]
117426351  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117408587  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117426603  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117414260  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117426544  caspase-8-like isoform X1 [KO:K04400] [EC:3.4.22.63]
117408574  caspase-8-like isoform X1 [KO:K04400] [EC:3.4.22.63]
117416037  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
117397678  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117421916  NF-kappa-B inhibitor alpha-like [KO:K04734]
117404215  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
117408542  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
117421210  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
117962714  putative transcription factor p65 homolog isoform X1 [KO:K04735]
117967842  putative transcription factor p65 homolog [KO:K04735]
117398684  putative transcription factor p65 homolog isoform X1 [KO:K04735]
117962289  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117962309  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117396690  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
117396934  TNF receptor-associated factor 2-like isoform X2 [KO:K03173] [EC:2.3.2.27]
117411069  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117402843  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
117435117  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
117432247  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
117963658  mitogen-activated protein kinase kinase kinase 1-like isoform X1 [KO:K04416] [EC:2.7.11.25]
117425788  mitogen-activated protein kinase kinase kinase 1 isoform X3 [KO:K04416] [EC:2.7.11.25]
117409061  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117415548  LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117962527  mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
117418084  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117431535  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
117413208  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117414718  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
117973539  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
117414715  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117413780  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
117428934  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117430486  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117419844  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
117411959  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
117963411  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
117973747  interleukin-8-like [KO:K10030]
117974153  LOW QUALITY PROTEIN: interleukin-8-like [KO:K10030]
117970472  interleukin-8-like [KO:K10030]
117408798  interleukin-8-like [KO:K10030]
117408799  interleukin-8-like [KO:K10030]
117408800  interleukin-8-like [KO:K10030]
117409670  interleukin-8-like [KO:K10030]
117420409  interleukin-8-like isoform X1 [KO:K10030]
117420439  interleukin-8-like [KO:K10030]
117420440  interleukin-8-like [KO:K10030]
117421434  interleukin-8-like [KO:K10030]
117421523  interleukin-8-like [KO:K10030]
117421524  interleukin-8-like [KO:K10030]
117965004  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
117433977  lymphotoxin-alpha-like isoform X1 [KO:K03156]
117433981  tumor necrosis factor-like [KO:K03156]
117416699  interleukin-12 subunit alpha-like [KO:K05406]
117423220  interleukin-12 subunit alpha-like [KO:K05406]
117431159  interleukin-12 subunit beta-like [KO:K05425]
117412916  interleukin-12 subunit beta-like [KO:K05425]
117403858  si:dkey-88e18.2; interleukin-12 subunit beta [KO:K05425]
117403924  C-X-C motif chemokine 10-like [KO:K12671]
117973779  C-X-C motif chemokine 11-1-like [KO:K12671]
117973867  C-X-C motif chemokine 10-like [KO:K12671]
117403528  C-X-C motif chemokine 10-like [KO:K12671]
117403669  C-X-C motif chemokine 10-like [KO:K12671]
117403926  C-X-C motif chemokine 10-like [KO:K12671]
117403941  C-X-C motif chemokine 10-like [KO:K12671]
117403942  C-X-C motif chemokine 11-1-like [KO:K12671]
117969533  tripartite motif-containing protein 16-like [KO:K10652] [EC:2.3.2.27]
117969855  tripartite motif-containing protein 15-like [KO:K10652] [EC:2.3.2.27]
117424516  E3 ubiquitin-protein ligase RNF135-like [KO:K10652] [EC:2.3.2.27]
117424591  E3 ubiquitin/ISG15 ligase TRIM25-like isoform X1 [KO:K10652] [EC:2.3.2.27]
117964433  E3 ubiquitin/ISG15 ligase TRIM25-like [KO:K10652] [EC:2.3.2.27]
117426251  tripartite motif-containing protein 16-like [KO:K10652] [EC:2.3.2.27]
117423023  E3 ubiquitin/ISG15 ligase TRIM25-like isoform X1 [KO:K10652] [EC:2.3.2.27]
117423237  E3 ubiquitin-protein ligase RNF135-like [KO:K10652] [EC:2.3.2.27]
117395027  E3 ubiquitin/ISG15 ligase TRIM25-like [KO:K10652] [EC:2.3.2.27]
117434063  E3 ubiquitin-protein ligase TRIM39-like [KO:K10652] [EC:2.3.2.27]
117428168  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
117403925  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
117424568  cylda; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
117398846  si:cabz01101003.1; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
117425677  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
117400424  cyldl; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
117403419  autophagy protein 5-like [KO:K08339]
117410566  autophagy protein 5 isoform X1 [KO:K08339]
117968888  ubiquitin-like protein ATG12 [KO:K08336]
117966793  ubiquitin-like protein ATG12 [KO:K08336]
117410198  ubiquitin-like protein ATG12 [KO:K08336]
117397214  NLR family member X1 [KO:K12653]
117966541  LOW QUALITY PROTEIN: NLR family member X1-like [KO:K12653]
117431195  stimulator of interferon genes protein-like [KO:K12654]
117413138  sting1; stimulator of interferon genes protein isoform X1 [KO:K12654]
117404184  otud5a; OTU domain-containing protein 5-A isoform X1 [KO:K12655] [EC:3.4.19.12]
117962399  suppressor of IKBKE 1-like [KO:K12656]
117428028  suppressor of IKBKE 1 [KO:K12656]
117406451  putative ATP-dependent RNA helicase an3 isoform X1 [KO:K11594] [EC:5.6.2.7]
117405460  putative ATP-dependent RNA helicase an3 isoform X1 [KO:K11594] [EC:5.6.2.7]
117402007  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
117965631  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1-like [KO:K09578] [EC:5.2.1.8]
117432065  tkfc; triokinase/FMN cyclase isoform X1 [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
Compound
C00046  RNA
Reference
PMID:15208624
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:19120475
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
PMID:19539500
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
PMID:18549796
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
PMID:19615405
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
PMID:19120476
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
PMID:18591413
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
PMID:19076341
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
PMID:18439848
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
PMID:18984593
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
PMID:19224920
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Reference
PMID:32668226
  Authors
Liu G, Gack MU
  Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
  Journal
Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017
Related
pathway
arut04010  MAPK signaling pathway
arut04120  Ubiquitin mediated proteolysis
arut04210  Apoptosis
KO pathway
ko04622   
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